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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HAS3
Full Name:
Hyaluronan synthase 3
Alias:
HA synthase 3
Type:
EC 2.4.1.212; Transferase
Mass (Da):
63070
Number AA:
553
UniProt ID:
O00219
International Prot ID:
IPI00297981
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005887
Uniprot
OncoNet
Molecular Function:
GO:0050501
PhosphoSite+
KinaseNET
Biological Process:
GO:0005975
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T6
_
_
M
P
V
Q
L
T
T
A
L
R
V
V
G
Site 2
T38
T
G
Y
Q
F
I
H
T
E
K
H
Y
L
S
F
Site 3
Y42
F
I
H
T
E
K
H
Y
L
S
F
G
L
Y
G
Site 4
S44
H
T
E
K
H
Y
L
S
F
G
L
Y
G
A
I
Site 5
S81
G
Q
A
L
K
L
P
S
P
R
R
G
S
V
A
Site 6
Y100
A
Y
Q
E
D
P
D
Y
L
R
K
C
L
R
S
Site 7
S107
Y
L
R
K
C
L
R
S
A
Q
R
I
S
F
P
Site 8
S112
L
R
S
A
Q
R
I
S
F
P
D
L
K
V
V
Site 9
Y131
G
N
R
Q
E
D
A
Y
M
L
D
I
F
H
E
Site 10
S166
G
E
G
E
T
E
A
S
L
Q
E
G
M
D
R
Site 11
T182
R
D
V
V
R
A
S
T
F
S
C
I
M
Q
K
Site 12
Y198
G
G
K
R
E
V
M
Y
T
A
F
K
A
L
G
Site 13
T199
G
K
R
E
V
M
Y
T
A
F
K
A
L
G
D
Site 14
Y210
A
L
G
D
S
V
D
Y
I
Q
V
C
D
S
D
Site 15
S216
D
Y
I
Q
V
C
D
S
D
T
V
L
D
P
A
Site 16
Y251
D
V
Q
I
L
N
K
Y
D
S
W
I
S
F
L
Site 17
S253
Q
I
L
N
K
Y
D
S
W
I
S
F
L
S
S
Site 18
S256
N
K
Y
D
S
W
I
S
F
L
S
S
V
R
Y
Site 19
Y290
I
S
G
P
L
G
M
Y
R
N
S
L
L
Q
Q
Site 20
S293
P
L
G
M
Y
R
N
S
L
L
Q
Q
F
L
E
Site 21
Y303
Q
Q
F
L
E
D
W
Y
H
Q
K
F
L
G
S
Site 22
S313
K
F
L
G
S
K
C
S
F
G
D
D
R
H
L
Site 23
T321
F
G
D
D
R
H
L
T
N
R
V
L
S
L
G
Site 24
S326
H
L
T
N
R
V
L
S
L
G
Y
R
T
K
Y
Site 25
Y333
S
L
G
Y
R
T
K
Y
T
A
R
S
K
C
L
Site 26
T334
L
G
Y
R
T
K
Y
T
A
R
S
K
C
L
T
Site 27
S337
R
T
K
Y
T
A
R
S
K
C
L
T
E
T
P
Site 28
T341
T
A
R
S
K
C
L
T
E
T
P
T
K
Y
L
Site 29
T343
R
S
K
C
L
T
E
T
P
T
K
Y
L
R
W
Site 30
Y347
L
T
E
T
P
T
K
Y
L
R
W
L
N
Q
Q
Site 31
Y361
Q
T
R
W
S
K
S
Y
F
R
E
W
L
Y
N
Site 32
Y381
K
H
H
L
W
M
T
Y
E
S
V
V
T
G
F
Site 33
S464
A
I
A
T
I
N
K
S
G
W
G
T
S
G
R
Site 34
T468
I
N
K
S
G
W
G
T
S
G
R
K
T
I
V
Site 35
S469
N
K
S
G
W
G
T
S
G
R
K
T
I
V
V
Site 36
Y500
G
G
L
A
Y
T
A
Y
C
Q
D
L
F
S
E
Site 37
Y520
L
V
S
G
A
I
L
Y
G
C
Y
W
V
A
L
Site 38
Y523
G
A
I
L
Y
G
C
Y
W
V
A
L
L
M
L
Site 39
S547
G
K
K
P
E
Q
Y
S
L
A
F
A
E
V
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation