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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
WWP2
Full Name:
NEDD4-like E3 ubiquitin-protein ligase WWP2
Alias:
AIP2; Atrophin-1-interacting protein 2; EC 6.3.2.-; WW domain containing E3 ubiquitin protein ligase 2; WW domain- containing protein 2
Type:
Ligase; Ubiquitin ligase; EC 6.3.2.-; Ubiquitin conjugating system
Mass (Da):
98912
Number AA:
870
UniProt ID:
O00308
International Prot ID:
IPI00013010
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000151
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0004842
PhosphoSite+
KinaseNET
Biological Process:
GO:0046718
GO:0019941
GO:0010629
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
A
S
A
S
S
S
R
A
G
V
A
L
P
Site 2
T21
P
F
E
K
S
Q
L
T
L
K
V
V
S
A
K
Site 3
S40
N
R
Q
P
R
I
N
S
Y
V
E
V
A
V
D
Site 4
Y41
R
Q
P
R
I
N
S
Y
V
E
V
A
V
D
G
Site 5
T56
L
P
S
E
T
K
K
T
G
K
R
I
G
S
S
Site 6
S62
K
T
G
K
R
I
G
S
S
E
L
L
W
N
E
Site 7
T90
L
K
V
W
S
C
H
T
L
R
N
E
L
L
G
Site 8
T98
L
R
N
E
L
L
G
T
A
S
V
N
L
S
N
Site 9
S104
G
T
A
S
V
N
L
S
N
V
L
K
N
N
G
Site 10
T120
K
M
E
N
M
Q
L
T
L
N
L
Q
T
E
N
Site 11
S130
L
Q
T
E
N
K
G
S
V
V
S
G
G
E
L
Site 12
S155
L
G
N
V
P
N
G
S
A
L
T
D
G
S
Q
Site 13
S161
G
S
A
L
T
D
G
S
Q
L
P
S
R
D
S
Site 14
S165
T
D
G
S
Q
L
P
S
R
D
S
S
G
T
A
Site 15
S168
S
Q
L
P
S
R
D
S
S
G
T
A
V
A
P
Site 16
S169
Q
L
P
S
R
D
S
S
G
T
A
V
A
P
E
Site 17
T171
P
S
R
D
S
S
G
T
A
V
A
P
E
N
R
Site 18
S183
E
N
R
H
Q
P
P
S
T
N
C
F
G
G
R
Site 19
T184
N
R
H
Q
P
P
S
T
N
C
F
G
G
R
S
Site 20
T193
C
F
G
G
R
S
R
T
H
R
H
S
G
A
S
Site 21
S197
R
S
R
T
H
R
H
S
G
A
S
A
R
T
T
Site 22
S200
T
H
R
H
S
G
A
S
A
R
T
T
P
A
T
Site 23
T204
S
G
A
S
A
R
T
T
P
A
T
G
E
Q
S
Site 24
T207
S
A
R
T
T
P
A
T
G
E
Q
S
P
G
A
Site 25
S211
T
P
A
T
G
E
Q
S
P
G
A
R
S
R
H
Site 26
S216
E
Q
S
P
G
A
R
S
R
H
R
Q
P
V
K
Site 27
T234
H
S
G
L
A
N
G
T
V
N
D
E
P
T
T
Site 28
S249
A
T
D
P
E
E
P
S
V
V
G
V
T
S
P
Site 29
S262
S
P
P
A
A
P
L
S
V
T
P
N
P
N
T
Site 30
T264
P
A
A
P
L
S
V
T
P
N
P
N
T
T
S
Site 31
T277
T
S
L
P
A
P
A
T
P
A
E
G
E
E
P
Site 32
T286
A
E
G
E
E
P
S
T
S
G
T
Q
Q
L
P
Site 33
S287
E
G
E
E
P
S
T
S
G
T
Q
Q
L
P
A
Site 34
T289
E
E
P
S
T
S
G
T
Q
Q
L
P
A
A
A
Site 35
Y317
E
L
P
N
G
R
V
Y
Y
V
D
H
N
T
K
Site 36
Y318
L
P
N
G
R
V
Y
Y
V
D
H
N
T
K
T
Site 37
T340
P
P
G
W
E
K
R
T
D
P
R
G
R
F
Y
Site 38
Y347
T
D
P
R
G
R
F
Y
Y
V
D
H
N
T
R
Site 39
Y348
D
P
R
G
R
F
Y
Y
V
D
H
N
T
R
T
Site 40
T356
V
D
H
N
T
R
T
T
T
W
Q
R
P
T
A
Site 41
T357
D
H
N
T
R
T
T
T
W
Q
R
P
T
A
E
Site 42
T362
T
T
T
W
Q
R
P
T
A
E
Y
V
R
N
Y
Site 43
Y365
W
Q
R
P
T
A
E
Y
V
R
N
Y
E
Q
W
Site 44
Y369
T
A
E
Y
V
R
N
Y
E
Q
W
Q
S
Q
R
Site 45
Y392
H
F
S
Q
R
F
L
Y
Q
S
S
S
A
S
T
Site 46
S394
S
Q
R
F
L
Y
Q
S
S
S
A
S
T
D
H
Site 47
S396
R
F
L
Y
Q
S
S
S
A
S
T
D
H
D
P
Site 48
S398
L
Y
Q
S
S
S
A
S
T
D
H
D
P
L
G
Site 49
T399
Y
Q
S
S
S
A
S
T
D
H
D
P
L
G
P
Site 50
Y421
R
Q
D
N
G
R
V
Y
Y
V
N
H
N
T
R
Site 51
Y422
Q
D
N
G
R
V
Y
Y
V
N
H
N
T
R
T
Site 52
T430
V
N
H
N
T
R
T
T
Q
W
E
D
P
R
T
Site 53
T437
T
Q
W
E
D
P
R
T
Q
G
M
I
Q
E
P
Site 54
Y454
P
P
G
W
E
M
K
Y
T
S
E
G
V
R
Y
Site 55
T455
P
G
W
E
M
K
Y
T
S
E
G
V
R
Y
F
Site 56
Y461
Y
T
S
E
G
V
R
Y
F
V
D
H
N
T
R
Site 57
T467
R
Y
F
V
D
H
N
T
R
T
T
T
F
K
D
Site 58
T469
F
V
D
H
N
T
R
T
T
T
F
K
D
P
R
Site 59
T470
V
D
H
N
T
R
T
T
T
F
K
D
P
R
P
Site 60
T471
D
H
N
T
R
T
T
T
F
K
D
P
R
P
G
Site 61
S481
D
P
R
P
G
F
E
S
G
T
K
Q
G
S
P
Site 62
T483
R
P
G
F
E
S
G
T
K
Q
G
S
P
G
A
Site 63
S487
E
S
G
T
K
Q
G
S
P
G
A
Y
D
R
S
Site 64
Y491
K
Q
G
S
P
G
A
Y
D
R
S
F
R
W
K
Site 65
S513
C
H
S
N
A
L
P
S
H
V
K
I
S
V
S
Site 66
T523
K
I
S
V
S
R
Q
T
L
F
E
D
S
F
Q
Site 67
Y538
Q
I
M
N
M
K
P
Y
D
L
R
R
R
L
Y
Site 68
Y545
Y
D
L
R
R
R
L
Y
I
I
M
R
G
E
E
Site 69
Y556
R
G
E
E
G
L
D
Y
G
G
I
A
R
E
W
Site 70
Y587
E
Y
A
G
K
N
N
Y
C
L
Q
I
N
P
A
Site 71
S595
C
L
Q
I
N
P
A
S
S
I
N
P
D
H
L
Site 72
Y604
I
N
P
D
H
L
T
Y
F
R
F
I
G
R
F
Site 73
T624
Y
H
G
K
F
I
D
T
G
F
T
L
P
F
Y
Site 74
Y631
T
G
F
T
L
P
F
Y
K
R
M
L
N
K
R
Site 75
T640
R
M
L
N
K
R
P
T
L
K
D
L
E
S
I
Site 76
S646
P
T
L
K
D
L
E
S
I
D
P
E
F
Y
N
Site 77
Y652
E
S
I
D
P
E
F
Y
N
S
I
V
W
I
K
Site 78
S693
E
L
K
E
G
G
E
S
I
R
V
T
E
E
N
Site 79
T697
G
G
E
S
I
R
V
T
E
E
N
K
E
E
Y
Site 80
T714
L
L
T
D
W
R
F
T
R
G
V
E
E
Q
T
Site 81
Y739
A
P
L
E
W
L
R
Y
F
D
E
K
E
L
E
Site 82
Y769
K
S
T
I
Y
R
H
Y
T
K
N
S
K
Q
I
Site 83
T770
S
T
I
Y
R
H
Y
T
K
N
S
K
Q
I
Q
Site 84
S815
G
F
A
E
L
I
G
S
N
G
P
Q
K
F
C
Site 85
T830
I
D
K
V
G
K
E
T
W
L
P
R
S
H
T
Site 86
T837
T
W
L
P
R
S
H
T
C
F
N
R
L
D
L
Site 87
Y847
N
R
L
D
L
P
P
Y
K
S
Y
E
Q
L
R
Site 88
S849
L
D
L
P
P
Y
K
S
Y
E
Q
L
R
E
K
Site 89
Y859
Q
L
R
E
K
L
L
Y
A
I
E
E
T
E
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation