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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MANBA
Full Name:
Beta-mannosidase
Alias:
EC 3.2.1.25; Lysosomal beta A mannosidase; MANB1; Mannanase; Mannase; Mannosidase, beta A, lysosomal
Type:
Hydrolase, Glycan Biosynthesis and Metabolism group, Glycan structures - degradation family, N-Glycan degradation family
Mass (Da):
100895
Number AA:
879
UniProt ID:
O00462
International Prot ID:
IPI00298793
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005764
Uniprot
OncoNet
Molecular Function:
GO:0004567
GO:0043169
PhosphoSite+
KinaseNET
Biological Process:
GO:0005975
GO:0006464
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S22
G
T
T
A
A
E
L
S
Y
S
L
R
G
N
W
Site 2
S24
T
A
A
E
L
S
Y
S
L
R
G
N
W
S
I
Site 3
Y62
Q
G
L
I
Q
D
S
Y
Y
R
F
N
D
L
N
Site 4
Y63
G
L
I
Q
D
S
Y
Y
R
F
N
D
L
N
Y
Site 5
Y70
Y
R
F
N
D
L
N
Y
R
W
V
S
L
D
N
Site 6
T131
N
R
Y
S
F
D
I
T
N
V
V
R
D
V
N
Site 7
S139
N
V
V
R
D
V
N
S
I
E
L
R
F
Q
S
Site 8
Y150
R
F
Q
S
A
V
L
Y
A
A
Q
Q
S
K
A
Site 9
T159
A
Q
Q
S
K
A
H
T
R
Y
Q
V
P
P
D
Site 10
Y161
Q
S
K
A
H
T
R
Y
Q
V
P
P
D
C
P
Site 11
Y210
K
D
V
R
I
E
A
Y
N
I
C
H
L
N
Y
Site 12
T219
I
C
H
L
N
Y
F
T
F
S
P
I
Y
D
K
Site 13
S221
H
L
N
Y
F
T
F
S
P
I
Y
D
K
S
A
Site 14
Y224
Y
F
T
F
S
P
I
Y
D
K
S
A
Q
E
W
Site 15
S227
F
S
P
I
Y
D
K
S
A
Q
E
W
N
L
E
Site 16
T238
W
N
L
E
I
E
S
T
F
D
V
V
S
S
K
Site 17
S243
E
S
T
F
D
V
V
S
S
K
P
V
G
G
Q
Site 18
T263
P
K
L
Q
T
Q
Q
T
Y
S
I
E
L
Q
P
Site 19
S265
L
Q
T
Q
Q
T
Y
S
I
E
L
Q
P
G
K
Site 20
Y301
G
H
G
N
Q
T
G
Y
N
M
T
V
L
F
E
Site 21
T304
N
Q
T
G
Y
N
M
T
V
L
F
E
L
D
G
Site 22
S318
G
G
L
N
I
E
K
S
A
K
V
Y
F
R
T
Site 23
T325
S
A
K
V
Y
F
R
T
V
E
L
I
E
E
P
Site 24
S336
I
E
E
P
I
K
G
S
P
G
L
S
F
Y
F
Site 25
S340
I
K
G
S
P
G
L
S
F
Y
F
K
I
N
G
Site 26
Y342
G
S
P
G
L
S
F
Y
F
K
I
N
G
F
P
Site 27
S362
S
N
W
I
P
A
D
S
F
Q
D
R
V
T
S
Site 28
T368
D
S
F
Q
D
R
V
T
S
E
L
L
R
L
L
Site 29
Y395
R
V
W
G
G
G
I
Y
E
Q
D
E
F
Y
E
Site 30
Y401
I
Y
E
Q
D
E
F
Y
E
L
C
D
E
L
G
Site 31
S431
T
D
Q
G
F
L
D
S
V
T
A
E
V
A
Y
Site 32
S448
K
R
L
K
S
H
P
S
I
I
I
W
S
G
N
Site 33
Y477
S
F
T
D
R
P
I
Y
I
K
D
Y
V
T
L
Site 34
Y481
R
P
I
Y
I
K
D
Y
V
T
L
Y
V
K
N
Site 35
T483
I
Y
I
K
D
Y
V
T
L
Y
V
K
N
I
R
Site 36
Y485
R
P
I
Y
I
K
D
Y
V
T
L
Y
V
K
N
Site 37
S505
K
S
R
P
F
I
T
S
S
P
T
N
G
A
E
Site 38
S506
S
R
P
F
I
T
S
S
P
T
N
G
A
E
T
Site 39
T513
S
P
T
N
G
A
E
T
V
A
E
A
W
V
S
Site 40
Y527
S
Q
N
P
N
S
N
Y
F
G
D
V
H
F
Y
Site 41
S553
F
P
K
A
R
F
A
S
E
Y
G
Y
Q
S
W
Site 42
Y555
K
A
R
F
A
S
E
Y
G
Y
Q
S
W
P
S
Site 43
Y557
R
F
A
S
E
Y
G
Y
Q
S
W
P
S
F
S
Site 44
S559
A
S
E
Y
G
Y
Q
S
W
P
S
F
S
T
L
Site 45
S562
Y
G
Y
Q
S
W
P
S
F
S
T
L
E
K
V
Site 46
S564
Y
Q
S
W
P
S
F
S
T
L
E
K
V
S
S
Site 47
T565
Q
S
W
P
S
F
S
T
L
E
K
V
S
S
T
Site 48
S571
S
T
L
E
K
V
S
S
T
E
D
W
S
F
N
Site 49
T572
T
L
E
K
V
S
S
T
E
D
W
S
F
N
S
Site 50
S576
V
S
S
T
E
D
W
S
F
N
S
K
F
S
L
Site 51
S579
T
E
D
W
S
F
N
S
K
F
S
L
H
R
Q
Site 52
Y597
G
G
N
K
Q
M
L
Y
Q
A
G
L
H
F
K
Site 53
S608
L
H
F
K
L
P
Q
S
T
D
P
L
R
T
F
Site 54
T614
Q
S
T
D
P
L
R
T
F
K
D
T
I
Y
L
Site 55
Y620
R
T
F
K
D
T
I
Y
L
T
Q
V
M
Q
A
Site 56
T634
A
Q
C
V
K
T
E
T
E
F
Y
R
R
S
R
Site 57
Y637
V
K
T
E
T
E
F
Y
R
R
S
R
S
E
I
Site 58
S640
E
T
E
F
Y
R
R
S
R
S
E
I
V
D
Q
Site 59
S642
E
F
Y
R
R
S
R
S
E
I
V
D
Q
Q
G
Site 60
Y703
F
E
N
E
N
T
F
Y
I
Y
G
V
S
D
L
Site 61
Y705
N
E
N
T
F
Y
I
Y
G
V
S
D
L
H
S
Site 62
S708
T
F
Y
I
Y
G
V
S
D
L
H
S
D
Y
S
Site 63
S712
Y
G
V
S
D
L
H
S
D
Y
S
M
T
L
S
Site 64
Y714
V
S
D
L
H
S
D
Y
S
M
T
L
S
V
R
Site 65
S715
S
D
L
H
S
D
Y
S
M
T
L
S
V
R
V
Site 66
T717
L
H
S
D
Y
S
M
T
L
S
V
R
V
H
T
Site 67
S719
S
D
Y
S
M
T
L
S
V
R
V
H
T
W
S
Site 68
T724
T
L
S
V
R
V
H
T
W
S
S
L
E
P
V
Site 69
S726
S
V
R
V
H
T
W
S
S
L
E
P
V
C
S
Site 70
S727
V
R
V
H
T
W
S
S
L
E
P
V
C
S
R
Site 71
S733
S
S
L
E
P
V
C
S
R
V
T
E
R
F
V
Site 72
T736
E
P
V
C
S
R
V
T
E
R
F
V
M
K
G
Site 73
S755
C
L
Y
E
E
P
V
S
E
L
L
R
R
C
G
Site 74
T765
L
R
R
C
G
N
C
T
R
E
S
C
V
V
S
Site 75
S772
T
R
E
S
C
V
V
S
F
Y
L
S
A
D
H
Site 76
S783
S
A
D
H
E
L
L
S
P
T
N
Y
H
F
L
Site 77
T785
D
H
E
L
L
S
P
T
N
Y
H
F
L
S
S
Site 78
Y787
E
L
L
S
P
T
N
Y
H
F
L
S
S
P
K
Site 79
S792
T
N
Y
H
F
L
S
S
P
K
E
A
V
G
L
Site 80
S840
G
S
I
P
G
R
F
S
D
N
G
F
L
M
T
Site 81
T847
S
D
N
G
F
L
M
T
E
K
T
R
T
I
L
Site 82
T852
L
M
T
E
K
T
R
T
I
L
F
Y
P
W
E
Site 83
Y856
K
T
R
T
I
L
F
Y
P
W
E
P
T
S
K
Site 84
S862
F
Y
P
W
E
P
T
S
K
N
E
L
E
Q
S
Site 85
S869
S
K
N
E
L
E
Q
S
F
H
V
T
S
L
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation