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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SH2D7
Full Name:
SH2 domain-containing protein 7
Alias:
Type:
Mass (Da):
49807
Number AA:
451
UniProt ID:
A6NKC9
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
E
D
S
L
K
Q
L
S
L
G
R
D
P
E
G
Site 2
S20
D
P
E
G
A
G
D
S
Q
A
L
A
E
L
Q
Site 3
T61
G
F
I
T
R
K
Q
T
E
Q
L
L
R
D
K
Site 4
T82
I
R
L
S
D
R
A
T
G
Y
I
L
S
Y
R
Site 5
Y84
L
S
D
R
A
T
G
Y
I
L
S
Y
R
G
S
Site 6
S87
R
A
T
G
Y
I
L
S
Y
R
G
S
D
R
C
Site 7
Y107
N
Q
L
R
N
R
R
Y
I
I
S
G
D
T
Q
Site 8
S110
R
N
R
R
Y
I
I
S
G
D
T
Q
S
H
S
Site 9
T113
R
Y
I
I
S
G
D
T
Q
S
H
S
T
L
A
Site 10
S115
I
I
S
G
D
T
Q
S
H
S
T
L
A
E
L
Site 11
S117
S
G
D
T
Q
S
H
S
T
L
A
E
L
V
H
Site 12
Y151
R
P
E
D
N
D
L
Y
D
A
I
T
R
G
L
Site 13
T161
I
T
R
G
L
H
Q
T
I
V
D
P
E
N
P
Site 14
S183
V
V
P
D
K
A
A
S
P
R
S
S
P
K
P
Site 15
S186
D
K
A
A
S
P
R
S
S
P
K
P
Q
V
S
Site 16
S187
K
A
A
S
P
R
S
S
P
K
P
Q
V
S
F
Site 17
S193
S
S
P
K
P
Q
V
S
F
L
H
A
Q
K
S
Site 18
S200
S
F
L
H
A
Q
K
S
L
D
V
S
P
R
N
Site 19
S204
A
Q
K
S
L
D
V
S
P
R
N
L
S
Q
E
Site 20
S209
D
V
S
P
R
N
L
S
Q
E
E
S
M
E
A
Site 21
S213
R
N
L
S
Q
E
E
S
M
E
A
P
I
R
V
Site 22
S221
M
E
A
P
I
R
V
S
P
L
P
E
K
S
S
Site 23
S227
V
S
P
L
P
E
K
S
S
S
L
L
E
E
S
Site 24
S228
S
P
L
P
E
K
S
S
S
L
L
E
E
S
F
Site 25
S229
P
L
P
E
K
S
S
S
L
L
E
E
S
F
G
Site 26
S234
S
S
S
L
L
E
E
S
F
G
G
P
S
D
I
Site 27
Y243
G
G
P
S
D
I
I
Y
A
D
L
R
R
M
N
Site 28
T258
Q
A
R
L
G
L
G
T
E
G
S
G
R
H
G
Site 29
S261
L
G
L
G
T
E
G
S
G
R
H
G
P
V
P
Site 30
S271
H
G
P
V
P
A
G
S
Q
A
Y
S
P
G
R
Site 31
S275
P
A
G
S
Q
A
Y
S
P
G
R
E
A
Q
R
Site 32
S285
R
E
A
Q
R
R
L
S
D
G
E
Q
N
R
P
Site 33
S300
D
G
L
G
P
V
L
S
G
V
S
P
D
Q
G
Site 34
S303
G
P
V
L
S
G
V
S
P
D
Q
G
P
T
E
Site 35
T309
V
S
P
D
Q
G
P
T
E
S
P
T
S
W
G
Site 36
S311
P
D
Q
G
P
T
E
S
P
T
S
W
G
C
S
Site 37
S314
G
P
T
E
S
P
T
S
W
G
C
S
D
A
M
Site 38
S318
S
P
T
S
W
G
C
S
D
A
M
G
S
L
G
Site 39
S323
G
C
S
D
A
M
G
S
L
G
A
T
W
R
Q
Site 40
T327
A
M
G
S
L
G
A
T
W
R
Q
E
F
P
K
Site 41
S336
R
Q
E
F
P
K
L
S
Q
E
A
Q
P
C
S
Site 42
S343
S
Q
E
A
Q
P
C
S
Q
G
S
S
A
D
I
Site 43
S347
Q
P
C
S
Q
G
S
S
A
D
I
Y
E
F
I
Site 44
Y351
Q
G
S
S
A
D
I
Y
E
F
I
G
T
E
G
Site 45
T366
L
L
Q
E
A
R
D
T
P
D
Q
E
G
S
T
Site 46
Y374
P
D
Q
E
G
S
T
Y
E
Q
I
P
A
C
W
Site 47
S393
R
A
P
H
P
G
A
S
P
T
Y
S
P
W
V
Site 48
T395
P
H
P
G
A
S
P
T
Y
S
P
W
V
H
G
Site 49
Y396
H
P
G
A
S
P
T
Y
S
P
W
V
H
G
Y
Site 50
S397
P
G
A
S
P
T
Y
S
P
W
V
H
G
Y
K
Site 51
Y403
Y
S
P
W
V
H
G
Y
K
R
I
S
G
T
P
Site 52
S407
V
H
G
Y
K
R
I
S
G
T
P
E
L
S
E
Site 53
T409
G
Y
K
R
I
S
G
T
P
E
L
S
E
P
G
Site 54
S413
I
S
G
T
P
E
L
S
E
P
G
N
T
Y
E
Site 55
T418
E
L
S
E
P
G
N
T
Y
E
Q
I
P
A
T
Site 56
T425
T
Y
E
Q
I
P
A
T
K
S
K
E
T
G
R
Site 57
T433
K
S
K
E
T
G
R
T
H
K
P
D
K
L
R
Site 58
T445
K
L
R
R
L
F
F
T
Y
R
K
H
K
F
_
Site 59
Y446
L
R
R
L
F
F
T
Y
R
K
H
K
F
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation