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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
LOH11CR2A
Full Name:
von Willebrand factor A domain-containing protein 5A
Alias:
BCSC1; BCSC-1; Breast cancer suppressor candidate 1; LHR2A; Loss of heterozygosity 11 chromosomal region 2 gene A; Von Willebrand factor A domain containing 5A
Type:
Tumor suppressor
Mass (Da):
86490
Number AA:
UniProt ID:
O00534
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S59
V
F
P
M
D
E
D
S
A
V
Y
S
F
E
A
Site 2
S63
D
E
D
S
A
V
Y
S
F
E
A
L
V
D
G
Site 3
Y87
K
M
K
A
R
T
N
Y
E
K
A
I
S
Q
G
Site 4
S92
T
N
Y
E
K
A
I
S
Q
G
H
Q
A
F
L
Site 5
S104
A
F
L
L
E
G
D
S
S
S
R
D
V
F
S
Site 6
S105
F
L
L
E
G
D
S
S
S
R
D
V
F
S
C
Site 7
S106
L
L
E
G
D
S
S
S
R
D
V
F
S
C
N
Site 8
S111
S
S
S
R
D
V
F
S
C
N
V
G
N
L
Q
Site 9
S121
V
G
N
L
Q
P
G
S
K
A
A
V
T
L
K
Site 10
Y153
P
A
V
L
N
P
R
Y
Q
F
S
G
S
S
K
Site 11
S156
L
N
P
R
Y
Q
F
S
G
S
S
K
D
S
C
Site 12
S158
P
R
Y
Q
F
S
G
S
S
K
D
S
C
L
N
Site 13
S159
R
Y
Q
F
S
G
S
S
K
D
S
C
L
N
V
Site 14
S162
F
S
G
S
S
K
D
S
C
L
N
V
K
T
P
Site 15
T168
D
S
C
L
N
V
K
T
P
I
V
P
V
E
D
Site 16
S188
S
M
V
A
T
I
D
S
Q
H
G
I
E
K
V
Site 17
S197
H
G
I
E
K
V
Q
S
N
C
P
L
S
P
T
Site 18
S202
V
Q
S
N
C
P
L
S
P
T
E
Y
L
G
E
Site 19
T204
S
N
C
P
L
S
P
T
E
Y
L
G
E
D
K
Site 20
T212
E
Y
L
G
E
D
K
T
S
A
Q
V
S
L
A
Site 21
S213
Y
L
G
E
D
K
T
S
A
Q
V
S
L
A
A
Site 22
S217
D
K
T
S
A
Q
V
S
L
A
A
G
H
K
F
Site 23
Y233
R
D
V
E
L
L
I
Y
Y
N
E
V
H
T
P
Site 24
Y234
D
V
E
L
L
I
Y
Y
N
E
V
H
T
P
S
Site 25
S265
G
D
P
S
A
M
V
S
F
Y
P
N
I
P
E
Site 26
Y267
P
S
A
M
V
S
F
Y
P
N
I
P
E
D
Q
Site 27
S289
F
I
F
L
M
D
R
S
G
S
M
Q
S
P
M
Site 28
S291
F
L
M
D
R
S
G
S
M
Q
S
P
M
S
S
Site 29
S294
D
R
S
G
S
M
Q
S
P
M
S
S
Q
D
T
Site 30
S297
G
S
M
Q
S
P
M
S
S
Q
D
T
S
Q
L
Site 31
S298
S
M
Q
S
P
M
S
S
Q
D
T
S
Q
L
R
Site 32
T301
S
P
M
S
S
Q
D
T
S
Q
L
R
I
Q
A
Site 33
S302
P
M
S
S
Q
D
T
S
Q
L
R
I
Q
A
A
Site 34
Y335
I
Y
G
F
G
S
S
Y
E
A
C
F
P
E
S
Site 35
Y345
C
F
P
E
S
V
K
Y
T
Q
Q
T
M
E
E
Site 36
Y377
L
A
P
L
Q
N
I
Y
R
G
P
S
I
P
G
Site 37
S381
Q
N
I
Y
R
G
P
S
I
P
G
H
P
L
Q
Site 38
T400
T
D
G
E
V
T
D
T
F
S
V
I
K
E
V
Site 39
S418
R
Q
K
H
R
C
F
S
F
G
I
G
E
G
T
Site 40
S441
A
R
A
S
G
G
T
S
E
F
I
T
G
K
D
Site 41
T445
G
G
T
S
E
F
I
T
G
K
D
R
M
Q
S
Site 42
S452
T
G
K
D
R
M
Q
S
K
A
L
R
T
L
K
Site 43
T457
M
Q
S
K
A
L
R
T
L
K
R
S
L
Q
P
Site 44
S461
A
L
R
T
L
K
R
S
L
Q
P
V
V
E
D
Site 45
S470
Q
P
V
V
E
D
V
S
L
S
W
H
L
P
P
Site 46
S480
W
H
L
P
P
G
L
S
A
K
M
L
S
P
E
Site 47
T489
K
M
L
S
P
E
Q
T
V
I
F
R
G
Q
R
Site 48
S499
F
R
G
Q
R
L
I
S
Y
A
Q
L
T
G
R
Site 49
Y500
R
G
Q
R
L
I
S
Y
A
Q
L
T
G
R
M
Site 50
Y520
T
G
E
V
C
L
K
Y
T
L
Q
G
K
T
F
Site 51
T526
K
Y
T
L
Q
G
K
T
F
E
D
K
V
T
F
Site 52
T532
K
T
F
E
D
K
V
T
F
P
L
Q
P
K
P
Site 53
T544
P
K
P
D
V
N
L
T
I
H
R
L
A
A
K
Site 54
S552
I
H
R
L
A
A
K
S
L
L
Q
T
K
D
M
Site 55
T556
A
A
K
S
L
L
Q
T
K
D
M
G
L
R
E
Site 56
T564
K
D
M
G
L
R
E
T
P
A
S
D
K
K
D
Site 57
S567
G
L
R
E
T
P
A
S
D
K
K
D
A
L
N
Site 58
S576
K
K
D
A
L
N
L
S
L
E
S
G
V
I
S
Site 59
S626
P
L
K
I
K
C
Q
S
G
F
R
K
A
L
H
Site 60
S634
G
F
R
K
A
L
H
S
D
R
P
P
S
A
S
Site 61
S639
L
H
S
D
R
P
P
S
A
S
Q
P
R
G
E
Site 62
S641
S
D
R
P
P
S
A
S
Q
P
R
G
E
L
M
Site 63
Y650
P
R
G
E
L
M
C
Y
K
A
K
T
F
Q
M
Site 64
Y660
K
T
F
Q
M
D
D
Y
S
L
C
G
L
I
S
Site 65
S661
T
F
Q
M
D
D
Y
S
L
C
G
L
I
S
H
Site 66
S667
Y
S
L
C
G
L
I
S
H
K
D
Q
H
S
P
Site 67
S673
I
S
H
K
D
Q
H
S
P
G
F
G
E
N
H
Site 68
Y686
N
H
L
V
Q
L
I
Y
H
Q
N
A
N
G
S
Site 69
S762
W
M
R
A
H
A
G
S
T
M
P
S
V
V
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation