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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SIRT4
All Species:
21.52
Human Site:
T191
Identified Species:
39.44
UniProt:
Q9Y6E7
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9Y6E7
NP_036372.1
314
35188
T191
R
F
Q
V
L
N
P
T
W
S
A
E
A
H
G
Chimpanzee
Pan troglodytes
XP_001160214
314
35188
T191
R
F
Q
V
L
N
P
T
W
S
A
E
A
H
G
Rhesus Macaque
Macaca mulatta
XP_001115744
165
18788
S54
L
Q
R
F
I
T
L
S
K
R
L
L
V
M
T
Dog
Lupus familis
XP_863164
312
34885
T189
R
F
E
A
L
N
P
T
W
S
A
E
A
H
G
Cat
Felis silvestris
Mouse
Mus musculus
Q8R216
333
37536
S188
R
F
Q
A
L
N
P
S
W
S
A
E
A
Q
G
Rat
Rattus norvegicus
NP_001100617
311
35126
S188
R
F
Q
A
L
N
P
S
W
S
A
E
A
Q
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001517990
321
35140
R187
P
G
W
T
A
E
A
R
G
A
A
P
D
G
D
Chicken
Gallus gallus
XP_415273
512
56313
G389
H
F
E
A
L
N
P
G
W
K
A
E
A
L
G
Frog
Xenopus laevis
NP_001084634
322
36258
S190
R
F
L
I
L
N
P
S
W
N
E
Q
A
H
G
Zebra Danio
Brachydanio rerio
NP_001005988
310
34078
G187
R
F
T
A
L
N
P
G
W
E
A
T
A
C
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_572241
312
34972
D188
P
A
F
K
D
A
P
D
M
I
R
P
D
G
D
Honey Bee
Apis mellifera
XP_623654
302
34567
D188
T
S
Q
M
I
R
P
D
G
D
V
E
L
T
Q
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_793816
295
33325
G184
E
Y
A
A
A
P
D
G
D
V
I
L
P
E
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
51.2
84
N.A.
80.7
84.3
N.A.
71
45.7
61.1
59.8
N.A.
47.7
45.5
N.A.
56.3
Protein Similarity:
100
99.6
51.5
91.4
N.A.
86.1
90.4
N.A.
80.3
51.9
76
73.8
N.A.
67.1
63
N.A.
71
P-Site Identity:
100
100
0
86.6
N.A.
80
80
N.A.
6.6
60
60
53.3
N.A.
6.6
20
N.A.
0
P-Site Similarity:
100
100
20
93.3
N.A.
86.6
86.6
N.A.
13.3
66.6
86.6
53.3
N.A.
6.6
33.3
N.A.
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
8
47
16
8
8
0
0
8
62
0
62
0
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% C
% Asp:
0
0
0
0
8
0
8
16
8
8
0
0
16
0
16
% D
% Glu:
8
0
16
0
0
8
0
0
0
8
8
54
0
8
8
% E
% Phe:
0
62
8
8
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
8
0
0
0
0
0
24
16
0
0
0
0
16
54
% G
% His:
8
0
0
0
0
0
0
0
0
0
0
0
0
31
0
% H
% Ile:
0
0
0
8
16
0
0
0
0
8
8
0
0
0
0
% I
% Lys:
0
0
0
8
0
0
0
0
8
8
0
0
0
0
0
% K
% Leu:
8
0
8
0
62
0
8
0
0
0
8
16
8
8
0
% L
% Met:
0
0
0
8
0
0
0
0
8
0
0
0
0
8
0
% M
% Asn:
0
0
0
0
0
62
0
0
0
8
0
0
0
0
0
% N
% Pro:
16
0
0
0
0
8
77
0
0
0
0
16
8
0
0
% P
% Gln:
0
8
39
0
0
0
0
0
0
0
0
8
0
16
8
% Q
% Arg:
54
0
8
0
0
8
0
8
0
8
8
0
0
0
0
% R
% Ser:
0
8
0
0
0
0
0
31
0
39
0
0
0
0
0
% S
% Thr:
8
0
8
8
0
8
0
24
0
0
0
8
0
8
8
% T
% Val:
0
0
0
16
0
0
0
0
0
8
8
0
8
0
0
% V
% Trp:
0
0
8
0
0
0
0
0
62
0
0
0
0
0
0
% W
% Tyr:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _