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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SIRT4
All Species:
25.15
Human Site:
S255
Identified Species:
46.11
UniProt:
Q9Y6E7
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9Y6E7
NP_036372.1
314
35188
S255
K
R
V
K
E
A
D
S
L
L
V
V
G
S
S
Chimpanzee
Pan troglodytes
XP_001160214
314
35188
S255
K
R
V
K
E
A
D
S
L
L
V
V
G
S
S
Rhesus Macaque
Macaca mulatta
XP_001115744
165
18788
G112
Y
W
A
R
N
F
V
G
W
P
Q
F
S
S
H
Dog
Lupus familis
XP_863164
312
34885
S253
R
R
V
K
E
A
D
S
L
L
V
V
G
S
S
Cat
Felis silvestris
Mouse
Mus musculus
Q8R216
333
37536
S252
R
R
V
K
E
A
D
S
L
L
V
V
G
S
S
Rat
Rattus norvegicus
NP_001100617
311
35126
S252
Q
R
V
K
E
A
D
S
L
L
V
V
G
S
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001517990
321
35140
A245
E
R
V
R
E
A
D
A
V
L
V
V
G
S
S
Chicken
Gallus gallus
XP_415273
512
56313
S453
Q
R
L
A
E
S
D
S
M
L
V
A
G
S
S
Frog
Xenopus laevis
NP_001084634
322
36258
A254
E
Q
M
N
Q
A
D
A
V
L
V
V
G
S
S
Zebra Danio
Brachydanio rerio
NP_001005988
310
34078
A251
N
K
L
A
E
S
D
A
V
L
V
A
G
S
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_572241
312
34972
G246
G
M
V
Y
N
S
D
G
L
L
V
L
G
S
S
Honey Bee
Apis mellifera
XP_623654
302
34567
T247
D
S
L
L
I
I
G
T
T
L
T
T
F
S
S
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_793816
295
33325
S242
D
S
V
L
V
I
G
S
S
L
E
V
Y
S
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
51.2
84
N.A.
80.7
84.3
N.A.
71
45.7
61.1
59.8
N.A.
47.7
45.5
N.A.
56.3
Protein Similarity:
100
99.6
51.5
91.4
N.A.
86.1
90.4
N.A.
80.3
51.9
76
73.8
N.A.
67.1
63
N.A.
71
P-Site Identity:
100
100
6.6
93.3
N.A.
93.3
93.3
N.A.
73.3
60
53.3
46.6
N.A.
53.3
20
N.A.
33.3
P-Site Similarity:
100
100
13.3
100
N.A.
100
100
N.A.
100
86.6
93.3
80
N.A.
66.6
33.3
N.A.
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
16
0
54
0
24
0
0
0
16
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
16
0
0
0
0
0
77
0
0
0
0
0
0
0
0
% D
% Glu:
16
0
0
0
62
0
0
0
0
0
8
0
0
0
0
% E
% Phe:
0
0
0
0
0
8
0
0
0
0
0
8
8
0
0
% F
% Gly:
8
0
0
0
0
0
16
16
0
0
0
0
77
0
8
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% H
% Ile:
0
0
0
0
8
16
0
0
0
0
0
0
0
0
0
% I
% Lys:
16
8
0
39
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
24
16
0
0
0
0
47
93
0
8
0
0
0
% L
% Met:
0
8
8
0
0
0
0
0
8
0
0
0
0
0
0
% M
% Asn:
8
0
0
8
16
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% P
% Gln:
16
8
0
0
8
0
0
0
0
0
8
0
0
0
0
% Q
% Arg:
16
54
0
16
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
16
0
0
0
24
0
54
8
0
0
0
8
100
85
% S
% Thr:
0
0
0
0
0
0
0
8
8
0
8
8
0
0
0
% T
% Val:
0
0
62
0
8
0
8
0
24
0
77
62
0
0
0
% V
% Trp:
0
8
0
0
0
0
0
0
8
0
0
0
0
0
0
% W
% Tyr:
8
0
0
8
0
0
0
0
0
0
0
0
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _