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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
AIM2
Full Name:
Interferon-inducible protein AIM2
Alias:
Absent in melanoma 2; PYHIN4
Type:
Tumor suppressor
Mass (Da):
38954
Number AA:
343
UniProt ID:
O14862
International Prot ID:
IPI00844168
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006955
GO:0045786
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T18
L
T
G
L
D
N
I
T
D
E
E
L
D
R
F
Site 2
S30
D
R
F
K
F
F
L
S
D
E
F
N
I
A
T
Site 3
S60
I
Q
N
A
G
A
V
S
A
V
M
K
T
I
R
Site 4
Y74
R
I
F
Q
K
L
N
Y
M
L
L
A
K
R
L
Site 5
Y92
K
E
K
V
D
K
Q
Y
K
S
V
T
K
P
K
Site 6
S94
K
V
D
K
Q
Y
K
S
V
T
K
P
K
P
L
Site 7
S102
V
T
K
P
K
P
L
S
Q
A
E
M
S
P
A
Site 8
S111
A
E
M
S
P
A
A
S
A
A
I
R
N
D
V
Site 9
S128
Q
R
A
A
P
K
V
S
P
H
V
K
P
E
Q
Site 10
S144
Q
M
V
A
Q
Q
E
S
I
R
E
G
F
Q
K
Site 11
T166
L
K
A
K
K
P
F
T
F
E
T
Q
E
G
K
Site 12
T180
K
Q
E
M
F
H
A
T
V
A
T
E
K
E
F
Site 13
S216
I
A
R
Y
Y
R
H
S
G
F
L
E
V
N
S
Site 14
S232
S
R
V
L
D
A
E
S
D
Q
K
V
N
V
P
Site 15
T249
I
I
R
K
A
G
E
T
P
K
I
N
T
L
Q
Site 16
T254
G
E
T
P
K
I
N
T
L
Q
T
Q
P
L
G
Site 17
T257
P
K
I
N
T
L
Q
T
Q
P
L
G
T
I
V
Site 18
T262
L
Q
T
Q
P
L
G
T
I
V
N
G
L
F
V
Site 19
S285
K
N
I
L
F
D
L
S
D
N
T
G
K
M
E
Site 20
T301
L
G
V
R
N
E
D
T
M
K
C
K
E
G
D
Site 21
T313
E
G
D
K
V
R
L
T
F
F
T
L
S
K
N
Site 22
T316
K
V
R
L
T
F
F
T
L
S
K
N
G
E
K
Site 23
S318
R
L
T
F
F
T
L
S
K
N
G
E
K
L
Q
Site 24
T327
N
G
E
K
L
Q
L
T
S
G
V
H
S
T
I
Site 25
S328
G
E
K
L
Q
L
T
S
G
V
H
S
T
I
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation