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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ARVCF
Full Name:
Armadillo repeat protein deleted in velo-cardio-facial syndrome
Alias:
ARVC
Type:
Cytoskeletal protein
Mass (Da):
104642
Number AA:
962
UniProt ID:
O00192
International Prot ID:
IPI00010490
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005622
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007155
GO:0007275
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S15
S
A
A
S
I
L
A
S
V
K
E
Q
E
A
R
Site 2
T27
E
A
R
F
E
R
L
T
R
A
L
E
Q
E
R
Site 3
S51
A
Q
Q
P
G
M
V
S
G
G
M
G
S
G
Q
Site 4
S73
Q
L
V
L
Q
E
Q
S
P
G
S
Q
A
S
L
Site 5
S76
L
Q
E
Q
S
P
G
S
Q
A
S
L
A
T
M
Site 6
S79
Q
S
P
G
S
Q
A
S
L
A
T
M
P
E
A
Site 7
T93
A
P
D
V
L
E
E
T
V
T
V
E
E
D
P
Site 8
T95
D
V
L
E
E
T
V
T
V
E
E
D
P
G
T
Site 9
T102
T
V
E
E
D
P
G
T
P
T
S
H
V
S
I
Site 10
S105
E
D
P
G
T
P
T
S
H
V
S
I
V
T
S
Site 11
S108
G
T
P
T
S
H
V
S
I
V
T
S
E
D
G
Site 12
S112
S
H
V
S
I
V
T
S
E
D
G
T
T
R
R
Site 13
T116
I
V
T
S
E
D
G
T
T
R
R
T
E
T
K
Site 14
T117
V
T
S
E
D
G
T
T
R
R
T
E
T
K
V
Site 15
T120
E
D
G
T
T
R
R
T
E
T
K
V
T
K
T
Site 16
T122
G
T
T
R
R
T
E
T
K
V
T
K
T
V
K
Site 17
T125
R
R
T
E
T
K
V
T
K
T
V
K
T
V
T
Site 18
T127
T
E
T
K
V
T
K
T
V
K
T
V
T
T
R
Site 19
T130
K
V
T
K
T
V
K
T
V
T
T
R
T
V
R
Site 20
T135
V
K
T
V
T
T
R
T
V
R
Q
V
P
V
G
Site 21
T177
R
G
G
G
P
V
A
T
L
S
R
A
Y
L
S
Site 22
S184
T
L
S
R
A
Y
L
S
S
G
G
G
F
P
E
Site 23
S185
L
S
R
A
Y
L
S
S
G
G
G
F
P
E
G
Site 24
S198
E
G
P
E
P
R
D
S
P
S
Y
G
S
L
S
Site 25
S200
P
E
P
R
D
S
P
S
Y
G
S
L
S
R
G
Site 26
Y201
E
P
R
D
S
P
S
Y
G
S
L
S
R
G
L
Site 27
S203
R
D
S
P
S
Y
G
S
L
S
R
G
L
G
M
Site 28
S205
S
P
S
Y
G
S
L
S
R
G
L
G
M
R
P
Site 29
T228
G
P
G
D
G
C
F
T
L
P
G
H
R
E
A
Site 30
S249
P
G
P
P
G
G
R
S
L
P
E
R
F
Q
A
Site 31
Y259
E
R
F
Q
A
E
P
Y
G
L
E
D
D
T
R
Site 32
T265
P
Y
G
L
E
D
D
T
R
S
L
A
A
D
D
Site 33
S267
G
L
E
D
D
T
R
S
L
A
A
D
D
E
G
Site 34
Y282
G
P
E
L
E
P
D
Y
G
T
A
T
R
R
R
Site 35
T284
E
L
E
P
D
Y
G
T
A
T
R
R
R
P
E
Site 36
T286
E
P
D
Y
G
T
A
T
R
R
R
P
E
C
G
Site 37
Y301
R
G
L
H
T
R
A
Y
E
D
T
A
D
D
G
Site 38
T304
H
T
R
A
Y
E
D
T
A
D
D
G
G
E
L
Site 39
S332
L
A
Q
P
E
R
G
S
M
G
S
L
D
R
L
Site 40
S335
P
E
R
G
S
M
G
S
L
D
R
L
V
R
R
Site 41
S343
L
D
R
L
V
R
R
S
P
S
V
D
S
A
R
Site 42
S345
R
L
V
R
R
S
P
S
V
D
S
A
R
K
E
Site 43
S348
R
R
S
P
S
V
D
S
A
R
K
E
P
R
W
Site 44
S428
C
G
A
L
R
N
L
S
Y
G
R
D
T
D
N
Site 45
Y429
G
A
L
R
N
L
S
Y
G
R
D
T
D
N
K
Site 46
T433
N
L
S
Y
G
R
D
T
D
N
K
A
A
I
R
Site 47
S473
G
T
L
W
N
L
S
S
Y
E
P
L
K
M
V
Site 48
T490
D
H
G
L
Q
T
L
T
H
E
V
I
V
P
H
Site 49
S498
H
E
V
I
V
P
H
S
G
W
E
R
E
P
N
Site 50
T516
K
P
R
D
A
E
W
T
T
V
F
K
N
T
S
Site 51
S530
S
G
C
L
R
N
V
S
S
D
G
A
E
A
R
Site 52
S531
G
C
L
R
N
V
S
S
D
G
A
E
A
R
R
Site 53
S556
A
L
L
H
A
L
Q
S
A
V
G
R
K
D
T
Site 54
T563
S
A
V
G
R
K
D
T
D
N
K
S
V
E
N
Site 55
Y592
E
V
P
G
A
D
R
Y
Q
E
A
E
P
G
P
Site 56
S602
A
E
P
G
P
L
G
S
A
V
G
S
Q
R
R
Site 57
S606
P
L
G
S
A
V
G
S
Q
R
R
R
R
D
D
Site 58
S615
R
R
R
R
D
D
A
S
C
F
G
G
K
K
A
Site 59
T642
E
M
D
R
N
F
D
T
L
D
L
P
K
R
T
Site 60
S669
E
V
V
R
L
Y
L
S
L
L
T
E
S
R
N
Site 61
T672
R
L
Y
L
S
L
L
T
E
S
R
N
F
N
T
Site 62
T704
W
A
T
Y
I
R
A
T
V
R
K
E
R
G
L
Site 63
S737
A
I
A
L
R
N
L
S
L
D
R
R
N
K
D
Site 64
S790
I
H
E
I
V
S
D
S
L
D
N
A
R
S
L
Site 65
S796
D
S
L
D
N
A
R
S
L
L
Q
A
R
G
V
Site 66
S831
H
V
L
Q
T
V
W
S
Y
K
E
L
R
G
T
Site 67
T838
S
Y
K
E
L
R
G
T
L
Q
K
D
G
W
T
Site 68
T845
T
L
Q
K
D
G
W
T
K
A
R
F
Q
S
A
Site 69
S851
W
T
K
A
R
F
Q
S
A
A
A
T
A
K
G
Site 70
S864
K
G
P
K
G
A
L
S
P
G
G
F
D
D
S
Site 71
S871
S
P
G
G
F
D
D
S
T
L
P
L
V
D
K
Site 72
T872
P
G
G
F
D
D
S
T
L
P
L
V
D
K
S
Site 73
S879
T
L
P
L
V
D
K
S
L
E
G
E
K
T
G
Site 74
T885
K
S
L
E
G
E
K
T
G
S
R
D
V
I
P
Site 75
S887
L
E
G
E
K
T
G
S
R
D
V
I
P
M
D
Site 76
Y901
D
A
L
G
P
D
G
Y
S
T
V
D
R
R
E
Site 77
T903
L
G
P
D
G
Y
S
T
V
D
R
R
E
R
R
Site 78
S915
E
R
R
P
R
G
A
S
S
A
G
E
A
S
E
Site 79
S921
A
S
S
A
G
E
A
S
E
K
E
P
L
K
L
Site 80
S931
E
P
L
K
L
D
P
S
R
K
A
P
P
P
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation