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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SIRT4
All Species:
5.45
Human Site:
Y138
Identified Species:
10
UniProt:
Q9Y6E7
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9Y6E7
NP_036372.1
314
35188
Y138
W
E
K
L
G
K
L
Y
W
L
V
T
Q
N
V
Chimpanzee
Pan troglodytes
XP_001160214
314
35188
Y138
W
E
K
L
G
K
L
Y
W
L
V
T
Q
N
V
Rhesus Macaque
Macaca mulatta
XP_001115744
165
18788
Dog
Lupus familis
XP_863164
312
34885
V139
L
G
K
L
Y
W
L
V
T
Q
N
V
D
A
L
Cat
Felis silvestris
Mouse
Mus musculus
Q8R216
333
37536
V138
L
G
K
L
H
W
L
V
T
Q
N
V
D
A
L
Rat
Rattus norvegicus
NP_001100617
311
35126
V138
L
G
K
L
H
W
L
V
T
Q
N
V
D
A
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001517990
321
35140
A137
L
V
T
Q
N
V
D
A
L
H
T
K
A
G
N
Chicken
Gallus gallus
XP_415273
512
56313
H336
W
E
K
L
G
K
L
H
W
L
V
T
Q
N
V
Frog
Xenopus laevis
NP_001084634
322
36258
H137
W
E
R
A
G
R
L
H
W
L
V
T
Q
N
V
Zebra Danio
Brachydanio rerio
NP_001005988
310
34078
V137
K
G
K
L
H
W
L
V
T
Q
N
V
D
A
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_572241
312
34972
R138
V
V
T
Q
N
V
D
R
L
H
T
K
A
G
S
Honey Bee
Apis mellifera
XP_623654
302
34567
K137
N
V
D
N
L
H
T
K
A
G
S
K
K
V
I
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_793816
295
33325
S134
A
L
H
T
K
A
G
S
R
C
L
T
E
L
H
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
51.2
84
N.A.
80.7
84.3
N.A.
71
45.7
61.1
59.8
N.A.
47.7
45.5
N.A.
56.3
Protein Similarity:
100
99.6
51.5
91.4
N.A.
86.1
90.4
N.A.
80.3
51.9
76
73.8
N.A.
67.1
63
N.A.
71
P-Site Identity:
100
100
0
20
N.A.
20
20
N.A.
0
93.3
73.3
20
N.A.
0
0
N.A.
6.6
P-Site Similarity:
100
100
0
26.6
N.A.
26.6
26.6
N.A.
0
100
93.3
26.6
N.A.
0
13.3
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
8
0
8
0
8
8
0
0
0
16
31
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% C
% Asp:
0
0
8
0
0
0
16
0
0
0
0
0
31
0
0
% D
% Glu:
0
31
0
0
0
0
0
0
0
0
0
0
8
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
31
0
0
31
0
8
0
0
8
0
0
0
16
0
% G
% His:
0
0
8
0
24
8
0
16
0
16
0
0
0
0
8
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% I
% Lys:
8
0
54
0
8
24
0
8
0
0
0
24
8
0
0
% K
% Leu:
31
8
0
54
8
0
62
0
16
31
8
0
0
8
31
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
8
0
0
8
16
0
0
0
0
0
31
0
0
31
8
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
16
0
0
0
0
0
31
0
0
31
0
0
% Q
% Arg:
0
0
8
0
0
8
0
8
8
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
0
0
0
8
0
0
8
0
0
0
8
% S
% Thr:
0
0
16
8
0
0
8
0
31
0
16
39
0
0
0
% T
% Val:
8
24
0
0
0
16
0
31
0
0
31
31
0
8
31
% V
% Trp:
31
0
0
0
0
31
0
0
31
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
8
0
0
16
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _