KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
RNF103
Full Name:
E3 ubiquitin-protein ligase RNF103
Alias:
KF-1;RING finger protein 103;Zinc finger protein 103 homolog
Type:
Mass (Da):
79405
Number AA:
685
UniProt ID:
O00237
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S60
E
C
R
G
L
G
Y
S
G
L
P
E
K
K
D
Site 2
S75
V
R
E
L
V
E
K
S
G
D
L
M
E
G
E
Site 3
Y84
D
L
M
E
G
E
L
Y
S
A
L
K
E
E
E
Site 4
S93
A
L
K
E
E
E
A
S
E
S
V
S
S
T
N
Site 5
S95
K
E
E
E
A
S
E
S
V
S
S
T
N
F
S
Site 6
S97
E
E
A
S
E
S
V
S
S
T
N
F
S
G
E
Site 7
S98
E
A
S
E
S
V
S
S
T
N
F
S
G
E
M
Site 8
T99
A
S
E
S
V
S
S
T
N
F
S
G
E
M
H
Site 9
S102
S
V
S
S
T
N
F
S
G
E
M
H
F
Y
E
Site 10
Y108
F
S
G
E
M
H
F
Y
E
L
V
E
D
T
K
Site 11
S129
Q
V
I
A
N
D
R
S
P
L
V
G
K
I
H
Site 12
T151
V
S
R
F
G
I
R
T
G
T
F
N
C
S
S
Site 13
T153
R
F
G
I
R
T
G
T
F
N
C
S
S
D
P
Site 14
S157
R
T
G
T
F
N
C
S
S
D
P
R
Y
C
R
Site 15
S158
T
G
T
F
N
C
S
S
D
P
R
Y
C
R
R
Site 16
Y162
N
C
S
S
D
P
R
Y
C
R
R
R
G
W
V
Site 17
S171
R
R
R
G
W
V
R
S
T
L
I
M
S
V
P
Site 18
T172
R
R
G
W
V
R
S
T
L
I
M
S
V
P
Q
Site 19
S176
V
R
S
T
L
I
M
S
V
P
Q
T
S
T
S
Site 20
T180
L
I
M
S
V
P
Q
T
S
T
S
K
G
K
V
Site 21
S181
I
M
S
V
P
Q
T
S
T
S
K
G
K
V
M
Site 22
S193
K
V
M
L
K
E
Y
S
G
R
K
I
E
V
E
Site 23
T216
H
A
A
S
R
I
K
T
I
Y
N
A
E
H
L
Site 24
Y218
A
S
R
I
K
T
I
Y
N
A
E
H
L
K
E
Site 25
Y233
E
W
N
K
S
D
Q
Y
W
L
K
I
Y
L
F
Site 26
Y238
D
Q
Y
W
L
K
I
Y
L
F
A
N
L
D
Q
Site 27
Y276
E
N
W
D
N
K
S
Y
M
T
D
I
G
I
Y
Site 28
Y288
G
I
Y
N
M
P
S
Y
I
L
R
T
P
E
G
Site 29
T292
M
P
S
Y
I
L
R
T
P
E
G
I
Y
R
Y
Site 30
Y299
T
P
E
G
I
Y
R
Y
G
N
H
T
G
E
F
Site 31
T303
I
Y
R
Y
G
N
H
T
G
E
F
I
S
L
Q
Site 32
S308
N
H
T
G
E
F
I
S
L
Q
A
M
D
S
F
Site 33
S318
A
M
D
S
F
L
R
S
L
Q
P
E
V
N
D
Site 34
S385
L
Q
L
P
Y
L
D
S
F
Y
E
Y
S
L
K
Site 35
Y389
Y
L
D
S
F
Y
E
Y
S
L
K
L
L
R
Y
Site 36
S390
L
D
S
F
Y
E
Y
S
L
K
L
L
R
Y
S
Site 37
S397
S
L
K
L
L
R
Y
S
N
T
T
T
L
A
S
Site 38
T399
K
L
L
R
Y
S
N
T
T
T
L
A
S
W
V
Site 39
T400
L
L
R
Y
S
N
T
T
T
L
A
S
W
V
R
Site 40
T401
L
R
Y
S
N
T
T
T
L
A
S
W
V
R
A
Site 41
Y433
G
H
G
L
L
I
D
Y
F
E
K
K
R
R
R
Site 42
Y462
L
S
S
L
W
D
W
Y
T
S
Y
L
F
H
P
Site 43
Y508
H
P
L
I
P
T
D
Y
I
K
N
L
P
M
W
Site 44
S524
F
K
C
L
G
V
Q
S
E
E
E
M
S
E
G
Site 45
S529
V
Q
S
E
E
E
M
S
E
G
S
Q
D
T
E
Site 46
T535
M
S
E
G
S
Q
D
T
E
N
D
S
E
S
E
Site 47
S539
S
Q
D
T
E
N
D
S
E
S
E
N
T
D
T
Site 48
S541
D
T
E
N
D
S
E
S
E
N
T
D
T
L
S
Site 49
T544
N
D
S
E
S
E
N
T
D
T
L
S
S
E
K
Site 50
T546
S
E
S
E
N
T
D
T
L
S
S
E
K
E
V
Site 51
S548
S
E
N
T
D
T
L
S
S
E
K
E
V
F
E
Site 52
S559
E
V
F
E
D
K
Q
S
V
L
H
N
S
P
G
Site 53
S564
K
Q
S
V
L
H
N
S
P
G
T
A
S
H
C
Site 54
S569
H
N
S
P
G
T
A
S
H
C
D
A
E
A
C
Site 55
S586
A
N
K
Y
C
Q
T
S
P
C
E
R
K
G
R
Site 56
Y595
C
E
R
K
G
R
S
Y
G
S
Y
N
T
N
E
Site 57
Y598
K
G
R
S
Y
G
S
Y
N
T
N
E
D
M
E
Site 58
Y667
P
V
C
R
W
P
S
Y
K
K
K
Q
P
Y
A
Site 59
Y673
S
Y
K
K
K
Q
P
Y
A
Q
H
Q
P
L
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation