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Updated November 2019
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Protein Info
Short Name:
FAM186A
Full Name:
Protein FAM186A
Alias:
Type:
Mass (Da):
262758
Number AA:
2351
UniProt ID:
A6NE01
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S15
E
I
D
N
D
P
E
S
E
K
C
I
K
D
S
Site 2
T23
E
K
C
I
K
D
S
T
I
M
R
R
E
P
Q
Site 3
S34
R
E
P
Q
N
I
L
S
P
L
M
L
P
N
L
Site 4
S46
P
N
L
E
I
P
F
S
V
K
D
I
I
S
R
Site 5
Y84
V
H
R
I
M
T
R
Y
T
L
V
F
N
S
S
Site 6
T85
H
R
I
M
T
R
Y
T
L
V
F
N
S
S
S
Site 7
S91
Y
T
L
V
F
N
S
S
S
E
R
N
V
S
L
Site 8
S92
T
L
V
F
N
S
S
S
E
R
N
V
S
L
T
Site 9
S97
S
S
S
E
R
N
V
S
L
T
E
H
K
K
K
Site 10
T99
S
E
R
N
V
S
L
T
E
H
K
K
K
Q
R
Site 11
T115
N
F
L
E
K
M
A
T
Y
A
K
T
I
E
I
Site 12
T165
Q
M
E
L
L
P
D
T
L
K
A
I
E
N
N
Site 13
S177
E
N
N
V
K
I
L
S
R
F
S
T
S
F
L
Site 14
S180
V
K
I
L
S
R
F
S
T
S
F
L
D
E
K
Site 15
T181
K
I
L
S
R
F
S
T
S
F
L
D
E
K
K
Site 16
S182
I
L
S
R
F
S
T
S
F
L
D
E
K
K
K
Site 17
T199
K
K
I
L
S
R
G
T
L
W
K
S
W
K
E
Site 18
S203
S
R
G
T
L
W
K
S
W
K
E
R
V
I
K
Site 19
S213
E
R
V
I
K
R
P
S
T
A
R
A
L
R
P
Site 20
T214
R
V
I
K
R
P
S
T
A
R
A
L
R
P
D
Site 21
Y260
L
E
N
N
A
I
K
Y
I
S
S
T
I
V
N
Site 22
S262
N
N
A
I
K
Y
I
S
S
T
I
V
N
L
S
Site 23
S263
N
A
I
K
Y
I
S
S
T
I
V
N
L
S
T
Site 24
S273
V
N
L
S
T
A
L
S
M
L
N
D
E
L
K
Site 25
Y290
N
F
Q
S
S
T
V
Y
A
H
E
T
S
E
A
Site 26
S302
S
E
A
E
K
E
L
S
L
K
I
I
R
D
L
Site 27
S310
L
K
I
I
R
D
L
S
N
E
N
E
M
L
Q
Site 28
S345
E
Q
L
Y
A
K
L
S
T
S
S
T
L
K
V
Site 29
T349
A
K
L
S
T
S
S
T
L
K
V
L
P
G
P
Site 30
S357
L
K
V
L
P
G
P
S
P
Q
S
S
R
A
I
Site 31
S360
L
P
G
P
S
P
Q
S
S
R
A
I
I
K
V
Site 32
S361
P
G
P
S
P
Q
S
S
R
A
I
I
K
V
G
Site 33
T394
D
E
V
Q
R
K
E
T
K
D
S
G
I
K
W
Site 34
S397
Q
R
K
E
T
K
D
S
G
I
K
W
D
S
T
Site 35
S403
D
S
G
I
K
W
D
S
T
I
S
Y
T
A
Q
Site 36
T404
S
G
I
K
W
D
S
T
I
S
Y
T
A
Q
A
Site 37
Y407
K
W
D
S
T
I
S
Y
T
A
Q
A
E
R
T
Site 38
T414
Y
T
A
Q
A
E
R
T
P
D
L
T
E
L
R
Site 39
T418
A
E
R
T
P
D
L
T
E
L
R
Q
Q
P
V
Site 40
S427
L
R
Q
Q
P
V
A
S
E
D
I
S
E
D
S
Site 41
S431
P
V
A
S
E
D
I
S
E
D
S
T
K
D
N
Site 42
S434
S
E
D
I
S
E
D
S
T
K
D
N
V
S
L
Site 43
T435
E
D
I
S
E
D
S
T
K
D
N
V
S
L
K
Site 44
S440
D
S
T
K
D
N
V
S
L
K
K
G
D
F
Y
Site 45
Y447
S
L
K
K
G
D
F
Y
Q
E
D
E
T
D
E
Site 46
Y455
Q
E
D
E
T
D
E
Y
Q
S
W
K
R
S
H
Site 47
S457
D
E
T
D
E
Y
Q
S
W
K
R
S
H
K
K
Site 48
Y467
R
S
H
K
K
A
T
Y
V
Y
E
T
S
G
P
Site 49
Y469
H
K
K
A
T
Y
V
Y
E
T
S
G
P
N
L
Site 50
S472
A
T
Y
V
Y
E
T
S
G
P
N
L
S
D
N
Site 51
S477
E
T
S
G
P
N
L
S
D
N
K
S
G
Q
K
Site 52
S481
P
N
L
S
D
N
K
S
G
Q
K
V
S
E
A
Site 53
S486
N
K
S
G
Q
K
V
S
E
A
K
P
S
Q
Y
Site 54
S491
K
V
S
E
A
K
P
S
Q
Y
Y
E
L
Q
V
Site 55
Y493
S
E
A
K
P
S
Q
Y
Y
E
L
Q
V
L
K
Site 56
S508
K
K
R
K
E
M
K
S
F
S
E
D
K
S
K
Site 57
S510
R
K
E
M
K
S
F
S
E
D
K
S
K
S
P
Site 58
S514
K
S
F
S
E
D
K
S
K
S
P
T
E
A
K
Site 59
S516
F
S
E
D
K
S
K
S
P
T
E
A
K
R
K
Site 60
T518
E
D
K
S
K
S
P
T
E
A
K
R
K
H
L
Site 61
S526
E
A
K
R
K
H
L
S
L
T
E
T
K
S
Q
Site 62
T528
K
R
K
H
L
S
L
T
E
T
K
S
Q
G
G
Site 63
T530
K
H
L
S
L
T
E
T
K
S
Q
G
G
K
S
Site 64
S532
L
S
L
T
E
T
K
S
Q
G
G
K
S
G
T
Site 65
S537
T
K
S
Q
G
G
K
S
G
T
S
M
M
M
L
Site 66
S554
F
R
K
V
K
R
E
S
P
F
D
K
R
P
T
Site 67
T561
S
P
F
D
K
R
P
T
A
A
E
I
K
V
E
Site 68
S573
K
V
E
P
T
T
E
S
L
D
K
E
G
K
G
Site 69
S584
E
G
K
G
E
I
R
S
L
V
E
P
L
S
M
Site 70
S590
R
S
L
V
E
P
L
S
M
I
Q
F
D
D
T
Site 71
T597
S
M
I
Q
F
D
D
T
A
E
P
Q
K
G
K
Site 72
S613
K
G
K
K
H
H
I
S
S
G
T
I
T
S
K
Site 73
S614
G
K
K
H
H
I
S
S
G
T
I
T
S
K
E
Site 74
T631
T
E
E
K
E
E
L
T
K
Q
V
K
S
H
Q
Site 75
S636
E
L
T
K
Q
V
K
S
H
Q
L
V
K
S
L
Site 76
S642
K
S
H
Q
L
V
K
S
L
S
R
V
A
K
E
Site 77
S644
H
Q
L
V
K
S
L
S
R
V
A
K
E
T
S
Site 78
T650
L
S
R
V
A
K
E
T
S
E
S
T
R
V
L
Site 79
S653
V
A
K
E
T
S
E
S
T
R
V
L
E
S
P
Site 80
S659
E
S
T
R
V
L
E
S
P
D
G
K
S
E
Q
Site 81
S664
L
E
S
P
D
G
K
S
E
Q
S
N
L
E
E
Site 82
T695
G
K
A
F
D
K
K
T
V
P
K
E
E
E
L
Site 83
Y721
I
K
A
K
M
E
E
Y
F
Q
K
V
A
E
T
Site 84
Y736
V
T
K
I
L
R
K
Y
K
D
T
K
K
E
E
Site 85
T739
I
L
R
K
Y
K
D
T
K
K
E
E
Q
V
G
Site 86
S767
P
G
L
H
F
Q
K
S
P
I
S
A
K
S
E
Site 87
S770
H
F
Q
K
S
P
I
S
A
K
S
E
S
S
T
Site 88
S773
K
S
P
I
S
A
K
S
E
S
S
T
L
L
S
Site 89
S775
P
I
S
A
K
S
E
S
S
T
L
L
S
Y
E
Site 90
S776
I
S
A
K
S
E
S
S
T
L
L
S
Y
E
S
Site 91
T777
S
A
K
S
E
S
S
T
L
L
S
Y
E
S
T
Site 92
S780
S
E
S
S
T
L
L
S
Y
E
S
T
D
P
V
Site 93
Y781
E
S
S
T
L
L
S
Y
E
S
T
D
P
V
I
Site 94
S783
S
T
L
L
S
Y
E
S
T
D
P
V
I
N
N
Site 95
T784
T
L
L
S
Y
E
S
T
D
P
V
I
N
N
L
Site 96
T807
E
S
E
R
D
I
P
T
V
S
T
V
Q
K
D
Site 97
Y826
E
K
Q
R
Q
E
Q
Y
L
Q
E
G
Q
E
Q
Site 98
S838
Q
E
Q
M
S
G
M
S
L
K
Q
Q
L
L
G
Site 99
Y854
R
N
L
L
K
E
H
Y
E
K
I
S
E
N
W
Site 100
S858
K
E
H
Y
E
K
I
S
E
N
W
E
E
K
K
Site 101
S879
E
G
K
Q
E
Q
Q
S
Q
K
Q
W
Q
E
E
Site 102
T897
K
E
E
Q
K
Q
A
T
P
K
Q
A
E
Q
E
Site 103
S920
E
E
E
E
L
P
K
S
S
L
Q
R
L
E
E
Site 104
S921
E
E
E
L
P
K
S
S
L
Q
R
L
E
E
G
Site 105
T929
L
Q
R
L
E
E
G
T
Q
K
M
K
T
Q
G
Site 106
T934
E
G
T
Q
K
M
K
T
Q
G
L
L
L
E
K
Site 107
T1005
L
E
K
M
V
I
Q
T
P
M
T
L
S
P
R
Site 108
T1008
M
V
I
Q
T
P
M
T
L
S
P
R
W
K
S
Site 109
S1010
I
Q
T
P
M
T
L
S
P
R
W
K
S
V
L
Site 110
S1015
T
L
S
P
R
W
K
S
V
L
K
D
V
Q
R
Site 111
Y1024
L
K
D
V
Q
R
S
Y
E
G
K
E
F
Q
R
Site 112
T1035
E
F
Q
R
N
L
K
T
L
E
N
L
P
D
E
Site 113
S1047
P
D
E
K
E
P
I
S
I
T
P
P
P
S
L
Site 114
T1049
E
K
E
P
I
S
I
T
P
P
P
S
L
Q
Y
Site 115
S1053
I
S
I
T
P
P
P
S
L
Q
Y
S
L
P
G
Site 116
Y1056
T
P
P
P
S
L
Q
Y
S
L
P
G
A
L
P
Site 117
T1070
P
I
S
G
Q
P
L
T
K
C
I
H
L
T
P
Site 118
T1076
L
T
K
C
I
H
L
T
P
Q
Q
A
Q
E
V
Site 119
T1086
Q
A
Q
E
V
G
I
T
L
T
P
Q
Q
A
Q
Site 120
T1088
Q
E
V
G
I
T
L
T
P
Q
Q
A
Q
A
Q
Site 121
T1112
Q
E
L
G
I
P
L
T
P
Q
Q
A
Q
A
L
Site 122
T1136
Q
A
L
G
I
P
L
T
P
Q
Q
T
Q
V
Q
Site 123
T1148
Q
V
Q
G
I
T
L
T
P
Q
Q
D
Q
A
P
Site 124
T1172
Q
K
L
G
I
P
L
T
P
Q
Q
A
Q
A
L
Site 125
T1184
Q
A
L
G
I
P
L
T
P
Q
Q
A
Q
E
L
Site 126
S1206
Q
A
Q
A
L
R
V
S
L
T
P
Q
Q
A
Q
Site 127
T1208
Q
A
L
R
V
S
L
T
P
Q
Q
A
Q
E
L
Site 128
T1244
Q
Q
L
G
I
P
L
T
P
Q
Q
A
Q
A
L
Site 129
T1280
Q
A
L
G
I
T
L
T
P
K
Q
A
Q
E
L
Site 130
T1304
Q
T
L
G
I
P
L
T
P
K
Q
A
Q
A
L
Site 131
T1328
Q
A
L
G
I
P
L
T
P
Q
Q
A
Q
T
Q
Site 132
T1340
Q
T
Q
E
I
T
L
T
P
Q
Q
A
Q
A
L
Site 133
T1352
Q
A
L
G
M
P
L
T
T
Q
Q
A
Q
E
L
Site 134
T1364
Q
E
L
G
I
P
L
T
P
Q
H
A
Q
A
L
Site 135
T1412
Q
E
L
G
I
P
L
T
P
Q
Q
A
Q
E
L
Site 136
T1424
Q
E
L
G
I
P
F
T
P
Q
Q
A
Q
A
Q
Site 137
T1436
Q
A
Q
E
I
T
L
T
P
Q
Q
A
Q
A
L
Site 138
T1448
Q
A
L
G
M
P
L
T
A
Q
Q
A
Q
E
L
Site 139
T1458
Q
A
Q
E
L
G
I
T
L
T
P
Q
Q
A
Q
Site 140
T1460
Q
E
L
G
I
T
L
T
P
Q
Q
A
Q
E
L
Site 141
T1544
Q
E
L
G
I
P
L
T
P
Q
Q
V
Q
A
L
Site 142
T1568
Q
E
L
E
I
P
L
T
P
Q
Q
A
Q
A
L
Site 143
T1604
Q
E
L
G
I
P
L
T
P
Q
Q
A
Q
A
Q
Site 144
T1616
Q
A
Q
G
I
P
L
T
P
Q
Q
A
Q
A
L
Site 145
S1626
Q
A
Q
A
L
G
I
S
L
T
P
Q
Q
A
Q
Site 146
T1628
Q
A
L
G
I
S
L
T
P
Q
Q
A
Q
A
Q
Site 147
T1640
Q
A
Q
G
I
T
L
T
P
Q
Q
A
Q
A
L
Site 148
S1673
E
Q
T
H
A
L
E
S
P
M
N
L
E
Q
A
Site 149
T1698
L
T
L
D
K
A
H
T
L
G
S
P
L
T
L
Site 150
S1701
D
K
A
H
T
L
G
S
P
L
T
L
K
Q
V
Site 151
T1704
H
T
L
G
S
P
L
T
L
K
Q
V
Q
W
S
Site 152
S1711
T
L
K
Q
V
Q
W
S
H
R
P
F
Q
K
S
Site 153
S1718
S
H
R
P
F
Q
K
S
K
A
S
L
P
T
G
Site 154
S1721
P
F
Q
K
S
K
A
S
L
P
T
G
Q
S
I
Site 155
S1727
A
S
L
P
T
G
Q
S
I
I
S
R
L
S
P
Site 156
S1730
P
T
G
Q
S
I
I
S
R
L
S
P
S
L
R
Site 157
S1742
S
L
R
L
S
L
A
S
S
A
P
T
A
E
K
Site 158
S1743
L
R
L
S
L
A
S
S
A
P
T
A
E
K
S
Site 159
T1746
S
L
A
S
S
A
P
T
A
E
K
S
S
I
F
Site 160
S1750
S
A
P
T
A
E
K
S
S
I
F
G
V
S
S
Site 161
S1763
S
S
T
P
L
Q
I
S
R
V
P
L
N
Q
G
Site 162
T1794
G
K
L
G
A
P
Q
T
L
R
S
S
G
Q
T
Site 163
S1797
G
A
P
Q
T
L
R
S
S
G
Q
T
L
V
Y
Site 164
S1798
A
P
Q
T
L
R
S
S
G
Q
T
L
V
Y
G
Site 165
T1801
T
L
R
S
S
G
Q
T
L
V
Y
G
G
Q
S
Site 166
Y1804
S
S
G
Q
T
L
V
Y
G
G
Q
S
T
S
A
Site 167
S1821
P
A
P
Q
A
P
P
S
P
G
Q
L
P
I
S
Site 168
S1828
S
P
G
Q
L
P
I
S
R
A
P
P
T
P
G
Site 169
T1833
P
I
S
R
A
P
P
T
P
G
Q
P
F
I
A
Site 170
S1851
P
T
S
G
Q
I
P
S
L
W
A
P
L
S
P
Site 171
S1876
I
P
G
D
L
L
E
S
G
P
L
T
F
S
E
Site 172
T1880
L
L
E
S
G
P
L
T
F
S
E
Q
L
Q
E
Site 173
S1882
E
S
G
P
L
T
F
S
E
Q
L
Q
E
F
Q
Site 174
T1893
Q
E
F
Q
P
P
A
T
A
E
Q
S
P
Y
L
Site 175
S1897
P
P
A
T
A
E
Q
S
P
Y
L
Q
A
P
S
Site 176
Y1899
A
T
A
E
Q
S
P
Y
L
Q
A
P
S
T
P
Site 177
S1904
S
P
Y
L
Q
A
P
S
T
P
G
Q
H
L
A
Site 178
T1905
P
Y
L
Q
A
P
S
T
P
G
Q
H
L
A
T
Site 179
T1914
G
Q
H
L
A
T
W
T
L
P
G
R
A
S
S
Site 180
S1920
W
T
L
P
G
R
A
S
S
L
W
I
P
P
T
Site 181
S1921
T
L
P
G
R
A
S
S
L
W
I
P
P
T
S
Site 182
T1927
S
S
L
W
I
P
P
T
S
R
H
P
P
T
L
Site 183
S1928
S
L
W
I
P
P
T
S
R
H
P
P
T
L
W
Site 184
T1933
P
T
S
R
H
P
P
T
L
W
P
S
P
A
P
Site 185
S1937
H
P
P
T
L
W
P
S
P
A
P
G
K
P
Q
Site 186
S1946
A
P
G
K
P
Q
K
S
W
S
P
S
V
A
K
Site 187
S1948
G
K
P
Q
K
S
W
S
P
S
V
A
K
K
R
Site 188
S1950
P
Q
K
S
W
S
P
S
V
A
K
K
R
L
A
Site 189
S1960
K
K
R
L
A
I
I
S
S
L
K
S
K
S
V
Site 190
T1984
K
V
A
Q
V
P
F
T
T
K
K
F
Q
M
S
Site 191
S1991
T
T
K
K
F
Q
M
S
E
V
S
D
T
S
E
Site 192
T1996
Q
M
S
E
V
S
D
T
S
E
E
T
Q
I
L
Site 193
S1997
M
S
E
V
S
D
T
S
E
E
T
Q
I
L
R
Site 194
T2006
E
T
Q
I
L
R
D
T
F
A
I
E
S
F
R
Site 195
S2011
R
D
T
F
A
I
E
S
F
R
T
F
Q
S
H
Site 196
T2014
F
A
I
E
S
F
R
T
F
Q
S
H
F
T
K
Site 197
T2020
R
T
F
Q
S
H
F
T
K
Y
R
T
P
V
Y
Site 198
Y2022
F
Q
S
H
F
T
K
Y
R
T
P
V
Y
Q
T
Site 199
T2024
S
H
F
T
K
Y
R
T
P
V
Y
Q
T
P
Y
Site 200
Y2027
T
K
Y
R
T
P
V
Y
Q
T
P
Y
T
D
E
Site 201
T2029
Y
R
T
P
V
Y
Q
T
P
Y
T
D
E
R
A
Site 202
T2032
P
V
Y
Q
T
P
Y
T
D
E
R
A
L
L
T
Site 203
T2039
T
D
E
R
A
L
L
T
L
M
K
P
T
T
S
Site 204
T2045
L
T
L
M
K
P
T
T
S
P
S
S
L
T
T
Site 205
S2046
T
L
M
K
P
T
T
S
P
S
S
L
T
T
L
Site 206
S2048
M
K
P
T
T
S
P
S
S
L
T
T
L
L
R
Site 207
S2049
K
P
T
T
S
P
S
S
L
T
T
L
L
R
T
Site 208
T2052
T
S
P
S
S
L
T
T
L
L
R
T
S
Q
I
Site 209
T2056
S
L
T
T
L
L
R
T
S
Q
I
S
P
L
E
Site 210
S2057
L
T
T
L
L
R
T
S
Q
I
S
P
L
E
W
Site 211
S2060
L
L
R
T
S
Q
I
S
P
L
E
W
Y
Q
K
Site 212
S2080
I
D
K
P
W
I
L
S
S
V
S
D
T
K
K
Site 213
S2081
D
K
P
W
I
L
S
S
V
S
D
T
K
K
P
Site 214
S2083
P
W
I
L
S
S
V
S
D
T
K
K
P
K
V
Site 215
T2085
I
L
S
S
V
S
D
T
K
K
P
K
V
M
V
Site 216
S2095
P
K
V
M
V
P
P
S
S
P
Q
E
L
E
E
Site 217
S2096
K
V
M
V
P
P
S
S
P
Q
E
L
E
E
K
Site 218
Y2105
Q
E
L
E
E
K
R
Y
F
V
D
V
E
A
Q
Site 219
S2130
I
K
T
C
G
L
P
S
Q
L
H
T
M
A
R
Site 220
Y2158
L
G
Y
L
F
R
K
Y
I
A
Y
R
L
I
Q
Site 221
Y2161
L
F
R
K
Y
I
A
Y
R
L
I
Q
H
A
R
Site 222
Y2185
I
Q
N
T
G
K
G
Y
E
A
R
N
L
H
M
Site 223
S2195
R
N
L
H
M
M
L
S
R
L
D
D
Y
G
K
Site 224
Y2200
M
L
S
R
L
D
D
Y
G
K
K
V
M
Q
V
Site 225
S2214
V
W
T
E
K
Q
K
S
L
G
Q
K
R
N
Q
Site 226
S2257
E
E
K
Q
I
P
A
S
T
T
F
V
Q
K
P
Site 227
T2259
K
Q
I
P
A
S
T
T
F
V
Q
K
P
F
L
Site 228
T2275
L
L
M
E
E
D
R
T
S
D
I
C
K
K
F
Site 229
S2276
L
M
E
E
D
R
T
S
D
I
C
K
K
F
R
Site 230
S2300
W
N
V
D
L
S
T
S
S
Y
P
I
A
E
K
Site 231
Y2302
V
D
L
S
T
S
S
Y
P
I
A
E
K
T
S
Site 232
T2308
S
Y
P
I
A
E
K
T
S
M
H
S
L
W
A
Site 233
S2312
A
E
K
T
S
M
H
S
L
W
A
Q
L
G
G
Site 234
T2334
L
Q
L
E
V
Q
S
T
F
R
K
S
L
A
S
Site 235
S2338
V
Q
S
T
F
R
K
S
L
A
S
L
Q
S
R
Site 236
S2341
T
F
R
K
S
L
A
S
L
Q
S
R
V
K
K
Site 237
S2344
K
S
L
A
S
L
Q
S
R
V
K
K
I
P
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation