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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CLCA1
Full Name:
Calcium-activated chloride channel regulator 1
Alias:
Calcium-activated chloride channel family member 1;Calcium-activated chloride channel protein 1
Type:
Mass (Da):
100168
Number AA:
914
UniProt ID:
A8K7I4
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S23
L
E
G
A
L
S
N
S
L
I
Q
L
N
N
N
Site 2
T48
P
N
V
P
E
D
E
T
L
I
Q
Q
I
K
D
Site 3
Y73
E
A
T
G
K
R
F
Y
F
K
N
V
A
I
L
Site 4
T87
L
I
P
E
T
W
K
T
K
A
D
Y
V
R
P
Site 5
Y91
T
W
K
T
K
A
D
Y
V
R
P
K
L
E
T
Site 6
Y99
V
R
P
K
L
E
T
Y
K
N
A
D
V
L
V
Site 7
T110
D
V
L
V
A
E
S
T
P
P
G
N
D
E
P
Site 8
Y118
P
P
G
N
D
E
P
Y
T
E
Q
M
G
N
C
Site 9
T135
K
G
E
R
I
H
L
T
P
D
F
I
A
G
K
Site 10
Y147
A
G
K
K
L
A
E
Y
G
P
Q
G
R
A
F
Site 11
Y169
R
W
G
V
F
D
E
Y
N
N
D
E
K
F
Y
Site 12
Y176
Y
N
N
D
E
K
F
Y
L
S
N
G
R
I
Q
Site 13
S178
N
D
E
K
F
Y
L
S
N
G
R
I
Q
A
V
Site 14
S188
R
I
Q
A
V
R
C
S
A
G
I
T
G
T
N
Site 15
Y206
K
C
Q
G
G
S
C
Y
T
K
R
C
T
F
N
Site 16
T211
S
C
Y
T
K
R
C
T
F
N
K
V
T
G
L
Site 17
Y219
F
N
K
V
T
G
L
Y
E
K
G
C
E
F
V
Site 18
T232
F
V
L
Q
S
R
Q
T
E
K
A
S
I
M
F
Site 19
T272
Q
K
C
N
L
R
S
T
W
E
V
I
R
D
S
Site 20
S279
T
W
E
V
I
R
D
S
E
D
F
K
K
T
T
Site 21
T286
S
E
D
F
K
K
T
T
P
M
T
T
Q
P
P
Site 22
T289
F
K
K
T
T
P
M
T
T
Q
P
P
N
P
T
Site 23
T290
K
K
T
T
P
M
T
T
Q
P
P
N
P
T
F
Site 24
T296
T
T
Q
P
P
N
P
T
F
S
L
L
Q
I
G
Site 25
S316
L
V
L
D
K
S
G
S
M
A
T
G
N
R
L
Site 26
S364
S
E
L
I
Q
I
N
S
G
S
D
R
D
T
L
Site 27
S366
L
I
Q
I
N
S
G
S
D
R
D
T
L
A
K
Site 28
T370
N
S
G
S
D
R
D
T
L
A
K
R
L
P
A
Site 29
S380
K
R
L
P
A
A
A
S
G
G
T
S
I
C
S
Site 30
T394
S
G
L
R
S
A
F
T
V
I
R
K
K
Y
P
Site 31
Y400
F
T
V
I
R
K
K
Y
P
T
D
G
S
E
I
Site 32
T402
V
I
R
K
K
Y
P
T
D
G
S
E
I
V
L
Site 33
S405
K
K
Y
P
T
D
G
S
E
I
V
L
L
T
D
Site 34
T417
L
T
D
G
E
D
N
T
I
S
G
C
F
N
E
Site 35
S419
D
G
E
D
N
T
I
S
G
C
F
N
E
V
K
Site 36
S449
A
Q
E
L
E
E
L
S
K
M
T
G
G
L
Q
Site 37
Y458
M
T
G
G
L
Q
T
Y
A
S
D
Q
V
Q
N
Site 38
S460
G
G
L
Q
T
Y
A
S
D
Q
V
Q
N
N
G
Site 39
S477
D
A
F
G
A
L
S
S
G
N
G
A
V
S
Q
Site 40
S483
S
S
G
N
G
A
V
S
Q
R
S
I
Q
L
E
Site 41
S486
N
G
A
V
S
Q
R
S
I
Q
L
E
S
K
G
Site 42
T495
Q
L
E
S
K
G
L
T
L
Q
N
S
Q
W
M
Site 43
S535
Q
I
L
L
W
D
P
S
G
Q
K
Q
G
G
F
Site 44
Y552
D
K
N
T
K
M
A
Y
L
Q
I
P
G
I
A
Site 45
T563
P
G
I
A
K
V
G
T
W
K
Y
S
L
Q
A
Site 46
Y566
A
K
V
G
T
W
K
Y
S
L
Q
A
S
S
Q
Site 47
S567
K
V
G
T
W
K
Y
S
L
Q
A
S
S
Q
T
Site 48
S571
W
K
Y
S
L
Q
A
S
S
Q
T
L
T
L
T
Site 49
S572
K
Y
S
L
Q
A
S
S
Q
T
L
T
L
T
V
Site 50
T576
Q
A
S
S
Q
T
L
T
L
T
V
T
S
R
A
Site 51
T578
S
S
Q
T
L
T
L
T
V
T
S
R
A
S
N
Site 52
T580
Q
T
L
T
L
T
V
T
S
R
A
S
N
A
T
Site 53
T587
T
S
R
A
S
N
A
T
L
P
P
I
T
V
T
Site 54
T592
N
A
T
L
P
P
I
T
V
T
S
K
T
N
K
Site 55
T597
P
I
T
V
T
S
K
T
N
K
D
T
S
K
F
Site 56
S602
S
K
T
N
K
D
T
S
K
F
P
S
P
L
V
Site 57
S606
K
D
T
S
K
F
P
S
P
L
V
V
Y
A
N
Site 58
T652
N
G
A
G
A
D
A
T
K
D
D
G
V
Y
S
Site 59
Y658
A
T
K
D
D
G
V
Y
S
R
Y
F
T
T
Y
Site 60
Y661
D
D
G
V
Y
S
R
Y
F
T
T
Y
D
T
N
Site 61
T663
G
V
Y
S
R
Y
F
T
T
Y
D
T
N
G
R
Site 62
Y665
Y
S
R
Y
F
T
T
Y
D
T
N
G
R
Y
S
Site 63
T667
R
Y
F
T
T
Y
D
T
N
G
R
Y
S
V
K
Site 64
Y671
T
Y
D
T
N
G
R
Y
S
V
K
V
R
A
L
Site 65
S672
Y
D
T
N
G
R
Y
S
V
K
V
R
A
L
G
Site 66
Y697
P
Q
Q
S
G
A
L
Y
I
P
G
W
I
E
N
Site 67
S729
Q
H
K
Q
V
C
F
S
R
T
S
S
G
G
S
Site 68
T731
K
Q
V
C
F
S
R
T
S
S
G
G
S
F
V
Site 69
S736
S
R
T
S
S
G
G
S
F
V
A
S
D
V
P
Site 70
T772
G
G
S
L
I
N
L
T
W
T
A
P
G
D
D
Site 71
Y780
W
T
A
P
G
D
D
Y
D
H
G
T
A
H
K
Site 72
Y788
D
H
G
T
A
H
K
Y
I
I
R
I
S
T
S
Site 73
T794
K
Y
I
I
R
I
S
T
S
I
L
D
L
R
D
Site 74
S795
Y
I
I
R
I
S
T
S
I
L
D
L
R
D
K
Site 75
S806
L
R
D
K
F
N
E
S
L
Q
V
N
T
T
A
Site 76
S821
L
I
P
K
E
A
N
S
E
E
V
F
L
F
K
Site 77
S854
V
D
K
V
D
L
K
S
E
I
S
N
I
A
R
Site 78
S857
V
D
L
K
S
E
I
S
N
I
A
R
V
S
L
Site 79
T870
S
L
F
I
P
P
Q
T
P
P
E
T
P
S
P
Site 80
T874
P
P
Q
T
P
P
E
T
P
S
P
D
E
T
S
Site 81
S876
Q
T
P
P
E
T
P
S
P
D
E
T
S
A
P
Site 82
T880
E
T
P
S
P
D
E
T
S
A
P
C
P
N
I
Site 83
S881
T
P
S
P
D
E
T
S
A
P
C
P
N
I
H
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation