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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ARHGEF14
Full Name:
Guanine nucleotide exchange factor DBS
Alias:
DBL's big sister; DBS; KIAA0362; MCF.2 cell line derived transforming sequence-like; MCF2L; MCF2-transforming sequence-like protein; OST
Type:
Guanine nucleotide exchange factor, Rac/Rho
Mass (Da):
128110
Number AA:
UniProt ID:
O15068
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005739
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0005089
PhosphoSite+
KinaseNET
Biological Process:
GO:0006915
GO:0008624
GO:0007242
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S15
I
L
C
K
R
P
G
S
N
S
Y
S
S
P
Q
Site 2
S17
C
K
R
P
G
S
N
S
Y
S
S
P
Q
R
P
Site 3
Y18
K
R
P
G
S
N
S
Y
S
S
P
Q
R
P
N
Site 4
S19
R
P
G
S
N
S
Y
S
S
P
Q
R
P
N
E
Site 5
S20
P
G
S
N
S
Y
S
S
P
Q
R
P
N
E
A
Site 6
S39
T
D
H
Q
I
D
V
S
D
V
I
R
L
V
Q
Site 7
Y82
Q
L
K
K
R
F
A
Y
L
S
G
G
R
G
Q
Site 8
S84
K
K
R
F
A
Y
L
S
G
G
R
G
Q
D
G
Site 9
S92
G
G
R
G
Q
D
G
S
P
V
I
T
F
P
D
Site 10
T96
Q
D
G
S
P
V
I
T
F
P
D
Y
P
A
F
Site 11
S104
F
P
D
Y
P
A
F
S
E
I
P
D
K
E
F
Site 12
T119
Q
N
V
M
T
Y
L
T
S
I
P
S
L
Q
D
Site 13
T143
D
R
R
R
D
K
W
T
S
V
K
A
S
V
L
Site 14
S144
R
R
R
D
K
W
T
S
V
K
A
S
V
L
R
Site 15
T175
P
T
G
F
F
Q
R
T
L
S
D
I
A
F
K
Site 16
S177
G
F
F
Q
R
T
L
S
D
I
A
F
K
F
N
Site 17
Y206
S
V
P
D
L
H
G
Y
I
D
K
S
Q
L
T
Site 18
S210
L
H
G
Y
I
D
K
S
Q
L
T
E
D
L
G
Site 19
Y222
D
L
G
G
T
L
D
Y
C
H
S
R
W
L
C
Site 20
T232
S
R
W
L
C
Q
R
T
A
I
E
S
F
A
L
Site 21
S250
Q
T
A
Q
M
L
Q
S
F
G
T
E
L
A
E
Site 22
T258
F
G
T
E
L
A
E
T
E
L
P
N
D
V
Q
Site 23
S266
E
L
P
N
D
V
Q
S
T
S
S
V
L
C
A
Site 24
S268
P
N
D
V
Q
S
T
S
S
V
L
C
A
H
T
Site 25
S269
N
D
V
Q
S
T
S
S
V
L
C
A
H
T
E
Site 26
S294
L
A
L
K
E
G
H
S
V
L
E
S
L
R
E
Site 27
S298
E
G
H
S
V
L
E
S
L
R
E
L
Q
A
E
Site 28
S307
R
E
L
Q
A
E
G
S
E
P
S
V
N
Q
D
Site 29
T321
D
Q
L
D
N
Q
A
T
V
Q
R
L
L
A
Q
Site 30
S371
K
A
I
L
D
A
A
S
Q
K
I
A
T
F
T
Site 31
T376
A
A
S
Q
K
I
A
T
F
T
D
I
G
N
S
Site 32
T378
S
Q
K
I
A
T
F
T
D
I
G
N
S
L
A
Site 33
S396
H
L
L
R
D
L
A
S
F
E
E
K
S
G
V
Site 34
S412
V
E
R
A
R
A
L
S
L
D
G
E
Q
L
I
Site 35
Y424
Q
L
I
G
N
K
H
Y
A
V
D
S
I
R
P
Site 36
S444
R
H
L
C
D
Q
F
S
A
E
I
A
R
R
R
Site 37
S455
A
R
R
R
G
L
L
S
K
S
L
E
L
H
R
Site 38
S457
R
R
G
L
L
S
K
S
L
E
L
H
R
R
L
Site 39
T466
E
L
H
R
R
L
E
T
S
M
K
W
C
D
E
Site 40
Y476
K
W
C
D
E
G
I
Y
L
L
A
S
Q
P
V
Site 41
S480
E
G
I
Y
L
L
A
S
Q
P
V
D
K
C
Q
Site 42
S488
Q
P
V
D
K
C
Q
S
Q
D
G
A
E
A
A
Site 43
Y518
I
Q
E
L
N
A
I
Y
K
E
Y
E
S
I
L
Site 44
S542
K
V
F
Q
K
Q
A
S
M
E
E
V
F
H
R
Site 45
S553
V
F
H
R
R
Q
A
S
L
K
K
L
A
A
R
Site 46
T562
K
K
L
A
A
R
Q
T
R
P
V
Q
P
V
A
Site 47
S578
R
P
E
A
L
A
K
S
P
C
P
S
P
G
I
Site 48
S582
L
A
K
S
P
C
P
S
P
G
I
R
R
G
S
Site 49
S589
S
P
G
I
R
R
G
S
E
N
S
S
S
E
G
Site 50
S592
I
R
R
G
S
E
N
S
S
S
E
G
G
A
L
Site 51
S593
R
R
G
S
E
N
S
S
S
E
G
G
A
L
R
Site 52
S594
R
G
S
E
N
S
S
S
E
G
G
A
L
R
R
Site 53
Y604
G
A
L
R
R
G
P
Y
R
R
A
K
S
E
M
Site 54
S609
G
P
Y
R
R
A
K
S
E
M
S
E
S
R
Q
Site 55
S612
R
R
A
K
S
E
M
S
E
S
R
Q
G
R
G
Site 56
S614
A
K
S
E
M
S
E
S
R
Q
G
R
G
S
A
Site 57
S620
E
S
R
Q
G
R
G
S
A
G
E
E
E
E
S
Site 58
S627
S
A
G
E
E
E
E
S
L
A
I
L
R
R
H
Site 59
S637
I
L
R
R
H
V
M
S
E
L
L
D
T
E
R
Site 60
T642
V
M
S
E
L
L
D
T
E
R
A
Y
V
E
E
Site 61
Y703
F
L
R
E
L
E
N
Y
T
D
C
P
E
L
V
Site 62
T704
L
R
E
L
E
N
Y
T
D
C
P
E
L
V
G
Site 63
Y724
R
M
E
D
F
Q
I
Y
E
K
Y
C
Q
N
K
Site 64
Y727
D
F
Q
I
Y
E
K
Y
C
Q
N
K
P
R
S
Site 65
S736
Q
N
K
P
R
S
E
S
L
W
R
Q
C
S
D
Site 66
S759
R
K
L
D
H
K
L
S
L
D
S
Y
L
L
K
Site 67
S762
D
H
K
L
S
L
D
S
Y
L
L
K
P
V
Q
Site 68
Y763
H
K
L
S
L
D
S
Y
L
L
K
P
V
Q
R
Site 69
T772
L
K
P
V
Q
R
I
T
K
Y
Q
L
L
L
K
Site 70
Y774
P
V
Q
R
I
T
K
Y
Q
L
L
L
K
E
M
Site 71
Y784
L
L
K
E
M
L
K
Y
S
R
N
C
E
G
A
Site 72
S785
L
K
E
M
L
K
Y
S
R
N
C
E
G
A
E
Site 73
S835
G
K
L
L
M
Q
G
S
F
S
V
W
T
D
H
Site 74
S837
L
L
M
Q
G
S
F
S
V
W
T
D
H
K
R
Site 75
T840
Q
G
S
F
S
V
W
T
D
H
K
R
G
H
T
Site 76
T847
T
D
H
K
R
G
H
T
K
V
K
E
L
A
R
Site 77
Y882
R
E
E
N
G
E
G
Y
E
K
A
P
S
Y
S
Site 78
S887
E
G
Y
E
K
A
P
S
Y
S
Y
K
Q
S
L
Site 79
Y888
G
Y
E
K
A
P
S
Y
S
Y
K
Q
S
L
N
Site 80
S889
Y
E
K
A
P
S
Y
S
Y
K
Q
S
L
N
M
Site 81
S893
P
S
Y
S
Y
K
Q
S
L
N
M
A
A
V
G
Site 82
T902
N
M
A
A
V
G
I
T
E
N
V
K
G
D
A
Site 83
Y916
A
K
K
F
E
I
W
Y
N
A
R
E
E
V
Y
Site 84
S946
E
I
R
K
V
L
T
S
Q
L
Q
A
C
R
E
Site 85
S955
L
Q
A
C
R
E
A
S
Q
H
R
A
L
E
Q
Site 86
S963
Q
H
R
A
L
E
Q
S
Q
S
L
P
L
P
A
Site 87
S965
R
A
L
E
Q
S
Q
S
L
P
L
P
A
P
T
Site 88
S973
L
P
L
P
A
P
T
S
T
S
P
S
R
G
N
Site 89
S975
L
P
A
P
T
S
T
S
P
S
R
G
N
S
R
Site 90
S977
A
P
T
S
T
S
P
S
R
G
N
S
R
N
I
Site 91
S981
T
S
P
S
R
G
N
S
R
N
I
K
K
L
E
Site 92
T992
K
K
L
E
E
R
K
T
D
P
L
S
L
E
G
Site 93
S996
E
R
K
T
D
P
L
S
L
E
G
Y
V
S
S
Site 94
Y1000
D
P
L
S
L
E
G
Y
V
S
S
A
P
L
T
Site 95
S1003
S
L
E
G
Y
V
S
S
A
P
L
T
K
P
P
Site 96
T1007
Y
V
S
S
A
P
L
T
K
P
P
E
K
G
K
Site 97
S1017
P
E
K
G
K
G
W
S
K
T
S
H
S
L
E
Site 98
T1019
K
G
K
G
W
S
K
T
S
H
S
L
E
A
P
Site 99
S1020
G
K
G
W
S
K
T
S
H
S
L
E
A
P
E
Site 100
S1022
G
W
S
K
T
S
H
S
L
E
A
P
E
D
D
Site 101
S1034
E
D
D
G
G
W
S
S
A
E
E
Q
I
N
S
Site 102
S1041
S
A
E
E
Q
I
N
S
S
D
A
E
E
D
G
Site 103
S1042
A
E
E
Q
I
N
S
S
D
A
E
E
D
G
G
Site 104
Y1060
K
K
L
V
P
G
K
Y
T
V
V
A
D
H
E
Site 105
T1061
K
L
V
P
G
K
Y
T
V
V
A
D
H
E
K
Site 106
Y1094
E
G
D
E
G
L
W
Y
V
R
D
P
T
T
G
Site 107
T1099
L
W
Y
V
R
D
P
T
T
G
K
E
G
W
V
Site 108
T1100
W
Y
V
R
D
P
T
T
G
K
E
G
W
V
P
Site 109
S1109
K
E
G
W
V
P
A
S
S
L
S
V
R
L
G
Site 110
S1110
E
G
W
V
P
A
S
S
L
S
V
R
L
G
P
Site 111
S1120
V
R
L
G
P
S
G
S
A
Q
C
L
S
S
S
Site 112
S1125
S
G
S
A
Q
C
L
S
S
S
G
K
A
H
V
Site 113
S1127
S
A
Q
C
L
S
S
S
G
K
A
H
V
P
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation