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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SEMA3E
Full Name:
Semaphorin-3E
Alias:
Type:
Mass (Da):
89228
Number AA:
775
UniProt ID:
O15041
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T28
T
G
G
H
T
A
D
T
T
H
P
R
L
R
L
Site 2
T29
G
G
H
T
A
D
T
T
H
P
R
L
R
L
S
Site 3
S36
T
H
P
R
L
R
L
S
H
K
E
L
L
N
L
Site 4
T46
E
L
L
N
L
N
R
T
S
I
F
H
S
P
F
Site 5
S51
N
R
T
S
I
F
H
S
P
F
G
F
L
D
L
Site 6
Y66
H
T
M
L
L
D
E
Y
Q
E
R
L
F
V
G
Site 7
S80
G
G
R
D
L
V
Y
S
L
S
L
E
R
I
S
Site 8
S82
R
D
L
V
Y
S
L
S
L
E
R
I
S
D
G
Site 9
S87
S
L
S
L
E
R
I
S
D
G
Y
K
E
I
H
Site 10
Y90
L
E
R
I
S
D
G
Y
K
E
I
H
W
P
S
Site 11
Y118
D
A
G
E
C
A
N
Y
V
R
V
L
H
H
Y
Site 12
Y125
Y
V
R
V
L
H
H
Y
N
R
T
H
L
L
T
Site 13
T132
Y
N
R
T
H
L
L
T
C
G
T
G
A
F
D
Site 14
S160
D
P
L
F
H
L
E
S
P
R
S
E
R
G
R
Site 15
S163
F
H
L
E
S
P
R
S
E
R
G
R
G
R
C
Site 16
S175
G
R
C
P
F
D
P
S
S
S
F
I
S
T
L
Site 17
Y192
S
E
L
F
A
G
L
Y
S
D
Y
W
S
R
D
Site 18
S193
E
L
F
A
G
L
Y
S
D
Y
W
S
R
D
A
Site 19
Y195
F
A
G
L
Y
S
D
Y
W
S
R
D
A
A
I
Site 20
Y231
E
P
K
F
V
G
S
Y
M
I
P
D
N
E
D
Site 21
Y245
D
R
D
D
N
K
V
Y
F
F
F
T
E
K
A
Site 22
Y263
E
N
N
A
H
A
I
Y
T
R
V
G
R
L
C
Site 23
T304
P
G
M
N
G
I
D
T
Y
F
D
E
L
E
D
Site 24
Y305
G
M
N
G
I
D
T
Y
F
D
E
L
E
D
V
Site 25
T331
V
I
F
G
L
F
N
T
T
S
N
I
F
R
G
Site 26
Y357
R
A
A
F
N
G
P
Y
A
H
K
E
G
P
E
Site 27
Y365
A
H
K
E
G
P
E
Y
H
W
S
V
Y
E
G
Site 28
S368
E
G
P
E
Y
H
W
S
V
Y
E
G
K
V
P
Site 29
Y370
P
E
Y
H
W
S
V
Y
E
G
K
V
P
Y
P
Site 30
Y376
V
Y
E
G
K
V
P
Y
P
R
P
G
S
C
A
Site 31
S381
V
P
Y
P
R
P
G
S
C
A
S
K
V
N
G
Site 32
S384
P
R
P
G
S
C
A
S
K
V
N
G
G
R
Y
Site 33
T393
V
N
G
G
R
Y
G
T
T
K
D
Y
P
D
D
Site 34
Y397
R
Y
G
T
T
K
D
Y
P
D
D
A
I
R
F
Site 35
Y412
A
R
S
H
P
L
M
Y
Q
A
I
K
P
A
H
Site 36
T427
K
K
P
I
L
V
K
T
D
G
K
Y
N
L
K
Site 37
Y431
L
V
K
T
D
G
K
Y
N
L
K
Q
I
A
V
Site 38
S493
K
D
P
V
P
I
I
S
M
E
I
S
S
K
R
Site 39
S497
P
I
I
S
M
E
I
S
S
K
R
Q
Q
L
Y
Site 40
S498
I
I
S
M
E
I
S
S
K
R
Q
Q
L
Y
I
Site 41
Y504
S
S
K
R
Q
Q
L
Y
I
G
S
A
S
A
V
Site 42
S509
Q
L
Y
I
G
S
A
S
A
V
A
Q
V
R
F
Site 43
Y547
D
G
I
S
C
S
R
Y
Y
P
T
G
T
H
A
Site 44
Y548
G
I
S
C
S
R
Y
Y
P
T
G
T
H
A
K
Site 45
T552
S
R
Y
Y
P
T
G
T
H
A
K
R
R
F
R
Site 46
T585
V
G
D
A
L
D
K
T
E
E
H
L
A
Y
G
Site 47
Y591
K
T
E
E
H
L
A
Y
G
I
E
N
N
S
T
Site 48
T598
Y
G
I
E
N
N
S
T
L
L
E
C
T
P
R
Site 49
T603
N
S
T
L
L
E
C
T
P
R
S
L
Q
A
K
Site 50
T621
F
V
Q
K
G
R
E
T
R
K
E
E
V
K
T
Site 51
T628
T
R
K
E
E
V
K
T
D
D
R
V
V
K
M
Site 52
T651
L
H
K
S
D
A
G
T
Y
F
C
Q
T
V
E
Site 53
Y652
H
K
S
D
A
G
T
Y
F
C
Q
T
V
E
H
Site 54
T664
V
E
H
S
F
V
H
T
V
R
K
I
T
L
E
Site 55
T669
V
H
T
V
R
K
I
T
L
E
V
V
E
E
E
Site 56
S700
R
M
P
C
P
A
Q
S
S
I
S
Q
G
A
K
Site 57
S701
M
P
C
P
A
Q
S
S
I
S
Q
G
A
K
P
Site 58
S703
C
P
A
Q
S
S
I
S
Q
G
A
K
P
W
Y
Site 59
Y710
S
Q
G
A
K
P
W
Y
K
E
F
L
Q
L
I
Site 60
Y719
E
F
L
Q
L
I
G
Y
S
N
F
Q
R
V
E
Site 61
S745
K
R
K
K
L
K
M
S
P
S
K
W
K
Y
A
Site 62
S747
K
K
L
K
M
S
P
S
K
W
K
Y
A
N
P
Site 63
Y751
M
S
P
S
K
W
K
Y
A
N
P
Q
E
K
K
Site 64
Y766
L
R
S
K
P
E
H
Y
R
L
P
R
H
T
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation