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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SEC63D1
Full Name:
Probable ATP-dependent DNA helicase HFM1
Alias:
FLJ36760; FLJ39011; HFM1, ATP-dependent DNA helicase; MER3; RP11-539G11.1; SEC63 domain containing 1; SEC63 domain-containing protein 1
Type:
Helicase; DNA binding protein; EC 3.6.1.-
Mass (Da):
162610
Number AA:
1435
UniProt ID:
A2PYH4
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0008026
GO:0003676
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
K
S
N
D
C
L
F
S
L
E
N
L
F
F
E
Site 2
S31
N
H
P
D
N
E
K
S
L
D
W
F
L
P
P
Site 3
S43
L
P
P
A
P
L
I
S
E
I
P
D
T
Q
E
Site 4
T48
L
I
S
E
I
P
D
T
Q
E
L
E
E
E
L
Site 5
T71
E
K
R
P
K
M
L
T
S
N
L
K
I
T
N
Site 6
T81
L
K
I
T
N
E
D
T
N
Y
I
S
L
T
Q
Site 7
Y83
I
T
N
E
D
T
N
Y
I
S
L
T
Q
K
F
Site 8
T87
D
T
N
Y
I
S
L
T
Q
K
F
Q
F
A
F
Site 9
S96
K
F
Q
F
A
F
P
S
D
K
Y
E
Q
D
D
Site 10
Y99
F
A
F
P
S
D
K
Y
E
Q
D
D
L
N
L
Site 11
S115
G
V
G
N
N
D
L
S
H
I
A
G
K
L
T
Site 12
T122
S
H
I
A
G
K
L
T
Y
A
S
Q
K
Y
K
Site 13
S125
A
G
K
L
T
Y
A
S
Q
K
Y
K
N
H
I
Site 14
Y128
L
T
Y
A
S
Q
K
Y
K
N
H
I
G
T
E
Site 15
S141
T
E
I
A
P
E
K
S
V
P
D
D
T
K
L
Site 16
T146
E
K
S
V
P
D
D
T
K
L
V
N
F
A
E
Site 17
S160
E
D
K
G
E
S
T
S
V
F
R
K
R
L
F
Site 18
S170
R
K
R
L
F
K
I
S
D
N
I
H
G
S
A
Site 19
S179
N
I
H
G
S
A
Y
S
N
D
N
E
L
D
S
Site 20
S186
S
N
D
N
E
L
D
S
H
I
G
S
V
K
I
Site 21
S190
E
L
D
S
H
I
G
S
V
K
I
V
Q
T
E
Site 22
S203
T
E
M
N
K
G
K
S
R
N
Y
S
N
S
K
Site 23
Y206
N
K
G
K
S
R
N
Y
S
N
S
K
Q
K
F
Site 24
S207
K
G
K
S
R
N
Y
S
N
S
K
Q
K
F
Q
Site 25
S209
K
S
R
N
Y
S
N
S
K
Q
K
F
Q
Y
S
Site 26
S216
S
K
Q
K
F
Q
Y
S
A
N
V
F
T
A
N
Site 27
S227
F
T
A
N
N
A
F
S
A
S
E
I
G
E
G
Site 28
S229
A
N
N
A
F
S
A
S
E
I
G
E
G
M
F
Site 29
S240
E
G
M
F
K
A
P
S
F
S
V
A
F
Q
P
Site 30
S242
M
F
K
A
P
S
F
S
V
A
F
Q
P
H
D
Site 31
T254
P
H
D
I
Q
E
V
T
E
N
G
L
G
S
L
Site 32
S273
E
I
P
A
K
F
R
S
I
F
K
E
F
P
Y
Site 33
Y280
S
I
F
K
E
F
P
Y
F
N
Y
I
Q
S
K
Site 34
Y283
K
E
F
P
Y
F
N
Y
I
Q
S
K
A
F
D
Site 35
Y294
K
A
F
D
D
L
L
Y
T
D
R
N
F
V
I
Site 36
S307
V
I
C
A
P
T
G
S
G
K
T
V
V
F
E
Site 37
S344
A
P
I
K
A
L
C
S
Q
R
F
D
D
W
K
Site 38
T368
C
K
E
L
T
G
D
T
V
M
D
D
L
F
E
Site 39
T385
H
A
H
I
I
M
T
T
P
E
K
W
D
S
M
Site 40
T393
P
E
K
W
D
S
M
T
R
K
W
R
D
N
S
Site 41
S400
T
R
K
W
R
D
N
S
L
V
Q
L
V
R
L
Site 42
T424
K
D
E
N
R
G
P
T
L
E
V
V
V
S
R
Site 43
S437
S
R
M
K
T
V
Q
S
V
S
Q
T
L
K
N
Site 44
S439
M
K
T
V
Q
S
V
S
Q
T
L
K
N
T
S
Site 45
T441
T
V
Q
S
V
S
Q
T
L
K
N
T
S
T
A
Site 46
S471
E
D
I
A
E
W
L
S
D
G
E
R
P
A
V
Site 47
S485
V
C
L
K
M
D
E
S
H
R
P
V
K
L
Q
Site 48
S501
V
V
L
G
F
P
C
S
S
N
Q
T
E
F
K
Site 49
T505
F
P
C
S
S
N
Q
T
E
F
K
F
D
L
T
Site 50
T512
T
E
F
K
F
D
L
T
L
N
Y
K
I
A
S
Site 51
S525
A
S
V
I
Q
M
Y
S
D
Q
K
P
T
L
V
Site 52
S545
K
G
V
Q
Q
A
A
S
V
L
V
K
D
A
K
Site 53
T556
K
D
A
K
F
I
M
T
V
E
Q
K
Q
R
L
Site 54
Y566
Q
K
Q
R
L
Q
K
Y
A
Y
S
V
R
D
S
Site 55
Y568
Q
R
L
Q
K
Y
A
Y
S
V
R
D
S
K
L
Site 56
S569
R
L
Q
K
Y
A
Y
S
V
R
D
S
K
L
R
Site 57
S573
Y
A
Y
S
V
R
D
S
K
L
R
D
I
L
K
Site 58
S593
H
H
A
G
M
E
L
S
D
R
K
V
V
E
G
Site 59
Y635
V
I
K
S
T
M
H
Y
A
G
G
L
F
E
E
Site 60
Y643
A
G
G
L
F
E
E
Y
S
E
T
D
I
L
Q
Site 61
S644
G
G
L
F
E
E
Y
S
E
T
D
I
L
Q
M
Site 62
T646
L
F
E
E
Y
S
E
T
D
I
L
Q
M
I
G
Site 63
S673
A
V
I
M
T
R
L
S
T
R
D
K
Y
I
Q
Site 64
T674
V
I
M
T
R
L
S
T
R
D
K
Y
I
Q
M
Site 65
Y678
R
L
S
T
R
D
K
Y
I
Q
M
L
A
C
R
Site 66
T687
Q
M
L
A
C
R
D
T
V
E
S
S
L
H
R
Site 67
S690
A
C
R
D
T
V
E
S
S
L
H
R
H
L
I
Site 68
S691
C
R
D
T
V
E
S
S
L
H
R
H
L
I
E
Site 69
Y725
W
I
R
S
T
L
L
Y
I
R
A
L
K
N
P
Site 70
Y735
A
L
K
N
P
S
H
Y
G
F
A
S
G
L
N
Site 71
S762
L
K
N
L
N
D
L
S
S
L
D
L
I
K
M
Site 72
S763
K
N
L
N
D
L
S
S
L
D
L
I
K
M
D
Site 73
T778
E
G
V
N
F
K
P
T
E
A
G
R
L
M
A
Site 74
Y788
G
R
L
M
A
W
Y
Y
I
T
F
E
T
V
K
Site 75
Y798
F
E
T
V
K
K
F
Y
T
I
S
G
K
E
T
Site 76
T799
E
T
V
K
K
F
Y
T
I
S
G
K
E
T
L
Site 77
S801
V
K
K
F
Y
T
I
S
G
K
E
T
L
S
D
Site 78
T831
L
R
I
N
E
K
K
T
L
N
T
L
N
K
D
Site 79
T843
N
K
D
P
N
R
I
T
I
R
F
P
M
E
G
Site 80
T854
P
M
E
G
R
I
K
T
R
E
M
K
V
N
C
Site 81
T881
D
F
A
L
T
Q
D
T
A
K
I
F
R
H
G
Site 82
S889
A
K
I
F
R
H
G
S
R
I
T
R
W
L
S
Site 83
T892
F
R
H
G
S
R
I
T
R
W
L
S
D
F
V
Site 84
S896
S
R
I
T
R
W
L
S
D
F
V
A
A
Q
E
Site 85
S927
R
C
K
L
W
E
N
S
L
H
V
S
K
Q
L
Site 86
S931
W
E
N
S
L
H
V
S
K
Q
L
E
K
I
G
Site 87
S952
I
V
N
A
G
L
T
S
F
K
K
I
E
E
T
Site 88
T959
S
F
K
K
I
E
E
T
D
A
R
E
L
E
L
Site 89
T981
F
G
T
Q
I
K
E
T
V
M
Y
L
P
K
Y
Site 90
Y984
Q
I
K
E
T
V
M
Y
L
P
K
Y
E
L
K
Site 91
Y988
T
V
M
Y
L
P
K
Y
E
L
K
V
E
Q
I
Site 92
S999
V
E
Q
I
T
R
Y
S
D
T
T
A
E
I
L
Site 93
T1019
R
N
F
E
Q
L
Q
T
K
R
T
A
S
D
S
Site 94
T1022
E
Q
L
Q
T
K
R
T
A
S
D
S
H
Y
V
Site 95
S1024
L
Q
T
K
R
T
A
S
D
S
H
Y
V
T
L
Site 96
S1026
T
K
R
T
A
S
D
S
H
Y
V
T
L
I
I
Site 97
Y1028
R
T
A
S
D
S
H
Y
V
T
L
I
I
G
D
Site 98
Y1042
D
A
D
N
Q
V
V
Y
L
H
K
I
T
D
S
Site 99
S1069
A
V
K
R
A
L
K
S
E
D
L
S
I
N
L
Site 100
S1073
A
L
K
S
E
D
L
S
I
N
L
I
S
S
E
Site 101
T1091
L
D
I
Q
Q
K
L
T
V
F
Y
L
E
P
K
Site 102
Y1094
Q
Q
K
L
T
V
F
Y
L
E
P
K
R
F
G
Site 103
T1105
K
R
F
G
N
Q
I
T
M
Q
R
K
S
E
T
Site 104
S1110
Q
I
T
M
Q
R
K
S
E
T
Q
I
S
H
S
Site 105
T1112
T
M
Q
R
K
S
E
T
Q
I
S
H
S
K
H
Site 106
S1115
R
K
S
E
T
Q
I
S
H
S
K
H
S
D
I
Site 107
S1117
S
E
T
Q
I
S
H
S
K
H
S
D
I
S
T
Site 108
S1120
Q
I
S
H
S
K
H
S
D
I
S
T
I
A
G
Site 109
S1123
H
S
K
H
S
D
I
S
T
I
A
G
P
N
K
Site 110
T1124
S
K
H
S
D
I
S
T
I
A
G
P
N
K
G
Site 111
T1132
I
A
G
P
N
K
G
T
T
A
S
K
K
P
G
Site 112
T1133
A
G
P
N
K
G
T
T
A
S
K
K
P
G
N
Site 113
S1135
P
N
K
G
T
T
A
S
K
K
P
G
N
R
E
Site 114
S1166
K
I
G
V
A
Q
K
S
E
I
K
E
S
T
I
Site 115
S1171
Q
K
S
E
I
K
E
S
T
I
S
S
Y
L
S
Site 116
T1172
K
S
E
I
K
E
S
T
I
S
S
Y
L
S
D
Site 117
S1174
E
I
K
E
S
T
I
S
S
Y
L
S
D
L
R
Site 118
S1175
I
K
E
S
T
I
S
S
Y
L
S
D
L
R
N
Site 119
S1178
S
T
I
S
S
Y
L
S
D
L
R
N
R
N
A
Site 120
S1188
R
N
R
N
A
V
S
S
V
P
P
V
K
R
L
Site 121
S1202
L
K
I
Q
M
N
K
S
Q
S
V
D
L
K
E
Site 122
T1213
D
L
K
E
F
G
F
T
P
K
P
S
L
P
S
Site 123
S1217
F
G
F
T
P
K
P
S
L
P
S
I
S
R
S
Site 124
S1220
T
P
K
P
S
L
P
S
I
S
R
S
E
Y
L
Site 125
S1222
K
P
S
L
P
S
I
S
R
S
E
Y
L
N
I
Site 126
S1224
S
L
P
S
I
S
R
S
E
Y
L
N
I
S
E
Site 127
Y1226
P
S
I
S
R
S
E
Y
L
N
I
S
E
L
P
Site 128
S1230
R
S
E
Y
L
N
I
S
E
L
P
I
M
E
Q
Site 129
Y1254
V
R
Q
E
P
S
E
Y
Q
D
K
E
V
L
N
Site 130
S1283
D
E
N
L
E
V
T
S
F
S
T
D
T
E
K
Site 131
T1299
K
I
S
G
F
G
N
T
L
S
S
S
T
R
G
Site 132
S1301
S
G
F
G
N
T
L
S
S
S
T
R
G
S
K
Site 133
S1302
G
F
G
N
T
L
S
S
S
T
R
G
S
K
L
Site 134
S1303
F
G
N
T
L
S
S
S
T
R
G
S
K
L
P
Site 135
S1307
L
S
S
S
T
R
G
S
K
L
P
L
Q
E
S
Site 136
S1314
S
K
L
P
L
Q
E
S
K
S
K
F
Q
R
E
Site 137
S1316
L
P
L
Q
E
S
K
S
K
F
Q
R
E
M
S
Site 138
S1323
S
K
F
Q
R
E
M
S
N
S
F
V
S
S
H
Site 139
S1325
F
Q
R
E
M
S
N
S
F
V
S
S
H
E
M
Site 140
S1329
M
S
N
S
F
V
S
S
H
E
M
S
D
I
S
Site 141
S1333
F
V
S
S
H
E
M
S
D
I
S
L
S
N
S
Site 142
S1336
S
H
E
M
S
D
I
S
L
S
N
S
A
M
P
Site 143
S1338
E
M
S
D
I
S
L
S
N
S
A
M
P
K
F
Site 144
S1340
S
D
I
S
L
S
N
S
A
M
P
K
F
S
A
Site 145
S1346
N
S
A
M
P
K
F
S
A
S
S
M
T
K
L
Site 146
S1348
A
M
P
K
F
S
A
S
S
M
T
K
L
P
Q
Site 147
S1374
E
R
K
P
Q
N
L
S
P
E
I
E
K
Q
C
Site 148
T1383
E
I
E
K
Q
C
F
T
F
S
E
K
N
P
N
Site 149
S1385
E
K
Q
C
F
T
F
S
E
K
N
P
N
S
S
Site 150
S1391
F
S
E
K
N
P
N
S
S
N
Y
K
K
V
D
Site 151
S1392
S
E
K
N
P
N
S
S
N
Y
K
K
V
D
F
Site 152
S1404
V
D
F
F
I
R
N
S
E
C
K
K
E
V
D
Site 153
Y1415
K
E
V
D
F
S
M
Y
H
P
D
D
E
A
D
Site 154
S1426
D
E
A
D
E
M
K
S
L
L
G
I
F
D
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation