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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
FLJ32810
Full Name:
Rho GTPase-activating protein 42
Alias:
Similar to Oligophrenin 1 isoform 2
Type:
GTPase activating protein, misc.
Mass (Da):
89005
Number AA:
781
UniProt ID:
A6NI28
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005622
Uniprot
OncoNet
Molecular Function:
GO:0005096
PhosphoSite+
KinaseNET
Biological Process:
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
G
L
P
T
L
E
F
S
D
S
Y
L
D
S
P
Site 2
S11
P
T
L
E
F
S
D
S
Y
L
D
S
P
D
F
Site 3
Y12
T
L
E
F
S
D
S
Y
L
D
S
P
D
F
R
Site 4
S15
F
S
D
S
Y
L
D
S
P
D
F
R
E
R
L
Site 5
T32
H
E
I
E
L
E
R
T
N
K
F
I
K
E
L
Site 6
S61
S
M
A
V
Q
K
F
S
Q
S
L
Q
D
F
Q
Site 7
S63
A
V
Q
K
F
S
Q
S
L
Q
D
F
Q
F
E
Site 8
T77
E
C
I
G
D
A
E
T
D
D
E
I
S
I
A
Site 9
S82
A
E
T
D
D
E
I
S
I
A
Q
S
L
K
E
Site 10
S86
D
E
I
S
I
A
Q
S
L
K
E
F
A
R
L
Site 11
S138
K
K
K
F
D
K
E
S
E
K
Y
Y
S
I
L
Site 12
Y141
F
D
K
E
S
E
K
Y
Y
S
I
L
E
K
H
Site 13
Y142
D
K
E
S
E
K
Y
Y
S
I
L
E
K
H
L
Site 14
S143
K
E
S
E
K
Y
Y
S
I
L
E
K
H
L
N
Site 15
S152
L
E
K
H
L
N
L
S
A
K
K
K
E
S
H
Site 16
T165
S
H
L
Q
E
A
D
T
Q
I
D
R
E
H
Q
Site 17
Y175
D
R
E
H
Q
N
F
Y
E
A
S
L
E
Y
V
Site 18
T209
S
F
L
Q
G
L
F
T
F
Y
H
E
G
Y
E
Site 19
Y224
L
A
Q
E
F
A
P
Y
K
Q
Q
L
Q
F
N
Site 20
Y260
M
K
S
A
N
Q
D
Y
R
P
P
S
Q
W
T
Site 21
Y271
S
Q
W
T
M
E
G
Y
L
Y
V
Q
E
K
P
Site 22
Y273
W
T
M
E
G
Y
L
Y
V
Q
E
K
P
L
G
Site 23
T299
T
Y
D
K
G
S
K
T
F
T
M
S
V
S
E
Site 24
T301
D
K
G
S
K
T
F
T
M
S
V
S
E
M
K
Site 25
S303
G
S
K
T
F
T
M
S
V
S
E
M
K
S
S
Site 26
S305
K
T
F
T
M
S
V
S
E
M
K
S
S
G
K
Site 27
S309
M
S
V
S
E
M
K
S
S
G
K
M
N
G
L
Site 28
S310
S
V
S
E
M
K
S
S
G
K
M
N
G
L
V
Site 29
T318
G
K
M
N
G
L
V
T
S
S
P
E
M
F
K
Site 30
S320
M
N
G
L
V
T
S
S
P
E
M
F
K
L
K
Site 31
S328
P
E
M
F
K
L
K
S
C
I
R
R
K
T
D
Site 32
T334
K
S
C
I
R
R
K
T
D
S
I
D
K
R
F
Site 33
Y378
M
D
G
K
E
P
I
Y
T
L
P
A
I
I
S
Site 34
T379
D
G
K
E
P
I
Y
T
L
P
A
I
I
S
K
Site 35
S385
Y
T
L
P
A
I
I
S
K
K
E
E
S
K
S
Site 36
S392
S
K
K
E
E
S
K
S
F
L
Y
L
N
E
A
Site 37
Y395
E
E
S
K
S
F
L
Y
L
N
E
A
G
F
N
Site 38
T438
V
Q
K
L
M
N
T
T
F
S
P
K
S
P
P
Site 39
S440
K
L
M
N
T
T
F
S
P
K
S
P
P
D
I
Site 40
S443
N
T
T
F
S
P
K
S
P
P
D
I
D
I
D
Site 41
T458
I
E
L
W
D
N
K
T
I
T
S
G
L
K
N
Site 42
Y466
I
T
S
G
L
K
N
Y
L
R
C
L
A
E
P
Site 43
Y494
V
K
S
D
D
Q
N
Y
R
V
E
A
V
H
A
Site 44
S585
F
H
T
A
P
D
P
S
I
P
L
P
Q
P
Q
Site 45
S593
I
P
L
P
Q
P
Q
S
R
S
G
S
R
R
T
Site 46
S595
L
P
Q
P
Q
S
R
S
G
S
R
R
T
R
A
Site 47
S597
Q
P
Q
S
R
S
G
S
R
R
T
R
A
I
C
Site 48
T600
S
R
S
G
S
R
R
T
R
A
I
C
L
S
T
Site 49
S606
R
T
R
A
I
C
L
S
T
G
S
R
K
P
R
Site 50
T607
T
R
A
I
C
L
S
T
G
S
R
K
P
R
G
Site 51
S609
A
I
C
L
S
T
G
S
R
K
P
R
G
R
Y
Site 52
Y616
S
R
K
P
R
G
R
Y
T
P
C
L
A
E
P
Site 53
T617
R
K
P
R
G
R
Y
T
P
C
L
A
E
P
D
Site 54
S625
P
C
L
A
E
P
D
S
D
S
Y
S
S
S
P
Site 55
S627
L
A
E
P
D
S
D
S
Y
S
S
S
P
D
S
Site 56
Y628
A
E
P
D
S
D
S
Y
S
S
S
P
D
S
T
Site 57
S629
E
P
D
S
D
S
Y
S
S
S
P
D
S
T
P
Site 58
S630
P
D
S
D
S
Y
S
S
S
P
D
S
T
P
M
Site 59
S631
D
S
D
S
Y
S
S
S
P
D
S
T
P
M
G
Site 60
S634
S
Y
S
S
S
P
D
S
T
P
M
G
S
I
E
Site 61
T635
Y
S
S
S
P
D
S
T
P
M
G
S
I
E
S
Site 62
S639
P
D
S
T
P
M
G
S
I
E
S
L
S
S
H
Site 63
S642
T
P
M
G
S
I
E
S
L
S
S
H
S
S
E
Site 64
S644
M
G
S
I
E
S
L
S
S
H
S
S
E
Q
N
Site 65
S645
G
S
I
E
S
L
S
S
H
S
S
E
Q
N
S
Site 66
S648
E
S
L
S
S
H
S
S
E
Q
N
S
T
T
K
Site 67
S652
S
H
S
S
E
Q
N
S
T
T
K
S
A
S
C
Site 68
T653
H
S
S
E
Q
N
S
T
T
K
S
A
S
C
Q
Site 69
T654
S
S
E
Q
N
S
T
T
K
S
A
S
C
Q
P
Site 70
S656
E
Q
N
S
T
T
K
S
A
S
C
Q
P
R
E
Site 71
S665
S
C
Q
P
R
E
K
S
G
G
I
P
W
I
A
Site 72
T673
G
G
I
P
W
I
A
T
P
S
S
S
N
G
Q
Site 73
S675
I
P
W
I
A
T
P
S
S
S
N
G
Q
K
S
Site 74
S676
P
W
I
A
T
P
S
S
S
N
G
Q
K
S
L
Site 75
S677
W
I
A
T
P
S
S
S
N
G
Q
K
S
L
G
Site 76
S682
S
S
S
N
G
Q
K
S
L
G
L
W
T
T
S
Site 77
T687
Q
K
S
L
G
L
W
T
T
S
P
E
S
S
S
Site 78
T688
K
S
L
G
L
W
T
T
S
P
E
S
S
S
K
Site 79
S689
S
L
G
L
W
T
T
S
P
E
S
S
S
K
E
Site 80
S692
L
W
T
T
S
P
E
S
S
S
K
E
T
P
K
Site 81
S693
W
T
T
S
P
E
S
S
S
K
E
T
P
K
A
Site 82
T697
P
E
S
S
S
K
E
T
P
K
A
S
P
N
P
Site 83
S701
S
K
E
T
P
K
A
S
P
N
P
D
L
P
P
Site 84
T718
C
R
R
L
R
L
D
T
A
S
S
N
G
S
F
Site 85
S720
R
L
R
L
D
T
A
S
S
N
G
S
F
S
Q
Site 86
S721
L
R
L
D
T
A
S
S
N
G
S
F
S
Q
A
Site 87
S724
D
T
A
S
S
N
G
S
F
S
Q
A
K
A
M
Site 88
S726
A
S
S
N
G
S
F
S
Q
A
K
A
M
Y
S
Site 89
S733
S
Q
A
K
A
M
Y
S
C
K
A
E
H
S
H
Site 90
S739
Y
S
C
K
A
E
H
S
H
E
L
S
F
P
Q
Site 91
S743
A
E
H
S
H
E
L
S
F
P
Q
G
A
I
F
Site 92
S751
F
P
Q
G
A
I
F
S
N
V
Y
P
S
V
E
Site 93
S756
G
S
I
Q
S
L
T
S
V
G
S
K
E
T
P
Site 94
Y766
P
G
W
L
K
A
T
Y
E
G
K
T
G
L
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation