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Updated November 2019
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Protein Info
Short Name:
BCL9
Full Name:
B-cell CLL/lymphoma 9 protein
Alias:
B-cell CLL/lymphoma 9; B-cell lymphoma 9 protein; Legless homolog; Protein legless homolog
Type:
Apoptosis protein, Bcl family
Mass (Da):
149290
Number AA:
1426
UniProt ID:
O00512
International Prot ID:
IPI00160290
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0016055
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
S
S
N
P
K
V
R
S
S
P
S
G
N
T
Q
Site 2
S11
S
N
P
K
V
R
S
S
P
S
G
N
T
Q
S
Site 3
S13
P
K
V
R
S
S
P
S
G
N
T
Q
S
S
P
Site 4
S18
S
P
S
G
N
T
Q
S
S
P
K
S
K
Q
E
Site 5
S19
P
S
G
N
T
Q
S
S
P
K
S
K
Q
E
V
Site 6
S22
N
T
Q
S
S
P
K
S
K
Q
E
V
M
V
R
Site 7
T32
E
V
M
V
R
P
P
T
V
M
S
P
S
G
N
Site 8
S35
V
R
P
P
T
V
M
S
P
S
G
N
P
Q
L
Site 9
S37
P
P
T
V
M
S
P
S
G
N
P
Q
L
D
S
Site 10
S44
S
G
N
P
Q
L
D
S
K
F
S
N
Q
G
K
Site 11
S47
P
Q
L
D
S
K
F
S
N
Q
G
K
Q
G
G
Site 12
S55
N
Q
G
K
Q
G
G
S
A
S
Q
S
Q
P
S
Site 13
S57
G
K
Q
G
G
S
A
S
Q
S
Q
P
S
P
C
Site 14
S59
Q
G
G
S
A
S
Q
S
Q
P
S
P
C
D
S
Site 15
S62
S
A
S
Q
S
Q
P
S
P
C
D
S
K
S
G
Site 16
S66
S
Q
P
S
P
C
D
S
K
S
G
G
H
T
P
Site 17
S68
P
S
P
C
D
S
K
S
G
G
H
T
P
K
A
Site 18
T72
D
S
K
S
G
G
H
T
P
K
A
L
P
G
P
Site 19
S82
A
L
P
G
P
G
G
S
M
G
L
K
N
G
A
Site 20
S102
G
K
G
K
R
E
R
S
I
S
A
D
S
F
D
Site 21
S104
G
K
R
E
R
S
I
S
A
D
S
F
D
Q
R
Site 22
S107
E
R
S
I
S
A
D
S
F
D
Q
R
D
P
G
Site 23
T115
F
D
Q
R
D
P
G
T
P
N
D
D
S
D
I
Site 24
S120
P
G
T
P
N
D
D
S
D
I
K
E
C
N
S
Site 25
S133
N
S
A
D
H
I
K
S
Q
D
S
Q
H
T
P
Site 26
S136
D
H
I
K
S
Q
D
S
Q
H
T
P
H
S
M
Site 27
T139
K
S
Q
D
S
Q
H
T
P
H
S
M
T
P
S
Site 28
S142
D
S
Q
H
T
P
H
S
M
T
P
S
N
A
T
Site 29
T144
Q
H
T
P
H
S
M
T
P
S
N
A
T
A
P
Site 30
S146
T
P
H
S
M
T
P
S
N
A
T
A
P
R
S
Site 31
T149
S
M
T
P
S
N
A
T
A
P
R
S
S
T
P
Site 32
S153
S
N
A
T
A
P
R
S
S
T
P
S
H
G
Q
Site 33
S154
N
A
T
A
P
R
S
S
T
P
S
H
G
Q
T
Site 34
T155
A
T
A
P
R
S
S
T
P
S
H
G
Q
T
T
Site 35
S157
A
P
R
S
S
T
P
S
H
G
Q
T
T
A
T
Site 36
T161
S
T
P
S
H
G
Q
T
T
A
T
E
P
T
P
Site 37
T164
S
H
G
Q
T
T
A
T
E
P
T
P
A
Q
K
Site 38
T167
Q
T
T
A
T
E
P
T
P
A
Q
K
T
P
A
Site 39
T172
E
P
T
P
A
Q
K
T
P
A
K
V
V
Y
V
Site 40
S209
S
F
H
I
Q
N
I
S
N
N
K
T
E
R
S
Site 41
T213
Q
N
I
S
N
N
K
T
E
R
S
T
A
P
L
Site 42
T217
N
N
K
T
E
R
S
T
A
P
L
N
T
Q
I
Site 43
S225
A
P
L
N
T
Q
I
S
A
L
R
N
D
P
K
Site 44
S249
A
N
Q
D
Q
N
S
S
Q
N
T
R
L
Q
P
Site 45
T257
Q
N
T
R
L
Q
P
T
P
P
I
P
A
P
A
Site 46
S278
P
R
P
L
D
R
E
S
P
G
V
E
N
K
L
Site 47
S288
V
E
N
K
L
I
P
S
V
G
S
P
A
S
S
Site 48
S291
K
L
I
P
S
V
G
S
P
A
S
S
T
P
L
Site 49
S294
P
S
V
G
S
P
A
S
S
T
P
L
P
P
D
Site 50
S295
S
V
G
S
P
A
S
S
T
P
L
P
P
D
G
Site 51
T296
V
G
S
P
A
S
S
T
P
L
P
P
D
G
T
Site 52
T303
T
P
L
P
P
D
G
T
G
P
N
S
T
P
N
Site 53
S307
P
D
G
T
G
P
N
S
T
P
N
N
R
A
V
Site 54
T308
D
G
T
G
P
N
S
T
P
N
N
R
A
V
T
Site 55
T315
T
P
N
N
R
A
V
T
P
V
S
Q
G
S
N
Site 56
S318
N
R
A
V
T
P
V
S
Q
G
S
N
S
S
S
Site 57
S321
V
T
P
V
S
Q
G
S
N
S
S
S
A
D
P
Site 58
S323
P
V
S
Q
G
S
N
S
S
S
A
D
P
K
A
Site 59
S325
S
Q
G
S
N
S
S
S
A
D
P
K
A
P
P
Site 60
S337
A
P
P
P
P
P
V
S
S
G
E
P
P
T
L
Site 61
S338
P
P
P
P
P
V
S
S
G
E
P
P
T
L
G
Site 62
T343
V
S
S
G
E
P
P
T
L
G
E
N
P
D
G
Site 63
S352
G
E
N
P
D
G
L
S
Q
E
Q
L
E
H
R
Site 64
S362
Q
L
E
H
R
E
R
S
L
Q
T
L
R
D
I
Site 65
T365
H
R
E
R
S
L
Q
T
L
R
D
I
Q
R
M
Site 66
T381
F
P
D
E
K
E
F
T
G
A
Q
S
G
G
P
Site 67
S413
I
Q
A
M
M
A
Q
S
Q
S
L
G
K
G
P
Site 68
S415
A
M
M
A
Q
S
Q
S
L
G
K
G
P
G
P
Site 69
T424
G
K
G
P
G
P
R
T
D
V
G
A
P
F
G
Site 70
S441
G
H
R
D
V
P
F
S
P
D
E
M
V
P
P
Site 71
S449
P
D
E
M
V
P
P
S
M
N
S
Q
S
G
T
Site 72
S452
M
V
P
P
S
M
N
S
Q
S
G
T
I
G
P
Site 73
S454
P
P
S
M
N
S
Q
S
G
T
I
G
P
D
H
Site 74
T456
S
M
N
S
Q
S
G
T
I
G
P
D
H
L
D
Site 75
T466
P
D
H
L
D
H
M
T
P
E
Q
I
A
W
L
Site 76
Y480
L
K
L
Q
Q
E
F
Y
E
E
K
R
R
K
Q
Site 77
Y518
V
R
G
P
P
P
P
Y
Q
M
T
P
S
E
G
Site 78
T521
P
P
P
P
Y
Q
M
T
P
S
E
G
W
A
P
Site 79
S523
P
P
Y
Q
M
T
P
S
E
G
W
A
P
G
G
Site 80
T531
E
G
W
A
P
G
G
T
E
P
F
S
D
G
I
Site 81
S535
P
G
G
T
E
P
F
S
D
G
I
N
M
P
H
Site 82
S543
D
G
I
N
M
P
H
S
L
P
P
R
G
M
A
Site 83
S558
P
H
P
N
M
P
G
S
Q
M
R
L
P
G
F
Site 84
S571
G
F
A
G
M
I
N
S
E
M
E
G
P
N
V
Site 85
S583
P
N
V
P
N
P
A
S
R
P
G
L
S
G
V
Site 86
S588
P
A
S
R
P
G
L
S
G
V
S
W
P
D
D
Site 87
S613
P
P
G
Q
G
I
F
S
G
P
G
R
G
E
R
Site 88
S665
M
N
R
M
I
P
G
S
Q
R
H
M
E
P
G
Site 89
S687
I
P
V
E
G
P
L
S
P
S
R
G
D
F
P
Site 90
S689
V
E
G
P
L
S
P
S
R
G
D
F
P
K
G
Site 91
S788
P
R
P
F
L
P
M
S
Q
G
P
G
S
N
S
Site 92
S793
P
M
S
Q
G
P
G
S
N
S
G
L
R
N
L
Site 93
T810
P
I
G
P
D
Q
R
T
N
S
R
L
S
H
M
Site 94
S812
G
P
D
Q
R
T
N
S
R
L
S
H
M
P
P
Site 95
S815
Q
R
T
N
S
R
L
S
H
M
P
P
L
P
L
Site 96
S825
P
P
L
P
L
N
P
S
S
N
P
T
S
L
N
Site 97
S826
P
L
P
L
N
P
S
S
N
P
T
S
L
N
T
Site 98
S830
N
P
S
S
N
P
T
S
L
N
T
A
P
P
V
Site 99
T833
S
N
P
T
S
L
N
T
A
P
P
V
Q
R
G
Site 100
S849
G
R
K
P
L
D
I
S
V
A
G
S
Q
V
H
Site 101
S857
V
A
G
S
Q
V
H
S
P
G
I
N
P
L
K
Site 102
S865
P
G
I
N
P
L
K
S
P
T
M
H
Q
V
Q
Site 103
T867
I
N
P
L
K
S
P
T
M
H
Q
V
Q
S
P
Site 104
S873
P
T
M
H
Q
V
Q
S
P
M
L
G
S
P
S
Site 105
S878
V
Q
S
P
M
L
G
S
P
S
G
N
L
K
S
Site 106
S880
S
P
M
L
G
S
P
S
G
N
L
K
S
P
Q
Site 107
S885
S
P
S
G
N
L
K
S
P
Q
T
P
S
Q
L
Site 108
T888
G
N
L
K
S
P
Q
T
P
S
Q
L
A
G
M
Site 109
S890
L
K
S
P
Q
T
P
S
Q
L
A
G
M
L
A
Site 110
S907
A
A
A
A
S
I
K
S
P
P
V
L
G
S
A
Site 111
S913
K
S
P
P
V
L
G
S
A
A
A
S
P
V
H
Site 112
S917
V
L
G
S
A
A
A
S
P
V
H
L
K
S
P
Site 113
S923
A
S
P
V
H
L
K
S
P
S
L
P
A
P
S
Site 114
S925
P
V
H
L
K
S
P
S
L
P
A
P
S
P
G
Site 115
S930
S
P
S
L
P
A
P
S
P
G
W
T
S
S
P
Site 116
T934
P
A
P
S
P
G
W
T
S
S
P
K
P
P
L
Site 117
S935
A
P
S
P
G
W
T
S
S
P
K
P
P
L
Q
Site 118
S936
P
S
P
G
W
T
S
S
P
K
P
P
L
Q
S
Site 119
S943
S
P
K
P
P
L
Q
S
P
G
I
P
P
N
H
Site 120
T955
P
N
H
K
A
P
L
T
M
A
S
P
A
M
L
Site 121
S958
K
A
P
L
T
M
A
S
P
A
M
L
G
N
V
Site 122
S967
A
M
L
G
N
V
E
S
G
G
P
P
P
P
T
Site 123
T974
S
G
G
P
P
P
P
T
A
S
Q
P
A
S
V
Site 124
S976
G
P
P
P
P
T
A
S
Q
P
A
S
V
N
I
Site 125
S980
P
T
A
S
Q
P
A
S
V
N
I
P
G
S
L
Site 126
S986
A
S
V
N
I
P
G
S
L
P
S
S
T
P
Y
Site 127
S989
N
I
P
G
S
L
P
S
S
T
P
Y
T
M
P
Site 128
S990
I
P
G
S
L
P
S
S
T
P
Y
T
M
P
P
Site 129
T991
P
G
S
L
P
S
S
T
P
Y
T
M
P
P
E
Site 130
Y993
S
L
P
S
S
T
P
Y
T
M
P
P
E
P
T
Site 131
T994
L
P
S
S
T
P
Y
T
M
P
P
E
P
T
L
Site 132
T1000
Y
T
M
P
P
E
P
T
L
S
Q
N
P
L
S
Site 133
S1002
M
P
P
E
P
T
L
S
Q
N
P
L
S
I
M
Site 134
S1007
T
L
S
Q
N
P
L
S
I
M
M
S
R
M
S
Site 135
S1014
S
I
M
M
S
R
M
S
K
F
A
M
P
S
S
Site 136
S1020
M
S
K
F
A
M
P
S
S
T
P
L
Y
H
D
Site 137
S1021
S
K
F
A
M
P
S
S
T
P
L
Y
H
D
A
Site 138
T1022
K
F
A
M
P
S
S
T
P
L
Y
H
D
A
I
Site 139
Y1025
M
P
S
S
T
P
L
Y
H
D
A
I
K
T
V
Site 140
T1031
L
Y
H
D
A
I
K
T
V
A
S
S
D
D
D
Site 141
S1034
D
A
I
K
T
V
A
S
S
D
D
D
S
P
P
Site 142
S1035
A
I
K
T
V
A
S
S
D
D
D
S
P
P
A
Site 143
S1039
V
A
S
S
D
D
D
S
P
P
A
R
S
P
N
Site 144
S1044
D
D
S
P
P
A
R
S
P
N
L
P
S
M
N
Site 145
S1049
A
R
S
P
N
L
P
S
M
N
N
M
P
G
M
Site 146
T1060
M
P
G
M
G
I
N
T
Q
N
P
R
I
S
G
Site 147
S1066
N
T
Q
N
P
R
I
S
G
P
N
P
V
V
P
Site 148
T1083
T
L
S
P
M
G
M
T
Q
P
L
S
H
S
N
Site 149
S1087
M
G
M
T
Q
P
L
S
H
S
N
Q
M
P
S
Site 150
S1089
M
T
Q
P
L
S
H
S
N
Q
M
P
S
P
N
Site 151
S1094
S
H
S
N
Q
M
P
S
P
N
A
V
G
P
N
Site 152
S1124
N
P
I
M
G
H
G
S
Q
E
P
P
M
V
P
Site 153
S1146
Q
G
F
P
P
V
Q
S
P
P
Q
Q
V
P
F
Site 154
S1159
P
F
P
H
N
G
P
S
G
G
Q
G
S
F
P
Site 155
S1164
G
P
S
G
G
Q
G
S
F
P
G
G
M
G
F
Site 156
S1181
E
G
P
L
G
R
P
S
N
L
P
Q
S
S
A
Site 157
S1186
R
P
S
N
L
P
Q
S
S
A
D
A
A
L
C
Site 158
S1203
G
G
P
G
G
P
D
S
F
T
V
L
G
N
S
Site 159
T1205
P
G
G
P
D
S
F
T
V
L
G
N
S
M
P
Site 160
S1237
G
I
P
E
F
D
L
S
R
I
I
P
S
E
K
Site 161
S1242
D
L
S
R
I
I
P
S
E
K
P
S
Q
T
L
Site 162
S1246
I
I
P
S
E
K
P
S
Q
T
L
Q
Y
F
P
Site 163
T1248
P
S
E
K
P
S
Q
T
L
Q
Y
F
P
R
G
Site 164
Y1251
K
P
S
Q
T
L
Q
Y
F
P
R
G
E
V
P
Site 165
T1299
G
G
P
G
P
V
G
T
P
D
I
P
L
G
T
Site 166
T1306
T
P
D
I
P
L
G
T
A
P
S
M
P
G
H
Site 167
S1309
I
P
L
G
T
A
P
S
M
P
G
H
N
P
M
Site 168
S1335
G
P
H
H
R
M
M
S
P
A
Q
S
T
M
P
Site 169
S1339
R
M
M
S
P
A
Q
S
T
M
P
G
Q
P
T
Site 170
T1346
S
T
M
P
G
Q
P
T
L
M
S
N
P
A
A
Site 171
S1349
P
G
Q
P
T
L
M
S
N
P
A
A
A
V
G
Site 172
Y1369
D
R
G
P
A
G
L
Y
T
H
P
G
P
V
G
Site 173
T1370
R
G
P
A
G
L
Y
T
H
P
G
P
V
G
S
Site 174
S1377
T
H
P
G
P
V
G
S
P
G
M
M
M
S
M
Site 175
S1415
D
V
G
M
G
G
F
S
Q
G
P
G
N
P
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation