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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
E2F8
Full Name:
Transcription factor E2F8
Alias:
E2F family member 8; E2F transcription factor 8; E2F-8; FLJ23311
Type:
Transcription protein
Mass (Da):
94166
Number AA:
867
UniProt ID:
A0AVK6
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005667
Uniprot
OncoNet
Molecular Function:
GO:0003700
PhosphoSite+
KinaseNET
Biological Process:
GO:0007049
GO:0006355
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T20
H
K
R
G
L
M
K
T
P
L
K
E
S
T
T
Site 2
T43
Q
P
D
F
G
P
L
T
T
P
T
K
P
K
E
Site 3
T44
P
D
F
G
P
L
T
T
P
T
K
P
K
E
G
Site 4
T46
F
G
P
L
T
T
P
T
K
P
K
E
G
S
Q
Site 5
S52
P
T
K
P
K
E
G
S
Q
G
E
P
W
T
P
Site 6
T58
G
S
Q
G
E
P
W
T
P
T
A
N
L
K
M
Site 7
S71
K
M
L
I
S
A
V
S
P
E
I
R
N
R
D
Site 8
S88
R
G
L
F
D
N
R
S
G
L
P
E
A
K
D
Site 9
S102
D
C
I
H
E
H
L
S
G
D
E
F
E
K
S
Site 10
S109
S
G
D
E
F
E
K
S
Q
P
S
R
K
E
K
Site 11
S112
E
F
E
K
S
Q
P
S
R
K
E
K
S
L
G
Site 12
S117
Q
P
S
R
K
E
K
S
L
G
L
L
C
H
K
Site 13
Y129
C
H
K
F
L
A
R
Y
P
N
Y
P
N
P
A
Site 14
Y132
F
L
A
R
Y
P
N
Y
P
N
P
A
V
N
N
Site 15
Y158
N
V
E
R
R
R
I
Y
D
I
V
N
V
L
E
Site 16
Y178
S
R
L
A
K
N
R
Y
T
W
H
G
R
H
N
Site 17
T189
G
R
H
N
L
N
K
T
L
G
T
L
K
S
I
Site 18
S195
K
T
L
G
T
L
K
S
I
G
E
E
N
K
Y
Site 19
Y202
S
I
G
E
E
N
K
Y
A
E
Q
I
M
M
I
Site 20
S257
G
V
E
F
R
A
A
S
V
N
S
R
K
D
K
Site 21
S265
V
N
S
R
K
D
K
S
L
R
V
M
S
Q
K
Site 22
S306
H
V
E
D
L
D
K
S
K
F
K
T
K
I
R
Site 23
T310
L
D
K
S
K
F
K
T
K
I
R
R
L
Y
D
Site 24
Y316
K
T
K
I
R
R
L
Y
D
I
A
N
V
L
S
Site 25
S351
K
W
T
G
P
E
I
S
P
N
T
S
G
S
S
Site 26
T354
G
P
E
I
S
P
N
T
S
G
S
S
P
V
I
Site 27
S355
P
E
I
S
P
N
T
S
G
S
S
P
V
I
H
Site 28
S357
I
S
P
N
T
S
G
S
S
P
V
I
H
F
T
Site 29
S358
S
P
N
T
S
G
S
S
P
V
I
H
F
T
P
Site 30
T364
S
S
P
V
I
H
F
T
P
S
D
L
E
V
R
Site 31
S366
P
V
I
H
F
T
P
S
D
L
E
V
R
R
S
Site 32
S373
S
D
L
E
V
R
R
S
S
K
E
N
C
A
K
Site 33
S374
D
L
E
V
R
R
S
S
K
E
N
C
A
K
N
Site 34
S384
N
C
A
K
N
L
F
S
T
R
G
K
P
N
F
Site 35
T392
T
R
G
K
P
N
F
T
R
H
P
S
L
I
K
Site 36
S396
P
N
F
T
R
H
P
S
L
I
K
L
V
K
S
Site 37
S403
S
L
I
K
L
V
K
S
I
E
S
D
R
R
K
Site 38
S406
K
L
V
K
S
I
E
S
D
R
R
K
I
N
S
Site 39
S413
S
D
R
R
K
I
N
S
A
P
S
S
P
I
K
Site 40
S417
K
I
N
S
A
P
S
S
P
I
K
T
N
K
A
Site 41
T421
A
P
S
S
P
I
K
T
N
K
A
E
S
S
Q
Site 42
S427
K
T
N
K
A
E
S
S
Q
N
S
A
P
F
P
Site 43
S430
K
A
E
S
S
Q
N
S
A
P
F
P
S
K
M
Site 44
S453
M
Q
L
E
E
Q
S
S
E
S
R
Q
K
V
K
Site 45
S520
P
Q
A
P
S
G
P
S
Y
A
I
Y
L
Q
P
Site 46
Y521
Q
A
P
S
G
P
S
Y
A
I
Y
L
Q
P
T
Site 47
Y524
S
G
P
S
Y
A
I
Y
L
Q
P
T
Q
A
H
Site 48
S533
Q
P
T
Q
A
H
Q
S
V
T
P
P
Q
G
L
Site 49
T535
T
Q
A
H
Q
S
V
T
P
P
Q
G
L
S
P
Site 50
S541
V
T
P
P
Q
G
L
S
P
T
V
C
T
T
H
Site 51
T543
P
P
Q
G
L
S
P
T
V
C
T
T
H
S
S
Site 52
S549
P
T
V
C
T
T
H
S
S
K
A
T
G
S
K
Site 53
T553
T
T
H
S
S
K
A
T
G
S
K
D
S
T
D
Site 54
S555
H
S
S
K
A
T
G
S
K
D
S
T
D
A
T
Site 55
T559
A
T
G
S
K
D
S
T
D
A
T
T
E
K
A
Site 56
T562
S
K
D
S
T
D
A
T
T
E
K
A
A
N
D
Site 57
S571
E
K
A
A
N
D
T
S
K
A
S
A
S
T
R
Site 58
S574
A
N
D
T
S
K
A
S
A
S
T
R
P
G
S
Site 59
S576
D
T
S
K
A
S
A
S
T
R
P
G
S
L
L
Site 60
S581
S
A
S
T
R
P
G
S
L
L
P
A
P
E
R
Site 61
S593
P
E
R
Q
G
A
K
S
R
T
R
E
P
A
G
Site 62
T595
R
Q
G
A
K
S
R
T
R
E
P
A
G
E
R
Site 63
S604
E
P
A
G
E
R
G
S
K
R
A
S
M
L
E
Site 64
S608
E
R
G
S
K
R
A
S
M
L
E
D
S
G
S
Site 65
S613
R
A
S
M
L
E
D
S
G
S
K
K
K
F
K
Site 66
S615
S
M
L
E
D
S
G
S
K
K
K
F
K
E
D
Site 67
S655
L
G
A
E
S
I
L
S
G
K
E
N
S
S
A
Site 68
S660
I
L
S
G
K
E
N
S
S
A
L
S
P
N
H
Site 69
S661
L
S
G
K
E
N
S
S
A
L
S
P
N
H
R
Site 70
S664
K
E
N
S
S
A
L
S
P
N
H
R
I
Y
S
Site 71
Y670
L
S
P
N
H
R
I
Y
S
S
P
I
A
G
V
Site 72
S671
S
P
N
H
R
I
Y
S
S
P
I
A
G
V
I
Site 73
S672
P
N
H
R
I
Y
S
S
P
I
A
G
V
I
P
Site 74
S720
G
N
S
P
A
L
A
S
S
H
P
V
P
I
Q
Site 75
S721
N
S
P
A
L
A
S
S
H
P
V
P
I
Q
N
Site 76
S767
P
V
S
P
R
I
E
S
V
N
V
A
P
E
N
Site 77
T777
V
A
P
E
N
A
G
T
Q
Q
G
R
A
T
N
Site 78
T783
G
T
Q
Q
G
R
A
T
N
Y
D
S
P
V
P
Site 79
Y785
Q
Q
G
R
A
T
N
Y
D
S
P
V
P
G
Q
Site 80
S787
G
R
A
T
N
Y
D
S
P
V
P
G
Q
S
Q
Site 81
S793
D
S
P
V
P
G
Q
S
Q
P
N
G
Q
S
V
Site 82
S799
Q
S
Q
P
N
G
Q
S
V
A
V
T
G
A
Q
Site 83
T803
N
G
Q
S
V
A
V
T
G
A
Q
Q
P
V
P
Site 84
T812
A
Q
Q
P
V
P
V
T
P
K
G
S
Q
L
V
Site 85
S822
G
S
Q
L
V
A
E
S
F
F
R
T
P
G
G
Site 86
T826
V
A
E
S
F
F
R
T
P
G
G
P
T
K
P
Site 87
T831
F
R
T
P
G
G
P
T
K
P
T
S
S
S
C
Site 88
T834
P
G
G
P
T
K
P
T
S
S
S
C
M
D
F
Site 89
S835
G
G
P
T
K
P
T
S
S
S
C
M
D
F
E
Site 90
S836
G
P
T
K
P
T
S
S
S
C
M
D
F
E
G
Site 91
S837
P
T
K
P
T
S
S
S
C
M
D
F
E
G
A
Site 92
S862
P
Q
R
K
L
E
V
S
T
E
D
V
H
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation