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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CCDC144A
Full Name:
Coiled-coil domain-containing protein 144A
Alias:
Type:
Mass (Da):
165125
Number AA:
1427
UniProt ID:
A2RUR9
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S15
K
R
G
G
A
E
G
S
P
K
P
A
V
Y
A
Site 2
Y21
G
S
P
K
P
A
V
Y
A
T
R
K
T
P
S
Site 3
T26
A
V
Y
A
T
R
K
T
P
S
V
G
S
Q
G
Site 4
S28
Y
A
T
R
K
T
P
S
V
G
S
Q
G
D
Q
Site 5
S31
R
K
T
P
S
V
G
S
Q
G
D
Q
W
Y
L
Site 6
Y37
G
S
Q
G
D
Q
W
Y
L
G
Y
P
G
D
Q
Site 7
Y40
G
D
Q
W
Y
L
G
Y
P
G
D
Q
W
S
S
Site 8
S57
P
Y
S
W
W
K
N
S
V
G
S
E
S
K
H
Site 9
S60
W
W
K
N
S
V
G
S
E
S
K
H
G
E
G
Site 10
T105
H
I
L
A
P
G
D
T
G
V
D
K
R
D
R
Site 11
S115
D
K
R
D
R
K
K
S
I
Q
Q
L
V
P
E
Site 12
T128
P
E
Y
K
E
K
Q
T
P
E
S
L
P
Q
N
Site 13
S131
K
E
K
Q
T
P
E
S
L
P
Q
N
N
N
P
Site 14
T146
D
W
H
P
T
N
L
T
L
S
D
E
T
C
Q
Site 15
S148
H
P
T
N
L
T
L
S
D
E
T
C
Q
R
S
Site 16
T151
N
L
T
L
S
D
E
T
C
Q
R
S
K
N
L
Site 17
S166
K
V
D
D
K
C
P
S
V
S
P
S
M
P
E
Site 18
S168
D
D
K
C
P
S
V
S
P
S
M
P
E
N
Q
Site 19
S170
K
C
P
S
V
S
P
S
M
P
E
N
Q
S
A
Site 20
S176
P
S
M
P
E
N
Q
S
A
T
K
E
L
G
Q
Site 21
T187
E
L
G
Q
M
N
L
T
E
R
E
K
M
D
T
Site 22
T194
T
E
R
E
K
M
D
T
G
V
V
L
L
S
G
Site 23
S200
D
T
G
V
V
L
L
S
G
N
D
T
L
H
D
Site 24
T204
V
L
L
S
G
N
D
T
L
H
D
L
C
Q
S
Site 25
S211
T
L
H
D
L
C
Q
S
Q
L
P
E
N
K
E
Site 26
S219
Q
L
P
E
N
K
E
S
K
E
A
E
Q
D
S
Site 27
S226
S
K
E
A
E
Q
D
S
E
L
T
S
E
E
E
Site 28
S230
E
Q
D
S
E
L
T
S
E
E
E
Q
E
R
L
Site 29
S249
N
K
Q
P
Q
K
T
S
Q
E
P
E
M
A
K
Site 30
Y266
D
R
E
D
I
P
I
Y
P
V
L
P
H
V
Q
Site 31
Y306
K
Q
R
F
G
E
I
Y
E
K
Y
K
I
P
A
Site 32
Y309
F
G
E
I
Y
E
K
Y
K
I
P
A
C
P
E
Site 33
S324
E
E
P
L
L
D
N
S
T
R
G
T
D
V
K
Site 34
T328
L
D
N
S
T
R
G
T
D
V
K
D
I
P
F
Site 35
T338
K
D
I
P
F
N
L
T
N
N
I
P
G
C
E
Site 36
S350
G
C
E
E
E
D
A
S
E
I
S
V
S
V
V
Site 37
S353
E
E
D
A
S
E
I
S
V
S
V
V
F
E
T
Site 38
S368
F
P
E
Q
K
E
P
S
L
K
N
I
I
H
P
Site 39
Y376
L
K
N
I
I
H
P
Y
Y
H
P
Y
S
G
S
Site 40
Y377
K
N
I
I
H
P
Y
Y
H
P
Y
S
G
S
Q
Site 41
S390
S
Q
E
H
V
C
Q
S
S
S
K
F
H
L
H
Site 42
S458
T
K
N
M
N
Q
N
S
D
S
G
S
T
N
N
Site 43
S460
N
M
N
Q
N
S
D
S
G
S
T
N
N
Y
K
Site 44
S462
N
Q
N
S
D
S
G
S
T
N
N
Y
K
S
L
Site 45
Y466
D
S
G
S
T
N
N
Y
K
S
L
K
P
K
L
Site 46
S468
G
S
T
N
N
Y
K
S
L
K
P
K
L
E
N
Site 47
S477
K
P
K
L
E
N
L
S
S
L
P
P
D
S
D
Site 48
S478
P
K
L
E
N
L
S
S
L
P
P
D
S
D
R
Site 49
S483
L
S
S
L
P
P
D
S
D
R
T
S
E
V
Y
Site 50
T486
L
P
P
D
S
D
R
T
S
E
V
Y
L
H
E
Site 51
S487
P
P
D
S
D
R
T
S
E
V
Y
L
H
E
E
Site 52
Y490
S
D
R
T
S
E
V
Y
L
H
E
E
L
Q
Q
Site 53
S536
E
E
M
E
K
H
R
S
N
S
T
E
L
S
G
Site 54
S538
M
E
K
H
R
S
N
S
T
E
L
S
G
T
L
Site 55
S542
R
S
N
S
T
E
L
S
G
T
L
T
D
G
T
Site 56
T544
N
S
T
E
L
S
G
T
L
T
D
G
T
T
V
Site 57
T546
T
E
L
S
G
T
L
T
D
G
T
T
V
G
N
Site 58
T549
S
G
T
L
T
D
G
T
T
V
G
N
D
D
D
Site 59
T550
G
T
L
T
D
G
T
T
V
G
N
D
D
D
G
Site 60
T577
H
D
R
P
A
D
K
T
S
N
E
K
N
E
V
Site 61
S578
D
R
P
A
D
K
T
S
N
E
K
N
E
V
K
Site 62
Y589
N
E
V
K
N
Q
I
Y
P
E
A
D
F
A
D
Site 63
S597
P
E
A
D
F
A
D
S
M
E
P
S
E
I
A
Site 64
S601
F
A
D
S
M
E
P
S
E
I
A
S
E
D
C
Site 65
S605
M
E
P
S
E
I
A
S
E
D
C
E
L
S
H
Site 66
S611
A
S
E
D
C
E
L
S
H
S
V
Y
E
N
F
Site 67
Y629
I
E
Q
L
R
M
E
Y
K
D
S
A
S
L
P
Site 68
S632
L
R
M
E
Y
K
D
S
A
S
L
P
R
I
Q
Site 69
S634
M
E
Y
K
D
S
A
S
L
P
R
I
Q
D
T
Site 70
T660
N
N
H
C
D
Q
L
T
V
K
L
K
Q
M
E
Site 71
S671
K
Q
M
E
N
M
V
S
V
L
Q
N
E
L
S
Site 72
S678
S
V
L
Q
N
E
L
S
E
T
K
K
T
K
L
Site 73
T680
L
Q
N
E
L
S
E
T
K
K
T
K
L
Q
L
Site 74
T683
E
L
S
E
T
K
K
T
K
L
Q
L
E
L
Q
Site 75
Y699
I
E
W
E
K
E
L
Y
D
L
R
L
A
L
K
Site 76
Y719
K
R
N
A
D
M
L
Y
N
K
D
S
E
Q
L
Site 77
T756
R
L
V
K
E
L
R
T
V
R
N
N
L
D
L
Site 78
S791
L
Q
D
Q
I
L
T
S
K
Q
K
E
L
E
M
Site 79
S805
M
A
R
K
K
M
N
S
E
I
S
H
R
H
Q
Site 80
S808
K
K
M
N
S
E
I
S
H
R
H
Q
K
E
K
Site 81
T837
L
L
R
L
E
I
D
T
I
K
N
Q
N
K
Q
Site 82
Y849
N
K
Q
K
E
K
K
Y
F
E
D
I
E
A
V
Site 83
T875
K
L
N
E
E
T
L
T
E
T
I
L
Q
Y
S
Site 84
S915
R
L
E
I
E
M
E
S
Y
R
C
R
L
A
A
Site 85
Y916
L
E
I
E
M
E
S
Y
R
C
R
L
A
A
A
Site 86
S930
A
V
R
D
C
D
Q
S
Q
T
A
R
D
L
K
Site 87
S969
Q
A
K
N
E
I
L
S
E
K
L
S
N
A
E
Site 88
S973
E
I
L
S
E
K
L
S
N
A
E
S
K
I
N
Site 89
S977
E
K
L
S
N
A
E
S
K
I
N
S
L
Q
I
Site 90
S981
N
A
E
S
K
I
N
S
L
Q
I
Q
L
H
N
Site 91
S997
R
D
A
L
G
R
E
S
L
I
L
E
R
V
Q
Site 92
S1008
E
R
V
Q
R
D
L
S
Q
T
Q
C
Q
K
K
Site 93
T1010
V
Q
R
D
L
S
Q
T
Q
C
Q
K
K
E
T
Site 94
Y1021
K
K
E
T
E
Q
M
Y
Q
I
E
Q
S
K
L
Site 95
Y1031
E
Q
S
K
L
K
K
Y
I
A
K
Q
E
S
V
Site 96
S1037
K
Y
I
A
K
Q
E
S
V
E
E
R
L
S
Q
Site 97
S1043
E
S
V
E
E
R
L
S
Q
L
Q
S
E
N
M
Site 98
S1047
E
R
L
S
Q
L
Q
S
E
N
M
L
L
R
Q
Site 99
S1065
D
A
H
K
K
A
N
S
Q
E
K
T
S
S
T
Site 100
S1071
N
S
Q
E
K
T
S
S
T
I
Q
D
Q
F
H
Site 101
S1079
T
I
Q
D
Q
F
H
S
A
A
K
N
L
Q
A
Site 102
S1094
E
S
E
K
Q
I
L
S
L
Q
E
K
N
K
E
Site 103
Y1106
N
K
E
L
M
D
E
Y
N
H
L
K
E
R
M
Site 104
T1128
A
G
R
K
I
D
L
T
E
A
Q
E
T
V
P
Site 105
T1133
D
L
T
E
A
Q
E
T
V
P
S
R
C
L
H
Site 106
S1136
E
A
Q
E
T
V
P
S
R
C
L
H
L
D
A
Site 107
Y1184
E
V
V
N
L
K
S
Y
M
E
R
N
M
L
E
Site 108
T1240
V
Q
L
R
E
D
N
T
T
S
I
K
T
Q
M
Site 109
T1241
Q
L
R
E
D
N
T
T
S
I
K
T
Q
M
E
Site 110
S1256
L
T
I
K
D
L
E
S
E
I
S
R
I
K
T
Site 111
S1259
K
D
L
E
S
E
I
S
R
I
K
T
S
Q
A
Site 112
T1263
S
E
I
S
R
I
K
T
S
Q
A
D
F
N
K
Site 113
S1264
E
I
S
R
I
K
T
S
Q
A
D
F
N
K
T
Site 114
Y1276
N
K
T
E
L
E
R
Y
K
E
L
Y
L
E
E
Site 115
Y1280
L
E
R
Y
K
E
L
Y
L
E
E
V
K
V
R
Site 116
S1289
E
E
V
K
V
R
E
S
L
S
N
E
L
S
R
Site 117
S1291
V
K
V
R
E
S
L
S
N
E
L
S
R
T
N
Site 118
S1295
E
S
L
S
N
E
L
S
R
T
N
E
M
I
A
Site 119
T1297
L
S
N
E
L
S
R
T
N
E
M
I
A
E
V
Site 120
T1309
A
E
V
S
T
Q
L
T
V
E
K
E
Q
T
R
Site 121
T1315
L
T
V
E
K
E
Q
T
R
S
R
S
L
F
T
Site 122
S1317
V
E
K
E
Q
T
R
S
R
S
L
F
T
A
Y
Site 123
S1319
K
E
Q
T
R
S
R
S
L
F
T
A
Y
A
T
Site 124
S1332
A
T
R
P
V
L
E
S
P
C
V
G
N
L
N
Site 125
S1362
S
A
L
K
D
M
E
S
Y
L
L
K
M
Q
Q
Site 126
T1376
Q
K
L
Q
N
D
L
T
A
E
V
A
G
S
S
Site 127
S1382
L
T
A
E
V
A
G
S
S
Q
T
G
L
H
R
Site 128
S1394
L
H
R
I
P
Q
C
S
S
F
S
S
S
S
L
Site 129
S1395
H
R
I
P
Q
C
S
S
F
S
S
S
S
L
H
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation