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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ARHGAP10
Full Name:
Rho GTPase-activating protein 10
Alias:
FLJ20896; FLJ41791; GRAF2; Graf-related protein 2; GTPase regulator associated with focal adhesion kinase 2; RHG10; Rho GTPase activating protein 10; Rho-type GTPase-activating protein 10
Type:
Guanine nucleotide exchange factor, Rac/Rho
Mass (Da):
89356
Number AA:
786
UniProt ID:
A1A4S6
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0048471
GO:0005886
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
G
L
Q
P
L
E
F
S
D
C
Y
L
D
S
P
Site 2
Y12
P
L
E
F
S
D
C
Y
L
D
S
P
W
F
R
Site 3
T32
H
E
A
E
L
E
R
T
N
K
F
I
K
E
L
Site 4
S52
N
L
I
A
A
T
K
S
L
S
V
A
Q
R
K
Site 5
S63
A
Q
R
K
F
A
H
S
L
R
D
F
K
F
E
Site 6
T77
E
F
I
G
D
A
V
T
D
D
E
R
C
I
D
Site 7
S86
D
E
R
C
I
D
A
S
L
R
E
F
S
N
F
Site 8
S91
D
A
S
L
R
E
F
S
N
F
L
K
N
L
E
Site 9
T109
E
I
M
A
L
S
V
T
E
T
L
I
K
P
L
Site 10
T111
M
A
L
S
V
T
E
T
L
I
K
P
L
E
K
Site 11
T138
K
K
K
F
D
K
E
T
E
K
N
Y
S
L
I
Site 12
S143
K
E
T
E
K
N
Y
S
L
I
D
K
H
L
N
Site 13
S152
I
D
K
H
L
N
L
S
A
K
K
K
D
S
H
Site 14
S178
R
Q
H
F
Y
E
L
S
L
E
Y
V
C
K
L
Site 15
S244
N
R
F
E
G
T
R
S
E
V
E
E
L
M
N
Site 16
S264
P
K
D
H
K
R
A
S
Q
F
T
A
E
G
Y
Site 17
T267
H
K
R
A
S
Q
F
T
A
E
G
Y
L
Y
V
Site 18
Y271
S
Q
F
T
A
E
G
Y
L
Y
V
Q
E
K
R
Site 19
Y273
F
T
A
E
G
Y
L
Y
V
Q
E
K
R
P
A
Site 20
S309
M
I
P
F
E
H
R
S
G
G
K
L
G
D
G
Site 21
T329
K
E
C
T
K
R
H
T
D
S
I
D
R
R
F
Site 22
T351
D
R
P
G
V
S
L
T
M
Q
A
F
S
E
E
Site 23
S356
S
L
T
M
Q
A
F
S
E
E
E
R
K
Q
W
Site 24
S374
L
G
G
K
E
A
L
S
H
S
F
N
T
A
I
Site 25
S376
G
K
E
A
L
S
H
S
F
N
T
A
I
I
P
Site 26
Y417
G
I
N
D
Q
G
L
Y
R
V
V
G
V
S
S
Site 27
S431
S
K
V
Q
R
L
L
S
M
L
M
D
V
K
T
Site 28
T438
S
M
L
M
D
V
K
T
C
N
E
V
D
L
E
Site 29
T454
S
A
D
W
E
V
K
T
I
T
S
A
L
K
Q
Site 30
Y462
I
T
S
A
L
K
Q
Y
L
R
S
L
P
E
P
Site 31
S465
A
L
K
Q
Y
L
R
S
L
P
E
P
L
M
T
Site 32
T472
S
L
P
E
P
L
M
T
Y
E
L
H
G
D
F
Site 33
S485
D
F
I
V
P
A
K
S
G
S
P
E
S
R
V
Site 34
S487
I
V
P
A
K
S
G
S
P
E
S
R
V
N
A
Site 35
S490
A
K
S
G
S
P
E
S
R
V
N
A
I
H
F
Site 36
T518
D
I
L
V
K
H
L
T
N
V
S
N
H
S
K
Site 37
T576
N
H
E
K
I
F
R
T
P
P
D
T
T
F
P
Site 38
T580
I
F
R
T
P
P
D
T
T
F
P
E
P
T
C
Site 39
T581
F
R
T
P
P
D
T
T
F
P
E
P
T
C
L
Site 40
T586
D
T
T
F
P
E
P
T
C
L
S
A
S
P
P
Site 41
S589
F
P
E
P
T
C
L
S
A
S
P
P
N
A
P
Site 42
S591
E
P
T
C
L
S
A
S
P
P
N
A
P
P
R
Site 43
S600
P
N
A
P
P
R
Q
S
K
R
Q
G
Q
R
T
Site 44
T607
S
K
R
Q
G
Q
R
T
K
R
P
V
A
V
Y
Site 45
Y627
L
E
D
G
D
N
P
Y
P
S
K
E
D
T
P
Site 46
S629
D
G
D
N
P
Y
P
S
K
E
D
T
P
T
S
Site 47
T633
P
Y
P
S
K
E
D
T
P
T
S
S
L
D
S
Site 48
T635
P
S
K
E
D
T
P
T
S
S
L
D
S
L
S
Site 49
S636
S
K
E
D
T
P
T
S
S
L
D
S
L
S
S
Site 50
S637
K
E
D
T
P
T
S
S
L
D
S
L
S
S
P
Site 51
S640
T
P
T
S
S
L
D
S
L
S
S
P
S
P
V
Site 52
S642
T
S
S
L
D
S
L
S
S
P
S
P
V
T
T
Site 53
S643
S
S
L
D
S
L
S
S
P
S
P
V
T
T
A
Site 54
T648
L
S
S
P
S
P
V
T
T
A
V
P
G
P
P
Site 55
T649
S
S
P
S
P
V
T
T
A
V
P
G
P
P
G
Site 56
S668
H
L
L
A
D
G
G
S
F
G
D
W
A
S
T
Site 57
S674
G
S
F
G
D
W
A
S
T
I
P
G
Q
T
R
Site 58
T675
S
F
G
D
W
A
S
T
I
P
G
Q
T
R
S
Site 59
S682
T
I
P
G
Q
T
R
S
S
M
V
Q
W
L
N
Site 60
S683
I
P
G
Q
T
R
S
S
M
V
Q
W
L
N
P
Site 61
S692
V
Q
W
L
N
P
Q
S
P
T
T
T
S
S
N
Site 62
T694
W
L
N
P
Q
S
P
T
T
T
S
S
N
S
A
Site 63
T695
L
N
P
Q
S
P
T
T
T
S
S
N
S
A
V
Site 64
T696
N
P
Q
S
P
T
T
T
S
S
N
S
A
V
T
Site 65
S698
Q
S
P
T
T
T
S
S
N
S
A
V
T
P
L
Site 66
S700
P
T
T
T
S
S
N
S
A
V
T
P
L
S
P
Site 67
T703
T
S
S
N
S
A
V
T
P
L
S
P
G
S
S
Site 68
S706
N
S
A
V
T
P
L
S
P
G
S
S
P
F
P
Site 69
S709
V
T
P
L
S
P
G
S
S
P
F
P
F
S
P
Site 70
S710
T
P
L
S
P
G
S
S
P
F
P
F
S
P
P
Site 71
S715
G
S
S
P
F
P
F
S
P
P
A
T
V
A
D
Site 72
T719
F
P
F
S
P
P
A
T
V
A
D
K
P
P
E
Site 73
S727
V
A
D
K
P
P
E
S
I
R
S
R
K
A
R
Site 74
Y737
S
R
K
A
R
A
V
Y
P
C
E
A
E
H
S
Site 75
S744
Y
P
C
E
A
E
H
S
S
E
L
S
F
E
I
Site 76
T760
A
I
F
E
D
V
Q
T
S
R
E
P
G
W
L
Site 77
S761
I
F
E
D
V
Q
T
S
R
E
P
G
W
L
E
Site 78
T770
E
P
G
W
L
E
G
T
L
N
G
K
R
G
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation