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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SIRT4
All Species:
12.12
Human Site:
T158
Identified Species:
22.22
UniProt:
Q9Y6E7
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9Y6E7
NP_036372.1
314
35188
T158
K
A
G
S
R
R
L
T
E
L
H
G
C
M
D
Chimpanzee
Pan troglodytes
XP_001160214
314
35188
T158
K
A
G
S
R
R
L
T
E
L
H
G
C
M
D
Rhesus Macaque
Macaca mulatta
XP_001115744
165
18788
C24
I
A
N
P
S
W
Q
C
S
K
A
S
I
G
L
Dog
Lupus familis
XP_863164
312
34885
H159
S
Q
R
L
T
E
L
H
G
C
M
H
R
V
L
Cat
Felis silvestris
Mouse
Mus musculus
Q8R216
333
37536
H158
S
Q
R
L
T
E
L
H
G
C
M
H
R
V
L
Rat
Rattus norvegicus
NP_001100617
311
35126
H158
N
Q
R
L
T
E
L
H
G
C
M
H
R
V
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001517990
321
35140
V157
L
H
G
C
M
H
R
V
L
C
L
G
C
G
E
Chicken
Gallus gallus
XP_415273
512
56313
T356
K
A
G
S
Q
R
M
T
E
L
H
G
C
T
H
Frog
Xenopus laevis
NP_001084634
322
36258
S157
K
A
G
Q
C
R
L
S
E
L
H
G
C
T
H
Zebra Danio
Brachydanio rerio
NP_001005988
310
34078
H157
Q
Q
R
L
T
E
L
H
G
S
T
H
R
V
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_572241
312
34972
V158
V
H
G
S
G
Y
V
V
K
C
L
S
C
E
Y
Honey Bee
Apis mellifera
XP_623654
302
34567
N157
A
F
R
V
M
C
L
N
C
N
E
R
I
C
R
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_793816
295
33325
T154
I
I
C
M
N
C
K
T
L
T
S
R
N
A
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
51.2
84
N.A.
80.7
84.3
N.A.
71
45.7
61.1
59.8
N.A.
47.7
45.5
N.A.
56.3
Protein Similarity:
100
99.6
51.5
91.4
N.A.
86.1
90.4
N.A.
80.3
51.9
76
73.8
N.A.
67.1
63
N.A.
71
P-Site Identity:
100
100
6.6
6.6
N.A.
6.6
6.6
N.A.
20
73.3
66.6
6.6
N.A.
20
6.6
N.A.
6.6
P-Site Similarity:
100
100
6.6
13.3
N.A.
13.3
13.3
N.A.
26.6
86.6
73.3
20
N.A.
33.3
6.6
N.A.
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
39
0
0
0
0
0
0
0
0
8
0
0
8
0
% A
% Cys:
0
0
8
8
8
16
0
8
8
39
0
0
47
8
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
16
% D
% Glu:
0
0
0
0
0
31
0
0
31
0
8
0
0
8
8
% E
% Phe:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
47
0
8
0
0
0
31
0
0
39
0
16
0
% G
% His:
0
16
0
0
0
8
0
31
0
0
31
31
0
0
16
% H
% Ile:
16
8
0
0
0
0
0
0
0
0
0
0
16
0
0
% I
% Lys:
31
0
0
0
0
0
8
0
8
8
0
0
0
0
0
% K
% Leu:
8
0
0
31
0
0
62
0
16
31
16
0
0
0
39
% L
% Met:
0
0
0
8
16
0
8
0
0
0
24
0
0
16
0
% M
% Asn:
8
0
8
0
8
0
0
8
0
8
0
0
8
0
0
% N
% Pro:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
8
31
0
8
8
0
8
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
39
0
16
31
8
0
0
0
0
16
31
0
8
% R
% Ser:
16
0
0
31
8
0
0
8
8
8
8
16
0
0
0
% S
% Thr:
0
0
0
0
31
0
0
31
0
8
8
0
0
16
0
% T
% Val:
8
0
0
8
0
0
8
16
0
0
0
0
0
31
8
% V
% Trp:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _