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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Nedd4-BP3
Full Name:
NEDD4-binding protein 3
Alias:
KIAA0341; N4B3; N4BP3; Nedd4-binding protein 3
Type:
Unknown function
Mass (Da):
60470
Number AA:
544
UniProt ID:
O15049
International Prot ID:
IPI00004500
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0031410
GO:0019898
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S25
L
L
E
R
Q
D
F
S
P
E
E
L
R
A
A
Site 2
S39
A
L
A
G
S
R
G
S
R
Q
P
D
G
L
L
Site 3
S57
L
G
Q
R
E
F
L
S
Y
L
H
L
P
K
K
Site 4
Y58
G
Q
R
E
F
L
S
Y
L
H
L
P
K
K
D
Site 5
S66
L
H
L
P
K
K
D
S
K
S
T
K
N
T
K
Site 6
S68
L
P
K
K
D
S
K
S
T
K
N
T
K
R
A
Site 7
T72
D
S
K
S
T
K
N
T
K
R
A
P
R
N
E
Site 8
Y83
P
R
N
E
P
A
D
Y
A
T
L
Y
Y
R
E
Site 9
T85
N
E
P
A
D
Y
A
T
L
Y
Y
R
E
H
S
Site 10
Y87
P
A
D
Y
A
T
L
Y
Y
R
E
H
S
R
A
Site 11
Y88
A
D
Y
A
T
L
Y
Y
R
E
H
S
R
A
G
Site 12
S92
T
L
Y
Y
R
E
H
S
R
A
G
D
F
S
K
Site 13
S98
H
S
R
A
G
D
F
S
K
T
S
L
P
E
R
Site 14
T100
R
A
G
D
F
S
K
T
S
L
P
E
R
G
R
Site 15
S101
A
G
D
F
S
K
T
S
L
P
E
R
G
R
F
Site 16
S116
D
K
C
R
I
R
P
S
V
F
K
P
T
A
G
Site 17
S130
G
N
G
K
G
F
L
S
M
Q
S
L
A
S
H
Site 18
S133
K
G
F
L
S
M
Q
S
L
A
S
H
K
G
Q
Site 19
S145
K
G
Q
K
L
W
R
S
N
G
S
L
H
T
L
Site 20
S148
K
L
W
R
S
N
G
S
L
H
T
L
A
C
H
Site 21
T151
R
S
N
G
S
L
H
T
L
A
C
H
P
P
L
Site 22
S159
L
A
C
H
P
P
L
S
P
G
P
R
A
S
Q
Site 23
S165
L
S
P
G
P
R
A
S
Q
A
R
A
Q
L
L
Site 24
S176
A
Q
L
L
H
A
L
S
L
D
E
G
G
P
E
Site 25
S187
G
G
P
E
P
E
P
S
L
S
D
S
S
S
G
Site 26
S189
P
E
P
E
P
S
L
S
D
S
S
S
G
G
S
Site 27
S191
P
E
P
S
L
S
D
S
S
S
G
G
S
F
G
Site 28
S192
E
P
S
L
S
D
S
S
S
G
G
S
F
G
R
Site 29
S193
P
S
L
S
D
S
S
S
G
G
S
F
G
R
S
Site 30
S196
S
D
S
S
S
G
G
S
F
G
R
S
P
G
T
Site 31
S200
S
G
G
S
F
G
R
S
P
G
T
G
P
S
P
Site 32
T203
S
F
G
R
S
P
G
T
G
P
S
P
F
S
S
Site 33
S206
R
S
P
G
T
G
P
S
P
F
S
S
S
L
G
Site 34
S209
G
T
G
P
S
P
F
S
S
S
L
G
H
L
N
Site 35
S210
T
G
P
S
P
F
S
S
S
L
G
H
L
N
H
Site 36
S211
G
P
S
P
F
S
S
S
L
G
H
L
N
H
L
Site 37
S221
H
L
N
H
L
G
G
S
L
D
R
A
S
Q
G
Site 38
S226
G
G
S
L
D
R
A
S
Q
G
P
K
E
A
G
Site 39
Y248
L
P
E
P
P
P
P
Y
E
F
S
C
S
S
A
Site 40
S251
P
P
P
P
Y
E
F
S
C
S
S
A
E
E
M
Site 41
S253
P
P
Y
E
F
S
C
S
S
A
E
E
M
G
A
Site 42
S254
P
Y
E
F
S
C
S
S
A
E
E
M
G
A
V
Site 43
T265
M
G
A
V
L
P
E
T
C
E
E
L
K
R
G
Site 44
S279
G
L
G
D
E
D
G
S
N
P
F
T
Q
V
L
Site 45
T283
E
D
G
S
N
P
F
T
Q
V
L
E
E
R
Q
Site 46
Y301
L
A
E
L
K
R
L
Y
V
E
R
L
H
E
V
Site 47
T309
V
E
R
L
H
E
V
T
Q
K
A
E
R
S
E
Site 48
S315
V
T
Q
K
A
E
R
S
E
R
N
L
Q
L
Q
Site 49
T352
P
E
P
R
A
P
G
T
L
P
E
A
D
P
S
Site 50
S359
T
L
P
E
A
D
P
S
A
R
P
E
E
E
A
Site 51
T374
R
W
E
V
C
Q
K
T
A
E
I
S
L
L
K
Site 52
S400
Q
K
L
A
E
I
F
S
L
K
T
Q
L
R
G
Site 53
T403
A
E
I
F
S
L
K
T
Q
L
R
G
S
R
A
Site 54
S408
L
K
T
Q
L
R
G
S
R
A
Q
A
Q
A
Q
Site 55
S428
R
L
R
E
A
V
R
S
L
Q
E
Q
A
P
R
Site 56
S441
P
R
E
E
A
P
G
S
C
E
T
D
D
C
K
Site 57
S449
C
E
T
D
D
C
K
S
R
G
L
L
G
E
A
Site 58
S459
L
L
G
E
A
G
G
S
E
A
R
D
S
A
E
Site 59
S464
G
G
S
E
A
R
D
S
A
E
Q
L
R
A
E
Site 60
T492
R
F
E
Q
E
R
R
T
W
Q
E
E
K
E
R
Site 61
Y503
E
K
E
R
V
L
R
Y
Q
R
E
I
Q
G
G
Site 62
Y511
Q
R
E
I
Q
G
G
Y
M
D
M
Y
R
R
N
Site 63
Y515
Q
G
G
Y
M
D
M
Y
R
R
N
Q
A
L
E
Site 64
T533
R
A
L
R
E
P
P
T
P
W
S
P
R
L
E
Site 65
S536
R
E
P
P
T
P
W
S
P
R
L
E
S
S
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation