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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PIK3R2
Full Name:
Phosphatidylinositol 3-kinase regulatory subunit beta
Alias:
P85; P85B; Phosphoinositide-3-kinase, regulatory subunit 2 (beta); PI3K p85-beta; PI3-kinase p85-beta; PtdIns-3-kinase p85-beta
Type:
Regulator, inositol phosphate metabolism
Mass (Da):
81624
Number AA:
728
UniProt ID:
O00459
International Prot ID:
IPI00011736
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005942
Uniprot
OncoNet
Molecular Function:
GO:0035014
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0019987
GO:0007165
GO:0042325
Phosida
TranscriptoNet
STRING
Kinexus Products
Phosphatidylinositol 3-kinase regulatory subunit beta (D461-Y467, human) pY464 phosphopeptide - Powder PE-04AFG99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AFG99
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y9
A
G
P
E
G
F
Q
Y
R
A
L
Y
P
F
R
Site 2
Y13
G
F
Q
Y
R
A
L
Y
P
F
R
R
E
R
P
Site 3
S34
P
G
D
V
L
V
V
S
R
A
A
L
Q
A
L
Site 4
S53
G
G
E
R
C
P
Q
S
V
G
W
M
P
G
L
Site 5
T73
Q
R
G
D
F
P
G
T
Y
V
E
F
L
G
P
Site 6
Y74
R
G
D
F
P
G
T
Y
V
E
F
L
G
P
V
Site 7
T110
G
A
P
E
P
G
L
T
L
P
D
L
P
E
Q
Site 8
S119
P
D
L
P
E
Q
F
S
P
P
D
V
A
P
P
Site 9
S142
I
E
R
T
G
L
D
S
E
S
H
Y
R
P
E
Site 10
S144
R
T
G
L
D
S
E
S
H
Y
R
P
E
L
P
Site 11
Y146
G
L
D
S
E
S
H
Y
R
P
E
L
P
A
P
Site 12
T155
P
E
L
P
A
P
R
T
D
W
S
L
S
D
V
Site 13
S158
P
A
P
R
T
D
W
S
L
S
D
V
D
Q
W
Site 14
S160
P
R
T
D
W
S
L
S
D
V
D
Q
W
D
T
Site 15
T213
G
P
A
L
E
P
P
T
L
P
L
H
R
A
L
Site 16
S262
L
R
A
P
P
P
P
S
S
P
P
P
G
G
A
Site 17
S263
R
A
P
P
P
P
S
S
P
P
P
G
G
A
P
Site 18
S273
P
G
G
A
P
D
G
S
E
P
S
P
D
F
P
Site 19
S276
A
P
D
G
S
E
P
S
P
D
F
P
A
L
L
Site 20
T314
P
K
A
K
P
A
P
T
V
L
A
N
G
G
S
Site 21
S321
T
V
L
A
N
G
G
S
P
P
S
L
Q
D
A
Site 22
S324
A
N
G
G
S
P
P
S
L
Q
D
A
E
W
Y
Site 23
Y331
S
L
Q
D
A
E
W
Y
W
G
D
I
S
R
E
Site 24
T347
V
N
E
K
L
R
D
T
P
D
G
T
F
L
V
Site 25
T351
L
R
D
T
P
D
G
T
F
L
V
R
D
A
S
Site 26
S358
T
F
L
V
R
D
A
S
S
K
I
Q
G
E
Y
Site 27
Y365
S
S
K
I
Q
G
E
Y
T
L
T
L
R
K
G
Site 28
T366
S
K
I
Q
G
E
Y
T
L
T
L
R
K
G
G
Site 29
T368
I
Q
G
E
Y
T
L
T
L
R
K
G
G
N
N
Site 30
Y387
V
F
H
R
D
G
H
Y
G
F
S
E
P
L
T
Site 31
S390
R
D
G
H
Y
G
F
S
E
P
L
T
F
C
S
Site 32
Y405
V
V
D
L
I
N
H
Y
R
H
E
S
L
A
Q
Site 33
Y413
R
H
E
S
L
A
Q
Y
N
A
K
L
D
T
R
Site 34
Y423
K
L
D
T
R
L
L
Y
P
V
S
K
Y
Q
Q
Site 35
S426
T
R
L
L
Y
P
V
S
K
Y
Q
Q
D
Q
I
Site 36
Y428
L
L
Y
P
V
S
K
Y
Q
Q
D
Q
I
V
K
Site 37
S438
D
Q
I
V
K
E
D
S
V
E
A
V
G
A
Q
Site 38
Y449
V
G
A
Q
L
K
V
Y
H
Q
Q
Y
Q
D
K
Site 39
Y453
L
K
V
Y
H
Q
Q
Y
Q
D
K
S
R
E
Y
Site 40
S457
H
Q
Q
Y
Q
D
K
S
R
E
Y
D
Q
L
Y
Site 41
Y460
Y
Q
D
K
S
R
E
Y
D
Q
L
Y
E
E
Y
Site 42
Y464
S
R
E
Y
D
Q
L
Y
E
E
Y
T
R
T
S
Phosphatidylinositol 3-kinase regulatory subunit beta (D461-Y467, human) pY464 phosphopeptide - Powder PE-04AFG99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AFG99
Site 43
Y467
Y
D
Q
L
Y
E
E
Y
T
R
T
S
Q
E
L
Site 44
T468
D
Q
L
Y
E
E
Y
T
R
T
S
Q
E
L
Q
Site 45
T470
L
Y
E
E
Y
T
R
T
S
Q
E
L
Q
M
K
Site 46
S471
Y
E
E
Y
T
R
T
S
Q
E
L
Q
M
K
R
Site 47
T487
A
I
E
A
F
N
E
T
I
K
I
F
E
E
Q
Site 48
T497
I
F
E
E
Q
G
Q
T
Q
E
K
C
S
K
E
Site 49
Y505
Q
E
K
C
S
K
E
Y
L
E
R
F
R
R
E
Site 50
S525
M
Q
R
I
L
L
N
S
E
R
L
K
S
R
I
Site 51
S530
L
N
S
E
R
L
K
S
R
I
A
E
I
H
E
Site 52
S538
R
I
A
E
I
H
E
S
R
T
K
L
E
Q
Q
Site 53
S551
Q
Q
L
R
A
Q
A
S
D
N
R
E
I
D
K
Site 54
S562
E
I
D
K
R
M
N
S
L
K
P
D
L
M
Q
Site 55
Y577
L
R
K
I
R
D
Q
Y
L
V
W
L
T
Q
K
Site 56
T582
D
Q
Y
L
V
W
L
T
Q
K
G
A
R
Q
K
Site 57
T601
W
L
G
I
K
N
E
T
E
D
Q
Y
A
L
M
Site 58
Y605
K
N
E
T
E
D
Q
Y
A
L
M
E
D
E
D
Site 59
Y623
H
H
E
E
R
T
W
Y
V
G
K
I
N
R
T
Site 60
S637
T
Q
A
E
E
M
L
S
G
K
R
D
G
T
F
Site 61
T643
L
S
G
K
R
D
G
T
F
L
I
R
E
S
S
Site 62
S649
G
T
F
L
I
R
E
S
S
Q
R
G
C
Y
A
Site 63
S650
T
F
L
I
R
E
S
S
Q
R
G
C
Y
A
C
Site 64
Y655
E
S
S
Q
R
G
C
Y
A
C
S
V
V
V
D
Site 65
Y671
D
T
K
H
C
V
I
Y
R
T
A
T
G
F
G
Site 66
Y683
G
F
G
F
A
E
P
Y
N
L
Y
G
S
L
K
Site 67
Y686
F
A
E
P
Y
N
L
Y
G
S
L
K
E
L
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation