KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
SSPO
Full Name:
SCO-spondin
Alias:
Type:
Mass (Da):
547504
Number AA:
5147
UniProt ID:
A2VEC9
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S44
E
D
L
V
P
C
A
S
L
D
H
Y
S
R
L
Site 2
Y48
P
C
A
S
L
D
H
Y
S
R
L
G
W
R
L
Site 3
S60
W
R
L
D
L
P
W
S
G
R
S
G
L
T
R
Site 4
T66
W
S
G
R
S
G
L
T
R
S
P
A
P
G
L
Site 5
S68
G
R
S
G
L
T
R
S
P
A
P
G
L
C
P
Site 6
Y77
A
P
G
L
C
P
I
Y
K
P
P
E
T
R
P
Site 7
T82
P
I
Y
K
P
P
E
T
R
P
A
K
W
N
R
Site 8
S111
T
E
A
L
A
K
A
S
P
E
G
H
C
F
A
Site 9
S128
Q
C
Q
L
Q
A
G
S
A
N
A
S
A
G
S
Site 10
S132
Q
A
G
S
A
N
A
S
A
G
S
L
E
E
C
Site 11
S135
S
A
N
A
S
A
G
S
L
E
E
C
C
A
R
Site 12
S158
G
S
S
Q
A
C
R
S
C
S
S
R
H
L
P
Site 13
S160
S
Q
A
C
R
S
C
S
S
R
H
L
P
G
S
Site 14
S167
S
S
R
H
L
P
G
S
A
S
S
P
A
L
L
Site 15
S169
R
H
L
P
G
S
A
S
S
P
A
L
L
Q
P
Site 16
S186
G
A
V
G
Q
L
W
S
Q
H
Q
R
P
S
A
Site 17
S197
R
P
S
A
T
C
A
S
W
S
G
F
H
Y
R
Site 18
Y203
A
S
W
S
G
F
H
Y
R
T
F
D
G
R
H
Site 19
Y211
R
T
F
D
G
R
H
Y
H
F
L
G
R
C
T
Site 20
T234
S
T
W
A
V
H
L
T
P
G
D
R
C
P
Q
Site 21
T249
P
G
H
C
Q
R
V
T
M
G
P
E
E
V
L
Site 22
S306
V
R
L
D
R
T
G
S
I
S
I
S
V
D
H
Site 23
S308
L
D
R
T
G
S
I
S
I
S
V
D
H
E
L
Site 24
S310
R
T
G
S
I
S
I
S
V
D
H
E
L
W
G
Site 25
Y326
T
Q
G
L
C
G
L
Y
N
G
W
P
E
D
D
Site 26
S351
L
A
A
T
F
G
N
S
W
R
L
P
G
S
E
Site 27
S357
N
S
W
R
L
P
G
S
E
S
G
C
L
D
A
Site 28
S359
W
R
L
P
G
S
E
S
G
C
L
D
A
V
E
Site 29
S410
G
Q
C
H
A
Q
V
S
P
A
E
Y
H
E
A
Site 30
S480
Q
L
Y
S
D
C
V
S
L
C
P
P
S
C
E
Site 31
S496
V
G
Q
G
E
E
E
S
C
R
E
E
C
V
S
Site 32
S503
S
C
R
E
E
C
V
S
G
C
E
C
P
R
G
Site 33
Y533
C
Y
Y
C
R
Q
R
Y
V
P
G
D
T
V
R
Site 34
T538
Q
R
Y
V
P
G
D
T
V
R
Q
L
C
N
P
Site 35
Y572
A
V
G
G
D
G
H
Y
L
T
F
D
G
R
S
Site 36
T574
G
G
D
G
H
Y
L
T
F
D
G
R
S
Y
S
Site 37
Y580
L
T
F
D
G
R
S
Y
S
F
W
G
G
Q
G
Site 38
Y590
W
G
G
Q
G
C
R
Y
S
L
V
Q
D
Y
V
Site 39
S591
G
G
Q
G
C
R
Y
S
L
V
Q
D
Y
V
K
Site 40
T626
I
S
V
S
L
E
D
T
H
I
Q
L
R
D
S
Site 41
S654
W
I
G
A
E
G
L
S
V
R
R
A
S
S
A
Site 42
T684
S
D
P
V
A
Y
I
T
L
D
P
R
H
A
H
Site 43
T699
Q
V
Q
G
L
C
G
T
F
T
Q
N
Q
Q
D
Site 44
T710
N
Q
Q
D
D
F
L
T
P
A
G
D
V
E
T
Site 45
S736
A
G
K
G
R
C
P
S
E
D
S
A
L
L
S
Site 46
S739
G
R
C
P
S
E
D
S
A
L
L
S
P
C
T
Site 47
S743
S
E
D
S
A
L
L
S
P
C
T
T
H
S
Q
Site 48
T746
S
A
L
L
S
P
C
T
T
H
S
Q
R
H
A
Site 49
T747
A
L
L
S
P
C
T
T
H
S
Q
R
H
A
F
Site 50
S749
L
S
P
C
T
T
H
S
Q
R
H
A
F
A
E
Site 51
S814
R
C
A
Q
E
G
A
S
P
P
W
R
N
Q
T
Site 52
Y833
M
C
P
G
G
Q
E
Y
R
E
C
A
P
A
C
Site 53
Y889
C
Q
L
G
A
R
R
Y
A
P
G
S
A
T
M
Site 54
S893
A
R
R
Y
A
P
G
S
A
T
M
K
E
C
N
Site 55
S942
L
L
T
C
D
S
P
S
A
N
H
S
C
P
A
Site 56
S946
D
S
P
S
A
N
H
S
C
P
A
G
S
T
D
Site 57
T1006
R
G
R
Q
W
H
C
T
G
Q
R
R
S
G
R
Site 58
S1011
H
C
T
G
Q
R
R
S
G
R
C
Q
A
S
G
Site 59
S1017
R
S
G
R
C
Q
A
S
G
A
P
H
Y
V
T
Site 60
Y1022
Q
A
S
G
A
P
H
Y
V
T
F
D
G
L
A
Site 61
Y1038
T
Y
P
G
A
C
E
Y
L
L
V
R
E
A
S
Site 62
T1049
R
E
A
S
G
L
F
T
V
S
A
Q
N
L
P
Site 63
T1093
T
V
N
G
V
S
V
T
P
P
K
V
Y
T
G
Site 64
S1135
T
R
V
L
V
Q
L
S
P
Q
F
R
G
R
V
Site 65
S1154
G
D
F
D
G
D
A
S
N
D
L
R
S
R
Q
Site 66
S1178
A
A
H
S
W
R
L
S
P
L
C
P
E
P
G
Site 67
T1192
G
D
L
P
H
P
C
T
M
N
T
H
R
A
G
Site 68
S1267
G
H
H
V
R
W
R
S
Q
E
L
C
S
L
Q
Site 69
S1272
W
R
S
Q
E
L
C
S
L
Q
C
E
G
G
Q
Site 70
Y1281
Q
C
E
G
G
Q
V
Y
E
A
C
G
P
T
C
Site 71
S1339
P
C
E
W
G
R
N
S
F
P
P
G
S
V
L
Site 72
S1344
R
N
S
F
P
P
G
S
V
L
Q
K
D
C
G
Site 73
S1406
Q
D
D
C
G
D
G
S
D
E
E
G
C
A
A
Site 74
S1424
G
E
G
Q
M
T
C
S
S
G
H
C
L
P
L
Site 75
T1445
Q
D
D
C
G
D
G
T
D
E
P
S
Y
P
C
Site 76
S1449
G
D
G
T
D
E
P
S
Y
P
C
P
Q
G
L
Site 77
Y1450
D
G
T
D
E
P
S
Y
P
C
P
Q
G
L
L
Site 78
S1485
L
D
A
A
D
E
E
S
C
L
G
Q
V
T
C
Site 79
S1532
P
G
H
C
P
L
P
S
L
P
T
P
P
A
S
Site 80
S1539
S
L
P
T
P
P
A
S
T
L
P
G
P
S
P
Site 81
T1540
L
P
T
P
P
A
S
T
L
P
G
P
S
P
G
Site 82
S1545
A
S
T
L
P
G
P
S
P
G
S
L
D
T
A
Site 83
S1548
L
P
G
P
S
P
G
S
L
D
T
A
S
S
P
Site 84
T1551
P
S
P
G
S
L
D
T
A
S
S
P
L
A
S
Site 85
S1553
P
G
S
L
D
T
A
S
S
P
L
A
S
A
S
Site 86
S1554
G
S
L
D
T
A
S
S
P
L
A
S
A
S
P
Site 87
S1558
T
A
S
S
P
L
A
S
A
S
P
A
P
P
C
Site 88
S1560
S
S
P
L
A
S
A
S
P
A
P
P
C
G
P
Site 89
S1574
P
F
E
F
R
C
G
S
G
E
C
T
P
R
G
Site 90
S1594
E
E
D
C
A
D
G
S
D
E
R
G
C
G
G
Site 91
S1618
A
R
G
P
H
C
V
S
P
E
Q
L
C
D
G
Site 92
S1633
V
R
Q
C
P
D
G
S
D
E
G
P
D
A
C
Site 93
T1652
A
L
G
G
P
N
R
T
G
L
P
C
P
E
Y
Site 94
Y1659
T
G
L
P
C
P
E
Y
T
C
P
N
G
T
C
Site 95
S1688
R
P
G
Q
V
G
P
S
P
E
E
Q
G
C
G
Site 96
S1718
G
P
W
G
Q
G
R
S
R
R
C
S
P
L
G
Site 97
S1722
Q
G
R
S
R
R
C
S
P
L
G
L
L
V
L
Site 98
T1769
C
S
E
P
C
R
G
T
M
T
R
Q
R
Q
C
Site 99
S1778
T
R
Q
R
Q
C
H
S
P
Q
N
G
G
R
T
Site 100
T1785
S
P
Q
N
G
G
R
T
C
A
A
L
P
G
G
Site 101
S1795
A
L
P
G
G
L
H
S
T
R
Q
T
K
P
C
Site 102
T1799
G
L
H
S
T
R
Q
T
K
P
C
P
Q
D
G
Site 103
T1827
P
C
A
P
C
P
L
T
C
D
D
I
S
G
Q
Site 104
S1832
P
L
T
C
D
D
I
S
G
Q
V
T
C
P
P
Site 105
T1836
D
D
I
S
G
Q
V
T
C
P
P
D
W
P
C
Site 106
S1927
K
C
L
G
P
C
G
S
Q
S
I
Q
W
S
F
Site 107
S1929
L
G
P
C
G
S
Q
S
I
Q
W
S
F
R
S
Site 108
S1933
G
S
Q
S
I
Q
W
S
F
R
S
S
N
N
P
Site 109
S1937
I
Q
W
S
F
R
S
S
N
N
P
R
P
S
G
Site 110
S1943
S
S
N
N
P
R
P
S
G
R
G
R
Q
C
R
Site 111
T1961
R
K
A
R
R
C
Q
T
E
P
C
E
G
C
E
Site 112
S1999
H
N
L
T
A
H
C
S
P
Y
C
P
L
G
S
Site 113
T2032
A
L
P
G
E
N
Q
T
V
Q
P
M
A
T
P
Site 114
T2038
Q
T
V
Q
P
M
A
T
P
A
A
A
P
A
P
Site 115
S2061
A
T
Y
I
L
P
P
S
G
D
P
C
Y
S
P
Site 116
Y2066
P
P
S
G
D
P
C
Y
S
P
L
G
L
A
G
Site 117
S2078
L
A
G
L
A
E
G
S
L
H
A
S
S
Q
Q
Site 118
S2082
A
E
G
S
L
H
A
S
S
Q
Q
L
E
H
P
Site 119
S2083
E
G
S
L
H
A
S
S
Q
Q
L
E
H
P
T
Site 120
T2099
A
A
L
L
G
A
P
T
Q
G
P
S
P
Q
G
Site 121
S2103
G
A
P
T
Q
G
P
S
P
Q
G
W
H
A
G
Site 122
Y2114
W
H
A
G
G
D
A
Y
A
K
W
H
T
R
P
Site 123
Y2123
K
W
H
T
R
P
H
Y
L
Q
L
D
L
L
Q
Site 124
T2135
L
L
Q
P
R
N
L
T
G
I
L
V
P
E
T
Site 125
S2145
L
V
P
E
T
G
S
S
N
A
Y
A
S
S
F
Site 126
Y2148
E
T
G
S
S
N
A
Y
A
S
S
F
S
L
Q
Site 127
S2150
G
S
S
N
A
Y
A
S
S
F
S
L
Q
F
S
Site 128
S2151
S
S
N
A
Y
A
S
S
F
S
L
Q
F
S
S
Site 129
S2153
N
A
Y
A
S
S
F
S
L
Q
F
S
S
N
G
Site 130
S2157
S
S
F
S
L
Q
F
S
S
N
G
L
H
W
H
Site 131
Y2166
N
G
L
H
W
H
D
Y
R
D
L
L
P
G
I
Site 132
S2263
V
L
D
C
E
D
G
S
D
E
E
G
C
V
L
Site 133
S2280
E
G
T
G
R
F
H
S
T
A
K
T
L
A
L
Site 134
T2284
R
F
H
S
T
A
K
T
L
A
L
S
S
A
Q
Site 135
S2288
T
A
K
T
L
A
L
S
S
A
Q
P
G
Q
L
Site 136
S2315
H
W
P
P
G
Q
E
S
P
T
S
P
T
E
T
Site 137
S2318
P
G
Q
E
S
P
T
S
P
T
E
T
R
P
V
Site 138
T2322
S
P
T
S
P
T
E
T
R
P
V
S
P
G
P
Site 139
S2326
P
T
E
T
R
P
V
S
P
G
P
A
S
G
V
Site 140
S2331
P
V
S
P
G
P
A
S
G
V
P
H
H
G
E
Site 141
T2355
I
P
Q
M
E
A
R
T
L
P
P
G
M
A
A
Site 142
T2372
V
V
P
P
H
P
V
T
P
A
T
P
A
G
Q
Site 143
T2375
P
H
P
V
T
P
A
T
P
A
G
Q
S
V
A
Site 144
S2380
P
A
T
P
A
G
Q
S
V
A
P
G
P
F
P
Site 145
S2420
R
E
D
C
L
D
G
S
D
E
R
H
C
A
R
Site 146
S2435
N
L
L
M
W
L
P
S
L
P
A
L
W
A
A
Site 147
S2465
P
A
S
R
A
L
C
S
P
S
Q
L
S
C
G
Site 148
S2467
S
R
A
L
C
S
P
S
Q
L
S
C
G
S
G
Site 149
S2473
P
S
Q
L
S
C
G
S
G
E
C
L
S
A
E
Site 150
S2478
C
G
S
G
E
C
L
S
A
E
R
R
C
D
L
Site 151
S2493
R
P
D
C
Q
D
G
S
D
E
D
G
C
V
D
Site 152
S2510
L
A
P
W
S
V
W
S
S
C
S
R
S
C
G
Site 153
S2511
A
P
W
S
V
W
S
S
C
S
R
S
C
G
L
Site 154
T2521
R
S
C
G
L
G
L
T
F
Q
R
Q
E
L
L
Site 155
S2536
R
P
P
L
P
G
G
S
C
P
R
D
R
F
R
Site 156
S2544
C
P
R
D
R
F
R
S
Q
S
C
F
V
Q
A
Site 157
S2546
R
D
R
F
R
S
Q
S
C
F
V
Q
A
C
P
Site 158
S2577
S
C
G
G
G
H
Q
S
R
Q
R
S
C
V
D
Site 159
S2581
G
H
Q
S
R
Q
R
S
C
V
D
P
P
P
K
Site 160
S2598
G
A
P
C
P
G
A
S
Q
E
R
A
P
C
G
Site 161
S2610
P
C
G
L
Q
P
C
S
G
G
T
D
C
E
L
Site 162
S2638
L
V
P
P
C
P
P
S
C
L
D
P
K
A
N
Site 163
S2647
L
D
P
K
A
N
R
S
C
S
G
H
C
V
E
Site 164
S2649
P
K
A
N
R
S
C
S
G
H
C
V
E
G
C
Site 165
S2730
S
W
A
P
C
D
R
S
C
G
S
G
V
R
A
Site 166
S2733
P
C
D
R
S
C
G
S
G
V
R
A
R
F
R
Site 167
S2741
G
V
R
A
R
F
R
S
P
S
N
P
P
A
A
Site 168
S2743
R
A
R
F
R
S
P
S
N
P
P
A
A
W
G
Site 169
S2783
T
P
W
T
S
W
S
S
C
S
Q
S
C
L
A
Site 170
S2785
W
T
S
W
S
S
C
S
Q
S
C
L
A
P
G
Site 171
S2787
S
W
S
S
C
S
Q
S
C
L
A
P
G
G
G
Site 172
S2799
G
G
G
P
G
W
R
S
R
S
R
L
C
P
S
Site 173
S2801
G
P
G
W
R
S
R
S
R
L
C
P
S
P
G
Site 174
S2806
S
R
S
R
L
C
P
S
P
G
D
S
S
C
P
Site 175
S2810
L
C
P
S
P
G
D
S
S
C
P
G
D
A
T
Site 176
S2811
C
P
S
P
G
D
S
S
C
P
G
D
A
T
Q
Site 177
T2817
S
S
C
P
G
D
A
T
Q
E
E
P
C
S
P
Site 178
S2823
A
T
Q
E
E
P
C
S
P
P
V
C
P
V
P
Site 179
T2852
P
C
D
G
G
I
Q
T
R
G
R
S
C
S
S
Site 180
S2856
G
I
Q
T
R
G
R
S
C
S
S
L
A
P
G
Site 181
S2858
Q
T
R
G
R
S
C
S
S
L
A
P
G
D
T
Site 182
S2859
T
R
G
R
S
C
S
S
L
A
P
G
D
T
T
Site 183
T2865
S
S
L
A
P
G
D
T
T
C
P
G
P
H
S
Site 184
T2866
S
L
A
P
G
D
T
T
C
P
G
P
H
S
Q
Site 185
S2872
T
T
C
P
G
P
H
S
Q
T
R
D
C
N
T
Site 186
T2879
S
Q
T
R
D
C
N
T
Q
P
C
T
A
Q
C
Site 187
Y2954
C
Q
L
H
G
Q
L
Y
A
S
G
A
M
A
R
Site 188
S2956
L
H
G
Q
L
Y
A
S
G
A
M
A
R
L
D
Site 189
T3013
R
R
R
F
R
A
G
T
A
P
P
A
A
F
G
Site 190
S3035
T
M
E
A
E
F
C
S
L
R
P
C
P
G
P
Site 191
Y3060
S
V
P
C
G
G
G
Y
R
N
R
T
R
G
S
Site 192
T3064
G
G
G
Y
R
N
R
T
R
G
S
S
R
S
L
Site 193
S3067
Y
R
N
R
T
R
G
S
S
R
S
L
M
E
F
Site 194
S3068
R
N
R
T
R
G
S
S
R
S
L
M
E
F
S
Site 195
S3070
R
T
R
G
S
S
R
S
L
M
E
F
S
T
C
Site 196
S3075
S
R
S
L
M
E
F
S
T
C
G
L
Q
P
C
Site 197
T3076
R
S
L
M
E
F
S
T
C
G
L
Q
P
C
A
Site 198
S3105
D
C
A
Q
G
P
A
S
C
A
E
L
S
A
P
Site 199
S3110
P
A
S
C
A
E
L
S
A
P
R
G
T
N
Q
Site 200
T3115
E
L
S
A
P
R
G
T
N
Q
T
C
H
P
G
Site 201
Y3151
C
A
H
E
G
H
L
Y
P
P
G
S
T
V
V
Site 202
S3155
G
H
L
Y
P
P
G
S
T
V
V
R
P
C
E
Site 203
S3213
R
H
R
F
C
A
R
S
P
S
A
V
P
S
T
Site 204
S3267
P
W
S
H
C
S
R
S
C
G
G
G
L
R
S
Site 205
S3274
S
C
G
G
G
L
R
S
R
T
R
A
C
D
Q
Site 206
T3276
G
G
G
L
R
S
R
T
R
A
C
D
Q
P
P
Site 207
Y3290
P
P
Q
G
L
G
D
Y
C
E
G
P
R
A
Q
Site 208
Y3319
T
A
I
E
G
A
E
Y
S
P
C
G
P
P
C
Site 209
S3320
A
I
E
G
A
E
Y
S
P
C
G
P
P
C
P
Site 210
T3372
C
S
C
L
D
L
L
T
G
Q
R
H
H
P
G
Site 211
T3401
L
E
G
R
L
N
C
T
D
L
P
C
P
V
P
Site 212
T3428
S
Q
P
C
R
G
Q
T
R
S
R
S
R
A
C
Site 213
S3430
P
C
R
G
Q
T
R
S
R
S
R
A
C
A
C
Site 214
S3432
R
G
Q
T
R
S
R
S
R
A
C
A
C
P
T
Site 215
T3439
S
R
A
C
A
C
P
T
P
Q
H
G
G
A
P
Site 216
S3494
C
L
G
Q
S
H
R
S
R
A
C
S
R
P
P
Site 217
S3498
S
H
R
S
R
A
C
S
R
P
P
T
P
E
G
Site 218
T3502
R
A
C
S
R
P
P
T
P
E
G
G
R
P
C
Site 219
T3514
R
P
C
P
G
N
H
T
Q
S
R
P
C
Q
E
Site 220
T3527
Q
E
N
S
T
Q
C
T
D
C
G
G
G
Q
S
Site 221
S3534
T
D
C
G
G
G
Q
S
L
H
P
C
G
Q
P
Site 222
S3545
C
G
Q
P
C
P
R
S
C
Q
D
L
S
P
G
Site 223
S3550
P
R
S
C
Q
D
L
S
P
G
S
V
C
Q
P
Site 224
S3553
C
Q
D
L
S
P
G
S
V
C
Q
P
G
S
V
Site 225
S3601
M
G
I
P
E
N
Q
S
R
S
A
G
S
R
F
Site 226
S3603
I
P
E
N
Q
S
R
S
A
G
S
R
F
S
S
Site 227
S3606
N
Q
S
R
S
A
G
S
R
F
S
S
W
E
S
Site 228
S3609
R
S
A
G
S
R
F
S
S
W
E
S
L
E
P
Site 229
S3610
S
A
G
S
R
F
S
S
W
E
S
L
E
P
G
Site 230
S3613
S
R
F
S
S
W
E
S
L
E
P
G
E
V
V
Site 231
S3660
P
W
E
D
C
S
V
S
C
G
G
G
E
Q
L
Site 232
S3669
G
G
G
E
Q
L
R
S
R
R
C
A
R
P
P
Site 233
S3684
C
P
G
P
A
R
Q
S
R
T
C
S
T
Q
V
Site 234
S3688
A
R
Q
S
R
T
C
S
T
Q
V
C
R
E
A
Site 235
Y3703
G
C
P
A
G
R
L
Y
R
E
C
Q
P
G
E
Site 236
T3740
G
C
H
C
P
E
G
T
F
Q
H
R
L
A
C
Site 237
T3766
L
L
Q
E
L
G
A
T
I
G
D
P
G
Q
P
Site 238
S3782
G
P
G
D
E
L
D
S
G
Q
T
L
R
T
S
Site 239
T3785
D
E
L
D
S
G
Q
T
L
R
T
S
C
G
N
Site 240
T3788
D
S
G
Q
T
L
R
T
S
C
G
N
C
S
C
Site 241
S3789
S
G
Q
T
L
R
T
S
C
G
N
C
S
C
A
Site 242
S3794
R
T
S
C
G
N
C
S
C
A
H
G
K
L
S
Site 243
S3803
A
H
G
K
L
S
C
S
L
D
D
C
F
E
A
Site 244
S3818
D
G
G
F
G
P
W
S
P
W
G
P
C
S
R
Site 245
S3826
P
W
G
P
C
S
R
S
C
G
G
L
G
T
R
Site 246
T3832
R
S
C
G
G
L
G
T
R
T
R
S
R
Q
C
Site 247
T3834
C
G
G
L
G
T
R
T
R
S
R
Q
C
V
L
Site 248
S3836
G
L
G
T
R
T
R
S
R
Q
C
V
L
T
M
Site 249
T3842
R
S
R
Q
C
V
L
T
M
P
T
L
S
G
Q
Site 250
S3862
R
Q
D
L
E
C
P
S
P
D
C
P
G
A
E
Site 251
S3871
D
C
P
G
A
E
G
S
T
V
E
P
V
T
G
Site 252
T3877
G
S
T
V
E
P
V
T
G
L
P
G
G
W
G
Site 253
S3888
G
G
W
G
P
W
S
S
W
S
P
C
S
R
S
Site 254
S3893
W
S
S
W
S
P
C
S
R
S
C
T
D
P
A
Site 255
S3895
S
W
S
P
C
S
R
S
C
T
D
P
A
R
P
Site 256
T3897
S
P
C
S
R
S
C
T
D
P
A
R
P
A
W
Site 257
S3906
P
A
R
P
A
W
R
S
R
T
R
L
C
L
A
Site 258
T3908
R
P
A
W
R
S
R
T
R
L
C
L
A
N
C
Site 259
S3930
E
R
P
C
N
L
P
S
C
T
E
L
P
V
C
Site 260
S3961
P
W
E
P
C
S
R
S
C
G
V
G
Q
Q
R
Site 261
Y3973
Q
Q
R
R
L
R
A
Y
R
P
P
G
P
G
G
Site 262
Y3990
C
P
N
I
L
T
A
Y
Q
E
R
R
F
C
N
Site 263
S4025
R
S
C
G
G
G
Q
S
L
R
S
R
S
C
S
Site 264
S4028
G
G
G
Q
S
L
R
S
R
S
C
S
S
P
P
Site 265
S4030
G
Q
S
L
R
S
R
S
C
S
S
P
P
S
K
Site 266
S4032
S
L
R
S
R
S
C
S
S
P
P
S
K
N
G
Site 267
S4033
L
R
S
R
S
C
S
S
P
P
S
K
N
G
G
Site 268
S4036
R
S
C
S
S
P
P
S
K
N
G
G
A
P
C
Site 269
S4080
N
R
C
P
R
R
C
S
D
L
Q
E
G
I
V
Site 270
S4104
G
C
R
C
P
K
G
S
L
E
Q
D
G
G
C
Site 271
S4148
S
C
Q
A
G
Q
L
S
C
T
A
Q
P
C
P
Site 272
T4150
Q
A
G
Q
L
S
C
T
A
Q
P
C
P
P
P
Site 273
S4182
C
G
P
R
G
Q
Q
S
R
F
R
S
S
T
S
Site 274
S4186
G
Q
Q
S
R
F
R
S
S
T
S
G
S
W
A
Site 275
S4187
Q
Q
S
R
F
R
S
S
T
S
G
S
W
A
P
Site 276
T4188
Q
S
R
F
R
S
S
T
S
G
S
W
A
P
E
Site 277
S4189
S
R
F
R
S
S
T
S
G
S
W
A
P
E
C
Site 278
S4191
F
R
S
S
T
S
G
S
W
A
P
E
C
R
E
Site 279
S4201
P
E
C
R
E
E
Q
S
Q
S
Q
P
C
P
Q
Site 280
S4203
C
R
E
E
Q
S
Q
S
Q
P
C
P
Q
P
S
Site 281
S4210
S
Q
P
C
P
Q
P
S
C
P
P
L
C
L
Q
Site 282
T4219
P
P
L
C
L
Q
G
T
R
S
R
T
L
G
D
Site 283
S4221
L
C
L
Q
G
T
R
S
R
T
L
G
D
S
W
Site 284
T4223
L
Q
G
T
R
S
R
T
L
G
D
S
W
L
Q
Site 285
S4227
R
S
R
T
L
G
D
S
W
L
Q
G
E
C
Q
Site 286
T4239
E
C
Q
R
C
S
C
T
P
E
G
V
I
C
E
Site 287
S4289
A
A
A
P
H
H
R
S
P
P
C
L
G
P
D
Site 288
T4297
P
P
C
L
G
P
D
T
Q
T
R
Q
Q
P
C
Site 289
S4322
P
W
G
P
C
S
R
S
C
G
P
G
L
A
S
Site 290
S4329
S
C
G
P
G
L
A
S
R
S
G
S
C
P
C
Site 291
T4344
L
M
A
K
A
D
P
T
C
N
S
T
F
L
H
Site 292
T4354
S
T
F
L
H
L
D
T
Q
G
C
Y
S
G
P
Site 293
Y4358
H
L
D
T
Q
G
C
Y
S
G
P
C
P
E
E
Site 294
Y4387
R
V
L
V
Q
Q
R
Y
R
H
Q
G
P
A
S
Site 295
S4394
Y
R
H
Q
G
P
A
S
R
G
A
R
A
G
A
Site 296
S4419
P
C
L
I
S
N
C
S
E
D
S
C
T
P
P
Site 297
S4422
I
S
N
C
S
E
D
S
C
T
P
P
F
E
F
Site 298
T4424
N
C
S
E
D
S
C
T
P
P
F
E
F
H
A
Site 299
Y4460
P
P
C
Q
P
G
C
Y
C
P
K
G
L
L
E
Site 300
T4515
R
R
G
E
L
H
C
T
S
Q
G
C
Q
G
L
Site 301
S4516
R
G
E
L
H
C
T
S
Q
G
C
Q
G
L
L
Site 302
S4526
C
Q
G
L
L
P
L
S
E
W
S
E
W
S
P
Site 303
S4529
L
L
P
L
S
E
W
S
E
W
S
P
C
G
P
Site 304
S4532
L
S
E
W
S
E
W
S
P
C
G
P
C
L
P
Site 305
S4547
P
S
A
L
A
P
A
S
R
T
A
L
E
E
H
Site 306
T4560
E
H
W
L
R
D
P
T
G
L
S
P
T
L
A
Site 307
T4585
R
L
C
L
D
P
A
T
G
R
P
W
T
G
A
Site 308
T4590
P
A
T
G
R
P
W
T
G
A
P
H
L
C
T
Site 309
T4597
T
G
A
P
H
L
C
T
A
P
L
S
Q
Q
R
Site 310
S4601
H
L
C
T
A
P
L
S
Q
Q
R
L
C
P
D
Site 311
T4672
P
E
C
E
A
Q
D
T
V
F
T
L
D
C
A
Site 312
S4721
D
G
R
C
V
P
I
S
S
C
R
C
G
L
P
Site 313
S4729
S
C
R
C
G
L
P
S
A
N
A
S
W
E
L
Site 314
S4733
G
L
P
S
A
N
A
S
W
E
L
A
P
A
Q
Site 315
S4773
L
G
P
W
S
A
W
S
S
C
S
A
P
C
G
Site 316
S4774
G
P
W
S
A
W
S
S
C
S
A
P
C
G
G
Site 317
T4789
G
T
M
E
R
H
R
T
C
E
G
G
P
G
V
Site 318
T4884
H
S
L
P
W
G
L
T
L
T
L
E
E
Q
A
Site 319
T4886
L
P
W
G
L
T
L
T
L
E
E
Q
A
Q
E
Site 320
T4898
A
Q
E
L
P
P
G
T
V
L
T
R
N
C
T
Site 321
T4950
T
C
L
E
M
N
A
T
K
T
Q
S
N
C
S
Site 322
T4952
L
E
M
N
A
T
K
T
Q
S
N
C
S
S
A
Site 323
S4954
M
N
A
T
K
T
Q
S
N
C
S
S
A
R
A
Site 324
S4957
T
K
T
Q
S
N
C
S
S
A
R
A
S
G
C
Site 325
S4958
K
T
Q
S
N
C
S
S
A
R
A
S
G
C
V
Site 326
S4962
N
C
S
S
A
R
A
S
G
C
V
C
Q
P
G
Site 327
S4973
C
Q
P
G
H
F
R
S
Q
A
G
P
C
V
P
Site 328
S4997
G
R
P
H
L
P
G
S
E
W
Q
E
A
C
E
Site 329
T5016
L
S
G
R
P
V
C
T
Q
H
C
S
P
L
T
Site 330
T5023
T
Q
H
C
S
P
L
T
C
A
Q
G
E
E
M
Site 331
S5036
E
M
V
L
E
P
G
S
C
C
P
S
C
R
R
Site 332
S5040
E
P
G
S
C
C
P
S
C
R
R
E
A
P
E
Site 333
S5050
R
E
A
P
E
E
Q
S
P
S
C
Q
L
L
T
Site 334
S5052
A
P
E
E
Q
S
P
S
C
Q
L
L
T
E
L
Site 335
T5057
S
P
S
C
Q
L
L
T
E
L
R
N
F
T
K
Site 336
T5063
L
T
E
L
R
N
F
T
K
G
T
C
Y
L
D
Site 337
Y5068
N
F
T
K
G
T
C
Y
L
D
Q
V
E
V
S
Site 338
Y5076
L
D
Q
V
E
V
S
Y
C
S
G
Y
C
P
S
Site 339
S5078
Q
V
E
V
S
Y
C
S
G
Y
C
P
S
S
T
Site 340
Y5080
E
V
S
Y
C
S
G
Y
C
P
S
S
T
H
V
Site 341
T5085
S
G
Y
C
P
S
S
T
H
V
M
P
E
E
P
Site 342
S5109
S
Y
R
L
D
P
E
S
P
V
R
I
L
N
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation