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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PTPDC1
Full Name:
Protein tyrosine phosphatase domain-containing protein 1
Alias:
Type:
Mass (Da):
84457
Number AA:
754
UniProt ID:
A2A3K4
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S14
P
Q
N
E
Q
P
Y
S
T
L
V
N
N
S
E
Site 2
T34
K
G
N
L
E
R
P
T
P
K
Y
T
K
V
G
Site 3
Y37
L
E
R
P
T
P
K
Y
T
K
V
G
E
R
L
Site 4
Y65
C
G
G
R
A
C
K
Y
E
N
P
A
R
W
S
Site 5
S72
Y
E
N
P
A
R
W
S
E
Q
E
Q
A
I
K
Site 6
S97
I
L
A
M
A
R
P
S
S
E
L
L
E
K
Y
Site 7
S98
L
A
M
A
R
P
S
S
E
L
L
E
K
Y
H
Site 8
Y104
S
S
E
L
L
E
K
Y
H
I
I
D
Q
F
L
Site 9
S129
Q
R
P
G
E
H
A
S
C
G
N
P
L
E
Q
Site 10
T141
L
E
Q
E
S
G
F
T
Y
L
P
E
A
F
M
Site 11
Y142
E
Q
E
S
G
F
T
Y
L
P
E
A
F
M
E
Site 12
Y162
Y
N
F
G
W
K
D
Y
G
V
A
S
L
T
T
Site 13
S227
V
R
A
K
R
P
N
S
I
Q
T
R
G
Q
L
Site 14
T245
R
E
F
T
Q
F
L
T
P
L
R
N
I
F
S
Site 15
Y266
H
A
V
T
L
P
Q
Y
L
I
R
Q
R
H
L
Site 16
Y277
Q
R
H
L
L
H
G
Y
E
A
R
L
L
K
H
Site 17
S311
P
V
M
M
K
D
V
S
E
G
P
G
L
S
A
Site 18
S317
V
S
E
G
P
G
L
S
A
E
I
E
K
T
M
Site 19
S325
A
E
I
E
K
T
M
S
E
M
V
T
M
Q
L
Site 20
S341
K
E
L
L
R
H
D
S
D
V
S
N
P
P
N
Site 21
S344
L
R
H
D
S
D
V
S
N
P
P
N
P
T
A
Site 22
T385
V
E
C
L
Q
P
L
T
H
L
K
R
R
L
S
Site 23
S392
T
H
L
K
R
R
L
S
Y
S
D
S
D
L
K
Site 24
Y393
H
L
K
R
R
L
S
Y
S
D
S
D
L
K
R
Site 25
S394
L
K
R
R
L
S
Y
S
D
S
D
L
K
R
A
Site 26
S396
R
R
L
S
Y
S
D
S
D
L
K
R
A
E
N
Site 27
T410
N
L
L
E
Q
G
E
T
P
Q
T
V
P
A
Q
Site 28
T413
E
Q
G
E
T
P
Q
T
V
P
A
Q
I
L
V
Site 29
S431
P
R
Q
Q
K
L
I
S
H
C
Y
I
P
Q
S
Site 30
Y434
Q
K
L
I
S
H
C
Y
I
P
Q
S
P
E
P
Site 31
S438
S
H
C
Y
I
P
Q
S
P
E
P
D
L
H
K
Site 32
T452
K
E
A
L
V
R
S
T
L
S
F
W
S
Q
S
Site 33
S454
A
L
V
R
S
T
L
S
F
W
S
Q
S
K
F
Site 34
S457
R
S
T
L
S
F
W
S
Q
S
K
F
G
G
L
Site 35
S459
T
L
S
F
W
S
Q
S
K
F
G
G
L
E
G
Site 36
S472
E
G
L
K
D
N
G
S
P
I
F
H
G
R
I
Site 37
S487
I
P
K
E
A
Q
Q
S
G
A
F
S
A
D
V
Site 38
S491
A
Q
Q
S
G
A
F
S
A
D
V
S
G
S
H
Site 39
S495
G
A
F
S
A
D
V
S
G
S
H
S
P
G
E
Site 40
S497
F
S
A
D
V
S
G
S
H
S
P
G
E
P
V
Site 41
S499
A
D
V
S
G
S
H
S
P
G
E
P
V
S
P
Site 42
S505
H
S
P
G
E
P
V
S
P
S
F
A
N
V
H
Site 43
S507
P
G
E
P
V
S
P
S
F
A
N
V
H
K
D
Site 44
T529
V
S
H
C
Q
C
K
T
H
G
V
G
S
P
G
Site 45
S534
C
K
T
H
G
V
G
S
P
G
S
V
R
Q
N
Site 46
S537
H
G
V
G
S
P
G
S
V
R
Q
N
S
R
T
Site 47
S542
P
G
S
V
R
Q
N
S
R
T
P
R
S
P
L
Site 48
T544
S
V
R
Q
N
S
R
T
P
R
S
P
L
D
C
Site 49
S547
Q
N
S
R
T
P
R
S
P
L
D
C
G
S
S
Site 50
S553
R
S
P
L
D
C
G
S
S
P
K
A
Q
F
L
Site 51
S554
S
P
L
D
C
G
S
S
P
K
A
Q
F
L
V
Site 52
S568
V
E
H
E
T
Q
D
S
K
D
L
S
E
A
A
Site 53
S572
T
Q
D
S
K
D
L
S
E
A
A
S
H
S
A
Site 54
S576
K
D
L
S
E
A
A
S
H
S
A
L
Q
S
E
Site 55
S578
L
S
E
A
A
S
H
S
A
L
Q
S
E
L
S
Site 56
S582
A
S
H
S
A
L
Q
S
E
L
S
A
E
A
R
Site 57
S585
S
A
L
Q
S
E
L
S
A
E
A
R
R
I
L
Site 58
S603
A
L
A
N
L
N
E
S
V
E
K
E
E
L
K
Site 59
T656
Q
L
K
E
P
V
I
T
K
E
D
V
D
M
L
Site 60
S721
F
T
K
V
N
F
D
S
E
N
G
P
T
V
Y
Site 61
T726
F
D
S
E
N
G
P
T
V
Y
N
T
L
K
K
Site 62
Y728
S
E
N
G
P
T
V
Y
N
T
L
K
K
I
F
Site 63
T730
N
G
P
T
V
Y
N
T
L
K
K
I
F
K
H
Site 64
T746
L
E
E
K
R
K
M
T
K
D
G
P
K
P
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation