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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SOCS6
Full Name:
Suppressor of cytokine signaling 6
Alias:
CIS4; CIS-4; Cish4; Cytokine-inducible SH2 4; HSPC060; SOCS4; SOCS-4; SOCS-6; SSI4; STAI4; STAT induced STAT inhibitor-4; STAT4; STATI4; Suppressor of cytokine signaling 4
Type:
Inhibitor protein
Mass (Da):
59520
Number AA:
UniProt ID:
O14544
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0007259
GO:0006952
GO:0019941
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T8
M
K
K
I
S
L
K
T
L
R
K
S
F
N
L
Site 2
S12
S
L
K
T
L
R
K
S
F
N
L
N
K
S
K
Site 3
S18
K
S
F
N
L
N
K
S
K
E
E
T
D
F
M
Site 4
T22
L
N
K
S
K
E
E
T
D
F
M
V
V
Q
Q
Site 5
S41
S
D
F
G
K
D
D
S
L
F
G
S
C
Y
G
Site 6
S45
K
D
D
S
L
F
G
S
C
Y
G
K
D
M
A
Site 7
Y47
D
S
L
F
G
S
C
Y
G
K
D
M
A
S
C
Site 8
S68
E
K
G
G
K
N
R
S
K
S
E
S
L
M
G
Site 9
S70
G
G
K
N
R
S
K
S
E
S
L
M
G
T
L
Site 10
S72
K
N
R
S
K
S
E
S
L
M
G
T
L
K
R
Site 11
T76
K
S
E
S
L
M
G
T
L
K
R
R
L
S
A
Site 12
S82
G
T
L
K
R
R
L
S
A
K
Q
K
S
K
G
Site 13
T93
K
S
K
G
K
A
G
T
P
S
G
S
S
A
D
Site 14
S95
K
G
K
A
G
T
P
S
G
S
S
A
D
E
D
Site 15
S97
K
A
G
T
P
S
G
S
S
A
D
E
D
T
F
Site 16
T103
G
S
S
A
D
E
D
T
F
S
S
S
S
A
P
Site 17
S105
S
A
D
E
D
T
F
S
S
S
S
A
P
I
V
Site 18
S107
D
E
D
T
F
S
S
S
S
A
P
I
V
F
K
Site 19
S108
E
D
T
F
S
S
S
S
A
P
I
V
F
K
D
Site 20
S124
R
A
Q
R
P
I
R
S
T
S
L
R
S
H
H
Site 21
T125
A
Q
R
P
I
R
S
T
S
L
R
S
H
H
Y
Site 22
S126
Q
R
P
I
R
S
T
S
L
R
S
H
H
Y
S
Site 23
S129
I
R
S
T
S
L
R
S
H
H
Y
S
P
A
P
Site 24
Y132
T
S
L
R
S
H
H
Y
S
P
A
P
W
P
L
Site 25
S133
S
L
R
S
H
H
Y
S
P
A
P
W
P
L
R
Site 26
T142
A
P
W
P
L
R
P
T
N
S
E
E
T
C
I
Site 27
S144
W
P
L
R
P
T
N
S
E
E
T
C
I
K
M
Site 28
T147
R
P
T
N
S
E
E
T
C
I
K
M
E
V
R
Site 29
S161
R
V
K
A
L
V
H
S
S
S
P
S
P
A
L
Site 30
S163
K
A
L
V
H
S
S
S
P
S
P
A
L
N
G
Site 31
S165
L
V
H
S
S
S
P
S
P
A
L
N
G
V
R
Site 32
S180
K
D
F
H
D
L
Q
S
E
T
T
C
Q
E
Q
Site 33
S190
T
C
Q
E
Q
A
N
S
L
K
S
S
A
S
H
Site 34
S193
E
Q
A
N
S
L
K
S
S
A
S
H
N
G
D
Site 35
S194
Q
A
N
S
L
K
S
S
A
S
H
N
G
D
L
Site 36
S196
N
S
L
K
S
S
A
S
H
N
G
D
L
H
L
Site 37
Y220
I
G
L
M
P
Q
D
Y
I
Q
Y
T
V
P
L
Site 38
Y223
M
P
Q
D
Y
I
Q
Y
T
V
P
L
D
E
G
Site 39
T224
P
Q
D
Y
I
Q
Y
T
V
P
L
D
E
G
M
Site 40
Y232
V
P
L
D
E
G
M
Y
P
L
E
G
S
R
S
Site 41
S239
Y
P
L
E
G
S
R
S
Y
C
L
D
S
S
S
Site 42
Y240
P
L
E
G
S
R
S
Y
C
L
D
S
S
S
P
Site 43
S244
S
R
S
Y
C
L
D
S
S
S
P
M
E
V
S
Site 44
S245
R
S
Y
C
L
D
S
S
S
P
M
E
V
S
A
Site 45
S246
S
Y
C
L
D
S
S
S
P
M
E
V
S
A
V
Site 46
S251
S
S
S
P
M
E
V
S
A
V
P
P
Q
V
G
Site 47
S267
R
A
F
P
E
D
E
S
Q
V
D
Q
D
L
V
Site 48
S299
T
T
G
V
M
L
Q
S
P
R
A
G
H
D
D
Site 49
S311
H
D
D
V
P
P
L
S
P
L
L
P
P
M
Q
Site 50
S327
N
Q
I
Q
R
N
F
S
G
L
T
G
T
E
A
Site 51
S350
H
L
N
F
D
P
N
S
A
P
G
V
A
R
V
Site 52
Y358
A
P
G
V
A
R
V
Y
D
S
V
Q
S
S
G
Site 53
S360
G
V
A
R
V
Y
D
S
V
Q
S
S
G
P
M
Site 54
S371
S
G
P
M
V
V
T
S
L
T
E
E
L
K
K
Site 55
S405
L
A
N
V
P
D
G
S
F
L
V
R
D
S
S
Site 56
S411
G
S
F
L
V
R
D
S
S
D
D
R
Y
L
L
Site 57
S412
S
F
L
V
R
D
S
S
D
D
R
Y
L
L
S
Site 58
Y416
R
D
S
S
D
D
R
Y
L
L
S
L
S
F
R
Site 59
S419
S
D
D
R
Y
L
L
S
L
S
F
R
S
H
G
Site 60
S421
D
R
Y
L
L
S
L
S
F
R
S
H
G
K
T
Site 61
T428
S
F
R
S
H
G
K
T
L
H
T
R
I
E
H
Site 62
S441
E
H
S
N
G
R
F
S
F
Y
E
Q
P
D
V
Site 63
Y443
S
N
G
R
F
S
F
Y
E
Q
P
D
V
E
G
Site 64
S453
P
D
V
E
G
H
T
S
I
V
D
L
I
E
H
Site 65
S461
I
V
D
L
I
E
H
S
I
R
D
S
E
N
G
Site 66
Y472
S
E
N
G
A
F
C
Y
S
R
S
R
L
P
G
Site 67
S473
E
N
G
A
F
C
Y
S
R
S
R
L
P
G
S
Site 68
S475
G
A
F
C
Y
S
R
S
R
L
P
G
S
A
T
Site 69
S480
S
R
S
R
L
P
G
S
A
T
Y
P
V
R
L
Site 70
T482
S
R
L
P
G
S
A
T
Y
P
V
R
L
T
N
Site 71
Y483
R
L
P
G
S
A
T
Y
P
V
R
L
T
N
P
Site 72
T488
A
T
Y
P
V
R
L
T
N
P
V
S
R
F
M
Site 73
S492
V
R
L
T
N
P
V
S
R
F
M
Q
V
R
S
Site 74
T512
R
F
V
I
R
Q
Y
T
R
I
D
L
I
Q
K
Site 75
Y529
L
P
N
K
M
K
D
Y
L
Q
E
K
H
Y
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation