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Updated November 2019
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Protein Info
Short Name:
CHD-2
Full Name:
Chromodomain-helicase-DNA-binding protein 2
Alias:
ATP-dependent helicase CHD2; CHD2; Chromodomain helicase DNA binding 2; Chromodomain-helicase-DNA-binding 2; EC 3.6.1.-
Type:
Helicase, DNA binding protein
Mass (Da):
211344
Number AA:
1828
UniProt ID:
O14647
International Prot ID:
IPI00023109
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000785
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004003
GO:0003677
PhosphoSite+
KinaseNET
Biological Process:
GO:0006333
GO:0006357
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
M
R
N
K
D
K
S
Q
E
E
D
S
S
L
Site 2
S13
D
K
S
Q
E
E
D
S
S
L
H
S
N
A
S
Site 3
S14
K
S
Q
E
E
D
S
S
L
H
S
N
A
S
S
Site 4
S17
E
E
D
S
S
L
H
S
N
A
S
S
H
S
A
Site 5
S20
S
S
L
H
S
N
A
S
S
H
S
A
S
E
E
Site 6
S21
S
L
H
S
N
A
S
S
H
S
A
S
E
E
A
Site 7
S23
H
S
N
A
S
S
H
S
A
S
E
E
A
S
G
Site 8
S25
N
A
S
S
H
S
A
S
E
E
A
S
G
S
D
Site 9
S29
H
S
A
S
E
E
A
S
G
S
D
S
G
S
Q
Site 10
S31
A
S
E
E
A
S
G
S
D
S
G
S
Q
S
E
Site 11
S33
E
E
A
S
G
S
D
S
G
S
Q
S
E
S
E
Site 12
S35
A
S
G
S
D
S
G
S
Q
S
E
S
E
Q
G
Site 13
S37
G
S
D
S
G
S
Q
S
E
S
E
Q
G
S
D
Site 14
S39
D
S
G
S
Q
S
E
S
E
Q
G
S
D
P
G
Site 15
S43
Q
S
E
S
E
Q
G
S
D
P
G
S
G
H
G
Site 16
S47
E
Q
G
S
D
P
G
S
G
H
G
S
E
S
N
Site 17
S51
D
P
G
S
G
H
G
S
E
S
N
S
S
S
E
Site 18
S53
G
S
G
H
G
S
E
S
N
S
S
S
E
S
S
Site 19
S55
G
H
G
S
E
S
N
S
S
S
E
S
S
E
S
Site 20
S56
H
G
S
E
S
N
S
S
S
E
S
S
E
S
Q
Site 21
S57
G
S
E
S
N
S
S
S
E
S
S
E
S
Q
S
Site 22
S59
E
S
N
S
S
S
E
S
S
E
S
Q
S
E
S
Site 23
S60
S
N
S
S
S
E
S
S
E
S
Q
S
E
S
E
Site 24
S62
S
S
S
E
S
S
E
S
Q
S
E
S
E
S
E
Site 25
S64
S
E
S
S
E
S
Q
S
E
S
E
S
E
S
A
Site 26
S66
S
S
E
S
Q
S
E
S
E
S
E
S
A
G
S
Site 27
S68
E
S
Q
S
E
S
E
S
E
S
A
G
S
K
S
Site 28
S70
Q
S
E
S
E
S
E
S
A
G
S
K
S
Q
P
Site 29
S73
S
E
S
E
S
A
G
S
K
S
Q
P
V
L
P
Site 30
S75
S
E
S
A
G
S
K
S
Q
P
V
L
P
E
A
Site 31
S88
E
A
K
E
K
P
A
S
K
K
E
R
I
A
D
Site 32
Y103
V
K
K
M
W
E
E
Y
P
D
V
Y
G
V
R
Site 33
Y107
W
E
E
Y
P
D
V
Y
G
V
R
R
S
N
R
Site 34
S112
D
V
Y
G
V
R
R
S
N
R
S
R
Q
E
P
Site 35
S115
G
V
R
R
S
N
R
S
R
Q
E
P
S
R
F
Site 36
S129
F
N
I
K
E
E
A
S
S
G
S
E
S
G
S
Site 37
S130
N
I
K
E
E
A
S
S
G
S
E
S
G
S
P
Site 38
S132
K
E
E
A
S
S
G
S
E
S
G
S
P
K
R
Site 39
S134
E
A
S
S
G
S
E
S
G
S
P
K
R
R
G
Site 40
S136
S
S
G
S
E
S
G
S
P
K
R
R
G
Q
R
Site 41
S156
E
K
W
K
Q
E
P
S
E
D
E
Q
E
Q
G
Site 42
T164
E
D
E
Q
E
Q
G
T
S
A
E
S
E
P
E
Site 43
S165
D
E
Q
E
Q
G
T
S
A
E
S
E
P
E
Q
Site 44
S168
E
Q
G
T
S
A
E
S
E
P
E
Q
K
K
V
Site 45
T185
R
R
P
V
P
R
R
T
V
P
K
P
R
V
K
Site 46
T197
R
V
K
K
Q
P
K
T
Q
R
G
K
R
K
K
Site 47
S207
G
K
R
K
K
Q
D
S
S
D
E
D
D
D
D
Site 48
S208
K
R
K
K
Q
D
S
S
D
E
D
D
D
D
D
Site 49
T222
D
E
A
P
K
R
Q
T
R
R
R
A
A
K
N
Site 50
T240
K
E
D
D
D
F
E
T
D
S
D
D
L
I
E
Site 51
S242
D
D
D
F
E
T
D
S
D
D
L
I
E
M
T
Site 52
T262
E
Q
Q
D
N
S
E
T
I
E
K
V
L
D
S
Site 53
S269
T
I
E
K
V
L
D
S
R
L
G
K
K
G
A
Site 54
T282
G
A
T
G
A
S
T
T
V
Y
A
I
E
A
N
Site 55
Y284
T
G
A
S
T
T
V
Y
A
I
E
A
N
G
D
Site 56
S293
I
E
A
N
G
D
P
S
G
D
F
D
T
E
K
Site 57
T298
D
P
S
G
D
F
D
T
E
K
D
E
G
E
I
Site 58
Y307
K
D
E
G
E
I
Q
Y
L
I
K
W
K
G
W
Site 59
S319
K
G
W
S
Y
I
H
S
T
W
E
S
E
E
S
Site 60
T320
G
W
S
Y
I
H
S
T
W
E
S
E
E
S
L
Site 61
S323
Y
I
H
S
T
W
E
S
E
E
S
L
Q
Q
Q
Site 62
S326
S
T
W
E
S
E
E
S
L
Q
Q
Q
K
V
K
Site 63
S356
K
Q
W
L
G
K
V
S
P
E
D
V
E
Y
F
Site 64
Y362
V
S
P
E
D
V
E
Y
F
N
C
Q
Q
E
L
Site 65
S391
I
A
V
K
T
S
K
S
T
L
G
Q
T
D
F
Site 66
T396
S
K
S
T
L
G
Q
T
D
F
P
A
H
S
R
Site 67
S402
Q
T
D
F
P
A
H
S
R
K
P
A
P
S
N
Site 68
S408
H
S
R
K
P
A
P
S
N
E
P
E
Y
L
C
Site 69
Y413
A
P
S
N
E
P
E
Y
L
C
K
W
M
G
L
Site 70
S426
G
L
P
Y
S
E
C
S
W
E
D
E
A
L
I
Site 71
S450
S
F
H
S
R
N
N
S
K
T
I
P
T
R
E
Site 72
T452
H
S
R
N
N
S
K
T
I
P
T
R
E
C
K
Site 73
Y476
A
L
K
K
Q
P
A
Y
L
G
G
E
N
L
E
Site 74
Y487
E
N
L
E
L
R
D
Y
Q
L
E
G
L
N
W
Site 75
Y525
Q
T
I
S
F
L
S
Y
L
F
H
Q
H
Q
L
Site 76
S547
V
P
L
S
T
L
T
S
W
Q
R
E
F
E
I
Site 77
Y577
S
R
N
T
I
R
E
Y
E
W
I
H
S
Q
T
Site 78
Y596
F
N
A
L
I
T
T
Y
E
I
L
L
K
D
K
Site 79
S627
H
R
L
K
N
D
D
S
L
L
Y
K
T
L
I
Site 80
Y630
K
N
D
D
S
L
L
Y
K
T
L
I
D
F
K
Site 81
T632
D
D
S
L
L
Y
K
T
L
I
D
F
K
S
N
Site 82
S638
K
T
L
I
D
F
K
S
N
H
R
L
L
I
T
Site 83
T645
S
N
H
R
L
L
I
T
G
T
P
L
Q
N
S
Site 84
T647
H
R
L
L
I
T
G
T
P
L
Q
N
S
L
K
Site 85
S652
T
G
T
P
L
Q
N
S
L
K
E
L
W
S
L
Site 86
Y686
G
K
G
R
E
N
G
Y
Q
S
L
H
K
V
L
Site 87
S688
G
R
E
N
G
Y
Q
S
L
H
K
V
L
E
P
Site 88
S708
V
K
K
D
V
E
K
S
L
P
A
K
V
E
Q
Site 89
S722
Q
I
L
R
V
E
M
S
A
L
Q
K
Q
Y
Y
Site 90
Y728
M
S
A
L
Q
K
Q
Y
Y
K
W
I
L
T
R
Site 91
Y729
S
A
L
Q
K
Q
Y
Y
K
W
I
L
T
R
N
Site 92
Y737
K
W
I
L
T
R
N
Y
K
A
L
A
K
G
T
Site 93
S747
L
A
K
G
T
R
G
S
T
S
G
F
L
N
I
Site 94
T748
A
K
G
T
R
G
S
T
S
G
F
L
N
I
V
Site 95
Y766
K
K
C
C
N
H
C
Y
L
I
K
P
P
E
E
Site 96
S785
N
G
Q
E
I
L
L
S
L
I
R
S
S
G
K
Site 97
T828
D
I
L
A
E
Y
L
T
I
K
H
Y
P
F
Q
Site 98
Y832
E
Y
L
T
I
K
H
Y
P
F
Q
R
L
D
G
Site 99
S840
P
F
Q
R
L
D
G
S
I
K
G
E
I
R
K
Site 100
T917
V
N
I
Y
R
L
V
T
K
G
T
V
E
E
E
Site 101
T920
Y
R
L
V
T
K
G
T
V
E
E
E
I
I
E
Site 102
T946
V
I
Q
R
M
D
T
T
G
R
T
I
L
E
N
Site 103
S955
R
T
I
L
E
N
N
S
G
R
S
N
S
N
P
Site 104
S960
N
N
S
G
R
S
N
S
N
P
F
N
K
E
E
Site 105
S988
K
E
L
E
G
E
E
S
E
P
Q
E
M
D
I
Site 106
S1010
E
T
R
E
N
E
V
S
T
S
A
T
D
E
L
Site 107
S1012
R
E
N
E
V
S
T
S
A
T
D
E
L
L
S
Site 108
T1014
N
E
V
S
T
S
A
T
D
E
L
L
S
Q
F
Site 109
S1019
S
A
T
D
E
L
L
S
Q
F
K
V
A
N
F
Site 110
Y1068
Q
K
E
L
E
E
I
Y
M
L
P
R
I
R
S
Site 111
S1075
Y
M
L
P
R
I
R
S
S
T
K
K
A
Q
T
Site 112
S1076
M
L
P
R
I
R
S
S
T
K
K
A
Q
T
N
Site 113
T1077
L
P
R
I
R
S
S
T
K
K
A
Q
T
N
D
Site 114
S1085
K
K
A
Q
T
N
D
S
D
S
D
T
E
S
K
Site 115
S1087
A
Q
T
N
D
S
D
S
D
T
E
S
K
R
Q
Site 116
T1089
T
N
D
S
D
S
D
T
E
S
K
R
Q
A
Q
Site 117
S1091
D
S
D
S
D
T
E
S
K
R
Q
A
Q
R
S
Site 118
S1098
S
K
R
Q
A
Q
R
S
S
A
S
E
S
E
T
Site 119
S1099
K
R
Q
A
Q
R
S
S
A
S
E
S
E
T
E
Site 120
S1103
Q
R
S
S
A
S
E
S
E
T
E
D
S
D
D
Site 121
T1105
S
S
A
S
E
S
E
T
E
D
S
D
D
D
K
Site 122
S1108
S
E
S
E
T
E
D
S
D
D
D
K
K
P
K
Site 123
S1122
K
R
R
G
R
P
R
S
V
R
K
D
L
V
E
Site 124
Y1143
I
R
R
F
I
K
A
Y
K
K
F
G
L
P
L
Site 125
S1166
D
A
E
L
V
D
K
S
V
A
D
L
K
R
L
Site 126
S1197
E
Q
L
K
E
N
A
S
E
G
K
G
P
G
K
Site 127
T1209
P
G
K
R
R
G
P
T
I
K
I
S
G
V
Q
Site 128
S1221
G
V
Q
V
N
V
K
S
I
I
Q
H
E
E
E
Site 129
S1235
E
F
E
M
L
H
K
S
I
P
V
D
P
E
E
Site 130
Y1246
D
P
E
E
K
K
K
Y
C
L
T
C
R
V
K
Site 131
T1249
E
K
K
K
Y
C
L
T
C
R
V
K
A
A
H
Site 132
S1267
E
W
G
V
E
D
D
S
R
L
L
L
G
I
Y
Site 133
Y1274
S
R
L
L
L
G
I
Y
E
H
G
Y
G
N
W
Site 134
Y1278
L
G
I
Y
E
H
G
Y
G
N
W
E
L
I
K
Site 135
T1286
G
N
W
E
L
I
K
T
D
P
E
L
K
L
T
Site 136
T1293
T
D
P
E
L
K
L
T
D
K
I
L
P
V
E
Site 137
Y1316
Q
L
Q
T
R
A
D
Y
L
L
K
L
L
R
K
Site 138
S1364
E
E
H
G
I
E
L
S
S
P
R
H
S
D
N
Site 139
S1365
E
H
G
I
E
L
S
S
P
R
H
S
D
N
P
Site 140
S1369
E
L
S
S
P
R
H
S
D
N
P
S
E
E
G
Site 141
S1373
P
R
H
S
D
N
P
S
E
E
G
E
V
K
D
Site 142
S1386
K
D
D
G
L
E
K
S
P
M
K
K
K
Q
K
Site 143
S1406
E
N
K
E
K
Q
M
S
S
R
K
D
K
E
G
Site 144
S1407
N
K
E
K
Q
M
S
S
R
K
D
K
E
G
D
Site 145
S1420
G
D
K
E
R
K
K
S
K
D
K
K
E
K
P
Site 146
S1429
D
K
K
E
K
P
K
S
G
D
A
K
S
S
S
Site 147
S1434
P
K
S
G
D
A
K
S
S
S
K
S
K
R
S
Site 148
S1435
K
S
G
D
A
K
S
S
S
K
S
K
R
S
Q
Site 149
S1436
S
G
D
A
K
S
S
S
K
S
K
R
S
Q
G
Site 150
S1438
D
A
K
S
S
S
K
S
K
R
S
Q
G
P
V
Site 151
S1441
S
S
S
K
S
K
R
S
Q
G
P
V
H
I
T
Site 152
T1448
S
Q
G
P
V
H
I
T
A
G
S
E
P
V
P
Site 153
T1468
D
D
D
L
D
Q
E
T
F
S
I
C
K
E
R
Site 154
S1470
D
L
D
Q
E
T
F
S
I
C
K
E
R
M
R
Site 155
S1560
K
M
A
H
K
K
R
S
Q
E
E
E
E
Q
K
Site 156
T1573
Q
K
K
K
D
D
V
T
G
G
K
K
P
F
R
Site 157
S1584
K
P
F
R
P
E
A
S
G
S
S
R
D
S
L
Site 158
S1586
F
R
P
E
A
S
G
S
S
R
D
S
L
I
S
Site 159
S1590
A
S
G
S
S
R
D
S
L
I
S
Q
S
H
T
Site 160
S1593
S
S
R
D
S
L
I
S
Q
S
H
T
S
H
N
Site 161
S1595
R
D
S
L
I
S
Q
S
H
T
S
H
N
L
H
Site 162
T1597
S
L
I
S
Q
S
H
T
S
H
N
L
H
P
Q
Site 163
S1611
Q
K
P
H
L
P
A
S
H
G
P
Q
M
H
G
Site 164
Y1624
H
G
H
P
R
D
N
Y
N
H
P
N
K
R
H
Site 165
S1686
R
H
M
D
A
H
R
S
G
S
Y
R
P
N
N
Site 166
S1688
M
D
A
H
R
S
G
S
Y
R
P
N
N
M
S
Site 167
S1695
S
Y
R
P
N
N
M
S
R
K
R
P
Y
D
Q
Site 168
Y1700
N
M
S
R
K
R
P
Y
D
Q
Y
S
S
D
R
Site 169
Y1703
R
K
R
P
Y
D
Q
Y
S
S
D
R
D
H
R
Site 170
S1704
K
R
P
Y
D
Q
Y
S
S
D
R
D
H
R
G
Site 171
S1705
R
P
Y
D
Q
Y
S
S
D
R
D
H
R
G
H
Site 172
Y1715
D
H
R
G
H
R
D
Y
Y
D
R
H
H
H
D
Site 173
Y1716
H
R
G
H
R
D
Y
Y
D
R
H
H
H
D
S
Site 174
S1723
Y
D
R
H
H
H
D
S
K
R
R
R
S
D
E
Site 175
S1728
H
D
S
K
R
R
R
S
D
E
F
R
P
Q
N
Site 176
S1745
Q
Q
D
F
R
R
M
S
D
H
R
P
A
M
G
Site 177
Y1753
D
H
R
P
A
M
G
Y
H
G
Q
G
P
S
D
Site 178
Y1762
G
Q
G
P
S
D
H
Y
R
S
F
H
T
D
K
Site 179
S1764
G
P
S
D
H
Y
R
S
F
H
T
D
K
L
G
Site 180
Y1773
H
T
D
K
L
G
E
Y
K
Q
P
L
P
P
L
Site 181
S1785
P
P
L
H
P
A
V
S
D
P
R
S
P
P
S
Site 182
S1789
P
A
V
S
D
P
R
S
P
P
S
Q
K
S
P
Site 183
S1792
S
D
P
R
S
P
P
S
Q
K
S
P
H
D
S
Site 184
S1795
R
S
P
P
S
Q
K
S
P
H
D
S
K
S
P
Site 185
S1799
S
Q
K
S
P
H
D
S
K
S
P
L
D
H
R
Site 186
S1801
K
S
P
H
D
S
K
S
P
L
D
H
R
S
P
Site 187
S1807
K
S
P
L
D
H
R
S
P
L
E
R
S
L
E
Site 188
S1812
H
R
S
P
L
E
R
S
L
E
Q
K
N
N
P
Site 189
Y1821
E
Q
K
N
N
P
D
Y
N
W
N
V
R
K
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation