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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ESPN
Full Name:
Espin
Alias:
Autosomal recessive deafness type 36 protein;Ectoplasmic specialization protein
Type:
Mass (Da):
91733
Number AA:
854
UniProt ID:
B1AK53
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T72
A
R
A
R
N
G
A
T
P
A
H
D
A
S
A
Site 2
S78
A
T
P
A
H
D
A
S
A
T
G
H
L
A
C
Site 3
S103
R
V
Q
D
K
D
N
S
G
A
T
V
L
H
L
Site 4
T132
H
H
G
G
G
D
P
T
A
A
T
D
M
G
A
Site 5
S153
A
A
K
G
D
F
P
S
L
R
L
L
V
E
H
Site 6
Y161
L
R
L
L
V
E
H
Y
P
E
G
V
N
A
Q
Site 7
T174
A
Q
T
K
N
G
A
T
P
L
Y
L
A
C
Q
Site 8
Y177
K
N
G
A
T
P
L
Y
L
A
C
Q
E
G
H
Site 9
Y190
G
H
L
E
V
T
Q
Y
L
V
Q
E
C
G
A
Site 10
T208
A
R
A
H
D
G
M
T
P
L
H
A
A
A
Q
Site 11
S232
L
V
S
C
T
D
V
S
L
S
E
Q
D
K
D
Site 12
S234
S
C
T
D
V
S
L
S
E
Q
D
K
D
G
A
Site 13
T242
E
Q
D
K
D
G
A
T
A
M
H
F
A
A
S
Site 14
S257
R
G
H
T
K
V
L
S
W
L
L
L
H
G
G
Site 15
T274
S
A
D
L
W
G
G
T
P
L
H
D
A
A
E
Site 16
Y306
D
V
R
D
R
D
G
Y
T
A
A
D
L
S
D
Site 17
T307
V
R
D
R
D
G
Y
T
A
A
D
L
S
D
F
Site 18
S312
G
Y
T
A
A
D
L
S
D
F
N
G
H
S
H
Site 19
Y323
G
H
S
H
C
T
R
Y
L
R
T
V
E
N
L
Site 20
T326
H
C
T
R
Y
L
R
T
V
E
N
L
S
V
E
Site 21
S331
L
R
T
V
E
N
L
S
V
E
H
R
V
L
S
Site 22
S338
S
V
E
H
R
V
L
S
R
D
P
S
A
E
L
Site 23
S342
R
V
L
S
R
D
P
S
A
E
L
E
A
K
Q
Site 24
S352
L
E
A
K
Q
P
D
S
G
M
S
S
P
N
T
Site 25
S356
Q
P
D
S
G
M
S
S
P
N
T
T
V
S
V
Site 26
T359
S
G
M
S
S
P
N
T
T
V
S
V
Q
P
L
Site 27
T360
G
M
S
S
P
N
T
T
V
S
V
Q
P
L
N
Site 28
S362
S
S
P
N
T
T
V
S
V
Q
P
L
N
F
D
Site 29
S371
Q
P
L
N
F
D
L
S
S
P
T
S
T
L
S
Site 30
S372
P
L
N
F
D
L
S
S
P
T
S
T
L
S
N
Site 31
S375
F
D
L
S
S
P
T
S
T
L
S
N
Y
D
S
Site 32
T376
D
L
S
S
P
T
S
T
L
S
N
Y
D
S
C
Site 33
S378
S
S
P
T
S
T
L
S
N
Y
D
S
C
S
S
Site 34
Y380
P
T
S
T
L
S
N
Y
D
S
C
S
S
S
H
Site 35
S382
S
T
L
S
N
Y
D
S
C
S
S
S
H
S
S
Site 36
S384
L
S
N
Y
D
S
C
S
S
S
H
S
S
I
K
Site 37
S385
S
N
Y
D
S
C
S
S
S
H
S
S
I
K
G
Site 38
S386
N
Y
D
S
C
S
S
S
H
S
S
I
K
G
Q
Site 39
S388
D
S
C
S
S
S
H
S
S
I
K
G
Q
H
P
Site 40
S389
S
C
S
S
S
H
S
S
I
K
G
Q
H
P
P
Site 41
S401
H
P
P
C
G
L
S
S
A
R
A
A
D
I
Q
Site 42
S409
A
R
A
A
D
I
Q
S
Y
M
D
M
L
N
P
Site 43
T424
E
L
G
L
P
R
G
T
I
G
K
P
T
P
P
Site 44
T429
R
G
T
I
G
K
P
T
P
P
P
P
P
P
S
Site 45
S436
T
P
P
P
P
P
P
S
F
P
P
P
P
P
P
Site 46
T446
P
P
P
P
P
P
G
T
Q
L
P
P
P
P
P
Site 47
Y455
L
P
P
P
P
P
G
Y
P
A
P
K
P
P
V
Site 48
Y470
G
P
Q
A
A
D
I
Y
M
Q
T
K
N
K
L
Site 49
S490
E
A
L
K
K
E
L
S
S
C
D
G
H
D
G
Site 50
S503
D
G
L
R
R
Q
D
S
S
R
K
P
R
A
F
Site 51
S504
G
L
R
R
Q
D
S
S
R
K
P
R
A
F
S
Site 52
S511
S
R
K
P
R
A
F
S
K
Q
P
S
T
G
D
Site 53
S515
R
A
F
S
K
Q
P
S
T
G
D
Y
Y
R
Q
Site 54
Y519
K
Q
P
S
T
G
D
Y
Y
R
Q
L
G
R
C
Site 55
Y520
Q
P
S
T
G
D
Y
Y
R
Q
L
G
R
C
P
Site 56
T530
L
G
R
C
P
G
E
T
L
A
A
R
P
G
M
Site 57
S540
A
R
P
G
M
A
H
S
E
E
V
R
A
R
Q
Site 58
S563
L
G
P
A
A
R
G
S
L
E
G
P
S
A
P
Site 59
S568
R
G
S
L
E
G
P
S
A
P
P
Q
A
A
L
Site 60
S611
P
P
L
P
E
A
A
S
S
P
P
P
A
P
P
Site 61
S612
P
L
P
E
A
A
S
S
P
P
P
A
P
P
L
Site 62
S623
A
P
P
L
P
L
E
S
A
G
P
G
C
G
Q
Site 63
S633
P
G
C
G
Q
R
R
S
S
S
S
T
G
S
T
Site 64
S634
G
C
G
Q
R
R
S
S
S
S
T
G
S
T
K
Site 65
S635
C
G
Q
R
R
S
S
S
S
T
G
S
T
K
S
Site 66
S636
G
Q
R
R
S
S
S
S
T
G
S
T
K
S
F
Site 67
T637
Q
R
R
S
S
S
S
T
G
S
T
K
S
F
N
Site 68
S639
R
S
S
S
S
T
G
S
T
K
S
F
N
M
M
Site 69
T640
S
S
S
S
T
G
S
T
K
S
F
N
M
M
S
Site 70
S642
S
S
T
G
S
T
K
S
F
N
M
M
S
P
T
Site 71
S647
T
K
S
F
N
M
M
S
P
T
G
D
N
S
E
Site 72
T649
S
F
N
M
M
S
P
T
G
D
N
S
E
L
L
Site 73
S653
M
S
P
T
G
D
N
S
E
L
L
A
E
I
K
Site 74
S664
A
E
I
K
A
G
K
S
L
K
P
T
P
Q
S
Site 75
T668
A
G
K
S
L
K
P
T
P
Q
S
K
G
L
T
Site 76
S671
S
L
K
P
T
P
Q
S
K
G
L
T
T
V
F
Site 77
T675
T
P
Q
S
K
G
L
T
T
V
F
S
G
I
G
Site 78
T676
P
Q
S
K
G
L
T
T
V
F
S
G
I
G
Q
Site 79
S690
Q
P
A
F
Q
P
D
S
P
L
P
S
V
S
P
Site 80
S694
Q
P
D
S
P
L
P
S
V
S
P
A
L
S
P
Site 81
S696
D
S
P
L
P
S
V
S
P
A
L
S
P
V
R
Site 82
S700
P
S
V
S
P
A
L
S
P
V
R
S
P
T
P
Site 83
S704
P
A
L
S
P
V
R
S
P
T
P
P
A
A
G
Site 84
T706
L
S
P
V
R
S
P
T
P
P
A
A
G
F
Q
Site 85
S785
E
E
E
A
R
L
A
S
M
P
A
W
R
R
D
Site 86
S824
L
R
R
E
K
E
Q
S
E
K
L
R
T
L
G
Site 87
T829
E
Q
S
E
K
L
R
T
L
G
Y
D
E
S
K
Site 88
Y832
E
K
L
R
T
L
G
Y
D
E
S
K
L
A
P
Site 89
S835
R
T
L
G
Y
D
E
S
K
L
A
P
W
Q
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation