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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
POLR3A
Full Name:
DNA-directed RNA polymerase III subunit RPC1
Alias:
DNA-directed RNA polymerase III subunit A; RNA polymerase III subunit C1
Type:
Mass (Da):
155624
Number AA:
1390
UniProt ID:
O14802
International Prot ID:
IPI00024163
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000428
GO:0005634
GO:0005666
Uniprot
OncoNet
Molecular Function:
GO:0000287
GO:0003676
GO:0003677
PhosphoSite+
KinaseNET
Biological Process:
GO:0006139
GO:0006350
GO:0006351
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T9
V
K
E
Q
F
R
E
T
D
V
A
K
K
I
S
Site 2
Y42
Q
V
V
S
K
N
L
Y
S
Q
D
N
Q
H
A
Site 3
S43
V
V
S
K
N
L
Y
S
Q
D
N
Q
H
A
P
Site 4
Y53
N
Q
H
A
P
L
L
Y
G
V
L
D
H
R
M
Site 5
T62
V
L
D
H
R
M
G
T
S
E
K
D
R
P
C
Site 6
Y128
E
K
K
Q
F
L
D
Y
L
K
R
P
G
L
T
Site 7
Y136
L
K
R
P
G
L
T
Y
L
Q
K
R
G
L
K
Site 8
S147
R
G
L
K
K
K
I
S
D
K
C
R
K
K
N
Site 9
Y179
L
K
I
I
H
E
K
Y
K
T
N
K
K
V
V
Site 10
T181
I
I
H
E
K
Y
K
T
N
K
K
V
V
D
P
Site 11
S268
C
I
R
P
S
V
V
S
D
L
K
S
G
T
N
Site 12
S272
S
V
V
S
D
L
K
S
G
T
N
E
D
D
L
Site 13
T280
G
T
N
E
D
D
L
T
M
K
L
T
E
I
I
Site 14
S299
V
I
K
K
H
R
I
S
G
A
K
T
Q
M
I
Site 15
S357
G
R
F
R
G
N
L
S
G
K
R
V
D
F
S
Site 16
S364
S
G
K
R
V
D
F
S
G
R
T
V
I
S
P
Site 17
S370
F
S
G
R
T
V
I
S
P
D
P
N
L
R
I
Site 18
T426
N
F
I
Q
Q
R
H
T
Q
M
K
R
F
L
K
Site 19
Y434
Q
M
K
R
F
L
K
Y
G
N
R
E
K
M
A
Site 20
Y446
K
M
A
Q
E
L
K
Y
G
D
I
V
E
R
H
Site 21
S472
Q
P
S
L
H
K
L
S
I
M
A
H
L
A
R
Site 22
T485
A
R
V
K
P
H
R
T
F
R
F
N
E
C
V
Site 23
Y496
N
E
C
V
C
T
P
Y
N
A
D
F
D
G
D
Site 24
T525
E
A
L
V
L
M
G
T
K
A
N
L
V
T
P
Site 25
T531
G
T
K
A
N
L
V
T
P
R
N
G
E
P
L
Site 26
T557
Y
L
L
T
L
K
D
T
F
F
D
R
A
K
A
Site 27
S602
W
T
G
K
Q
I
F
S
V
I
L
R
P
S
D
Site 28
S608
F
S
V
I
L
R
P
S
D
D
N
P
V
R
A
Site 29
T619
P
V
R
A
N
L
R
T
K
G
K
Q
Y
C
G
Site 30
S636
E
D
L
C
A
N
D
S
Y
V
T
I
Q
N
S
Site 31
Y637
D
L
C
A
N
D
S
Y
V
T
I
Q
N
S
E
Site 32
S643
S
Y
V
T
I
Q
N
S
E
L
M
S
G
S
M
Site 33
S647
I
Q
N
S
E
L
M
S
G
S
M
D
K
G
T
Site 34
S649
N
S
E
L
M
S
G
S
M
D
K
G
T
L
G
Site 35
T654
S
G
S
M
D
K
G
T
L
G
S
G
S
K
N
Site 36
S657
M
D
K
G
T
L
G
S
G
S
K
N
N
I
F
Site 37
S659
K
G
T
L
G
S
G
S
K
N
N
I
F
Y
I
Site 38
Y714
Q
G
L
L
K
A
K
Y
E
L
L
N
A
G
Y
Site 39
Y727
G
Y
K
K
C
D
E
Y
I
E
A
L
N
T
G
Site 40
T733
E
Y
I
E
A
L
N
T
G
K
L
Q
Q
Q
P
Site 41
S765
V
I
R
D
H
A
G
S
A
C
L
R
E
L
D
Site 42
S774
C
L
R
E
L
D
K
S
N
S
P
L
T
M
A
Site 43
S776
R
E
L
D
K
S
N
S
P
L
T
M
A
L
C
Site 44
T779
D
K
S
N
S
P
L
T
M
A
L
C
G
S
K
Site 45
S807
G
Q
Q
A
I
S
G
S
R
V
P
D
G
F
E
Site 46
S817
P
D
G
F
E
N
R
S
L
P
H
F
E
K
H
Site 47
T843
N
S
F
Y
S
G
L
T
P
T
E
F
F
F
H
Site 48
T851
P
T
E
F
F
F
H
T
M
A
G
R
E
G
L
Site 49
Y870
V
K
T
A
E
T
G
Y
M
Q
R
R
L
V
K
Site 50
S878
M
Q
R
R
L
V
K
S
L
E
D
L
C
S
Q
Site 51
S884
K
S
L
E
D
L
C
S
Q
Y
D
L
T
V
R
Site 52
T889
L
C
S
Q
Y
D
L
T
V
R
S
S
T
G
D
Site 53
S893
Y
D
L
T
V
R
S
S
T
G
D
I
I
Q
F
Site 54
S936
K
A
V
F
P
C
P
S
E
P
A
L
S
K
N
Site 55
S941
C
P
S
E
P
A
L
S
K
N
E
L
I
L
T
Site 56
T948
S
K
N
E
L
I
L
T
T
E
S
I
M
K
K
Site 57
S951
E
L
I
L
T
T
E
S
I
M
K
K
S
E
F
Site 58
S977
K
K
F
I
K
G
V
S
E
K
I
K
K
T
R
Site 59
Y987
I
K
K
T
R
D
K
Y
G
I
N
D
N
G
T
Site 60
T994
Y
G
I
N
D
N
G
T
T
E
P
R
V
L
Y
Site 61
Y1001
T
T
E
P
R
V
L
Y
Q
L
D
R
I
T
P
Site 62
T1007
L
Y
Q
L
D
R
I
T
P
T
Q
V
E
K
F
Site 63
Y1022
L
E
T
C
R
D
K
Y
M
R
A
Q
M
E
P
Site 64
T1046
Q
S
I
G
E
P
G
T
Q
M
T
L
K
T
F
Site 65
T1049
G
E
P
G
T
Q
M
T
L
K
T
F
H
F
A
Site 66
Y1097
D
K
D
D
D
A
D
Y
A
R
L
V
K
G
R
Site 67
T1108
V
K
G
R
I
E
K
T
L
L
G
E
I
S
E
Site 68
T1148
R
L
E
V
N
A
E
T
V
R
Y
S
I
C
T
Site 69
Y1151
V
N
A
E
T
V
R
Y
S
I
C
T
S
K
L
Site 70
S1152
N
A
E
T
V
R
Y
S
I
C
T
S
K
L
R
Site 71
S1156
V
R
Y
S
I
C
T
S
K
L
R
V
K
P
G
Site 72
T1176
G
E
A
V
V
C
V
T
P
R
E
N
S
K
S
Site 73
S1181
C
V
T
P
R
E
N
S
K
S
S
M
Y
Y
V
Site 74
S1183
T
P
R
E
N
S
K
S
S
M
Y
Y
V
L
Q
Site 75
S1184
P
R
E
N
S
K
S
S
M
Y
Y
V
L
Q
F
Site 76
Y1187
N
S
K
S
S
M
Y
Y
V
L
Q
F
L
K
E
Site 77
T1238
N
L
R
A
V
M
A
T
H
G
V
K
G
T
R
Site 78
T1246
H
G
V
K
G
T
R
T
T
S
N
N
T
Y
E
Site 79
T1247
G
V
K
G
T
R
T
T
S
N
N
T
Y
E
V
Site 80
S1248
V
K
G
T
R
T
T
S
N
N
T
Y
E
V
E
Site 81
T1251
T
R
T
T
S
N
N
T
Y
E
V
E
K
T
L
Site 82
Y1252
R
T
T
S
N
N
T
Y
E
V
E
K
T
L
G
Site 83
T1257
N
T
Y
E
V
E
K
T
L
G
I
E
A
A
R
Site 84
T1266
G
I
E
A
A
R
T
T
I
I
N
E
I
Q
Y
Site 85
S1291
R
R
H
V
M
L
L
S
D
L
M
T
Y
K
G
Site 86
T1304
K
G
E
V
L
G
I
T
R
F
G
L
A
K
M
Site 87
S1320
E
S
V
L
M
L
A
S
F
E
K
T
A
D
H
Site 88
Y1333
D
H
L
F
D
A
A
Y
F
G
Q
K
D
S
V
Site 89
S1339
A
Y
F
G
Q
K
D
S
V
C
G
V
S
E
C
Site 90
T1381
K
R
P
L
I
F
D
T
N
E
F
H
I
P
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation