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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MARCH-XI
Full Name:
E3 ubiquitin-protein ligase MARCH11
Alias:
EC 6.3.2.-; MARCH-XI; Membrane-associated ring finger 11, C3HC4
Type:
Uncharacterized protein
Mass (Da):
43878
Number AA:
402
UniProt ID:
A6NNE9
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0031410
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0016874
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0019941
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
F
E
G
G
H
G
G
S
R
C
R
G
A
E
S
Site 2
T33
P
P
P
P
P
P
P
T
P
P
P
G
E
P
A
Site 3
Y48
P
V
P
A
A
P
R
Y
L
P
P
L
P
A
S
Site 4
S55
Y
L
P
P
L
P
A
S
P
E
T
P
E
R
A
Site 5
T58
P
L
P
A
S
P
E
T
P
E
R
A
A
G
P
Site 6
S66
P
E
R
A
A
G
P
S
E
P
L
G
E
V
A
Site 7
S102
E
V
A
A
A
G
D
S
G
E
G
P
R
R
L
Site 8
S122
A
K
G
G
P
G
E
S
E
A
G
A
G
G
E
Site 9
T141
G
A
G
D
Q
P
E
T
R
S
V
C
S
S
R
Site 10
S143
G
D
Q
P
E
T
R
S
V
C
S
S
R
S
S
Site 11
S146
P
E
T
R
S
V
C
S
S
R
S
S
S
S
G
Site 12
S147
E
T
R
S
V
C
S
S
R
S
S
S
S
G
G
Site 13
S149
R
S
V
C
S
S
R
S
S
S
S
G
G
G
D
Site 14
S150
S
V
C
S
S
R
S
S
S
S
G
G
G
D
Q
Site 15
S151
V
C
S
S
R
S
S
S
S
G
G
G
D
Q
R
Site 16
T195
C
D
G
S
V
R
Y
T
H
Q
L
C
L
L
K
Site 17
T238
Q
W
Q
S
I
S
I
T
L
V
E
K
V
Q
M
Site 18
T328
V
L
N
Y
D
K
A
T
D
I
E
E
S
S
R
Site 19
S333
K
A
T
D
I
E
E
S
S
R
G
E
S
S
T
Site 20
S334
A
T
D
I
E
E
S
S
R
G
E
S
S
T
S
Site 21
S338
E
E
S
S
R
G
E
S
S
T
S
R
T
L
W
Site 22
S339
E
S
S
R
G
E
S
S
T
S
R
T
L
W
L
Site 23
T340
S
S
R
G
E
S
S
T
S
R
T
L
W
L
P
Site 24
S341
S
R
G
E
S
S
T
S
R
T
L
W
L
P
L
Site 25
T343
G
E
S
S
T
S
R
T
L
W
L
P
L
T
A
Site 26
T349
R
T
L
W
L
P
L
T
A
L
R
N
R
N
L
Site 27
T360
N
R
N
L
V
H
P
T
Q
L
T
S
P
R
F
Site 28
T363
L
V
H
P
T
Q
L
T
S
P
R
F
Q
C
G
Site 29
S364
V
H
P
T
Q
L
T
S
P
R
F
Q
C
G
Y
Site 30
S387
M
R
P
H
E
D
L
S
E
D
N
S
S
G
E
Site 31
S391
E
D
L
S
E
D
N
S
S
G
E
V
V
M
R
Site 32
S392
D
L
S
E
D
N
S
S
G
E
V
V
M
R
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation