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Updated November 2019
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Protein Info
Short Name:
CUX2
Full Name:
Homeobox protein cut-like 2
Alias:
Cut like 2; CUTL2; Cut-like 2; Homeobox protein Cux-2
Type:
Nucleus protein
Mass (Da):
154196
Number AA:
1424
UniProt ID:
O14529
International Prot ID:
IPI00022370
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0043565
GO:0003700
PhosphoSite+
KinaseNET
Biological Process:
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S17
Q
A
E
V
V
A
L
S
K
R
S
Q
E
A
E
Site 2
S29
E
A
E
A
A
F
L
S
V
Y
K
Q
L
I
E
Site 3
S49
P
V
F
E
A
A
R
S
L
D
D
R
L
Q
P
Site 4
S58
D
D
R
L
Q
P
P
S
F
D
P
S
G
Q
P
Site 5
S62
Q
P
P
S
F
D
P
S
G
Q
P
R
R
D
L
Site 6
T71
Q
P
R
R
D
L
H
T
S
W
K
R
N
P
E
Site 7
S72
P
R
R
D
L
H
T
S
W
K
R
N
P
E
L
Site 8
S81
K
R
N
P
E
L
L
S
P
K
E
Q
R
E
G
Site 9
T89
P
K
E
Q
R
E
G
T
S
P
A
G
P
T
L
Site 10
S90
K
E
Q
R
E
G
T
S
P
A
G
P
T
L
T
Site 11
T95
G
T
S
P
A
G
P
T
L
T
E
G
S
R
L
Site 12
T97
S
P
A
G
P
T
L
T
E
G
S
R
L
P
G
Site 13
S100
G
P
T
L
T
E
G
S
R
L
P
G
I
P
G
Site 14
S150
E
K
I
K
V
L
H
S
A
L
K
A
T
Q
A
Site 15
Y166
L
L
E
L
R
R
K
Y
D
E
E
A
A
S
K
Site 16
S172
K
Y
D
E
E
A
A
S
K
A
D
E
V
G
L
Site 17
S200
A
A
Q
R
E
V
E
S
L
R
E
Q
L
A
S
Site 18
S207
S
L
R
E
Q
L
A
S
V
N
S
S
I
R
L
Site 19
S218
S
I
R
L
A
C
C
S
P
Q
G
P
S
G
D
Site 20
T230
S
G
D
K
V
N
F
T
L
C
S
G
P
R
L
Site 21
S243
R
L
E
A
A
L
A
S
K
D
R
E
I
L
R
Site 22
S261
D
V
Q
H
L
Q
S
S
L
Q
E
L
E
E
A
Site 23
T281
A
D
L
E
R
Q
L
T
A
K
S
E
A
I
E
Site 24
S284
E
R
Q
L
T
A
K
S
E
A
I
E
K
L
E
Site 25
Y300
K
L
Q
A
Q
S
D
Y
E
E
I
K
T
E
L
Site 26
T305
S
D
Y
E
E
I
K
T
E
L
S
I
L
K
A
Site 27
S318
K
A
M
K
L
A
S
S
T
C
S
L
P
Q
G
Site 28
S321
K
L
A
S
S
T
C
S
L
P
Q
G
M
A
K
Site 29
S352
K
F
L
L
E
K
P
S
L
L
A
S
P
E
E
Site 30
S356
E
K
P
S
L
L
A
S
P
E
E
D
P
S
E
Site 31
S362
A
S
P
E
E
D
P
S
E
D
D
S
I
K
D
Site 32
S366
E
D
P
S
E
D
D
S
I
K
D
S
L
G
T
Site 33
S370
E
D
D
S
I
K
D
S
L
G
T
E
Q
S
Y
Site 34
S376
D
S
L
G
T
E
Q
S
Y
P
S
P
Q
Q
L
Site 35
Y377
S
L
G
T
E
Q
S
Y
P
S
P
Q
Q
L
P
Site 36
S379
G
T
E
Q
S
Y
P
S
P
Q
Q
L
P
P
P
Site 37
S394
P
G
P
E
D
P
L
S
P
S
P
G
Q
P
L
Site 38
S396
P
E
D
P
L
S
P
S
P
G
Q
P
L
L
G
Site 39
S405
G
Q
P
L
L
G
P
S
L
G
P
D
G
T
R
Site 40
T411
P
S
L
G
P
D
G
T
R
T
F
S
L
S
P
Site 41
T413
L
G
P
D
G
T
R
T
F
S
L
S
P
F
P
Site 42
S415
P
D
G
T
R
T
F
S
L
S
P
F
P
S
L
Site 43
S417
G
T
R
T
F
S
L
S
P
F
P
S
L
A
S
Site 44
S424
S
P
F
P
S
L
A
S
G
E
R
L
M
M
P
Site 45
T456
F
Y
G
A
K
P
P
T
A
P
A
T
P
A
P
Site 46
T460
K
P
P
T
A
P
A
T
P
A
P
G
P
E
P
Site 47
T493
A
E
E
E
Q
L
D
T
A
E
I
A
F
Q
V
Site 48
Y517
G
Q
R
V
F
G
H
Y
V
L
G
L
S
Q
G
Site 49
S525
V
L
G
L
S
Q
G
S
V
S
E
I
L
A
R
Site 50
S527
G
L
S
Q
G
S
V
S
E
I
L
A
R
P
K
Site 51
T540
P
K
P
W
R
K
L
T
V
K
G
K
E
P
F
Site 52
S555
I
K
M
K
Q
F
L
S
D
E
Q
N
V
L
A
Site 53
S573
I
Q
V
R
Q
R
G
S
I
T
P
R
I
R
T
Site 54
T575
V
R
Q
R
G
S
I
T
P
R
I
R
T
P
E
Site 55
T580
S
I
T
P
R
I
R
T
P
E
T
G
S
D
D
Site 56
T583
P
R
I
R
T
P
E
T
G
S
D
D
A
I
K
Site 57
S585
I
R
T
P
E
T
G
S
D
D
A
I
K
S
I
Site 58
S591
G
S
D
D
A
I
K
S
I
L
E
Q
A
K
K
Site 59
T610
Q
K
G
G
E
P
K
T
S
V
A
P
L
S
I
Site 60
S611
K
G
G
E
P
K
T
S
V
A
P
L
S
I
A
Site 61
S616
K
T
S
V
A
P
L
S
I
A
N
G
T
T
P
Site 62
T621
P
L
S
I
A
N
G
T
T
P
A
S
T
S
E
Site 63
T622
L
S
I
A
N
G
T
T
P
A
S
T
S
E
D
Site 64
S625
A
N
G
T
T
P
A
S
T
S
E
D
A
I
K
Site 65
S627
G
T
T
P
A
S
T
S
E
D
A
I
K
S
I
Site 66
S660
E
V
A
P
R
G
R
S
V
P
P
S
P
P
E
Site 67
S664
R
G
R
S
V
P
P
S
P
P
E
R
P
S
L
Site 68
S670
P
S
P
P
E
R
P
S
L
A
T
A
S
Q
N
Site 69
T673
P
E
R
P
S
L
A
T
A
S
Q
N
G
A
P
Site 70
S675
R
P
S
L
A
T
A
S
Q
N
G
A
P
A
L
Site 71
S715
S
I
I
R
K
V
K
S
E
I
G
D
A
G
Y
Site 72
Y722
S
E
I
G
D
A
G
Y
F
D
H
H
W
A
S
Site 73
S729
Y
F
D
H
H
W
A
S
D
R
G
L
L
S
R
Site 74
S735
A
S
D
R
G
L
L
S
R
P
Y
A
S
V
S
Site 75
Y738
R
G
L
L
S
R
P
Y
A
S
V
S
P
S
L
Site 76
S740
L
L
S
R
P
Y
A
S
V
S
P
S
L
S
S
Site 77
S742
S
R
P
Y
A
S
V
S
P
S
L
S
S
S
S
Site 78
S744
P
Y
A
S
V
S
P
S
L
S
S
S
S
S
S
Site 79
S746
A
S
V
S
P
S
L
S
S
S
S
S
S
G
Y
Site 80
S747
S
V
S
P
S
L
S
S
S
S
S
S
G
Y
S
Site 81
S748
V
S
P
S
L
S
S
S
S
S
S
G
Y
S
G
Site 82
S749
S
P
S
L
S
S
S
S
S
S
G
Y
S
G
Q
Site 83
S750
P
S
L
S
S
S
S
S
S
G
Y
S
G
Q
P
Site 84
S751
S
L
S
S
S
S
S
S
G
Y
S
G
Q
P
N
Site 85
Y753
S
S
S
S
S
S
G
Y
S
G
Q
P
N
G
R
Site 86
S754
S
S
S
S
S
G
Y
S
G
Q
P
N
G
R
A
Site 87
T787
A
E
D
E
P
P
R
T
G
E
L
K
A
E
G
Site 88
Y805
E
A
G
A
R
L
P
Y
Y
P
A
Y
V
P
R
Site 89
Y806
A
G
A
R
L
P
Y
Y
P
A
Y
V
P
R
T
Site 90
Y809
R
L
P
Y
Y
P
A
Y
V
P
R
T
L
K
P
Site 91
T813
Y
P
A
Y
V
P
R
T
L
K
P
T
V
P
P
Site 92
T817
V
P
R
T
L
K
P
T
V
P
P
L
T
P
E
Site 93
T822
K
P
T
V
P
P
L
T
P
E
Q
Y
E
L
Y
Site 94
Y829
T
P
E
Q
Y
E
L
Y
M
Y
R
E
V
D
T
Site 95
Y831
E
Q
Y
E
L
Y
M
Y
R
E
V
D
T
L
E
Site 96
S865
G
E
K
V
L
G
L
S
Q
G
S
V
S
D
M
Site 97
S868
V
L
G
L
S
Q
G
S
V
S
D
M
L
S
R
Site 98
S870
G
L
S
Q
G
S
V
S
D
M
L
S
R
P
K
Site 99
S874
G
S
V
S
D
M
L
S
R
P
K
P
W
S
K
Site 100
S880
L
S
R
P
K
P
W
S
K
L
T
Q
K
G
R
Site 101
S912
V
G
Q
Q
P
G
A
S
Q
A
S
P
T
E
P
Site 102
S915
Q
P
G
A
S
Q
A
S
P
T
E
P
R
S
S
Site 103
T917
G
A
S
Q
A
S
P
T
E
P
R
S
S
P
S
Site 104
S921
A
S
P
T
E
P
R
S
S
P
S
P
P
P
S
Site 105
S922
S
P
T
E
P
R
S
S
P
S
P
P
P
S
P
Site 106
S924
T
E
P
R
S
S
P
S
P
P
P
S
P
T
E
Site 107
S928
S
S
P
S
P
P
P
S
P
T
E
P
E
K
S
Site 108
T930
P
S
P
P
P
S
P
T
E
P
E
K
S
S
Q
Site 109
S935
S
P
T
E
P
E
K
S
S
Q
E
P
L
S
L
Site 110
S936
P
T
E
P
E
K
S
S
Q
E
P
L
S
L
S
Site 111
S941
K
S
S
Q
E
P
L
S
L
S
L
E
S
S
K
Site 112
S943
S
Q
E
P
L
S
L
S
L
E
S
S
K
E
N
Site 113
S947
L
S
L
S
L
E
S
S
K
E
N
Q
Q
P
E
Site 114
S957
N
Q
Q
P
E
G
R
S
S
S
S
L
S
G
K
Site 115
S958
Q
Q
P
E
G
R
S
S
S
S
L
S
G
K
M
Site 116
S959
Q
P
E
G
R
S
S
S
S
L
S
G
K
M
Y
Site 117
S960
P
E
G
R
S
S
S
S
L
S
G
K
M
Y
S
Site 118
S962
G
R
S
S
S
S
L
S
G
K
M
Y
S
G
S
Site 119
Y966
S
S
L
S
G
K
M
Y
S
G
S
Q
A
P
G
Site 120
S967
S
L
S
G
K
M
Y
S
G
S
Q
A
P
G
G
Site 121
S969
S
G
K
M
Y
S
G
S
Q
A
P
G
G
I
Q
Site 122
S982
I
Q
E
I
V
A
M
S
P
E
L
D
T
Y
S
Site 123
T987
A
M
S
P
E
L
D
T
Y
S
I
T
K
R
V
Site 124
Y988
M
S
P
E
L
D
T
Y
S
I
T
K
R
V
K
Site 125
S989
S
P
E
L
D
T
Y
S
I
T
K
R
V
K
E
Site 126
T999
K
R
V
K
E
V
L
T
D
N
N
L
G
Q
R
Site 127
S1011
G
Q
R
L
F
G
E
S
I
L
G
L
T
Q
G
Site 128
S1019
I
L
G
L
T
Q
G
S
V
S
D
L
L
S
R
Site 129
S1021
G
L
T
Q
G
S
V
S
D
L
L
S
R
P
K
Site 130
S1025
G
S
V
S
D
L
L
S
R
P
K
P
W
H
K
Site 131
S1034
P
K
P
W
H
K
L
S
L
K
G
R
E
P
F
Site 132
Y1068
K
K
L
E
K
K
A
Y
L
K
R
R
Y
G
L
Site 133
Y1073
K
A
Y
L
K
R
R
Y
G
L
I
S
T
G
S
Site 134
S1077
K
R
R
Y
G
L
I
S
T
G
S
D
S
E
S
Site 135
T1078
R
R
Y
G
L
I
S
T
G
S
D
S
E
S
P
Site 136
S1080
Y
G
L
I
S
T
G
S
D
S
E
S
P
A
T
Site 137
S1082
L
I
S
T
G
S
D
S
E
S
P
A
T
R
S
Site 138
S1084
S
T
G
S
D
S
E
S
P
A
T
R
S
E
C
Site 139
T1087
S
D
S
E
S
P
A
T
R
S
E
C
P
S
P
Site 140
S1089
S
E
S
P
A
T
R
S
E
C
P
S
P
C
L
Site 141
S1093
A
T
R
S
E
C
P
S
P
C
L
Q
P
Q
D
Site 142
S1102
C
L
Q
P
Q
D
L
S
L
L
Q
I
K
K
P
Site 143
Y1125
K
E
A
L
R
K
A
Y
Q
L
E
P
Y
P
S
Site 144
Y1130
K
A
Y
Q
L
E
P
Y
P
S
Q
Q
T
I
E
Site 145
S1132
Y
Q
L
E
P
Y
P
S
Q
Q
T
I
E
L
L
Site 146
S1140
Q
Q
T
I
E
L
L
S
F
Q
L
N
L
K
T
Site 147
S1179
D
E
P
D
L
D
P
S
G
G
P
G
I
L
P
Site 148
S1190
G
I
L
P
P
G
H
S
H
P
D
P
T
P
Q
Site 149
T1195
G
H
S
H
P
D
P
T
P
Q
S
P
D
S
E
Site 150
S1198
H
P
D
P
T
P
Q
S
P
D
S
E
T
E
D
Site 151
S1201
P
T
P
Q
S
P
D
S
E
T
E
D
Q
K
P
Site 152
T1203
P
Q
S
P
D
S
E
T
E
D
Q
K
P
T
V
Site 153
T1224
E
G
P
E
E
N
S
T
P
L
T
T
Q
D
K
Site 154
T1227
E
E
N
S
T
P
L
T
T
Q
D
K
A
Q
V
Site 155
S1251
D
A
E
E
E
A
G
S
Q
P
Q
D
S
G
E
Site 156
S1256
A
G
S
Q
P
Q
D
S
G
E
L
D
K
G
Q
Site 157
S1292
G
P
L
L
P
G
G
S
T
P
D
C
P
S
L
Site 158
T1293
P
L
L
P
G
G
S
T
P
D
C
P
S
L
H
Site 159
S1298
G
S
T
P
D
C
P
S
L
H
P
Q
Q
E
S
Site 160
S1317
R
L
H
P
D
P
L
S
F
K
S
A
S
E
S
Site 161
S1320
P
D
P
L
S
F
K
S
A
S
E
S
S
R
C
Site 162
S1322
P
L
S
F
K
S
A
S
E
S
S
R
C
S
L
Site 163
S1324
S
F
K
S
A
S
E
S
S
R
C
S
L
E
V
Site 164
S1328
A
S
E
S
S
R
C
S
L
E
V
S
L
N
S
Site 165
S1332
S
R
C
S
L
E
V
S
L
N
S
P
S
A
A
Site 166
S1335
S
L
E
V
S
L
N
S
P
S
A
A
S
S
P
Site 167
S1337
E
V
S
L
N
S
P
S
A
A
S
S
P
G
L
Site 168
S1341
N
S
P
S
A
A
S
S
P
G
L
M
M
S
V
Site 169
S1354
S
V
S
P
V
P
S
S
S
A
P
I
S
P
S
Site 170
S1355
V
S
P
V
P
S
S
S
A
P
I
S
P
S
P
Site 171
S1359
P
S
S
S
A
P
I
S
P
S
P
P
G
A
P
Site 172
S1361
S
S
A
P
I
S
P
S
P
P
G
A
P
P
A
Site 173
S1372
A
P
P
A
K
V
P
S
A
S
P
T
A
D
M
Site 174
S1374
P
A
K
V
P
S
A
S
P
T
A
D
M
A
G
Site 175
S1386
M
A
G
A
L
H
P
S
A
K
V
N
P
N
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation