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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SIRT4
All Species:
17.27
Human Site:
T274
Identified Species:
31.67
UniProt:
Q9Y6E7
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.25
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9Y6E7
NP_036372.1
314
35188
T274
S
G
Y
R
F
I
L
T
A
W
E
K
K
L
P
Chimpanzee
Pan troglodytes
XP_001160214
314
35188
T274
S
G
Y
R
F
I
L
T
A
W
E
K
K
L
P
Rhesus Macaque
Macaca mulatta
XP_001115744
165
18788
W131
A
H
W
A
L
S
T
W
E
K
L
G
K
L
Y
Dog
Lupus familis
XP_863164
312
34885
T272
S
G
Y
R
F
I
L
T
A
R
E
K
Q
L
P
Cat
Felis silvestris
Mouse
Mus musculus
Q8R216
333
37536
T271
S
G
Y
R
F
I
L
T
A
R
E
Q
K
L
P
Rat
Rattus norvegicus
NP_001100617
311
35126
T271
S
G
Y
R
F
I
L
T
A
R
E
K
K
L
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001517990
321
35140
A264
S
G
Y
R
F
I
L
A
A
H
E
K
K
L
P
Chicken
Gallus gallus
XP_415273
512
56313
A472
S
G
Y
R
F
A
L
A
A
R
E
K
Q
L
P
Frog
Xenopus laevis
NP_001084634
322
36258
K273
S
G
Y
R
F
A
L
K
A
Q
E
L
H
L
P
Zebra Danio
Brachydanio rerio
NP_001005988
310
34078
A270
S
G
Y
R
F
L
L
A
A
S
E
R
K
L
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_572241
312
34972
Q265
S
G
Y
R
V
V
L
Q
T
K
D
L
K
L
P
Honey Bee
Apis mellifera
XP_623654
302
34567
K266
L
Q
A
N
N
I
G
K
P
I
A
I
L
N
I
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_793816
295
33325
K261
H
T
A
W
Q
Q
K
K
P
I
A
I
V
N
I
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
51.2
84
N.A.
80.7
84.3
N.A.
71
45.7
61.1
59.8
N.A.
47.7
45.5
N.A.
56.3
Protein Similarity:
100
99.6
51.5
91.4
N.A.
86.1
90.4
N.A.
80.3
51.9
76
73.8
N.A.
67.1
63
N.A.
71
P-Site Identity:
100
100
13.3
86.6
N.A.
86.6
93.3
N.A.
86.6
73.3
66.6
73.3
N.A.
53.3
6.6
N.A.
0
P-Site Similarity:
100
100
26.6
93.3
N.A.
93.3
93.3
N.A.
86.6
80
66.6
86.6
N.A.
66.6
6.6
N.A.
0
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
16
8
0
16
0
24
70
0
16
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
8
0
70
0
0
0
0
% E
% Phe:
0
0
0
0
70
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
77
0
0
0
0
8
0
0
0
0
8
0
0
0
% G
% His:
8
8
0
0
0
0
0
0
0
8
0
0
8
0
0
% H
% Ile:
0
0
0
0
0
54
0
0
0
16
0
16
0
0
16
% I
% Lys:
0
0
0
0
0
0
8
24
0
16
0
47
62
0
0
% K
% Leu:
8
0
0
0
8
8
77
0
0
0
8
16
8
85
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
8
8
0
0
0
0
0
0
0
0
16
0
% N
% Pro:
0
0
0
0
0
0
0
0
16
0
0
0
0
0
77
% P
% Gln:
0
8
0
0
8
8
0
8
0
8
0
8
16
0
0
% Q
% Arg:
0
0
0
77
0
0
0
0
0
31
0
8
0
0
0
% R
% Ser:
77
0
0
0
0
8
0
0
0
8
0
0
0
0
0
% S
% Thr:
0
8
0
0
0
0
8
39
8
0
0
0
0
0
0
% T
% Val:
0
0
0
0
8
8
0
0
0
0
0
0
8
0
0
% V
% Trp:
0
0
8
8
0
0
0
8
0
16
0
0
0
0
0
% W
% Tyr:
0
0
77
0
0
0
0
0
0
0
0
0
0
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _