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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DNMT3A
All Species:
31.82
Human Site:
S638
Identified Species:
87.5
UniProt:
Q9Y6K1
Number Species:
8
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9Y6K1
NP_072046.2
912
101858
S638
R
K
P
I
R
V
L
S
L
F
D
G
I
A
T
Chimpanzee
Pan troglodytes
XP_001148246
909
101579
S635
R
K
P
I
R
V
L
S
L
F
D
G
I
A
T
Rhesus Macaque
Macaca mulatta
XP_001083234
910
101709
S635
R
K
P
I
R
V
L
S
L
F
D
G
I
A
T
Dog
Lupus familis
XP_540110
969
107941
S695
R
K
P
I
R
V
L
S
L
F
D
G
I
A
T
Cat
Felis silvestris
Mouse
Mus musculus
O88508
908
101653
S634
R
K
P
I
R
V
L
S
L
F
D
G
I
A
T
Rat
Rattus norvegicus
Q1LZ53
908
101650
S634
R
K
P
I
R
V
L
S
L
F
D
G
I
A
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509081
815
90155
S541
R
K
P
I
R
V
L
S
L
F
D
G
I
A
T
Chicken
Gallus gallus
Q4W5Z4
877
98926
S603
R
K
P
I
R
V
L
S
L
F
D
G
I
A
T
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001018150
731
82962
I487
S
E
V
C
E
D
S
I
T
V
G
I
V
R
H
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
98.7
90.8
N.A.
95.9
95.7
N.A.
51.7
82.2
N.A.
65.9
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
99.4
99.1
91.6
N.A.
96.8
96.7
N.A.
61.1
86.4
N.A.
72.9
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
100
100
N.A.
0
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
100
100
N.A.
13.3
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
0
89
0
% A
% Cys:
0
0
0
12
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
12
0
0
0
0
89
0
0
0
0
% D
% Glu:
0
12
0
0
12
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
89
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
12
89
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
12
% H
% Ile:
0
0
0
89
0
0
0
12
0
0
0
12
89
0
0
% I
% Lys:
0
89
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
0
0
0
89
0
89
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
89
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
89
0
0
0
89
0
0
0
0
0
0
0
0
12
0
% R
% Ser:
12
0
0
0
0
0
12
89
0
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
12
0
0
0
0
0
89
% T
% Val:
0
0
12
0
0
89
0
0
0
12
0
0
12
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _