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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PDZD2
Full Name:
PDZ domain-containing protein 2
Alias:
Activated in prostate cancer; Activated in prostate cancer protein; AIPC; KIAA0300; PAPIN; PDZ domain containing 2; PDZ domain containing 3; PDZ domain-containing protein 3; PDZK3; PIN1; Plakophilin-related armadillo repeat protein-interacting PDZ protein-like; Processed PDZ domain-containing protein 2
Type:
Secreted protein
Mass (Da):
301622
Number AA:
2839
UniProt ID:
O15018
International Prot ID:
IPI00155647
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005911
GO:0005783
GO:0005576
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007155
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S22
L
Y
Q
W
L
Q
N
S
L
Q
E
G
G
D
G
Site 2
S55
L
N
F
A
V
D
E
S
T
V
P
P
D
H
S
Site 3
T56
N
F
A
V
D
E
S
T
V
P
P
D
H
S
P
Site 4
S62
S
T
V
P
P
D
H
S
P
P
E
M
E
I
C
Site 5
Y72
E
M
E
I
C
T
V
Y
L
T
K
E
L
G
D
Site 6
T80
L
T
K
E
L
G
D
T
E
T
V
G
L
S
F
Site 7
T82
K
E
L
G
D
T
E
T
V
G
L
S
F
G
N
Site 8
Y96
N
I
P
V
F
G
D
Y
G
E
K
R
R
G
G
Site 9
T108
R
G
G
K
K
R
K
T
H
Q
G
P
V
L
D
Site 10
S128
V
T
E
L
R
K
N
S
P
A
G
K
S
G
K
Site 11
S133
K
N
S
P
A
G
K
S
G
K
V
R
L
R
D
Site 12
Y160
V
D
V
S
G
A
S
Y
L
A
E
Q
C
W
N
Site 13
S185
R
F
K
H
K
A
H
S
T
Y
N
G
N
S
S
Site 14
T186
F
K
H
K
A
H
S
T
Y
N
G
N
S
S
N
Site 15
Y187
K
H
K
A
H
S
T
Y
N
G
N
S
S
N
S
Site 16
S191
H
S
T
Y
N
G
N
S
S
N
S
S
E
P
G
Site 17
S192
S
T
Y
N
G
N
S
S
N
S
S
E
P
G
E
Site 18
S194
Y
N
G
N
S
S
N
S
S
E
P
G
E
T
P
Site 19
S195
N
G
N
S
S
N
S
S
E
P
G
E
T
P
T
Site 20
T200
N
S
S
E
P
G
E
T
P
T
L
E
L
G
D
Site 21
T209
T
L
E
L
G
D
R
T
A
K
K
G
K
R
T
Site 22
S237
A
P
E
E
S
K
G
S
A
G
C
E
V
S
S
Site 23
S243
G
S
A
G
C
E
V
S
S
D
P
S
T
E
L
Site 24
S244
S
A
G
C
E
V
S
S
D
P
S
T
E
L
E
Site 25
S247
C
E
V
S
S
D
P
S
T
E
L
E
N
G
P
Site 26
T248
E
V
S
S
D
P
S
T
E
L
E
N
G
P
D
Site 27
S272
Q
L
E
N
G
P
D
S
L
K
E
V
A
G
P
Site 28
S284
A
G
P
H
L
E
R
S
E
V
D
R
G
T
E
Site 29
T290
R
S
E
V
D
R
G
T
E
H
R
I
P
K
T
Site 30
T297
T
E
H
R
I
P
K
T
D
A
P
L
T
T
S
Site 31
T302
P
K
T
D
A
P
L
T
T
S
N
D
K
R
R
Site 32
S304
T
D
A
P
L
T
T
S
N
D
K
R
R
F
S
Site 33
S311
S
N
D
K
R
R
F
S
K
G
G
K
T
D
F
Site 34
T316
R
F
S
K
G
G
K
T
D
F
Q
S
S
D
C
Site 35
S320
G
G
K
T
D
F
Q
S
S
D
C
L
A
R
E
Site 36
S321
G
K
T
D
F
Q
S
S
D
C
L
A
R
E
E
Site 37
S349
D
G
L
G
I
Q
V
S
G
G
R
G
S
K
R
Site 38
S354
Q
V
S
G
G
R
G
S
K
R
S
P
H
A
I
Site 39
S357
G
G
R
G
S
K
R
S
P
H
A
I
V
V
T
Site 40
S379
A
H
R
D
G
R
L
S
L
G
D
E
L
L
V
Site 41
S421
V
V
A
S
K
E
N
S
A
E
D
L
L
R
L
Site 42
T429
A
E
D
L
L
R
L
T
S
K
S
L
P
D
L
Site 43
S430
E
D
L
L
R
L
T
S
K
S
L
P
D
L
T
Site 44
S432
L
L
R
L
T
S
K
S
L
P
D
L
T
S
S
Site 45
T437
S
K
S
L
P
D
L
T
S
S
V
E
D
V
S
Site 46
S438
K
S
L
P
D
L
T
S
S
V
E
D
V
S
S
Site 47
S439
S
L
P
D
L
T
S
S
V
E
D
V
S
S
W
Site 48
S445
S
S
V
E
D
V
S
S
W
T
D
N
E
D
Q
Site 49
T462
D
G
E
E
D
E
G
T
S
S
S
V
Q
R
A
Site 50
S464
E
E
D
E
G
T
S
S
S
V
Q
R
A
M
P
Site 51
S465
E
D
E
G
T
S
S
S
V
Q
R
A
M
P
G
Site 52
T473
V
Q
R
A
M
P
G
T
D
E
P
Q
D
V
C
Site 53
S491
E
S
K
G
N
L
E
S
P
K
Q
G
S
N
K
Site 54
S503
S
N
K
I
K
L
K
S
R
L
S
G
G
V
H
Site 55
S506
I
K
L
K
S
R
L
S
G
G
V
H
R
L
E
Site 56
S514
G
G
V
H
R
L
E
S
V
E
E
Y
N
E
L
Site 57
Y518
R
L
E
S
V
E
E
Y
N
E
L
M
V
R
N
Site 58
S536
R
I
R
M
L
E
V
S
R
D
G
R
K
H
S
Site 59
S543
S
R
D
G
R
K
H
S
L
P
Q
L
L
D
S
Site 60
S550
S
L
P
Q
L
L
D
S
S
S
A
S
Q
E
Y
Site 61
S552
P
Q
L
L
D
S
S
S
A
S
Q
E
Y
H
I
Site 62
S554
L
L
D
S
S
S
A
S
Q
E
Y
H
I
V
K
Site 63
Y557
S
S
S
A
S
Q
E
Y
H
I
V
K
K
S
T
Site 64
S563
E
Y
H
I
V
K
K
S
T
R
S
L
S
T
T
Site 65
S566
I
V
K
K
S
T
R
S
L
S
T
T
Q
V
E
Site 66
S568
K
K
S
T
R
S
L
S
T
T
Q
V
E
S
P
Site 67
T570
S
T
R
S
L
S
T
T
Q
V
E
S
P
W
R
Site 68
S574
L
S
T
T
Q
V
E
S
P
W
R
L
I
R
P
Site 69
S600
K
G
K
G
L
G
F
S
I
A
G
G
R
D
C
Site 70
S624
K
T
I
F
P
N
G
S
A
A
E
D
G
R
L
Site 71
T656
T
F
Q
E
A
I
H
T
F
K
Q
I
R
S
G
Site 72
S675
T
V
R
T
K
L
V
S
P
S
L
T
P
C
S
Site 73
S677
R
T
K
L
V
S
P
S
L
T
P
C
S
T
P
Site 74
T679
K
L
V
S
P
S
L
T
P
C
S
T
P
T
H
Site 75
S682
S
P
S
L
T
P
C
S
T
P
T
H
M
S
R
Site 76
T683
P
S
L
T
P
C
S
T
P
T
H
M
S
R
S
Site 77
T685
L
T
P
C
S
T
P
T
H
M
S
R
S
A
S
Site 78
S688
C
S
T
P
T
H
M
S
R
S
A
S
P
N
F
Site 79
S690
T
P
T
H
M
S
R
S
A
S
P
N
F
N
T
Site 80
S692
T
H
M
S
R
S
A
S
P
N
F
N
T
S
G
Site 81
S698
A
S
P
N
F
N
T
S
G
G
A
S
A
G
G
Site 82
S702
F
N
T
S
G
G
A
S
A
G
G
S
D
E
G
Site 83
S706
G
G
A
S
A
G
G
S
D
E
G
S
S
S
S
Site 84
S710
A
G
G
S
D
E
G
S
S
S
S
L
G
R
K
Site 85
S711
G
G
S
D
E
G
S
S
S
S
L
G
R
K
T
Site 86
S712
G
S
D
E
G
S
S
S
S
L
G
R
K
T
P
Site 87
S713
S
D
E
G
S
S
S
S
L
G
R
K
T
P
G
Site 88
T718
S
S
S
L
G
R
K
T
P
G
P
K
D
R
I
Site 89
S764
I
H
S
L
A
P
G
S
V
A
K
M
E
S
N
Site 90
S770
G
S
V
A
K
M
E
S
N
L
S
R
G
D
Q
Site 91
S819
R
H
P
N
P
K
V
S
E
Q
E
M
D
E
V
Site 92
S830
M
D
E
V
I
A
R
S
T
Y
Q
E
S
K
E
Site 93
T831
D
E
V
I
A
R
S
T
Y
Q
E
S
K
E
A
Site 94
Y832
E
V
I
A
R
S
T
Y
Q
E
S
K
E
A
N
Site 95
S835
A
R
S
T
Y
Q
E
S
K
E
A
N
S
S
P
Site 96
S841
E
S
K
E
A
N
S
S
P
G
L
G
T
P
L
Site 97
T846
N
S
S
P
G
L
G
T
P
L
K
S
P
S
L
Site 98
S850
G
L
G
T
P
L
K
S
P
S
L
A
K
K
D
Site 99
S852
G
T
P
L
K
S
P
S
L
A
K
K
D
S
L
Site 100
S858
P
S
L
A
K
K
D
S
L
I
S
E
S
E
L
Site 101
S861
A
K
K
D
S
L
I
S
E
S
E
L
S
Q
Y
Site 102
S866
L
I
S
E
S
E
L
S
Q
Y
F
A
H
D
V
Site 103
Y868
S
E
S
E
L
S
Q
Y
F
A
H
D
V
P
G
Site 104
S885
S
D
F
M
V
A
G
S
E
D
E
D
H
P
G
Site 105
S893
E
D
E
D
H
P
G
S
G
C
S
T
S
E
E
Site 106
S896
D
H
P
G
S
G
C
S
T
S
E
E
G
S
L
Site 107
T897
H
P
G
S
G
C
S
T
S
E
E
G
S
L
P
Site 108
S898
P
G
S
G
C
S
T
S
E
E
G
S
L
P
P
Site 109
S902
C
S
T
S
E
E
G
S
L
P
P
S
T
S
T
Site 110
S906
E
E
G
S
L
P
P
S
T
S
T
H
K
E
P
Site 111
T907
E
G
S
L
P
P
S
T
S
T
H
K
E
P
G
Site 112
S908
G
S
L
P
P
S
T
S
T
H
K
E
P
G
K
Site 113
S920
P
G
K
P
R
A
N
S
L
V
T
L
G
S
H
Site 114
S930
T
L
G
S
H
R
A
S
G
L
F
H
K
Q
V
Site 115
S944
V
T
V
A
R
Q
A
S
L
P
G
S
P
Q
A
Site 116
S948
R
Q
A
S
L
P
G
S
P
Q
A
L
R
N
P
Site 117
Y965
R
Q
R
K
V
G
C
Y
D
A
N
D
A
S
D
Site 118
S971
C
Y
D
A
N
D
A
S
D
E
E
E
F
D
R
Site 119
S984
D
R
E
G
D
C
I
S
L
P
G
A
L
P
G
Site 120
S997
P
G
P
I
R
P
L
S
E
D
D
P
R
R
V
Site 121
S1005
E
D
D
P
R
R
V
S
I
S
S
S
K
G
M
Site 122
S1007
D
P
R
R
V
S
I
S
S
S
K
G
M
D
V
Site 123
S1008
P
R
R
V
S
I
S
S
S
K
G
M
D
V
H
Site 124
S1009
R
R
V
S
I
S
S
S
K
G
M
D
V
H
N
Site 125
T1024
Q
E
E
R
P
R
K
T
L
V
S
K
A
I
S
Site 126
S1027
R
P
R
K
T
L
V
S
K
A
I
S
A
P
L
Site 127
S1044
S
S
V
D
L
E
E
S
I
P
E
G
M
V
D
Site 128
S1054
E
G
M
V
D
A
A
S
Y
A
A
N
L
T
D
Site 129
S1062
Y
A
A
N
L
T
D
S
A
E
A
P
K
G
S
Site 130
S1069
S
A
E
A
P
K
G
S
P
G
S
W
W
K
K
Site 131
S1072
A
P
K
G
S
P
G
S
W
W
K
K
E
L
S
Site 132
S1079
S
W
W
K
K
E
L
S
G
S
S
S
A
P
K
Site 133
S1081
W
K
K
E
L
S
G
S
S
S
A
P
K
L
E
Site 134
S1082
K
K
E
L
S
G
S
S
S
A
P
K
L
E
Y
Site 135
S1083
K
E
L
S
G
S
S
S
A
P
K
L
E
Y
T
Site 136
Y1089
S
S
A
P
K
L
E
Y
T
V
R
T
D
T
Q
Site 137
T1090
S
A
P
K
L
E
Y
T
V
R
T
D
T
Q
S
Site 138
T1093
K
L
E
Y
T
V
R
T
D
T
Q
S
P
T
N
Site 139
T1095
E
Y
T
V
R
T
D
T
Q
S
P
T
N
T
G
Site 140
S1097
T
V
R
T
D
T
Q
S
P
T
N
T
G
S
P
Site 141
T1099
R
T
D
T
Q
S
P
T
N
T
G
S
P
S
S
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I
R
T
F
Site 294
T1977
L
K
P
S
V
S
D
T
S
I
R
T
F
V
S
Site 295
S1978
K
P
S
V
S
D
T
S
I
R
T
F
V
S
P
Site 296
S1984
T
S
I
R
T
F
V
S
P
L
T
S
P
K
P
Site 297
S1988
T
F
V
S
P
L
T
S
P
K
P
V
P
E
Q
Site 298
S2007
R
F
H
M
A
V
L
S
E
P
D
R
G
C
P
Site 299
T2015
E
P
D
R
G
C
P
T
T
P
K
S
P
K
C
Site 300
T2016
P
D
R
G
C
P
T
T
P
K
S
P
K
C
R
Site 301
S2019
G
C
P
T
T
P
K
S
P
K
C
R
A
E
G
Site 302
S2033
G
R
A
P
R
A
D
S
G
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S
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A
A
Site 303
S2037
R
A
D
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V
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P
A
A
S
R
N
G
Site 304
S2041
G
P
V
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P
A
A
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N
G
M
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V
A
Site 305
S2053
S
V
A
G
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A
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Site 306
S2059
Q
S
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A
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A
A
D
T
A
Site 307
T2065
A
S
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A
A
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A
Q
P
R
P
T
G
Site 308
T2071
D
T
A
Q
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P
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E
K
G
G
N
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Site 309
S2081
K
G
G
N
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A
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R
L
E
R
T
N
Site 310
T2103
S
A
E
A
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E
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V
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G
N
K
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A
Site 311
S2112
C
G
N
K
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A
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R
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C
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Site 312
S2128
Q
G
N
C
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R
Q
Site 313
Y2133
E
K
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A
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Site 314
S2139
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Site 315
S2140
Y
R
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Site 316
T2141
R
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A
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Site 317
S2142
Q
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A
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P
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Site 318
S2145
E
S
S
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A
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Site 319
S2146
S
S
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S
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Site 320
S2149
S
H
P
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P
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A
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A
E
Q
Site 321
S2152
S
S
L
P
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A
S
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A
E
Q
E
M
S
Site 322
S2159
S
Q
A
E
Q
E
M
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F
S
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A
K
Site 323
S2161
A
E
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E
M
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A
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A
Site 324
S2163
Q
E
M
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K
L
A
S
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Site 325
S2169
F
S
M
A
K
L
A
S
S
S
S
S
L
Q
T
Site 326
S2170
S
M
A
K
L
A
S
S
S
S
S
L
Q
T
A
Site 327
S2172
A
K
L
A
S
S
S
S
S
L
Q
T
A
I
R
Site 328
S2173
K
L
A
S
S
S
S
S
L
Q
T
A
I
R
K
Site 329
T2176
S
S
S
S
S
L
Q
T
A
I
R
K
A
E
Y
Site 330
S2184
A
I
R
K
A
E
Y
S
Q
G
K
S
S
L
M
Site 331
S2188
A
E
Y
S
Q
G
K
S
S
L
M
S
D
S
R
Site 332
S2189
E
Y
S
Q
G
K
S
S
L
M
S
D
S
R
G
Site 333
S2192
Q
G
K
S
S
L
M
S
D
S
R
G
V
P
R
Site 334
S2194
K
S
S
L
M
S
D
S
R
G
V
P
R
N
S
Site 335
S2201
S
R
G
V
P
R
N
S
I
P
G
G
P
S
G
Site 336
S2207
N
S
I
P
G
G
P
S
G
E
D
H
L
Y
F
Site 337
Y2213
P
S
G
E
D
H
L
Y
F
T
P
R
P
A
T
Site 338
T2215
G
E
D
H
L
Y
F
T
P
R
P
A
T
R
T
Site 339
T2220
Y
F
T
P
R
P
A
T
R
T
Y
S
M
P
A
Site 340
T2222
T
P
R
P
A
T
R
T
Y
S
M
P
A
Q
F
Site 341
Y2223
P
R
P
A
T
R
T
Y
S
M
P
A
Q
F
S
Site 342
S2224
R
P
A
T
R
T
Y
S
M
P
A
Q
F
S
S
Site 343
S2242
R
E
G
H
P
P
H
S
L
G
R
S
R
D
S
Site 344
S2246
P
P
H
S
L
G
R
S
R
D
S
Q
V
P
V
Site 345
S2249
S
L
G
R
S
R
D
S
Q
V
P
V
T
S
S
Site 346
T2254
R
D
S
Q
V
P
V
T
S
S
V
V
P
E
A
Site 347
S2264
V
V
P
E
A
K
A
S
R
G
G
L
P
S
L
Site 348
S2270
A
S
R
G
G
L
P
S
L
A
N
G
Q
G
I
Site 349
S2279
A
N
G
Q
G
I
Y
S
V
K
P
L
L
D
T
Site 350
T2286
S
V
K
P
L
L
D
T
S
R
N
L
P
A
T
Site 351
T2293
T
S
R
N
L
P
A
T
D
E
G
D
I
I
S
Site 352
S2300
T
D
E
G
D
I
I
S
V
Q
E
T
S
C
L
Site 353
T2309
Q
E
T
S
C
L
V
T
D
K
I
K
V
T
R
Site 354
S2329
E
Q
N
W
P
H
E
S
T
S
F
F
S
V
K
Site 355
S2331
N
W
P
H
E
S
T
S
F
F
S
V
K
Q
R
Site 356
S2334
H
E
S
T
S
F
F
S
V
K
Q
R
I
K
S
Site 357
S2341
S
V
K
Q
R
I
K
S
F
E
N
L
A
N
A
Site 358
S2355
A
D
R
P
V
A
K
S
G
A
S
P
F
L
S
Site 359
S2362
S
G
A
S
P
F
L
S
V
S
S
K
P
P
I
Site 360
S2364
A
S
P
F
L
S
V
S
S
K
P
P
I
G
R
Site 361
S2365
S
P
F
L
S
V
S
S
K
P
P
I
G
R
R
Site 362
S2373
K
P
P
I
G
R
R
S
S
G
S
I
V
S
G
Site 363
S2374
P
P
I
G
R
R
S
S
G
S
I
V
S
G
S
Site 364
S2376
I
G
R
R
S
S
G
S
I
V
S
G
S
L
G
Site 365
S2379
R
S
S
G
S
I
V
S
G
S
L
G
H
P
G
Site 366
S2381
S
G
S
I
V
S
G
S
L
G
H
P
G
D
A
Site 367
S2396
A
A
R
L
L
R
R
S
L
S
S
C
S
E
N
Site 368
S2398
R
L
L
R
R
S
L
S
S
C
S
E
N
Q
S
Site 369
S2399
L
L
R
R
S
L
S
S
C
S
E
N
Q
S
E
Site 370
S2401
R
R
S
L
S
S
C
S
E
N
Q
S
E
A
G
Site 371
S2405
S
S
C
S
E
N
Q
S
E
A
G
T
L
L
P
Site 372
T2409
E
N
Q
S
E
A
G
T
L
L
P
Q
M
A
K
Site 373
S2417
L
L
P
Q
M
A
K
S
P
S
I
M
T
L
T
Site 374
S2419
P
Q
M
A
K
S
P
S
I
M
T
L
T
I
S
Site 375
T2422
A
K
S
P
S
I
M
T
L
T
I
S
R
Q
N
Site 376
T2424
S
P
S
I
M
T
L
T
I
S
R
Q
N
P
P
Site 377
S2426
S
I
M
T
L
T
I
S
R
Q
N
P
P
E
T
Site 378
T2433
S
R
Q
N
P
P
E
T
S
S
K
G
S
D
S
Site 379
S2434
R
Q
N
P
P
E
T
S
S
K
G
S
D
S
E
Site 380
S2435
Q
N
P
P
E
T
S
S
K
G
S
D
S
E
L
Site 381
S2438
P
E
T
S
S
K
G
S
D
S
E
L
K
K
S
Site 382
S2440
T
S
S
K
G
S
D
S
E
L
K
K
S
L
G
Site 383
S2445
S
D
S
E
L
K
K
S
L
G
P
L
G
I
P
Site 384
T2455
P
L
G
I
P
T
P
T
M
T
L
A
S
P
V
Site 385
T2457
G
I
P
T
P
T
M
T
L
A
S
P
V
K
R
Site 386
S2460
T
P
T
M
T
L
A
S
P
V
K
R
N
K
S
Site 387
S2467
S
P
V
K
R
N
K
S
S
V
R
H
T
Q
P
Site 388
S2468
P
V
K
R
N
K
S
S
V
R
H
T
Q
P
S
Site 389
T2472
N
K
S
S
V
R
H
T
Q
P
S
P
V
S
R
Site 390
S2475
S
V
R
H
T
Q
P
S
P
V
S
R
S
K
L
Site 391
S2478
H
T
Q
P
S
P
V
S
R
S
K
L
Q
E
L
Site 392
S2480
Q
P
S
P
V
S
R
S
K
L
Q
E
L
R
A
Site 393
S2489
L
Q
E
L
R
A
L
S
M
P
D
L
D
K
L
Site 394
S2498
P
D
L
D
K
L
C
S
E
D
Y
S
A
G
P
Site 395
Y2501
D
K
L
C
S
E
D
Y
S
A
G
P
S
A
V
Site 396
S2502
K
L
C
S
E
D
Y
S
A
G
P
S
A
V
L
Site 397
S2506
E
D
Y
S
A
G
P
S
A
V
L
F
K
T
E
Site 398
T2512
P
S
A
V
L
F
K
T
E
L
E
I
T
P
R
Site 399
T2517
F
K
T
E
L
E
I
T
P
R
R
S
P
G
P
Site 400
S2521
L
E
I
T
P
R
R
S
P
G
P
P
A
G
G
Site 401
S2530
G
P
P
A
G
G
V
S
C
P
E
K
G
G
N
Site 402
S2544
N
R
A
C
P
G
G
S
G
P
K
T
S
A
A
Site 403
T2548
P
G
G
S
G
P
K
T
S
A
A
E
T
P
S
Site 404
S2549
G
G
S
G
P
K
T
S
A
A
E
T
P
S
S
Site 405
T2553
P
K
T
S
A
A
E
T
P
S
S
A
S
D
T
Site 406
S2556
S
A
A
E
T
P
S
S
A
S
D
T
G
E
A
Site 407
T2560
T
P
S
S
A
S
D
T
G
E
A
A
Q
D
L
Site 408
S2572
Q
D
L
P
F
R
R
S
W
S
V
N
L
D
Q
Site 409
S2574
L
P
F
R
R
S
W
S
V
N
L
D
Q
L
L
Site 410
S2592
G
D
Q
Q
R
L
Q
S
V
L
S
S
V
G
S
Site 411
S2595
Q
R
L
Q
S
V
L
S
S
V
G
S
K
S
T
Site 412
S2596
R
L
Q
S
V
L
S
S
V
G
S
K
S
T
I
Site 413
T2605
G
S
K
S
T
I
L
T
L
I
Q
E
A
K
A
Site 414
S2647
G
T
D
V
E
P
K
S
I
T
V
H
R
V
F
Site 415
S2655
I
T
V
H
R
V
F
S
Q
G
A
A
S
Q
E
Site 416
S2660
V
F
S
Q
G
A
A
S
Q
E
G
T
M
N
R
Site 417
T2664
G
A
A
S
Q
E
G
T
M
N
R
G
D
F
L
Site 418
S2714
G
M
D
Q
P
R
P
S
A
R
Q
E
P
P
T
Site 419
T2721
S
A
R
Q
E
P
P
T
A
N
G
K
G
L
L
Site 420
T2732
K
G
L
L
S
R
K
T
I
P
L
E
P
G
I
Site 421
T2756
L
C
V
E
V
L
K
T
S
A
G
L
G
L
S
Site 422
S2757
C
V
E
V
L
K
T
S
A
G
L
G
L
S
L
Site 423
S2763
T
S
A
G
L
G
L
S
L
D
G
G
K
S
S
Site 424
S2769
L
S
L
D
G
G
K
S
S
V
T
G
D
G
P
Site 425
S2770
S
L
D
G
G
K
S
S
V
T
G
D
G
P
L
Site 426
Y2783
P
L
V
I
K
R
V
Y
K
G
G
A
A
E
Q
Site 427
S2822
D
A
W
N
I
M
K
S
V
P
E
G
P
V
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation