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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PPEF1
Full Name:
Serine/threonine-protein phosphatase with EF-hands 1
Alias:
Protein phosphatase with EF calcium-binding domain;Serine/threonine-protein phosphatase 7
Type:
Mass (Da):
75792
Number AA:
653
UniProt ID:
O14829
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
G
C
S
S
S
S
T
K
T
R
R
S
Site 2
S7
_
M
G
C
S
S
S
S
T
K
T
R
R
S
D
Site 3
T8
M
G
C
S
S
S
S
T
K
T
R
R
S
D
T
Site 4
T10
C
S
S
S
S
T
K
T
R
R
S
D
T
S
L
Site 5
S13
S
S
T
K
T
R
R
S
D
T
S
L
R
A
A
Site 6
T15
T
K
T
R
R
S
D
T
S
L
R
A
A
L
I
Site 7
S16
K
T
R
R
S
D
T
S
L
R
A
A
L
I
I
Site 8
Y30
I
Q
N
W
Y
R
G
Y
K
A
R
L
K
A
R
Site 9
Y40
R
L
K
A
R
Q
H
Y
A
L
T
I
F
Q
S
Site 10
T43
A
R
Q
H
Y
A
L
T
I
F
Q
S
I
E
Y
Site 11
S47
Y
A
L
T
I
F
Q
S
I
E
Y
A
D
E
Q
Site 12
Y50
T
I
F
Q
S
I
E
Y
A
D
E
Q
G
Q
M
Site 13
S84
E
L
E
L
R
N
Q
S
L
E
S
E
Q
D
M
Site 14
Y97
D
M
R
D
R
W
D
Y
V
D
S
I
D
V
P
Site 15
S106
D
S
I
D
V
P
D
S
Y
N
G
P
R
L
Q
Site 16
Y107
S
I
D
V
P
D
S
Y
N
G
P
R
L
Q
F
Site 17
S162
N
F
T
H
I
Q
T
S
P
S
K
E
V
T
I
Site 18
T168
T
S
P
S
K
E
V
T
I
C
G
D
L
H
G
Site 19
Y185
D
D
L
F
L
I
F
Y
K
N
G
L
P
S
E
Site 20
S191
F
Y
K
N
G
L
P
S
E
R
N
P
Y
V
F
Site 21
Y196
L
P
S
E
R
N
P
Y
V
F
N
G
D
F
V
Site 22
Y243
D
F
M
M
N
L
R
Y
G
F
T
K
E
I
L
Site 23
Y253
T
K
E
I
L
H
K
Y
K
L
H
G
K
R
I
Site 24
T292
H
G
G
I
S
E
T
T
D
L
N
L
L
H
R
Site 25
S307
V
E
R
N
K
M
K
S
V
L
I
P
P
T
E
Site 26
T313
K
S
V
L
I
P
P
T
E
T
N
R
D
H
D
Site 27
T321
E
T
N
R
D
H
D
T
D
S
K
H
N
K
V
Site 28
S323
N
R
D
H
D
T
D
S
K
H
N
K
V
G
V
Site 29
T331
K
H
N
K
V
G
V
T
F
N
A
H
G
R
I
Site 30
T340
N
A
H
G
R
I
K
T
N
G
S
P
T
E
H
Site 31
S343
G
R
I
K
T
N
G
S
P
T
E
H
L
T
E
Site 32
S362
Q
I
I
D
I
L
W
S
D
P
R
G
K
N
G
Site 33
Y381
T
C
R
G
G
G
C
Y
F
G
P
D
V
T
S
Site 34
Y394
T
S
K
I
L
N
K
Y
Q
L
K
M
L
I
R
Site 35
S402
Q
L
K
M
L
I
R
S
H
E
C
K
P
E
G
Site 36
S423
G
K
V
V
T
I
F
S
A
S
N
Y
Y
E
E
Site 37
Y427
T
I
F
S
A
S
N
Y
Y
E
E
G
S
N
R
Site 38
Y428
I
F
S
A
S
N
Y
Y
E
E
G
S
N
R
G
Site 39
S432
S
N
Y
Y
E
E
G
S
N
R
G
A
Y
I
K
Site 40
Y437
E
G
S
N
R
G
A
Y
I
K
L
C
S
G
T
Site 41
T444
Y
I
K
L
C
S
G
T
T
P
R
F
F
Q
Y
Site 42
T445
I
K
L
C
S
G
T
T
P
R
F
F
Q
Y
Q
Site 43
Y451
T
T
P
R
F
F
Q
Y
Q
V
T
K
A
T
C
Site 44
T468
P
L
R
Q
R
V
D
T
M
E
N
S
A
I
K
Site 45
S483
I
L
R
E
R
V
I
S
R
K
S
D
L
T
R
Site 46
S486
E
R
V
I
S
R
K
S
D
L
T
R
A
F
Q
Site 47
T489
I
S
R
K
S
D
L
T
R
A
F
Q
L
Q
D
Site 48
S500
Q
L
Q
D
H
R
K
S
G
K
L
S
V
S
Q
Site 49
S504
H
R
K
S
G
K
L
S
V
S
Q
W
A
F
C
Site 50
S506
K
S
G
K
L
S
V
S
Q
W
A
F
C
M
E
Site 51
S524
G
L
N
L
P
W
R
S
L
S
S
N
L
V
N
Site 52
S526
N
L
P
W
R
S
L
S
S
N
L
V
N
I
D
Site 53
Y540
D
Q
N
G
N
V
E
Y
M
S
S
F
Q
N
I
Site 54
S543
G
N
V
E
Y
M
S
S
F
Q
N
I
R
I
E
Site 55
T559
P
V
Q
E
A
H
S
T
L
V
E
T
L
Y
R
Site 56
T563
A
H
S
T
L
V
E
T
L
Y
R
Y
R
S
D
Site 57
Y565
S
T
L
V
E
T
L
Y
R
Y
R
S
D
L
E
Site 58
Y567
L
V
E
T
L
Y
R
Y
R
S
D
L
E
I
I
Site 59
S569
E
T
L
Y
R
Y
R
S
D
L
E
I
I
F
N
Site 60
S583
N
A
I
D
T
D
H
S
G
L
I
S
V
E
E
Site 61
S587
T
D
H
S
G
L
I
S
V
E
E
F
R
A
M
Site 62
S625
M
D
L
N
K
D
G
S
I
D
F
N
E
F
L
Site 63
Y636
N
E
F
L
K
A
F
Y
V
V
H
R
Y
E
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation