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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
YSK1
Full Name:
Serine/threonine-protein kinase 25
Alias:
EC 2.7.11.1; SOK1; ST25; Ste20,oxidant stress response kinase-1; Ste20-like kinase; Sterile 20,oxidant stress-response kinase 1; STK25
Type:
Protein-serine kinase, STE group, STE20 family, YSK subfamily
Mass (Da):
48112
Number AA:
426
UniProt ID:
O00506
International Prot ID:
IPI00012093
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0042802
GO:0000287
PhosphoSite+
KinaseNET
Biological Process:
GO:0006468
GO:0006979
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Serine/threonine-protein kinase 25 T174 phosphosite-specific antibody AB-PK859#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK859#Serine/threonine-protein kinase 25 (K171-G177, human) pT174 phosphopeptide - Powder PE-04ALL99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04ALL99
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
R
G
F
A
N
Q
H
S
R
V
D
P
E
E
L
Site 2
T21
V
D
P
E
E
L
F
T
K
L
D
R
I
G
K
Site 3
S30
L
D
R
I
G
K
G
S
F
G
E
V
Y
K
G
Site 4
Y35
K
G
S
F
G
E
V
Y
K
G
I
D
N
H
T
Site 5
T42
Y
K
G
I
D
N
H
T
K
E
V
V
A
I
K
Site 6
S71
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
I
Site 7
S75
T
V
L
S
Q
C
D
S
P
Y
I
T
R
Y
F
Site 8
Y77
L
S
Q
C
D
S
P
Y
I
T
R
Y
F
G
S
Site 9
Y81
D
S
P
Y
I
T
R
Y
F
G
S
Y
L
K
S
Site 10
S84
Y
I
T
R
Y
F
G
S
Y
L
K
S
T
K
L
Site 11
Y85
I
T
R
Y
F
G
S
Y
L
K
S
T
K
L
W
Site 12
Y116
P
G
P
L
E
E
T
Y
I
A
T
I
L
R
E
Site 13
Y130
E
I
L
K
G
L
D
Y
L
H
S
E
R
K
I
Site 14
S133
K
G
L
D
Y
L
H
S
E
R
K
I
H
R
D
Site 15
T166
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
Site 16
T168
V
A
G
Q
L
T
D
T
Q
I
K
R
N
T
F
Site 17
T174
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
Serine/threonine-protein kinase 25 T174 phosphosite-specific antibody AB-PK859#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK859#Serine/threonine-protein kinase 25 (K171-G177, human) pT174 phosphopeptide - Powder PE-04ALL99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04ALL99
Site 18
T178
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
Site 19
S216
A
K
G
E
P
P
N
S
D
L
H
P
M
R
V
Site 20
S231
L
F
L
I
P
K
N
S
P
P
T
L
E
G
Q
Site 21
T234
I
P
K
N
S
P
P
T
L
E
G
Q
H
S
K
Site 22
S240
P
T
L
E
G
Q
H
S
K
P
F
K
E
F
V
Site 23
T260
K
D
P
R
F
R
P
T
A
K
E
L
L
K
H
Site 24
Y273
K
H
K
F
I
T
R
Y
T
K
K
T
S
F
L
Site 25
T274
H
K
F
I
T
R
Y
T
K
K
T
S
F
L
T
Site 26
T277
I
T
R
Y
T
K
K
T
S
F
L
T
E
L
I
Site 27
S278
T
R
Y
T
K
K
T
S
F
L
T
E
L
I
D
Site 28
Y287
L
T
E
L
I
D
R
Y
K
R
W
K
S
E
G
Site 29
S292
D
R
Y
K
R
W
K
S
E
G
H
G
E
E
S
Site 30
S299
S
E
G
H
G
E
E
S
S
S
E
D
S
D
I
Site 31
S300
E
G
H
G
E
E
S
S
S
E
D
S
D
I
D
Site 32
S301
G
H
G
E
E
S
S
S
E
D
S
D
I
D
G
Site 33
S304
E
E
S
S
S
E
D
S
D
I
D
G
E
A
E
Site 34
T320
G
E
Q
G
P
I
W
T
F
P
P
T
I
R
P
Site 35
T324
P
I
W
T
F
P
P
T
I
R
P
S
P
H
S
Site 36
S328
F
P
P
T
I
R
P
S
P
H
S
K
L
H
K
Site 37
S331
T
I
R
P
S
P
H
S
K
L
H
K
G
T
A
Site 38
S342
K
G
T
A
L
H
S
S
Q
K
P
A
E
P
V
Site 39
S355
P
V
K
R
Q
P
R
S
Q
C
L
S
T
L
V
Site 40
S359
Q
P
R
S
Q
C
L
S
T
L
V
R
P
V
F
Site 41
T360
P
R
S
Q
C
L
S
T
L
V
R
P
V
F
G
Site 42
S391
E
E
L
E
N
A
F
S
L
A
E
E
S
C
P
Site 43
S396
A
F
S
L
A
E
E
S
C
P
G
I
S
D
K
Site 44
S401
E
E
S
C
P
G
I
S
D
K
L
M
V
H
L
Site 45
S416
V
E
R
V
Q
R
F
S
H
N
R
N
H
L
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation