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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SAPAP1
Full Name:
Disks large-associated protein 1
Alias:
DAP-1; discs, large-associated protein 1; DLGAP1; DLGP1; GKAP; Guanylate kinase-associated protein; hGKAP; PSD- 95/SAP90-binding protein 1; SAP90/PSD-95-associated protein 1
Type:
Cytoskeletal protein
Mass (Da):
108873
Number AA:
977
UniProt ID:
O14490
International Prot ID:
IPI00021941
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030054
GO:0019898
GO:0014069
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007268
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
K
G
L
S
G
S
R
S
H
H
H
G
V
Site 2
S9
K
G
L
S
G
S
R
S
H
H
H
G
V
T
C
Site 3
S22
T
C
D
S
A
C
D
S
L
S
H
H
S
D
R
Site 4
S24
D
S
A
C
D
S
L
S
H
H
S
D
R
K
P
Site 5
S27
C
D
S
L
S
H
H
S
D
R
K
P
Y
L
L
Site 6
Y32
H
H
S
D
R
K
P
Y
L
L
S
P
V
E
H
Site 7
S35
D
R
K
P
Y
L
L
S
P
V
E
H
H
P
A
Site 8
Y46
H
H
P
A
D
H
P
Y
Y
T
Q
R
N
S
F
Site 9
Y47
H
P
A
D
H
P
Y
Y
T
Q
R
N
S
F
Q
Site 10
T48
P
A
D
H
P
Y
Y
T
Q
R
N
S
F
Q
A
Site 11
S52
P
Y
Y
T
Q
R
N
S
F
Q
A
E
C
V
G
Site 12
S67
P
F
S
D
P
L
A
S
S
T
F
P
R
R
H
Site 13
S68
F
S
D
P
L
A
S
S
T
F
P
R
R
H
Y
Site 14
T69
S
D
P
L
A
S
S
T
F
P
R
R
H
Y
T
Site 15
Y75
S
T
F
P
R
R
H
Y
T
S
Q
Q
E
L
K
Site 16
T76
T
F
P
R
R
H
Y
T
S
Q
Q
E
L
K
D
Site 17
S77
F
P
R
R
H
Y
T
S
Q
Q
E
L
K
D
E
Site 18
T91
E
C
A
L
V
P
R
T
L
A
T
K
A
N
R
Site 19
S114
F
E
R
Q
L
P
L
S
R
D
G
Y
H
T
L
Site 20
Y118
L
P
L
S
R
D
G
Y
H
T
L
Q
Y
K
R
Site 21
T120
L
S
R
D
G
Y
H
T
L
Q
Y
K
R
T
A
Site 22
Y123
D
G
Y
H
T
L
Q
Y
K
R
T
A
V
E
H
Site 23
S132
R
T
A
V
E
H
R
S
D
S
P
G
R
I
R
Site 24
S134
A
V
E
H
R
S
D
S
P
G
R
I
R
H
L
Site 25
S144
R
I
R
H
L
V
H
S
V
Q
K
L
F
T
K
Site 26
T150
H
S
V
Q
K
L
F
T
K
S
H
S
L
E
G
Site 27
S152
V
Q
K
L
F
T
K
S
H
S
L
E
G
P
S
Site 28
S154
K
L
F
T
K
S
H
S
L
E
G
P
S
K
G
Site 29
S159
S
H
S
L
E
G
P
S
K
G
S
V
N
G
G
Site 30
S162
L
E
G
P
S
K
G
S
V
N
G
G
K
A
S
Site 31
S169
S
V
N
G
G
K
A
S
P
D
E
A
Q
A
A
Site 32
Y178
D
E
A
Q
A
A
R
Y
G
K
R
S
K
S
K
Site 33
S182
A
A
R
Y
G
K
R
S
K
S
K
E
R
R
A
Site 34
S184
R
Y
G
K
R
S
K
S
K
E
R
R
A
E
P
Site 35
S196
A
E
P
K
A
R
P
S
T
S
P
G
W
W
S
Site 36
T197
E
P
K
A
R
P
S
T
S
P
G
W
W
S
S
Site 37
S198
P
K
A
R
P
S
T
S
P
G
W
W
S
S
D
Site 38
S203
S
T
S
P
G
W
W
S
S
D
D
N
L
D
G
Site 39
S204
T
S
P
G
W
W
S
S
D
D
N
L
D
G
D
Site 40
T223
H
A
P
S
G
V
M
T
M
G
R
C
P
D
R
Site 41
S231
M
G
R
C
P
D
R
S
A
S
Q
Y
F
L
E
Site 42
S233
R
C
P
D
R
S
A
S
Q
Y
F
L
E
A
Y
Site 43
Y235
P
D
R
S
A
S
Q
Y
F
L
E
A
Y
N
T
Site 44
Y240
S
Q
Y
F
L
E
A
Y
N
T
I
S
E
Q
A
Site 45
T242
Y
F
L
E
A
Y
N
T
I
S
E
Q
A
V
K
Site 46
S244
L
E
A
Y
N
T
I
S
E
Q
A
V
K
A
S
Site 47
T271
N
L
P
V
S
L
D
T
P
L
L
K
K
S
A
Site 48
S277
D
T
P
L
L
K
K
S
A
W
S
S
T
L
T
Site 49
S281
L
K
K
S
A
W
S
S
T
L
T
V
S
R
A
Site 50
T282
K
K
S
A
W
S
S
T
L
T
V
S
R
A
R
Site 51
T284
S
A
W
S
S
T
L
T
V
S
R
A
R
E
V
Site 52
S286
W
S
S
T
L
T
V
S
R
A
R
E
V
Y
Q
Site 53
Y292
V
S
R
A
R
E
V
Y
Q
K
A
S
V
N
M
Site 54
S306
M
D
Q
A
M
V
K
S
E
S
C
Q
Q
E
R
Site 55
Y317
Q
Q
E
R
S
C
Q
Y
L
Q
V
P
Q
D
E
Site 56
Y328
P
Q
D
E
W
T
G
Y
T
P
R
G
K
D
D
Site 57
T329
Q
D
E
W
T
G
Y
T
P
R
G
K
D
D
E
Site 58
S344
I
P
C
R
R
M
R
S
G
S
Y
I
K
A
M
Site 59
S346
C
R
R
M
R
S
G
S
Y
I
K
A
M
G
D
Site 60
S356
K
A
M
G
D
E
D
S
G
D
S
D
T
S
P
Site 61
S359
G
D
E
D
S
G
D
S
D
T
S
P
K
P
S
Site 62
T361
E
D
S
G
D
S
D
T
S
P
K
P
S
P
K
Site 63
S362
D
S
G
D
S
D
T
S
P
K
P
S
P
K
V
Site 64
S366
S
D
T
S
P
K
P
S
P
K
V
A
A
R
R
Site 65
S375
K
V
A
A
R
R
E
S
Y
L
K
A
T
Q
P
Site 66
Y376
V
A
A
R
R
E
S
Y
L
K
A
T
Q
P
S
Site 67
T380
R
E
S
Y
L
K
A
T
Q
P
S
L
T
E
L
Site 68
S383
Y
L
K
A
T
Q
P
S
L
T
E
L
T
T
L
Site 69
T385
K
A
T
Q
P
S
L
T
E
L
T
T
L
K
I
Site 70
T389
P
S
L
T
E
L
T
T
L
K
I
S
N
E
H
Site 71
S393
E
L
T
T
L
K
I
S
N
E
H
S
P
K
L
Site 72
S397
L
K
I
S
N
E
H
S
P
K
L
Q
I
R
S
Site 73
S404
S
P
K
L
Q
I
R
S
H
S
Y
L
R
A
V
Site 74
S406
K
L
Q
I
R
S
H
S
Y
L
R
A
V
S
E
Site 75
Y407
L
Q
I
R
S
H
S
Y
L
R
A
V
S
E
V
Site 76
S412
H
S
Y
L
R
A
V
S
E
V
S
I
N
R
S
Site 77
S415
L
R
A
V
S
E
V
S
I
N
R
S
L
D
S
Site 78
S419
S
E
V
S
I
N
R
S
L
D
S
L
D
P
A
Site 79
S422
S
I
N
R
S
L
D
S
L
D
P
A
G
L
L
Site 80
T430
L
D
P
A
G
L
L
T
S
P
K
F
R
S
R
Site 81
S431
D
P
A
G
L
L
T
S
P
K
F
R
S
R
N
Site 82
S436
L
T
S
P
K
F
R
S
R
N
E
S
Y
M
R
Site 83
S440
K
F
R
S
R
N
E
S
Y
M
R
A
M
S
T
Site 84
Y441
F
R
S
R
N
E
S
Y
M
R
A
M
S
T
I
Site 85
S446
E
S
Y
M
R
A
M
S
T
I
S
Q
V
S
E
Site 86
T447
S
Y
M
R
A
M
S
T
I
S
Q
V
S
E
M
Site 87
S449
M
R
A
M
S
T
I
S
Q
V
S
E
M
E
V
Site 88
S462
E
V
N
G
Q
F
E
S
V
C
E
S
V
F
S
Site 89
S466
Q
F
E
S
V
C
E
S
V
F
S
E
L
E
S
Site 90
S473
S
V
F
S
E
L
E
S
Q
A
V
E
A
L
D
Site 91
S491
P
G
C
F
R
M
R
S
H
S
Y
V
R
A
I
Site 92
S493
C
F
R
M
R
S
H
S
Y
V
R
A
I
E
K
Site 93
Y494
F
R
M
R
S
H
S
Y
V
R
A
I
E
K
G
Site 94
S503
R
A
I
E
K
G
C
S
Q
D
D
E
C
V
S
Site 95
S510
S
Q
D
D
E
C
V
S
L
R
S
S
S
P
P
Site 96
S514
E
C
V
S
L
R
S
S
S
P
P
R
T
T
T
Site 97
S515
C
V
S
L
R
S
S
S
P
P
R
T
T
T
T
Site 98
T519
R
S
S
S
P
P
R
T
T
T
T
V
R
T
I
Site 99
T520
S
S
S
P
P
R
T
T
T
T
V
R
T
I
Q
Site 100
T521
S
S
P
P
R
T
T
T
T
V
R
T
I
Q
S
Site 101
T522
S
P
P
R
T
T
T
T
V
R
T
I
Q
S
S
Site 102
T525
R
T
T
T
T
V
R
T
I
Q
S
S
T
V
S
Site 103
S528
T
T
V
R
T
I
Q
S
S
T
V
S
S
C
I
Site 104
S529
T
V
R
T
I
Q
S
S
T
V
S
S
C
I
T
Site 105
T530
V
R
T
I
Q
S
S
T
V
S
S
C
I
T
T
Site 106
S532
T
I
Q
S
S
T
V
S
S
C
I
T
T
Y
K
Site 107
S533
I
Q
S
S
T
V
S
S
C
I
T
T
Y
K
K
Site 108
T536
S
T
V
S
S
C
I
T
T
Y
K
K
T
P
P
Site 109
T537
T
V
S
S
C
I
T
T
Y
K
K
T
P
P
P
Site 110
T541
C
I
T
T
Y
K
K
T
P
P
P
V
P
P
R
Site 111
T549
P
P
P
V
P
P
R
T
T
T
K
P
F
I
S
Site 112
T550
P
P
V
P
P
R
T
T
T
K
P
F
I
S
I
Site 113
T551
P
V
P
P
R
T
T
T
K
P
F
I
S
I
T
Site 114
S556
T
T
T
K
P
F
I
S
I
T
A
Q
S
S
T
Site 115
T558
T
K
P
F
I
S
I
T
A
Q
S
S
T
E
S
Site 116
S561
F
I
S
I
T
A
Q
S
S
T
E
S
A
Q
D
Site 117
S562
I
S
I
T
A
Q
S
S
T
E
S
A
Q
D
A
Site 118
S565
T
A
Q
S
S
T
E
S
A
Q
D
A
Y
M
D
Site 119
Y570
T
E
S
A
Q
D
A
Y
M
D
G
Q
G
Q
R
Site 120
S582
G
Q
R
G
D
I
I
S
Q
S
G
L
S
N
S
Site 121
S584
R
G
D
I
I
S
Q
S
G
L
S
N
S
T
E
Site 122
S587
I
I
S
Q
S
G
L
S
N
S
T
E
S
L
D
Site 123
S589
S
Q
S
G
L
S
N
S
T
E
S
L
D
S
M
Site 124
T590
Q
S
G
L
S
N
S
T
E
S
L
D
S
M
K
Site 125
S592
G
L
S
N
S
T
E
S
L
D
S
M
K
A
L
Site 126
S595
N
S
T
E
S
L
D
S
M
K
A
L
T
A
A
Site 127
T624
H
M
G
N
N
T
A
T
V
T
T
T
T
T
I
Site 128
S651
F
K
K
N
R
C
L
S
I
G
I
Q
V
D
D
Site 129
T665
D
A
E
E
P
D
K
T
G
E
N
K
A
P
S
Site 130
S672
T
G
E
N
K
A
P
S
K
F
Q
S
V
G
V
Site 131
S676
K
A
P
S
K
F
Q
S
V
G
V
Q
V
E
E
Site 132
T691
E
K
C
F
R
R
F
T
R
S
N
S
V
T
T
Site 133
S693
C
F
R
R
F
T
R
S
N
S
V
T
T
A
V
Site 134
S695
R
R
F
T
R
S
N
S
V
T
T
A
V
Q
A
Site 135
T697
F
T
R
S
N
S
V
T
T
A
V
Q
A
D
L
Site 136
S713
F
H
D
N
L
E
N
S
L
E
S
I
E
D
N
Site 137
S721
L
E
S
I
E
D
N
S
C
P
G
P
M
A
R
Site 138
S731
G
P
M
A
R
Q
F
S
R
D
A
S
T
S
T
Site 139
S735
R
Q
F
S
R
D
A
S
T
S
T
V
S
I
Q
Site 140
T736
Q
F
S
R
D
A
S
T
S
T
V
S
I
Q
G
Site 141
S737
F
S
R
D
A
S
T
S
T
V
S
I
Q
G
S
Site 142
T738
S
R
D
A
S
T
S
T
V
S
I
Q
G
S
G
Site 143
S740
D
A
S
T
S
T
V
S
I
Q
G
S
G
N
H
Site 144
Y748
I
Q
G
S
G
N
H
Y
H
A
C
A
A
D
D
Site 145
T759
A
A
D
D
D
F
D
T
D
F
D
P
S
I
L
Site 146
S764
F
D
T
D
F
D
P
S
I
L
P
P
P
D
P
Site 147
S775
P
P
D
P
W
I
D
S
I
T
E
D
P
L
E
Site 148
T777
D
P
W
I
D
S
I
T
E
D
P
L
E
A
V
Site 149
S787
P
L
E
A
V
Q
R
S
V
C
H
R
D
G
H
Site 150
Y847
L
L
M
A
Q
K
F
Y
Q
F
R
E
L
C
E
Site 151
T866
P
N
A
H
P
R
P
T
S
Q
D
L
A
G
F
Site 152
S867
N
A
H
P
R
P
T
S
Q
D
L
A
G
F
W
Site 153
S932
A
P
L
I
R
E
R
S
L
E
S
S
Q
R
Q
Site 154
S936
R
E
R
S
L
E
S
S
Q
R
Q
E
A
R
K
Site 155
S953
M
A
A
K
R
A
A
S
V
R
Q
N
S
A
T
Site 156
S958
A
A
S
V
R
Q
N
S
A
T
E
S
A
E
S
Site 157
T960
S
V
R
Q
N
S
A
T
E
S
A
E
S
I
E
Site 158
S962
R
Q
N
S
A
T
E
S
A
E
S
I
E
I
Y
Site 159
S965
S
A
T
E
S
A
E
S
I
E
I
Y
I
P
E
Site 160
Y969
S
A
E
S
I
E
I
Y
I
P
E
A
Q
T
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation