KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
PFAS
Full Name:
Phosphoribosylformylglycinamidine synthase
Alias:
FGAM synthase; FGAMS; FGAR amidotransferase; FGARAT; Formylglycinamide ribotide amidotransferase; Formylglycinamide ribotide synthetase; KIAA0361; PUR4; PURL
Type:
Ligase; EC 6.3.5.3; Nucleotide Metabolism - purine
Mass (Da):
144724
Number AA:
1338
UniProt ID:
O15067
International Prot ID:
IPI00004534
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004642
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006189
GO:0006541
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y8
M
S
P
V
L
H
F
Y
V
R
P
S
G
H
E
Site 2
S12
L
H
F
Y
V
R
P
S
G
H
E
G
A
A
S
Site 3
S19
S
G
H
E
G
A
A
S
G
H
T
R
R
K
L
Site 4
S53
W
T
A
E
A
L
P
S
A
E
E
T
K
K
L
Site 5
T57
A
L
P
S
A
E
E
T
K
K
L
M
W
L
F
Site 6
S77
L
D
D
V
A
R
E
S
W
L
L
P
G
S
N
Site 7
S83
E
S
W
L
L
P
G
S
N
D
L
L
L
E
V
Site 8
S97
V
G
P
R
L
N
F
S
T
P
T
S
T
N
I
Site 9
T98
G
P
R
L
N
F
S
T
P
T
S
T
N
I
V
Site 10
T102
N
F
S
T
P
T
S
T
N
I
V
S
V
C
R
Site 11
T121
G
P
V
D
R
V
E
T
T
R
R
Y
R
L
S
Site 12
T122
P
V
D
R
V
E
T
T
R
R
Y
R
L
S
F
Site 13
Y125
R
V
E
T
T
R
R
Y
R
L
S
F
A
H
P
Site 14
S128
T
T
R
R
Y
R
L
S
F
A
H
P
P
S
A
Site 15
S160
H
F
P
H
P
I
Q
S
F
S
P
E
S
M
P
Site 16
S162
P
H
P
I
Q
S
F
S
P
E
S
M
P
E
P
Site 17
S165
I
Q
S
F
S
P
E
S
M
P
E
P
L
N
G
Site 18
Y203
D
S
W
D
L
D
F
Y
T
K
R
F
Q
E
L
Site 19
S215
Q
E
L
Q
R
N
P
S
T
V
E
A
F
D
L
Site 20
T216
E
L
Q
R
N
P
S
T
V
E
A
F
D
L
A
Site 21
S225
E
A
F
D
L
A
Q
S
N
S
E
H
S
R
H
Site 22
S249
D
G
Q
K
L
V
H
S
L
F
E
S
I
M
S
Site 23
S253
L
V
H
S
L
F
E
S
I
M
S
T
Q
E
S
Site 24
S256
S
L
F
E
S
I
M
S
T
Q
E
S
S
N
P
Site 25
T257
L
F
E
S
I
M
S
T
Q
E
S
S
N
P
N
Site 26
S260
S
I
M
S
T
Q
E
S
S
N
P
N
N
V
L
Site 27
S274
L
K
F
C
D
N
S
S
A
I
Q
G
K
E
V
Site 28
T290
F
L
R
P
E
D
P
T
R
P
S
R
F
Q
Q
Site 29
S293
P
E
D
P
T
R
P
S
R
F
Q
Q
Q
Q
G
Site 30
T307
G
L
R
H
V
V
F
T
A
E
T
H
N
F
P
Site 31
T325
C
P
F
S
G
A
T
T
G
T
G
G
R
I
R
Site 32
T337
R
I
R
D
V
Q
C
T
G
R
G
A
H
V
V
Site 33
Y360
G
N
L
H
I
P
G
Y
N
L
P
W
E
D
P
Site 34
Y371
W
E
D
P
S
F
Q
Y
P
G
N
F
A
R
P
Site 35
S386
L
E
V
A
I
E
A
S
N
G
A
S
D
Y
G
Site 36
S390
I
E
A
S
N
G
A
S
D
Y
G
N
K
F
G
Site 37
Y392
A
S
N
G
A
S
D
Y
G
N
K
F
G
E
P
Site 38
S439
S
M
E
A
D
H
I
S
K
E
A
P
E
P
G
Site 39
Y457
V
K
V
G
G
P
V
Y
R
I
G
V
G
G
G
Site 40
S467
G
V
G
G
G
A
A
S
S
V
Q
V
Q
G
D
Site 41
S468
V
G
G
G
A
A
S
S
V
Q
V
Q
G
D
N
Site 42
S477
Q
V
Q
G
D
N
T
S
D
L
D
F
G
A
V
Site 43
S513
P
K
G
N
P
I
C
S
L
H
D
Q
G
A
G
Site 44
S530
G
N
V
L
K
E
L
S
D
P
A
G
A
I
I
Site 45
Y538
D
P
A
G
A
I
I
Y
T
S
R
F
Q
L
G
Site 46
T548
R
F
Q
L
G
D
P
T
L
N
A
L
E
I
W
Site 47
S562
W
G
A
E
Y
Q
E
S
N
A
L
L
L
R
S
Site 48
S569
S
N
A
L
L
L
R
S
P
N
R
D
F
L
T
Site 49
T576
S
P
N
R
D
F
L
T
H
V
S
A
R
E
R
Site 50
S579
R
D
F
L
T
H
V
S
A
R
E
R
C
P
A
Site 51
T619
N
Q
G
D
A
P
P
T
P
L
P
T
P
V
D
Site 52
T623
A
P
P
T
P
L
P
T
P
V
D
L
E
L
E
Site 53
S676
L
R
L
P
A
V
A
S
K
R
Y
L
T
N
K
Site 54
T681
V
A
S
K
R
Y
L
T
N
K
V
D
R
S
V
Site 55
S687
L
T
N
K
V
D
R
S
V
G
G
L
V
A
Q
Site 56
S732
L
G
E
Q
P
V
K
S
L
L
D
P
K
V
A
Site 57
S805
A
V
D
G
G
K
D
S
L
S
M
A
A
R
V
Site 58
S807
D
G
G
K
D
S
L
S
M
A
A
R
V
G
T
Site 59
T814
S
M
A
A
R
V
G
T
E
T
V
R
A
P
G
Site 60
T816
A
A
R
V
G
T
E
T
V
R
A
P
G
S
L
Site 61
T839
P
D
I
T
A
T
V
T
P
D
L
K
H
P
E
Site 62
Y853
E
G
R
G
H
L
L
Y
V
A
L
S
P
G
Q
Site 63
S873
T
A
L
A
Q
C
F
S
Q
L
G
E
H
P
P
Site 64
S906
L
K
D
R
L
L
C
S
G
H
D
V
S
D
G
Site 65
Y968
L
A
Q
V
L
K
R
Y
R
D
A
G
L
H
C
Site 66
T981
H
C
L
E
L
G
H
T
G
E
A
G
P
H
A
Site 67
S1015
R
A
L
W
E
E
T
S
F
Q
L
D
R
L
Q
Site 68
S1042
L
R
E
R
M
G
P
S
Y
C
L
P
P
T
F
Site 69
Y1043
R
E
R
M
G
P
S
Y
C
L
P
P
T
F
P
Site 70
T1048
P
S
Y
C
L
P
P
T
F
P
K
A
S
V
P
Site 71
S1053
P
P
T
F
P
K
A
S
V
P
R
E
P
G
G
Site 72
S1062
P
R
E
P
G
G
P
S
P
R
V
A
I
L
R
Site 73
Y1119
A
F
V
G
G
F
S
Y
A
D
V
L
G
S
A
Site 74
T1134
K
G
W
A
A
A
V
T
F
H
P
R
A
G
A
Site 75
T1152
R
F
R
K
R
P
D
T
F
S
L
G
V
C
N
Site 76
S1154
R
K
R
P
D
T
F
S
L
G
V
C
N
G
C
Site 77
S1185
A
A
E
M
G
P
D
S
Q
P
A
R
P
G
L
Site 78
S1199
L
L
L
R
H
N
L
S
G
R
Y
E
S
R
W
Site 79
Y1202
R
H
N
L
S
G
R
Y
E
S
R
W
A
S
V
Site 80
S1204
N
L
S
G
R
Y
E
S
R
W
A
S
V
R
V
Site 81
S1208
R
Y
E
S
R
W
A
S
V
R
V
G
P
G
P
Site 82
Y1237
W
S
A
H
G
E
G
Y
V
A
F
S
S
P
E
Site 83
S1242
E
G
Y
V
A
F
S
S
P
E
L
Q
A
Q
I
Site 84
Y1270
D
G
N
P
T
E
Q
Y
P
L
N
P
N
G
S
Site 85
S1277
Y
P
L
N
P
N
G
S
P
G
G
V
A
G
I
Site 86
T1316
W
R
P
P
P
F
D
T
L
T
T
S
P
W
L
Site 87
T1318
P
P
P
F
D
T
L
T
T
S
P
W
L
Q
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation