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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MEN1
Full Name:
Menin
Alias:
MEAI; multiple endocrine neoplasia I; multiple endocrine neoplasia type 1 gene; SCG2; Wermer syndrome; Zollinger-Ellison syndrome
Type:
Transcription, coactivator/corepressor
Mass (Da):
67993
Number AA:
615
UniProt ID:
O00255
International Prot ID:
IPI00328838
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000785
GO:0032154
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0070412
GO:0000403
GO:0003690
PhosphoSite+
KinaseNET
Biological Process:
GO:0006281
GO:0000165
GO:0046329
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T62
P
T
N
V
P
E
L
T
F
Q
P
S
P
A
P
Site 2
S66
P
E
L
T
F
Q
P
S
P
A
P
D
P
P
G
Site 3
T76
P
D
P
P
G
G
L
T
Y
F
P
V
A
D
L
Site 4
Y77
D
P
P
G
G
L
T
Y
F
P
V
A
D
L
S
Site 5
S104
I
R
G
A
V
D
L
S
L
Y
P
R
E
G
G
Site 6
Y106
G
A
V
D
L
S
L
Y
P
R
E
G
G
V
S
Site 7
S113
Y
P
R
E
G
G
V
S
S
R
E
L
V
K
K
Site 8
S122
R
E
L
V
K
K
V
S
D
V
I
W
N
S
L
Site 9
S128
V
S
D
V
I
W
N
S
L
S
R
S
Y
F
K
Site 10
S130
D
V
I
W
N
S
L
S
R
S
Y
F
K
D
R
Site 11
S132
I
W
N
S
L
S
R
S
Y
F
K
D
R
A
H
Site 12
Y133
W
N
S
L
S
R
S
Y
F
K
D
R
A
H
I
Site 13
S142
K
D
R
A
H
I
Q
S
L
F
S
F
I
T
G
Site 14
T155
T
G
W
S
P
V
G
T
K
L
D
S
S
G
V
Site 15
S183
R
D
V
H
L
A
L
S
E
D
H
A
W
V
V
Site 16
T198
F
G
P
N
G
E
Q
T
A
E
V
T
W
H
G
Site 17
T215
N
E
D
R
R
G
Q
T
V
N
A
G
V
A
E
Site 18
Y227
V
A
E
R
S
W
L
Y
L
K
G
S
Y
M
R
Site 19
T256
N
P
S
I
D
L
H
T
D
S
L
E
L
L
Q
Site 20
S258
S
I
D
L
H
T
D
S
L
E
L
L
Q
L
Q
Site 21
Y273
Q
K
L
L
W
L
L
Y
D
L
G
H
L
E
R
Site 22
Y281
D
L
G
H
L
E
R
Y
P
M
A
L
G
N
L
Site 23
T297
D
L
E
E
L
E
P
T
P
G
R
P
D
P
L
Site 24
T305
P
G
R
P
D
P
L
T
L
Y
H
K
G
I
A
Site 25
Y307
R
P
D
P
L
T
L
Y
H
K
G
I
A
S
A
Site 26
T316
K
G
I
A
S
A
K
T
Y
Y
R
D
E
H
I
Site 27
Y317
G
I
A
S
A
K
T
Y
Y
R
D
E
H
I
Y
Site 28
Y324
Y
Y
R
D
E
H
I
Y
P
Y
M
Y
L
A
G
Site 29
Y326
R
D
E
H
I
Y
P
Y
M
Y
L
A
G
Y
H
Site 30
Y332
P
Y
M
Y
L
A
G
Y
H
C
R
N
R
N
V
Site 31
T351
Q
A
W
A
D
T
A
T
V
I
Q
D
Y
N
Y
Site 32
Y356
T
A
T
V
I
Q
D
Y
N
Y
C
R
E
D
E
Site 33
Y358
T
V
I
Q
D
Y
N
Y
C
R
E
D
E
E
I
Site 34
Y366
C
R
E
D
E
E
I
Y
K
E
F
F
E
V
A
Site 35
S399
E
E
R
P
G
E
Q
S
Q
G
T
Q
S
Q
G
Site 36
T402
P
G
E
Q
S
Q
G
T
Q
S
Q
G
S
A
L
Site 37
S404
E
Q
S
Q
G
T
Q
S
Q
G
S
A
L
Q
D
Site 38
S432
I
C
K
W
E
E
G
S
P
T
P
V
L
H
V
Site 39
T434
K
W
E
E
G
S
P
T
P
V
L
H
V
G
W
Site 40
T443
V
L
H
V
G
W
A
T
F
L
V
Q
S
L
G
Site 41
S448
W
A
T
F
L
V
Q
S
L
G
R
F
E
G
Q
Site 42
S464
R
Q
K
V
R
I
V
S
R
E
A
E
A
A
E
Site 43
S492
R
R
G
P
R
R
E
S
K
P
E
E
P
P
P
Site 44
S517
G
T
G
Q
G
A
V
S
G
P
P
R
K
P
P
Site 45
T526
P
P
R
K
P
P
G
T
V
A
G
T
A
R
G
Site 46
T539
R
G
P
E
G
G
S
T
A
Q
V
P
A
P
A
Site 47
S548
Q
V
P
A
P
A
A
S
P
P
P
E
G
P
V
Site 48
T557
P
P
E
G
P
V
L
T
F
Q
S
E
K
M
K
Site 49
T585
S
A
I
K
L
Q
L
T
A
Q
S
Q
V
Q
M
Site 50
S588
K
L
Q
L
T
A
Q
S
Q
V
Q
M
K
K
Q
Site 51
T599
M
K
K
Q
K
V
S
T
P
S
D
Y
T
L
S
Site 52
S601
K
Q
K
V
S
T
P
S
D
Y
T
L
S
F
L
Site 53
Y603
K
V
S
T
P
S
D
Y
T
L
S
F
L
K
R
Site 54
T604
V
S
T
P
S
D
Y
T
L
S
F
L
K
R
Q
Site 55
S606
T
P
S
D
Y
T
L
S
F
L
K
R
Q
R
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation