KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
HGS
Full Name:
Hepatocyte growth factor-regulated tyrosine kinase substrate
Alias:
IMOS-1; Protein pp110; Vps27; ZFYVE8
Type:
Adapter/scaffold protein
Mass (Da):
86192
Number AA:
777
UniProt ID:
O14964
International Prot ID:
IPI00006176
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005769
GO:0019898
Uniprot
OncoNet
Molecular Function:
GO:0019904
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0016197
GO:0006886
GO:0046426
Phosida
TranscriptoNet
STRING
Kinexus Products
Hepatocyte growth factor-regulated tyrosine kinase substrate Y216 phosphosite-specific antibody AB-PN519#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PN519#Hepatocyte growth factor-regulated tyrosine kinase substrate (E213-L219, human) pY216 phosphopeptide - Powder PE-04AFB95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AFB95
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T7
_
M
G
R
G
S
G
T
F
E
R
L
L
D
K
Site 2
S17
R
L
L
D
K
A
T
S
Q
L
L
L
E
T
D
Site 3
Y44
Q
G
D
T
Q
A
K
Y
A
V
N
S
I
K
K
Site 4
Y110
N
V
R
N
K
I
L
Y
L
I
Q
A
W
A
H
Site 5
Y125
A
F
R
N
E
P
K
Y
K
V
V
Q
D
T
Y
Site 6
T131
K
Y
K
V
V
Q
D
T
Y
Q
I
M
K
V
E
Site 7
Y132
Y
K
V
V
Q
D
T
Y
Q
I
M
K
V
E
G
Site 8
S148
V
F
P
E
F
K
E
S
D
A
M
F
A
A
E
Site 9
Y197
C
G
K
C
S
S
K
Y
S
T
I
P
K
F
G
Site 10
S198
G
K
C
S
S
K
Y
S
T
I
P
K
F
G
I
Site 11
T199
K
C
S
S
K
Y
S
T
I
P
K
F
G
I
E
Site 12
Y216
V
R
V
C
E
P
C
Y
E
Q
L
N
R
K
A
Hepatocyte growth factor-regulated tyrosine kinase substrate Y216 phosphosite-specific antibody AB-PN519#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PN519#Hepatocyte growth factor-regulated tyrosine kinase substrate (E213-L219, human) pY216 phosphopeptide - Powder PE-04AFB95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AFB95
Site 13
T228
R
K
A
E
G
K
A
T
S
T
T
E
L
P
P
Site 14
T231
E
G
K
A
T
S
T
T
E
L
P
P
E
Y
L
Site 15
Y237
T
T
E
L
P
P
E
Y
L
T
S
P
L
S
Q
Site 16
T239
E
L
P
P
E
Y
L
T
S
P
L
S
Q
Q
S
Site 17
S240
L
P
P
E
Y
L
T
S
P
L
S
Q
Q
S
Q
Site 18
S243
E
Y
L
T
S
P
L
S
Q
Q
S
Q
L
P
P
Site 19
S246
T
S
P
L
S
Q
Q
S
Q
L
P
P
K
R
D
Site 20
T255
L
P
P
K
R
D
E
T
A
L
Q
E
E
E
E
Site 21
S270
L
Q
L
A
L
A
L
S
Q
S
E
A
E
E
K
Site 22
S272
L
A
L
A
L
S
Q
S
E
A
E
E
K
E
R
Site 23
S284
K
E
R
L
R
Q
K
S
T
Y
T
S
Y
P
K
Site 24
T285
E
R
L
R
Q
K
S
T
Y
T
S
Y
P
K
A
Site 25
Y286
R
L
R
Q
K
S
T
Y
T
S
Y
P
K
A
E
Site 26
T287
L
R
Q
K
S
T
Y
T
S
Y
P
K
A
E
P
Site 27
S288
R
Q
K
S
T
Y
T
S
Y
P
K
A
E
P
M
Site 28
Y289
Q
K
S
T
Y
T
S
Y
P
K
A
E
P
M
P
Site 29
S297
P
K
A
E
P
M
P
S
A
S
S
A
P
P
A
Site 30
S299
A
E
P
M
P
S
A
S
S
A
P
P
A
S
S
Site 31
S300
E
P
M
P
S
A
S
S
A
P
P
A
S
S
L
Site 32
S305
A
S
S
A
P
P
A
S
S
L
Y
S
S
P
V
Site 33
S306
S
S
A
P
P
A
S
S
L
Y
S
S
P
V
N
Site 34
Y308
A
P
P
A
S
S
L
Y
S
S
P
V
N
S
S
Site 35
S309
P
P
A
S
S
L
Y
S
S
P
V
N
S
S
A
Site 36
S310
P
A
S
S
L
Y
S
S
P
V
N
S
S
A
P
Site 37
S314
L
Y
S
S
P
V
N
S
S
A
P
L
A
E
D
Site 38
Y329
I
D
P
E
L
A
R
Y
L
N
R
N
Y
W
E
Site 39
Y334
A
R
Y
L
N
R
N
Y
W
E
K
K
Q
E
E
Site 40
S345
K
Q
E
E
A
R
K
S
P
T
P
S
A
P
V
Site 41
T347
E
E
A
R
K
S
P
T
P
S
A
P
V
P
L
Site 42
S349
A
R
K
S
P
T
P
S
A
P
V
P
L
T
E
Site 43
T355
P
S
A
P
V
P
L
T
E
P
A
A
Q
P
G
Site 44
S381
N
P
L
P
E
T
D
S
Q
P
I
P
P
S
G
Site 45
S387
D
S
Q
P
I
P
P
S
G
G
P
F
S
E
P
Site 46
S392
P
P
S
G
G
P
F
S
E
P
Q
F
H
N
G
Site 47
S404
H
N
G
E
S
E
E
S
H
E
Q
F
L
K
A
Site 48
T418
A
L
Q
N
A
V
T
T
F
V
N
R
M
K
S
Site 49
S432
S
N
H
M
R
G
R
S
I
T
N
D
S
A
V
Site 50
T434
H
M
R
G
R
S
I
T
N
D
S
A
V
L
S
Site 51
S437
G
R
S
I
T
N
D
S
A
V
L
S
L
F
Q
Site 52
Y466
Q
L
D
E
R
R
L
Y
Y
E
G
L
Q
D
K
Site 53
Y467
L
D
E
R
R
L
Y
Y
E
G
L
Q
D
K
L
Site 54
S485
R
D
A
R
G
A
L
S
A
L
R
E
E
H
R
Site 55
Y524
M
R
Q
K
K
Q
E
Y
L
E
V
Q
R
Q
L
Site 56
T553
R
L
E
Q
Q
K
Q
T
V
Q
M
R
A
Q
M
Site 57
Y567
M
P
A
F
P
L
P
Y
A
Q
L
Q
A
M
P
Site 58
Y581
P
A
A
G
G
V
L
Y
Q
P
S
G
P
A
S
Site 59
S584
G
G
V
L
Y
Q
P
S
G
P
A
S
F
P
S
Site 60
S588
Y
Q
P
S
G
P
A
S
F
P
S
T
F
S
P
Site 61
S591
S
G
P
A
S
F
P
S
T
F
S
P
A
G
S
Site 62
S594
A
S
F
P
S
T
F
S
P
A
G
S
V
E
G
Site 63
S598
S
T
F
S
P
A
G
S
V
E
G
S
P
M
H
Site 64
S602
P
A
G
S
V
E
G
S
P
M
H
G
V
Y
M
Site 65
Y608
G
S
P
M
H
G
V
Y
M
S
Q
P
A
P
A
Site 66
S610
P
M
H
G
V
Y
M
S
Q
P
A
P
A
A
G
Site 67
Y619
P
A
P
A
A
G
P
Y
P
S
M
P
S
T
A
Site 68
S621
P
A
A
G
P
Y
P
S
M
P
S
T
A
A
D
Site 69
S624
G
P
Y
P
S
M
P
S
T
A
A
D
P
S
M
Site 70
T625
P
Y
P
S
M
P
S
T
A
A
D
P
S
M
V
Site 71
S630
P
S
T
A
A
D
P
S
M
V
S
A
Y
M
Y
Site 72
Y635
D
P
S
M
V
S
A
Y
M
Y
P
A
G
A
T
Site 73
T655
P
Q
A
Q
A
G
P
T
A
S
P
A
Y
S
S
Site 74
S657
A
Q
A
G
P
T
A
S
P
A
Y
S
S
Y
Q
Site 75
Y660
G
P
T
A
S
P
A
Y
S
S
Y
Q
P
T
P
Site 76
S661
P
T
A
S
P
A
Y
S
S
Y
Q
P
T
P
T
Site 77
S662
T
A
S
P
A
Y
S
S
Y
Q
P
T
P
T
A
Site 78
T666
A
Y
S
S
Y
Q
P
T
P
T
A
G
Y
Q
N
Site 79
S676
A
G
Y
Q
N
V
A
S
Q
A
P
Q
S
L
P
Site 80
S681
V
A
S
Q
A
P
Q
S
L
P
A
I
S
Q
P
Site 81
S686
P
Q
S
L
P
A
I
S
Q
P
P
Q
S
S
T
Site 82
S691
A
I
S
Q
P
P
Q
S
S
T
M
G
Y
M
G
Site 83
S692
I
S
Q
P
P
Q
S
S
T
M
G
Y
M
G
S
Site 84
T693
S
Q
P
P
Q
S
S
T
M
G
Y
M
G
S
Q
Site 85
Y696
P
Q
S
S
T
M
G
Y
M
G
S
Q
S
V
S
Site 86
S699
S
T
M
G
Y
M
G
S
Q
S
V
S
M
G
Y
Site 87
T716
Y
N
M
Q
N
L
M
T
T
L
P
S
Q
D
A
Site 88
S720
N
L
M
T
T
L
P
S
Q
D
A
S
L
P
P
Site 89
S724
T
L
P
S
Q
D
A
S
L
P
P
Q
Q
P
Y
Site 90
Y731
S
L
P
P
Q
Q
P
Y
I
A
G
Q
Q
P
M
Site 91
Y739
I
A
G
Q
Q
P
M
Y
Q
Q
M
A
P
S
G
Site 92
S745
M
Y
Q
Q
M
A
P
S
G
G
P
P
Q
Q
Q
Site 93
S769
Q
G
P
P
A
Q
G
S
E
A
Q
L
I
S
F
Site 94
S775
G
S
E
A
Q
L
I
S
F
D
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation