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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DENND3
Full Name:
DENN domain-containing protein 3
Alias:
Type:
Mass (Da):
135872
Number AA:
1198
UniProt ID:
A2RUS2
International Prot ID:
IPI00448616
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T55
P
G
G
V
C
V
A
T
E
P
K
E
D
C
V
Site 2
Y76
D
V
C
G
N
R
T
Y
G
V
V
A
Q
Y
Y
Site 3
Y82
T
Y
G
V
V
A
Q
Y
Y
R
P
L
H
D
E
Site 4
Y83
Y
G
V
V
A
Q
Y
Y
R
P
L
H
D
E
Y
Site 5
Y90
Y
R
P
L
H
D
E
Y
C
F
Y
N
G
K
T
Site 6
Y93
L
H
D
E
Y
C
F
Y
N
G
K
T
H
R
E
Site 7
Y118
C
V
V
S
R
F
P
Y
Y
N
S
L
K
D
C
Site 8
Y119
V
V
S
R
F
P
Y
Y
N
S
L
K
D
C
L
Site 9
S121
S
R
F
P
Y
Y
N
S
L
K
D
C
L
S
C
Site 10
S153
K
D
F
A
A
K
L
S
L
I
P
S
P
P
P
Site 11
S157
A
K
L
S
L
I
P
S
P
P
P
G
P
L
H
Site 12
S184
P
A
R
A
D
P
E
S
P
I
L
D
L
D
L
Site 13
S292
L
I
N
I
D
H
G
S
I
T
Y
S
K
S
T
Site 14
T294
N
I
D
H
G
S
I
T
Y
S
K
S
T
D
D
Site 15
S296
D
H
G
S
I
T
Y
S
K
S
T
D
D
N
V
Site 16
S298
G
S
I
T
Y
S
K
S
T
D
D
N
V
D
I
Site 17
S322
T
F
I
Q
R
V
Q
S
L
Q
L
H
H
E
L
Site 18
S336
L
H
A
A
H
L
L
S
S
T
D
L
K
E
G
Site 19
S349
E
G
R
A
H
R
R
S
W
Q
Q
K
L
N
C
Site 20
T361
L
N
C
Q
I
Q
Q
T
T
L
Q
L
L
V
S
Site 21
S368
T
T
L
Q
L
L
V
S
I
F
R
D
V
K
N
Site 22
Y379
D
V
K
N
H
L
N
Y
E
H
R
V
F
N
S
Site 23
T392
N
S
E
E
F
L
K
T
R
A
P
G
D
H
Q
Site 24
Y401
A
P
G
D
H
Q
F
Y
K
Q
V
L
D
T
Y
Site 25
Y408
Y
K
Q
V
L
D
T
Y
M
F
H
S
F
L
K
Site 26
T432
F
A
Q
M
D
L
D
T
Q
S
E
E
D
R
I
Site 27
S434
Q
M
D
L
D
T
Q
S
E
E
D
R
I
N
G
Site 28
S445
R
I
N
G
M
L
L
S
P
R
R
P
T
V
E
Site 29
T450
L
L
S
P
R
R
P
T
V
E
K
R
A
S
R
Site 30
S456
P
T
V
E
K
R
A
S
R
K
S
S
H
L
H
Site 31
S459
E
K
R
A
S
R
K
S
S
H
L
H
V
T
H
Site 32
S460
K
R
A
S
R
K
S
S
H
L
H
V
T
H
R
Site 33
T465
K
S
S
H
L
H
V
T
H
R
R
M
V
V
S
Site 34
S472
T
H
R
R
M
V
V
S
M
P
N
L
Q
D
I
Site 35
S489
P
E
L
A
P
R
N
S
S
L
R
L
T
D
T
Site 36
S490
E
L
A
P
R
N
S
S
L
R
L
T
D
T
A
Site 37
T494
R
N
S
S
L
R
L
T
D
T
A
G
C
R
G
Site 38
T496
S
S
L
R
L
T
D
T
A
G
C
R
G
S
S
Site 39
T509
S
S
A
V
L
N
V
T
P
K
S
P
Y
T
F
Site 40
S512
V
L
N
V
T
P
K
S
P
Y
T
F
K
I
P
Site 41
T515
V
T
P
K
S
P
Y
T
F
K
I
P
E
I
H
Site 42
Y533
E
S
K
C
V
Q
A
Y
H
A
H
F
V
S
M
Site 43
T586
D
F
Q
N
L
Y
K
T
D
I
R
I
F
P
T
Site 44
S604
K
R
T
V
E
S
M
S
A
P
E
W
E
G
A
Site 45
S622
P
E
L
M
R
L
I
S
E
I
L
D
K
P
H
Site 46
T677
H
R
L
F
E
A
L
T
V
G
Q
E
K
Q
I
Site 47
T688
E
K
Q
I
D
P
E
T
F
K
D
F
Y
N
C
Site 48
Y693
P
E
T
F
K
D
F
Y
N
C
W
K
E
T
E
Site 49
S726
N
E
C
V
C
K
L
S
S
S
V
K
T
N
L
Site 50
T731
K
L
S
S
S
V
K
T
N
L
G
V
G
K
I
Site 51
T749
Q
K
R
L
F
L
L
T
E
G
R
P
G
Y
L
Site 52
Y755
L
T
E
G
R
P
G
Y
L
E
I
S
T
F
R
Site 53
S759
R
P
G
Y
L
E
I
S
T
F
R
N
I
E
E
Site 54
T760
P
G
Y
L
E
I
S
T
F
R
N
I
E
E
V
Site 55
T770
N
I
E
E
V
R
R
T
T
T
T
F
L
L
R
Site 56
T771
I
E
E
V
R
R
T
T
T
T
F
L
L
R
R
Site 57
T772
E
E
V
R
R
T
T
T
T
F
L
L
R
R
I
Site 58
T773
E
V
R
R
T
T
T
T
F
L
L
R
R
I
P
Site 59
T781
F
L
L
R
R
I
P
T
L
K
I
R
V
A
S
Site 60
S788
T
L
K
I
R
V
A
S
K
K
E
V
F
E
A
Site 61
Y826
D
D
H
K
D
P
H
Y
V
Q
Q
A
L
T
N
Site 62
S857
I
Y
A
A
S
K
L
S
Y
F
D
K
M
S
N
Site 63
Y858
Y
A
A
S
K
L
S
Y
F
D
K
M
S
N
E
Site 64
T869
M
S
N
E
M
P
M
T
L
P
E
T
T
L
E
Site 65
T983
M
S
C
N
K
Q
L
T
A
H
C
S
S
V
T
Site 66
S1002
Q
D
G
Q
E
A
P
S
N
V
Y
S
C
S
M
Site 67
S1006
E
A
P
S
N
V
Y
S
C
S
M
D
G
M
V
Site 68
S1036
L
P
R
G
G
L
T
S
I
R
L
H
G
G
R
Site 69
T1074
I
E
E
N
F
K
D
T
S
T
S
F
L
A
F
Site 70
S1104
R
S
E
V
Y
I
W
S
L
K
D
L
A
Q
P
Site 71
T1144
S
R
G
L
G
Q
G
T
P
K
G
K
I
Y
V
Site 72
Y1150
G
T
P
K
G
K
I
Y
V
I
D
A
E
R
K
Site 73
T1158
V
I
D
A
E
R
K
T
V
E
K
E
L
V
A
Site 74
Y1180
L
C
S
A
E
D
R
Y
V
L
S
G
S
G
R
Site 75
S1183
A
E
D
R
Y
V
L
S
G
S
G
R
E
E
G
Site 76
S1185
D
R
Y
V
L
S
G
S
G
R
E
E
G
K
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation