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Updated November 2019
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Protein Info
Short Name:
ZNF646
Full Name:
Zinc finger protein 646
Alias:
KIAA0296; Zinc finger 646; ZN646
Type:
Mass (Da):
200762
Number AA:
1829
UniProt ID:
O15015
International Prot ID:
IPI00004419
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0045449
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
E
D
T
P
P
S
L
S
C
S
D
C
Q
Site 2
S9
E
D
T
P
P
S
L
S
C
S
D
C
Q
R
H
Site 3
S11
T
P
P
S
L
S
C
S
D
C
Q
R
H
F
P
Site 4
S19
D
C
Q
R
H
F
P
S
L
P
E
L
S
R
H
Site 5
S24
F
P
S
L
P
E
L
S
R
H
R
E
L
L
H
Site 6
S33
H
R
E
L
L
H
P
S
P
N
Q
D
S
E
E
Site 7
S43
Q
D
S
E
E
A
D
S
I
P
R
P
Y
R
C
Site 8
Y48
A
D
S
I
P
R
P
Y
R
C
Q
Q
C
G
R
Site 9
Y57
C
Q
Q
C
G
R
G
Y
R
H
P
G
S
L
V
Site 10
S62
R
G
Y
R
H
P
G
S
L
V
N
H
R
R
T
Site 11
T69
S
L
V
N
H
R
R
T
H
E
T
G
L
F
P
Site 12
T78
E
T
G
L
F
P
C
T
T
C
G
K
D
F
S
Site 13
T79
T
G
L
F
P
C
T
T
C
G
K
D
F
S
N
Site 14
S85
T
T
C
G
K
D
F
S
N
P
M
A
L
K
S
Site 15
S92
S
N
P
M
A
L
K
S
H
M
R
T
H
A
P
Site 16
T96
A
L
K
S
H
M
R
T
H
A
P
E
G
R
R
Site 17
T114
P
P
R
P
K
E
A
T
P
H
L
Q
G
E
T
Site 18
T121
T
P
H
L
Q
G
E
T
V
S
T
D
S
W
G
Site 19
S123
H
L
Q
G
E
T
V
S
T
D
S
W
G
Q
R
Site 20
T124
L
Q
G
E
T
V
S
T
D
S
W
G
Q
R
L
Site 21
S126
G
E
T
V
S
T
D
S
W
G
Q
R
L
G
S
Site 22
S133
S
W
G
Q
R
L
G
S
S
E
G
W
E
N
Q
Site 23
T147
Q
T
K
H
T
E
E
T
P
D
C
E
S
V
P
Site 24
S152
E
E
T
P
D
C
E
S
V
P
D
P
R
A
A
Site 25
S160
V
P
D
P
R
A
A
S
G
T
W
E
D
L
P
Site 26
T162
D
P
R
A
A
S
G
T
W
E
D
L
P
T
R
Site 27
T168
G
T
W
E
D
L
P
T
R
Q
R
E
G
L
A
Site 28
S176
R
Q
R
E
G
L
A
S
H
P
G
P
E
D
G
Site 29
S190
G
A
D
G
W
G
P
S
T
N
S
A
R
A
P
Site 30
T191
A
D
G
W
G
P
S
T
N
S
A
R
A
P
P
Site 31
S193
G
W
G
P
S
T
N
S
A
R
A
P
P
L
P
Site 32
S230
G
G
Q
E
P
T
Q
S
P
P
A
E
E
E
R
Site 33
Y239
P
A
E
E
E
R
R
Y
K
C
S
Q
C
G
K
Site 34
S242
E
E
R
R
Y
K
C
S
Q
C
G
K
T
Y
K
Site 35
S253
K
T
Y
K
H
A
G
S
L
T
N
H
R
Q
S
Site 36
T255
Y
K
H
A
G
S
L
T
N
H
R
Q
S
H
T
Site 37
S260
S
L
T
N
H
R
Q
S
H
T
L
G
I
Y
P
Site 38
Y294
L
H
A
Q
Y
R
P
Y
H
C
P
H
C
P
R
Site 39
S315
E
L
L
E
H
Q
Q
S
H
E
G
E
R
Q
E
Site 40
S340
T
N
G
H
T
D
E
S
S
Q
D
Q
L
P
S
Site 41
S341
N
G
H
T
D
E
S
S
Q
D
Q
L
P
S
A
Site 42
S347
S
S
Q
D
Q
L
P
S
A
Q
M
L
N
G
S
Site 43
S354
S
A
Q
M
L
N
G
S
A
E
L
S
T
S
G
Site 44
S358
L
N
G
S
A
E
L
S
T
S
G
E
L
E
D
Site 45
S360
G
S
A
E
L
S
T
S
G
E
L
E
D
S
G
Site 46
S366
T
S
G
E
L
E
D
S
G
L
E
E
Y
R
P
Site 47
Y371
E
D
S
G
L
E
E
Y
R
P
F
R
C
G
D
Site 48
Y383
C
G
D
C
G
R
T
Y
R
H
A
G
S
L
I
Site 49
S388
R
T
Y
R
H
A
G
S
L
I
N
H
R
K
S
Site 50
S395
S
L
I
N
H
R
K
S
H
Q
T
G
V
Y
P
Site 51
T398
N
H
R
K
S
H
Q
T
G
V
Y
P
C
S
L
Site 52
Y401
K
S
H
Q
T
G
V
Y
P
C
S
L
C
S
K
Site 53
S437
V
G
E
N
G
Q
P
S
V
P
P
A
P
L
L
Site 54
T457
H
K
E
E
E
D
P
T
T
T
L
D
H
R
P
Site 55
T458
K
E
E
E
D
P
T
T
T
L
D
H
R
P
Y
Site 56
T459
E
E
E
D
P
T
T
T
L
D
H
R
P
Y
K
Site 57
Y465
T
T
L
D
H
R
P
Y
K
C
S
E
C
G
R
Site 58
Y474
C
S
E
C
G
R
A
Y
R
H
R
G
S
L
V
Site 59
S479
R
A
Y
R
H
R
G
S
L
V
N
H
R
H
S
Site 60
S486
S
L
V
N
H
R
H
S
H
R
T
G
E
Y
Q
Site 61
T489
N
H
R
H
S
H
R
T
G
E
Y
Q
C
S
L
Site 62
Y492
H
S
H
R
T
G
E
Y
Q
C
S
L
C
P
R
Site 63
S495
R
T
G
E
Y
Q
C
S
L
C
P
R
K
Y
P
Site 64
Y501
C
S
L
C
P
R
K
Y
P
N
L
M
A
L
R
Site 65
S521
H
C
K
A
A
R
R
S
A
D
I
G
A
E
G
Site 66
S531
I
G
A
E
G
A
P
S
H
L
K
V
E
L
P
Site 67
T566
E
E
E
A
T
D
I
T
P
A
A
D
K
T
A
Site 68
S589
L
L
F
E
D
A
E
S
L
E
R
H
G
L
T
Site 69
S605
G
A
G
E
K
E
N
S
R
T
E
T
T
M
S
Site 70
T607
G
E
K
E
N
S
R
T
E
T
T
M
S
P
P
Site 71
T609
K
E
N
S
R
T
E
T
T
M
S
P
P
R
A
Site 72
S612
S
R
T
E
T
T
M
S
P
P
R
A
F
A
C
Site 73
S625
A
C
R
D
C
G
K
S
Y
R
H
S
G
S
L
Site 74
Y626
C
R
D
C
G
K
S
Y
R
H
S
G
S
L
I
Site 75
S629
C
G
K
S
Y
R
H
S
G
S
L
I
N
H
R
Site 76
S631
K
S
Y
R
H
S
G
S
L
I
N
H
R
Q
T
Site 77
T638
S
L
I
N
H
R
Q
T
H
Q
T
G
D
F
S
Site 78
S667
K
N
H
L
R
R
H
S
R
R
R
S
R
R
H
Site 79
S671
R
R
H
S
R
R
R
S
R
R
H
R
K
R
A
Site 80
S682
R
K
R
A
G
G
A
S
G
G
R
E
A
K
L
Site 81
S694
A
K
L
L
A
A
E
S
W
T
R
E
L
E
D
Site 82
S707
E
D
N
E
G
L
E
S
P
Q
D
P
S
G
E
Site 83
S712
L
E
S
P
Q
D
P
S
G
E
S
P
H
G
A
Site 84
S715
P
Q
D
P
S
G
E
S
P
H
G
A
E
G
N
Site 85
S725
G
A
E
G
N
L
E
S
D
G
D
C
L
Q
A
Site 86
T746
C
G
L
E
R
D
E
T
H
F
Q
G
D
K
E
Site 87
S754
H
F
Q
G
D
K
E
S
G
G
T
G
E
G
L
Site 88
S767
G
L
E
R
K
D
A
S
L
L
D
N
L
D
I
Site 89
T782
P
G
E
E
G
G
G
T
H
F
C
D
S
L
T
Site 90
S787
G
G
T
H
F
C
D
S
L
T
G
V
D
E
D
Site 91
T789
T
H
F
C
D
S
L
T
G
V
D
E
D
Q
K
Site 92
T799
D
E
D
Q
K
P
A
T
G
Q
P
N
S
S
S
Site 93
S804
P
A
T
G
Q
P
N
S
S
S
H
S
A
N
A
Site 94
S806
T
G
Q
P
N
S
S
S
H
S
A
N
A
V
T
Site 95
S808
Q
P
N
S
S
S
H
S
A
N
A
V
T
G
W
Site 96
S824
A
G
A
A
H
T
C
S
D
C
G
H
S
F
P
Site 97
S838
P
H
A
T
G
L
L
S
H
R
P
C
H
P
P
Site 98
Y848
P
C
H
P
P
G
I
Y
Q
C
S
L
C
P
K
Site 99
S859
L
C
P
K
E
F
D
S
L
P
A
L
R
S
H
Site 100
S865
D
S
L
P
A
L
R
S
H
F
Q
N
H
R
P
Site 101
S877
H
R
P
G
E
A
T
S
A
Q
P
F
L
C
C
Site 102
Y896
I
F
P
G
R
A
G
Y
R
L
H
R
R
Q
A
Site 103
S905
L
H
R
R
Q
A
H
S
S
S
G
M
T
E
G
Site 104
S906
H
R
R
Q
A
H
S
S
S
G
M
T
E
G
S
Site 105
S907
R
R
Q
A
H
S
S
S
G
M
T
E
G
S
E
Site 106
S913
S
S
G
M
T
E
G
S
E
E
E
G
E
E
E
Site 107
S930
A
E
A
A
P
A
R
S
P
P
L
Q
L
S
E
Site 108
S936
R
S
P
P
L
Q
L
S
E
A
E
L
L
N
Q
Site 109
S953
R
E
V
E
A
L
D
S
A
G
Y
G
H
I
C
Site 110
Y967
C
G
C
C
G
Q
T
Y
D
D
L
G
S
L
E
Site 111
S972
Q
T
Y
D
D
L
G
S
L
E
R
H
H
Q
S
Site 112
S979
S
L
E
R
H
H
Q
S
Q
S
S
G
T
T
A
Site 113
T985
Q
S
Q
S
S
G
T
T
A
D
K
A
P
S
P
Site 114
S991
T
T
A
D
K
A
P
S
P
L
G
V
A
G
D
Site 115
S1006
A
M
E
M
V
V
D
S
V
L
E
D
I
V
N
Site 116
S1014
V
L
E
D
I
V
N
S
V
S
G
E
G
G
D
Site 117
S1016
E
D
I
V
N
S
V
S
G
E
G
G
D
A
K
Site 118
S1024
G
E
G
G
D
A
K
S
Q
E
G
A
G
T
P
Site 119
T1030
K
S
Q
E
G
A
G
T
P
L
G
D
S
L
C
Site 120
S1035
A
G
T
P
L
G
D
S
L
C
I
Q
G
G
E
Site 121
Y1088
C
P
V
C
S
R
C
Y
P
N
L
A
A
Y
R
Site 122
S1107
N
H
P
R
C
K
G
S
E
P
Q
V
G
P
I
Site 123
S1120
P
I
P
E
A
A
G
S
S
E
L
Q
V
G
P
Site 124
S1133
G
P
I
P
E
G
G
S
N
K
P
Q
H
M
A
Site 125
T1176
E
E
V
W
E
E
T
T
V
K
G
E
E
I
E
Site 126
T1188
E
I
E
P
R
L
E
T
A
E
K
G
C
Q
T
Site 127
T1195
T
A
E
K
G
C
Q
T
E
A
S
S
E
R
P
Site 128
S1198
K
G
C
Q
T
E
A
S
S
E
R
P
F
S
C
Site 129
S1199
G
C
Q
T
E
A
S
S
E
R
P
F
S
C
E
Site 130
S1204
A
S
S
E
R
P
F
S
C
E
V
C
G
R
S
Site 131
Y1212
C
E
V
C
G
R
S
Y
K
H
A
G
S
L
I
Site 132
S1217
R
S
Y
K
H
A
G
S
L
I
N
H
R
Q
S
Site 133
S1240
Q
A
C
S
K
G
F
S
N
L
M
S
L
K
N
Site 134
S1244
K
G
F
S
N
L
M
S
L
K
N
H
R
R
I
Site 135
S1261
D
P
R
R
F
R
C
S
E
C
G
K
A
F
R
Site 136
S1275
R
L
R
K
Q
L
A
S
H
Q
R
V
H
M
E
Site 137
T1289
E
R
R
G
G
G
G
T
R
K
A
T
R
E
D
Site 138
T1293
G
G
G
T
R
K
A
T
R
E
D
R
P
F
R
Site 139
T1307
R
C
G
Q
C
G
R
T
Y
R
H
A
G
S
L
Site 140
Y1308
C
G
Q
C
G
R
T
Y
R
H
A
G
S
L
L
Site 141
S1313
R
T
Y
R
H
A
G
S
L
L
N
H
R
R
S
Site 142
S1320
S
L
L
N
H
R
R
S
H
E
T
G
Q
Y
S
Site 143
T1323
N
H
R
R
S
H
E
T
G
Q
Y
S
C
P
T
Site 144
Y1326
R
S
H
E
T
G
Q
Y
S
C
P
T
C
P
K
Site 145
S1327
S
H
E
T
G
Q
Y
S
C
P
T
C
P
K
T
Site 146
T1330
T
G
Q
Y
S
C
P
T
C
P
K
T
Y
S
N
Site 147
T1334
S
C
P
T
C
P
K
T
Y
S
N
R
M
A
L
Site 148
S1336
P
T
C
P
K
T
Y
S
N
R
M
A
L
K
D
Site 149
S1349
K
D
H
Q
R
L
H
S
E
N
R
R
R
R
A
Site 150
S1359
R
R
R
R
A
G
R
S
R
R
T
A
V
R
C
Site 151
T1362
R
A
G
R
S
R
R
T
A
V
R
C
A
L
C
Site 152
S1372
R
C
A
L
C
G
R
S
F
P
G
R
G
S
L
Site 153
S1378
R
S
F
P
G
R
G
S
L
E
R
H
L
R
E
Site 154
T1389
H
L
R
E
H
E
E
T
E
R
E
P
A
N
G
Site 155
T1403
G
Q
G
G
L
D
G
T
A
A
S
E
A
N
L
Site 156
S1406
G
L
D
G
T
A
A
S
E
A
N
L
T
G
S
Site 157
T1411
A
A
S
E
A
N
L
T
G
S
Q
G
L
E
T
Site 158
S1413
S
E
A
N
L
T
G
S
Q
G
L
E
T
Q
L
Site 159
S1440
V
P
R
P
G
E
R
S
Q
S
P
I
R
A
A
Site 160
S1442
R
P
G
E
R
S
Q
S
P
I
R
A
A
S
S
Site 161
S1448
Q
S
P
I
R
A
A
S
S
E
A
P
E
P
L
Site 162
S1449
S
P
I
R
A
A
S
S
E
A
P
E
P
L
S
Site 163
S1456
S
E
A
P
E
P
L
S
W
G
A
G
K
A
G
Site 164
S1475
G
G
G
L
G
N
H
S
G
G
W
V
P
Q
F
Site 165
T1484
G
W
V
P
Q
F
L
T
R
S
E
E
P
E
D
Site 166
S1486
V
P
Q
F
L
T
R
S
E
E
P
E
D
S
V
Site 167
S1492
R
S
E
E
P
E
D
S
V
H
R
S
P
C
H
Site 168
S1496
P
E
D
S
V
H
R
S
P
C
H
A
G
D
C
Site 169
S1515
P
T
L
S
H
M
D
S
W
D
N
R
D
N
S
Site 170
S1522
S
W
D
N
R
D
N
S
S
Q
L
Q
P
G
S
Site 171
S1523
W
D
N
R
D
N
S
S
Q
L
Q
P
G
S
H
Site 172
S1529
S
S
Q
L
Q
P
G
S
H
S
S
C
S
Q
C
Site 173
S1532
L
Q
P
G
S
H
S
S
C
S
Q
C
G
K
T
Site 174
S1534
P
G
S
H
S
S
C
S
Q
C
G
K
T
Y
C
Site 175
T1539
S
C
S
Q
C
G
K
T
Y
C
Q
S
G
S
L
Site 176
Y1540
C
S
Q
C
G
K
T
Y
C
Q
S
G
S
L
L
Site 177
Y1558
T
N
K
T
D
R
H
Y
C
L
L
C
S
K
E
Site 178
T1572
E
F
L
N
P
V
A
T
K
S
H
S
H
N
H
Site 179
S1574
L
N
P
V
A
T
K
S
H
S
H
N
H
I
D
Site 180
S1612
Q
A
H
A
R
G
H
S
Q
V
P
A
Q
M
E
Site 181
S1646
G
K
A
Q
E
A
P
S
E
T
P
R
G
P
G
Site 182
T1648
A
Q
E
A
P
S
E
T
P
R
G
P
G
E
S
Site 183
S1655
T
P
R
G
P
G
E
S
V
E
R
A
R
G
G
Site 184
S1667
R
G
G
Q
A
V
T
S
M
A
A
E
D
K
E
Site 185
T1680
K
E
R
P
F
R
C
T
Q
C
G
R
S
Y
R
Site 186
S1685
R
C
T
Q
C
G
R
S
Y
R
H
A
G
S
L
Site 187
Y1686
C
T
Q
C
G
R
S
Y
R
H
A
G
S
L
L
Site 188
S1691
R
S
Y
R
H
A
G
S
L
L
N
H
Q
K
A
Site 189
Y1704
K
A
H
T
T
G
L
Y
P
C
S
L
C
P
K
Site 190
S1718
K
L
L
P
N
L
L
S
L
K
N
H
S
R
T
Site 191
T1727
K
N
H
S
R
T
H
T
D
P
K
R
H
C
C
Site 192
S1775
R
H
F
R
R
R
I
S
F
V
Q
H
Q
Q
Q
Site 193
T1788
Q
Q
H
Q
E
E
W
T
V
A
G
S
G
R
G
Site 194
S1792
E
E
W
T
V
A
G
S
G
R
G
H
E
G
S
Site 195
S1799
S
G
R
G
H
E
G
S
Q
E
E
V
G
T
Q
Site 196
T1805
G
S
Q
E
E
V
G
T
Q
W
R
G
K
S
S
Site 197
S1811
G
T
Q
W
R
G
K
S
S
P
K
V
G
G
G
Site 198
S1812
T
Q
W
R
G
K
S
S
P
K
V
G
G
G
A
Site 199
S1821
K
V
G
G
G
A
R
S
E
R
R
E
P
R
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation