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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ELL2
Full Name:
RNA polymerase II elongation factor ELL2
Alias:
ELL-related RNA polymerase II, elongation factor; Elongation factor, RNA polymerase II, 2; Putative DKFZp779C185; RNA polymerase II, 2
Type:
Transcription factor
Mass (Da):
72324
Number AA:
640
UniProt ID:
O00472
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0008023
Uniprot
OncoNet
Molecular Function:
GO:0016944
GO:0003702
PhosphoSite+
KinaseNET
Biological Process:
GO:0006368
GO:0045449
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y15
G
L
R
E
E
Q
R
Y
G
L
S
C
G
R
L
Site 2
S18
E
E
Q
R
Y
G
L
S
C
G
R
L
G
Q
D
Site 3
T28
R
L
G
Q
D
N
I
T
V
L
H
V
K
L
T
Site 4
Y45
A
I
R
A
L
E
T
Y
Q
S
H
K
N
L
I
Site 5
S47
R
A
L
E
T
Y
Q
S
H
K
N
L
I
P
F
Site 6
S57
N
L
I
P
F
R
P
S
I
Q
F
Q
G
L
H
Site 7
Y84
E
V
H
N
F
N
F
Y
L
S
N
V
G
K
D
Site 8
S96
G
K
D
N
P
Q
G
S
F
D
C
I
Q
Q
T
Site 9
T103
S
F
D
C
I
Q
Q
T
F
S
S
S
G
A
S
Site 10
S105
D
C
I
Q
Q
T
F
S
S
S
G
A
S
Q
L
Site 11
S106
C
I
Q
Q
T
F
S
S
S
G
A
S
Q
L
N
Site 12
S107
I
Q
Q
T
F
S
S
S
G
A
S
Q
L
N
C
Site 13
T123
G
F
I
Q
D
K
I
T
V
C
A
T
N
D
S
Site 14
Y131
V
C
A
T
N
D
S
Y
Q
M
T
R
E
R
M
Site 15
T134
T
N
D
S
Y
Q
M
T
R
E
R
M
T
Q
A
Site 16
T139
Q
M
T
R
E
R
M
T
Q
A
E
E
E
S
R
Site 17
S145
M
T
Q
A
E
E
E
S
R
N
R
S
T
K
V
Site 18
S149
E
E
E
S
R
N
R
S
T
K
V
I
K
P
G
Site 19
T150
E
E
S
R
N
R
S
T
K
V
I
K
P
G
G
Site 20
Y159
V
I
K
P
G
G
P
Y
V
G
K
R
V
Q
I
Site 21
S174
R
K
A
P
Q
A
V
S
D
T
V
P
E
R
K
Site 22
T176
A
P
Q
A
V
S
D
T
V
P
E
R
K
R
S
Site 23
S183
T
V
P
E
R
K
R
S
T
P
M
N
P
A
N
Site 24
T184
V
P
E
R
K
R
S
T
P
M
N
P
A
N
T
Site 25
T191
T
P
M
N
P
A
N
T
I
R
K
T
H
S
S
Site 26
T195
P
A
N
T
I
R
K
T
H
S
S
S
T
I
S
Site 27
S197
N
T
I
R
K
T
H
S
S
S
T
I
S
Q
R
Site 28
S198
T
I
R
K
T
H
S
S
S
T
I
S
Q
R
P
Site 29
S199
I
R
K
T
H
S
S
S
T
I
S
Q
R
P
Y
Site 30
T200
R
K
T
H
S
S
S
T
I
S
Q
R
P
Y
R
Site 31
S202
T
H
S
S
S
T
I
S
Q
R
P
Y
R
D
R
Site 32
Y206
S
T
I
S
Q
R
P
Y
R
D
R
V
I
H
L
Site 33
S240
V
N
Q
K
D
K
N
S
L
G
A
I
L
Q
Q
Site 34
S253
Q
Q
V
A
N
L
N
S
K
D
L
S
Y
T
L
Site 35
S257
N
L
N
S
K
D
L
S
Y
T
L
K
D
Y
V
Site 36
Y258
L
N
S
K
D
L
S
Y
T
L
K
D
Y
V
F
Site 37
Y263
L
S
Y
T
L
K
D
Y
V
F
K
E
L
Q
R
Site 38
Y275
L
Q
R
D
W
P
G
Y
S
E
I
D
R
R
S
Site 39
S282
Y
S
E
I
D
R
R
S
L
E
S
V
L
S
R
Site 40
S285
I
D
R
R
S
L
E
S
V
L
S
R
K
L
N
Site 41
S288
R
S
L
E
S
V
L
S
R
K
L
N
P
S
Q
Site 42
S294
L
S
R
K
L
N
P
S
Q
N
A
A
G
T
S
Site 43
S301
S
Q
N
A
A
G
T
S
R
S
E
S
P
V
C
Site 44
S303
N
A
A
G
T
S
R
S
E
S
P
V
C
S
S
Site 45
S305
A
G
T
S
R
S
E
S
P
V
C
S
S
R
D
Site 46
S309
R
S
E
S
P
V
C
S
S
R
D
A
V
S
S
Site 47
S310
S
E
S
P
V
C
S
S
R
D
A
V
S
S
P
Site 48
S315
C
S
S
R
D
A
V
S
S
P
Q
K
R
L
L
Site 49
S316
S
S
R
D
A
V
S
S
P
Q
K
R
L
L
D
Site 50
S324
P
Q
K
R
L
L
D
S
E
F
I
D
P
L
M
Site 51
S338
M
N
K
K
A
R
I
S
H
L
T
N
R
V
P
Site 52
T341
K
A
R
I
S
H
L
T
N
R
V
P
P
T
L
Site 53
T347
L
T
N
R
V
P
P
T
L
N
G
H
L
N
P
Site 54
S356
N
G
H
L
N
P
T
S
E
K
S
A
A
G
L
Site 55
S359
L
N
P
T
S
E
K
S
A
A
G
L
P
L
P
Site 56
S380
P
T
P
P
P
L
P
S
T
Y
L
P
I
S
H
Site 57
T381
T
P
P
P
L
P
S
T
Y
L
P
I
S
H
P
Site 58
Y382
P
P
P
L
P
S
T
Y
L
P
I
S
H
P
P
Site 59
S386
P
S
T
Y
L
P
I
S
H
P
P
Q
I
V
N
Site 60
S394
H
P
P
Q
I
V
N
S
N
S
N
S
P
S
T
Site 61
S396
P
Q
I
V
N
S
N
S
N
S
P
S
T
P
E
Site 62
S398
I
V
N
S
N
S
N
S
P
S
T
P
E
G
R
Site 63
S400
N
S
N
S
N
S
P
S
T
P
E
G
R
G
T
Site 64
T401
S
N
S
N
S
P
S
T
P
E
G
R
G
T
Q
Site 65
T407
S
T
P
E
G
R
G
T
Q
D
L
P
V
D
S
Site 66
S414
T
Q
D
L
P
V
D
S
F
S
Q
N
D
S
I
Site 67
S416
D
L
P
V
D
S
F
S
Q
N
D
S
I
Y
E
Site 68
S420
D
S
F
S
Q
N
D
S
I
Y
E
D
Q
Q
D
Site 69
Y422
F
S
Q
N
D
S
I
Y
E
D
Q
Q
D
K
Y
Site 70
Y429
Y
E
D
Q
Q
D
K
Y
T
S
R
T
S
L
E
Site 71
T430
E
D
Q
Q
D
K
Y
T
S
R
T
S
L
E
T
Site 72
S434
D
K
Y
T
S
R
T
S
L
E
T
L
P
P
G
Site 73
T437
T
S
R
T
S
L
E
T
L
P
P
G
S
V
L
Site 74
S456
K
P
M
E
E
N
H
S
M
S
H
K
K
S
K
Site 75
S462
H
S
M
S
H
K
K
S
K
K
K
S
K
K
H
Site 76
S466
H
K
K
S
K
K
K
S
K
K
H
K
E
K
D
Site 77
S502
E
I
A
K
L
N
N
S
S
P
N
S
S
G
G
Site 78
S503
I
A
K
L
N
N
S
S
P
N
S
S
G
G
V
Site 79
S506
L
N
N
S
S
P
N
S
S
G
G
V
K
E
D
Site 80
S507
N
N
S
S
P
N
S
S
G
G
V
K
E
D
C
Site 81
T515
G
G
V
K
E
D
C
T
A
S
M
E
P
S
A
Site 82
S517
V
K
E
D
C
T
A
S
M
E
P
S
A
I
E
Site 83
S521
C
T
A
S
M
E
P
S
A
I
E
L
P
D
Y
Site 84
Y538
K
Y
I
A
I
V
S
Y
E
Q
R
Q
N
Y
K
Site 85
Y544
S
Y
E
Q
R
Q
N
Y
K
D
D
F
N
A
E
Site 86
Y552
K
D
D
F
N
A
E
Y
D
E
Y
R
A
L
H
Site 87
Y555
F
N
A
E
Y
D
E
Y
R
A
L
H
A
R
M
Site 88
T564
A
L
H
A
R
M
E
T
V
A
R
R
F
I
K
Site 89
S580
D
A
Q
R
K
R
L
S
P
G
S
K
E
Y
Q
Site 90
S583
R
K
R
L
S
P
G
S
K
E
Y
Q
N
V
H
Site 91
Y597
H
E
E
V
L
Q
E
Y
Q
K
I
K
Q
S
S
Site 92
S604
Y
Q
K
I
K
Q
S
S
P
N
Y
H
E
E
K
Site 93
Y607
I
K
Q
S
S
P
N
Y
H
E
E
K
Y
R
C
Site 94
Y612
P
N
Y
H
E
E
K
Y
R
C
E
Y
L
H
N
Site 95
Y616
E
E
K
Y
R
C
E
Y
L
H
N
K
L
A
H
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation