PhosphoNET

           
Protein Info 
   
Short Name:  IkB-epsilon
Full Name:  NF-kappa-B inhibitor epsilon
Alias:  IkappaBepsilon; I-kappa-B-epsilon; IKBE; NF-kappaB inhibitor epsilon; NF-kappa-BIE; NFKBIE
Type:  Regulatory protein, transcription factor inhibitor
Mass (Da):  52864
Number AA:  500
UniProt ID:  O00221
International Prot ID:  IPI00414656
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005730     Uniprot OncoNet
Molecular Function:  GO:0005515     PhosphoSite+ KinaseNET
Biological Process:  GO:0042994     Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S8MNQRRSESRPGNHRL
Site 2Y18GNHRLQAYAEPGKGD
Site 3S26AEPGKGDSGGAGPLS
Site 4S33SGGAGPLSGSARRGR
Site 5S35GAGPLSGSARRGRGG
Site 6S54RVRRPCWSGGAGRGG
Site 7T83WTWPALRTLSSLRAG
Site 8S85WPALRTLSSLRAGPS
Site 9S86PALRTLSSLRAGPSE
Site 10S92SSLRAGPSEPHSPGR
Site 11S96AGPSEPHSPGRRPPR
Site 12S122PGKAARRSLEPDPAQ
Site 13S141PARAAGMSEARKGPD
Site 14S153GPDEAEESQYDSGIE
Site 15Y155DEAEESQYDSGIESL
Site 16S157AEESQYDSGIESLRS
Site 17S161QYDSGIESLRSLRSL
Site 18S164SGIESLRSLRSLPES
Site 19S167ESLRSLRSLPESTSA
Site 20S171SLRSLPESTSAPASG
Site 21S173RSLPESTSAPASGPS
Site 22S177ESTSAPASGPSDGSP
Site 23S180SAPASGPSDGSPQPC
Site 24S183ASGPSDGSPQPCTHP
Site 25T188DGSPQPCTHPPGPVK
Site 26S210ADGERADSTYGSSSL
Site 27T211DGERADSTYGSSSLT
Site 28Y212GERADSTYGSSSLTY
Site 29S214RADSTYGSSSLTYTL
Site 30S216DSTYGSSSLTYTLSL
Site 31Y254QQLEALTYISEDGDT
Site 32T357RPEPGRGTSHSLDLQ
Site 33S358PEPGRGTSHSLDLQL
Site 34S360PGRGTSHSLDLQLQN
Site 35S463LCKAGADSLLRNVED
Site 36T472LRNVEDETPQDLTEE
Site 37T477DETPQDLTEESLVLL
Site 38S480PQDLTEESLVLLPFD
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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