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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NAG
Full Name:
Neuroblastoma-amplified sequence
Alias:
Neuroblastoma amplified sequence; Neuroblastoma-amplified
Type:
Mass (Da):
268571
Number AA:
2371
UniProt ID:
A2RRP1
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
A
A
P
E
S
G
P
A
L
S
P
G
Site 2
S11
P
E
S
G
P
A
L
S
P
G
T
A
E
G
E
Site 3
Y24
G
E
E
E
T
I
L
Y
D
L
L
V
N
T
E
Site 4
S49
G
N
Q
K
H
G
A
S
F
I
I
T
K
A
I
Site 5
Y66
R
L
L
F
L
R
Q
Y
I
W
Y
S
P
A
P
Site 6
T119
R
S
A
K
D
D
F
T
S
I
I
G
K
C
Q
Site 7
S120
S
A
K
D
D
F
T
S
I
I
G
K
C
Q
V
Site 8
Y142
W
R
R
V
A
W
S
Y
D
C
T
L
L
A
Y
Site 9
S194
I
F
L
E
Y
K
A
S
A
Q
W
S
A
E
L
Site 10
S212
N
Y
R
G
E
L
R
S
Y
L
V
S
V
G
T
Site 11
Y213
Y
R
G
E
L
R
S
Y
L
V
S
V
G
T
N
Site 12
S216
E
L
R
S
Y
L
V
S
V
G
T
N
Q
S
Y
Site 13
S222
V
S
V
G
T
N
Q
S
Y
Q
E
S
H
C
F
Site 14
Y223
S
V
G
T
N
Q
S
Y
Q
E
S
H
C
F
S
Site 15
S226
T
N
Q
S
Y
Q
E
S
H
C
F
S
F
S
S
Site 16
Y244
H
G
I
N
T
A
I
Y
H
P
G
H
R
L
L
Site 17
S264
E
T
A
E
V
G
M
S
K
A
S
S
C
G
L
Site 18
S267
E
V
G
M
S
K
A
S
S
C
G
L
S
A
W
Site 19
S268
V
G
M
S
K
A
S
S
C
G
L
S
A
W
R
Site 20
S278
L
S
A
W
R
V
L
S
G
S
P
Y
Y
K
Q
Site 21
S280
A
W
R
V
L
S
G
S
P
Y
Y
K
Q
V
T
Site 22
Y282
R
V
L
S
G
S
P
Y
Y
K
Q
V
T
N
G
Site 23
Y283
V
L
S
G
S
P
Y
Y
K
Q
V
T
N
G
G
Site 24
T294
T
N
G
G
D
G
V
T
A
V
P
K
T
L
G
Site 25
Y311
R
M
L
S
V
K
F
Y
S
R
Q
G
Q
E
Q
Site 26
S325
Q
D
G
I
F
K
M
S
L
S
P
D
G
M
L
Site 27
S349
L
S
I
W
A
I
P
S
L
K
Q
Q
G
E
W
Site 28
Y364
G
Q
N
E
Q
P
G
Y
D
D
L
N
P
D
W
Site 29
S374
L
N
P
D
W
R
L
S
T
E
K
R
K
K
I
Site 30
T375
N
P
D
W
R
L
S
T
E
K
R
K
K
I
K
Site 31
S386
K
K
I
K
D
K
E
S
F
Y
P
L
I
D
V
Site 32
Y388
I
K
D
K
E
S
F
Y
P
L
I
D
V
N
W
Site 33
S425
L
K
N
L
L
G
K
S
C
E
W
F
E
P
S
Site 34
S432
S
C
E
W
F
E
P
S
P
Q
V
T
A
T
H
Site 35
T436
F
E
P
S
P
Q
V
T
A
T
H
D
G
G
F
Site 36
T438
P
S
P
Q
V
T
A
T
H
D
G
G
F
L
S
Site 37
S445
T
H
D
G
G
F
L
S
L
E
C
E
I
K
L
Site 38
T461
P
K
R
S
R
L
E
T
R
A
G
E
E
D
E
Site 39
S473
E
D
E
G
E
E
D
S
D
S
D
Y
E
I
S
Site 40
S475
E
G
E
E
D
S
D
S
D
Y
E
I
S
A
K
Site 41
Y477
E
E
D
S
D
S
D
Y
E
I
S
A
K
A
R
Site 42
S480
S
D
S
D
Y
E
I
S
A
K
A
R
Y
F
G
Site 43
Y485
E
I
S
A
K
A
R
Y
F
G
Y
I
K
Q
G
Site 44
Y488
A
K
A
R
Y
F
G
Y
I
K
Q
G
L
Y
L
Site 45
Y494
G
Y
I
K
Q
G
L
Y
L
V
T
E
M
E
R
Site 46
T497
K
Q
G
L
Y
L
V
T
E
M
E
R
F
A
P
Site 47
T511
P
P
R
K
R
P
R
T
I
T
K
N
Y
R
L
Site 48
T513
R
K
R
P
R
T
I
T
K
N
Y
R
L
V
S
Site 49
Y516
P
R
T
I
T
K
N
Y
R
L
V
S
L
R
S
Site 50
S520
T
K
N
Y
R
L
V
S
L
R
S
T
T
P
E
Site 51
S523
Y
R
L
V
S
L
R
S
T
T
P
E
E
L
Y
Site 52
T524
R
L
V
S
L
R
S
T
T
P
E
E
L
Y
Q
Site 53
T525
L
V
S
L
R
S
T
T
P
E
E
L
Y
Q
R
Site 54
Y530
S
T
T
P
E
E
L
Y
Q
R
K
I
E
S
E
Site 55
S536
L
Y
Q
R
K
I
E
S
E
E
Y
E
E
A
L
Site 56
Y539
R
K
I
E
S
E
E
Y
E
E
A
L
S
L
A
Site 57
S544
E
E
Y
E
E
A
L
S
L
A
H
T
Y
G
L
Site 58
T548
E
A
L
S
L
A
H
T
Y
G
L
D
T
D
L
Site 59
Y549
A
L
S
L
A
H
T
Y
G
L
D
T
D
L
V
Site 60
T553
A
H
T
Y
G
L
D
T
D
L
V
Y
Q
R
Q
Site 61
Y557
G
L
D
T
D
L
V
Y
Q
R
Q
W
R
K
S
Site 62
S564
Y
Q
R
Q
W
R
K
S
A
V
N
V
A
S
I
Site 63
S570
K
S
A
V
N
V
A
S
I
Q
N
Y
L
S
K
Site 64
Y574
N
V
A
S
I
Q
N
Y
L
S
K
I
K
K
R
Site 65
S576
A
S
I
Q
N
Y
L
S
K
I
K
K
R
S
W
Site 66
Y605
A
A
K
E
L
L
Q
Y
G
L
K
G
T
D
L
Site 67
T628
G
A
D
D
G
R
F
T
L
P
G
E
I
D
I
Site 68
S637
P
G
E
I
D
I
D
S
I
S
Y
E
E
L
S
Site 69
S639
E
I
D
I
D
S
I
S
Y
E
E
L
S
P
P
Site 70
Y640
I
D
I
D
S
I
S
Y
E
E
L
S
P
P
D
Site 71
S644
S
I
S
Y
E
E
L
S
P
P
D
E
E
P
A
Site 72
T690
R
C
R
R
K
L
L
T
Y
L
D
R
L
A
T
Site 73
Y691
C
R
R
K
L
L
T
Y
L
D
R
L
A
T
Y
Site 74
Y712
P
H
A
S
E
Q
R
Y
D
A
E
F
F
K
K
Site 75
S728
R
N
Q
N
I
V
L
S
A
R
T
Y
A
Q
E
Site 76
Y732
I
V
L
S
A
R
T
Y
A
Q
E
S
N
V
Q
Site 77
S761
P
H
R
L
A
I
L
S
N
F
P
E
T
T
S
Site 78
T766
I
L
S
N
F
P
E
T
T
S
P
H
E
Y
S
Site 79
S768
S
N
F
P
E
T
T
S
P
H
E
Y
S
V
L
Site 80
Y772
E
T
T
S
P
H
E
Y
S
V
L
L
P
E
A
Site 81
S773
T
T
S
P
H
E
Y
S
V
L
L
P
E
A
C
Site 82
Y823
Q
D
E
S
E
F
L
Y
A
A
Q
P
E
L
L
Site 83
T835
E
L
L
R
F
R
M
T
Q
L
T
V
E
K
V
Site 84
T838
R
F
R
M
T
Q
L
T
V
E
K
V
M
D
W
Site 85
Y846
V
E
K
V
M
D
W
Y
Q
T
R
A
E
E
I
Site 86
Y856
R
A
E
E
I
E
H
Y
A
R
Q
V
D
C
A
Site 87
Y893
V
T
L
E
T
L
V
Y
E
A
R
C
D
V
T
Site 88
T900
Y
E
A
R
C
D
V
T
L
T
L
K
E
L
Q
Site 89
T902
A
R
C
D
V
T
L
T
L
K
E
L
Q
Q
M
Site 90
S921
K
L
R
L
L
M
N
S
C
S
E
D
K
Y
V
Site 91
S923
R
L
L
M
N
S
C
S
E
D
K
Y
V
T
S
Site 92
Y927
N
S
C
S
E
D
K
Y
V
T
S
A
Y
Q
W
Site 93
Y932
D
K
Y
V
T
S
A
Y
Q
W
M
V
P
F
L
Site 94
S946
L
H
R
C
E
K
Q
S
P
G
V
A
N
E
L
Site 95
Y1000
A
I
A
L
E
C
I
Y
T
C
E
R
N
D
Q
Site 96
T1001
I
A
L
E
C
I
Y
T
C
E
R
N
D
Q
L
Site 97
Y1023
E
C
L
P
E
R
G
Y
G
D
K
T
E
A
T
Site 98
T1027
E
R
G
Y
G
D
K
T
E
A
T
T
K
L
H
Site 99
S1045
D
Q
L
E
Q
I
L
S
V
S
E
L
L
E
K
Site 100
S1060
H
G
L
E
K
P
I
S
F
V
K
N
T
Q
S
Site 101
T1065
P
I
S
F
V
K
N
T
Q
S
S
S
E
E
A
Site 102
S1067
S
F
V
K
N
T
Q
S
S
S
E
E
A
R
K
Site 103
S1069
V
K
N
T
Q
S
S
S
E
E
A
R
K
L
M
Site 104
T1080
R
K
L
M
V
R
L
T
R
H
T
G
R
K
Q
Site 105
T1083
M
V
R
L
T
R
H
T
G
R
K
Q
P
P
V
Site 106
S1091
G
R
K
Q
P
P
V
S
E
S
H
W
R
T
L
Site 107
T1097
V
S
E
S
H
W
R
T
L
L
Q
D
M
L
T
Site 108
T1104
T
L
L
Q
D
M
L
T
M
Q
Q
N
V
Y
T
Site 109
Y1110
L
T
M
Q
Q
N
V
Y
T
C
L
D
S
D
A
Site 110
T1111
T
M
Q
Q
N
V
Y
T
C
L
D
S
D
A
C
Site 111
S1129
F
T
E
S
L
L
C
S
S
R
L
E
N
I
H
Site 112
Y1163
A
H
K
G
K
P
H
Y
R
V
S
Y
E
K
S
Site 113
S1166
G
K
P
H
Y
R
V
S
Y
E
K
S
I
D
L
Site 114
Y1167
K
P
H
Y
R
V
S
Y
E
K
S
I
D
L
V
Site 115
Y1181
V
L
A
A
S
R
E
Y
F
N
S
S
T
N
L
Site 116
S1184
A
S
R
E
Y
F
N
S
S
T
N
L
T
D
S
Site 117
S1185
S
R
E
Y
F
N
S
S
T
N
L
T
D
S
C
Site 118
T1189
F
N
S
S
T
N
L
T
D
S
C
M
D
L
A
Site 119
S1191
S
S
T
N
L
T
D
S
C
M
D
L
A
R
C
Site 120
T1204
R
C
C
L
Q
L
I
T
D
R
P
P
A
I
Q
Site 121
S1243
R
L
C
P
D
R
I
S
L
I
K
E
C
I
S
Site 122
S1250
S
L
I
K
E
C
I
S
Q
S
P
T
C
Y
K
Site 123
S1252
I
K
E
C
I
S
Q
S
P
T
C
Y
K
Q
S
Site 124
T1254
E
C
I
S
Q
S
P
T
C
Y
K
Q
S
T
K
Site 125
Y1297
Q
A
L
R
F
H
D
Y
K
A
A
S
M
H
C
Site 126
Y1312
Q
E
L
M
A
T
G
Y
P
K
S
W
D
V
C
Site 127
S1320
P
K
S
W
D
V
C
S
Q
L
G
Q
S
E
G
Site 128
T1333
E
G
Y
Q
D
L
A
T
R
Q
E
L
M
A
F
Site 129
Y1366
S
L
Q
T
E
I
L
Y
Q
R
V
N
F
Q
I
Site 130
S1382
H
E
G
G
E
N
I
S
A
S
P
L
T
S
K
Site 131
S1384
G
G
E
N
I
S
A
S
P
L
T
S
K
A
V
Site 132
S1388
I
S
A
S
P
L
T
S
K
A
V
Q
E
D
E
Site 133
S1401
D
E
V
G
V
P
G
S
N
S
A
D
L
L
R
Site 134
S1403
V
G
V
P
G
S
N
S
A
D
L
L
R
W
T
Site 135
T1410
S
A
D
L
L
R
W
T
T
A
T
T
M
K
V
Site 136
S1419
A
T
T
M
K
V
L
S
N
T
T
T
T
T
K
Site 137
T1423
K
V
L
S
N
T
T
T
T
T
K
A
V
L
Q
Site 138
T1443
Q
W
W
K
K
S
L
T
Y
L
R
P
L
Q
G
Site 139
Y1444
W
W
K
K
S
L
T
Y
L
R
P
L
Q
G
Q
Site 140
Y1476
K
Q
G
C
H
P
F
Y
E
S
V
I
S
N
P
Site 141
S1488
S
N
P
F
V
A
E
S
E
G
T
Y
D
T
Y
Site 142
T1491
F
V
A
E
S
E
G
T
Y
D
T
Y
Q
H
V
Site 143
Y1492
V
A
E
S
E
G
T
Y
D
T
Y
Q
H
V
P
Site 144
T1494
E
S
E
G
T
Y
D
T
Y
Q
H
V
P
V
E
Site 145
Y1495
S
E
G
T
Y
D
T
Y
Q
H
V
P
V
E
S
Site 146
S1565
N
R
C
F
E
K
Q
S
P
S
A
L
S
L
Q
Site 147
S1567
C
F
E
K
Q
S
P
S
A
L
S
L
Q
L
A
Site 148
S1570
K
Q
S
P
S
A
L
S
L
Q
L
A
A
Y
Y
Site 149
Y1598
R
D
K
C
H
P
L
Y
R
A
D
P
K
E
L
Site 150
S1627
A
W
P
E
D
L
I
S
L
T
K
Q
L
H
C
Site 151
Y1635
L
T
K
Q
L
H
C
Y
N
E
R
L
L
D
F
Site 152
T1643
N
E
R
L
L
D
F
T
Q
A
Q
I
L
Q
G
Site 153
T1661
G
V
D
V
Q
R
F
T
A
D
D
Q
Y
K
R
Site 154
Y1666
R
F
T
A
D
D
Q
Y
K
R
E
T
I
L
G
Site 155
T1670
D
D
Q
Y
K
R
E
T
I
L
G
L
A
E
T
Site 156
S1694
I
S
L
A
Q
R
Y
S
V
S
R
W
E
V
F
Site 157
T1716
F
T
D
S
G
L
S
T
L
E
I
E
N
R
A
Site 158
T1731
Q
D
L
H
L
F
E
T
L
K
T
D
P
E
A
Site 159
T1734
H
L
F
E
T
L
K
T
D
P
E
A
F
H
Q
Site 160
Y1746
F
H
Q
H
M
V
K
Y
I
Y
P
T
I
G
G
Site 161
Y1748
Q
H
M
V
K
Y
I
Y
P
T
I
G
G
F
D
Site 162
Y1761
F
D
H
E
R
L
Q
Y
Y
F
T
L
L
E
N
Site 163
Y1762
D
H
E
R
L
Q
Y
Y
F
T
L
L
E
N
C
Site 164
T1783
N
C
A
I
K
P
E
T
H
I
R
L
L
K
K
Site 165
T1804
G
L
N
Y
K
K
L
T
D
E
N
M
S
P
L
Site 166
S1809
K
L
T
D
E
N
M
S
P
L
E
A
L
E
P
Site 167
S1842
E
K
D
G
Q
M
L
S
P
S
S
L
Y
T
I
Site 168
S1869
L
I
K
Q
V
P
G
S
S
P
E
W
L
H
A
Site 169
S1870
I
K
Q
V
P
G
S
S
P
E
W
L
H
A
Y
Site 170
Y1883
A
Y
D
V
C
M
K
Y
F
D
R
L
H
P
G
Site 171
T1894
L
H
P
G
D
L
I
T
V
V
D
A
V
T
F
Site 172
S1910
P
K
A
V
T
K
L
S
V
E
A
R
K
E
M
Site 173
T1924
M
T
R
K
A
I
K
T
V
K
H
F
I
E
K
Site 174
S1937
E
K
P
R
K
R
N
S
E
D
E
A
Q
E
A
Site 175
Y1951
A
K
D
S
K
V
T
Y
A
D
T
L
N
H
L
Site 176
T1954
S
K
V
T
Y
A
D
T
L
N
H
L
E
K
S
Site 177
S1961
T
L
N
H
L
E
K
S
L
A
H
L
E
T
L
Site 178
S1971
H
L
E
T
L
S
H
S
F
I
L
S
L
K
N
Site 179
S1975
L
S
H
S
F
I
L
S
L
K
N
S
E
Q
E
Site 180
S1979
F
I
L
S
L
K
N
S
E
Q
E
T
L
Q
K
Site 181
T1983
L
K
N
S
E
Q
E
T
L
Q
K
Y
S
H
L
Site 182
Y1991
L
Q
K
Y
S
H
L
Y
D
L
S
R
S
E
K
Site 183
S1994
Y
S
H
L
Y
D
L
S
R
S
E
K
E
K
L
Site 184
S1996
H
L
Y
D
L
S
R
S
E
K
E
K
L
H
D
Site 185
S2052
I
S
A
L
S
G
G
S
A
D
L
G
G
P
R
Site 186
S2084
D
K
G
E
E
L
V
S
P
E
D
L
L
E
W
Site 187
S2116
V
L
Q
I
L
G
Q
S
F
H
L
T
E
E
D
Site 188
T2120
L
G
Q
S
F
H
L
T
E
E
D
S
K
L
L
Site 189
S2124
F
H
L
T
E
E
D
S
K
L
L
V
F
F
R
Site 190
Y2157
I
E
N
E
E
N
R
Y
C
L
F
M
E
L
L
Site 191
S2166
L
F
M
E
L
L
E
S
S
H
H
E
A
E
F
Site 192
T2209
T
V
M
L
T
R
C
T
M
E
N
K
E
G
L
Site 193
Y2228
L
K
M
C
R
S
L
Y
N
T
K
Q
M
L
P
Site 194
T2230
M
C
R
S
L
Y
N
T
K
Q
M
L
P
A
E
Site 195
S2262
S
L
K
L
L
L
E
S
R
D
E
H
L
H
E
Site 196
T2280
E
Q
I
T
A
V
T
T
V
N
D
S
N
C
D
Site 197
S2284
A
V
T
T
V
N
D
S
N
C
D
Q
E
L
L
Site 198
Y2309
K
C
V
S
T
P
F
Y
P
R
I
V
D
H
L
Site 199
S2319
I
V
D
H
L
L
A
S
L
Q
Q
G
R
W
D
Site 200
T2359
G
T
H
Q
A
F
R
T
F
S
T
A
L
R
A
Site 201
S2361
H
Q
A
F
R
T
F
S
T
A
L
R
A
A
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation