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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GFRA2
Full Name:
GDNF family receptor alpha-2
Alias:
GDNF receptor beta;Neurturin receptor alpha;RET ligand 2;TGF-beta-related neurotrophic factor receptor 2
Type:
Mass (Da):
51544
Number AA:
464
UniProt ID:
O00451
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S19
F
L
D
E
T
L
R
S
L
A
S
P
S
S
L
Site 2
S22
E
T
L
R
S
L
A
S
P
S
S
L
Q
G
P
Site 3
S24
L
R
S
L
A
S
P
S
S
L
Q
G
P
E
L
Site 4
S25
R
S
L
A
S
P
S
S
L
Q
G
P
E
L
H
Site 5
S51
N
E
L
C
A
A
E
S
N
C
S
S
R
Y
R
Site 6
S54
C
A
A
E
S
N
C
S
S
R
Y
R
T
L
R
Site 7
S55
A
A
E
S
N
C
S
S
R
Y
R
T
L
R
Q
Site 8
T59
N
C
S
S
R
Y
R
T
L
R
Q
C
L
A
G
Site 9
T71
L
A
G
R
D
R
N
T
M
L
A
N
K
E
C
Site 10
S88
A
L
E
V
L
Q
E
S
P
L
Y
D
C
R
C
Site 11
Y91
V
L
Q
E
S
P
L
Y
D
C
R
C
K
R
G
Site 12
S126
G
E
E
F
Y
E
A
S
P
Y
E
P
V
T
S
Site 13
Y128
E
F
Y
E
A
S
P
Y
E
P
V
T
S
R
L
Site 14
T132
A
S
P
Y
E
P
V
T
S
R
L
S
D
I
F
Site 15
S133
S
P
Y
E
P
V
T
S
R
L
S
D
I
F
R
Site 16
S136
E
P
V
T
S
R
L
S
D
I
F
R
L
A
S
Site 17
S180
N
C
K
K
L
R
S
S
Y
I
S
I
C
N
R
Site 18
Y181
C
K
K
L
R
S
S
Y
I
S
I
C
N
R
E
Site 19
S183
K
L
R
S
S
Y
I
S
I
C
N
R
E
I
S
Site 20
S190
S
I
C
N
R
E
I
S
P
T
E
R
C
N
R
Site 21
T192
C
N
R
E
I
S
P
T
E
R
C
N
R
R
K
Site 22
S213
Q
F
F
D
R
V
P
S
E
Y
T
Y
R
M
L
Site 23
Y215
F
D
R
V
P
S
E
Y
T
Y
R
M
L
F
C
Site 24
Y217
R
V
P
S
E
Y
T
Y
R
M
L
F
C
S
C
Site 25
T236
C
A
E
R
R
R
Q
T
I
L
P
S
C
S
Y
Site 26
T260
D
L
R
G
V
C
R
T
D
H
L
C
R
S
R
Site 27
Y279
H
A
N
C
R
A
S
Y
Q
T
V
T
S
C
P
Site 28
T281
N
C
R
A
S
Y
Q
T
V
T
S
C
P
A
D
Site 29
T283
R
A
S
Y
Q
T
V
T
S
C
P
A
D
N
Y
Site 30
Y290
T
S
C
P
A
D
N
Y
Q
A
C
L
G
S
Y
Site 31
T306
G
M
I
G
F
D
M
T
P
N
Y
V
D
S
S
Site 32
Y309
G
F
D
M
T
P
N
Y
V
D
S
S
P
T
G
Site 33
S313
T
P
N
Y
V
D
S
S
P
T
G
I
V
V
S
Site 34
T343
E
K
F
L
R
D
F
T
E
N
P
C
L
R
N
Site 35
S364
N
G
T
D
V
N
V
S
P
K
G
P
S
F
Q
Site 36
S369
N
V
S
P
K
G
P
S
F
Q
A
T
Q
A
P
Site 37
T373
K
G
P
S
F
Q
A
T
Q
A
P
R
V
E
K
Site 38
T381
Q
A
P
R
V
E
K
T
P
S
L
P
D
D
L
Site 39
S383
P
R
V
E
K
T
P
S
L
P
D
D
L
S
D
Site 40
S389
P
S
L
P
D
D
L
S
D
S
T
S
L
G
T
Site 41
S391
L
P
D
D
L
S
D
S
T
S
L
G
T
S
V
Site 42
T392
P
D
D
L
S
D
S
T
S
L
G
T
S
V
I
Site 43
S393
D
D
L
S
D
S
T
S
L
G
T
S
V
I
T
Site 44
S415
Q
G
L
K
A
N
N
S
K
E
L
S
M
C
F
Site 45
S419
A
N
N
S
K
E
L
S
M
C
F
T
E
L
T
Site 46
S433
T
T
N
I
I
P
G
S
N
K
V
I
K
P
N
Site 47
S441
N
K
V
I
K
P
N
S
G
P
S
R
A
R
P
Site 48
S444
I
K
P
N
S
G
P
S
R
A
R
P
S
A
A
Site 49
S449
G
P
S
R
A
R
P
S
A
A
L
T
V
L
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation