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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SIRT4
All Species:
26.67
Human Site:
S208
Identified Species:
48.89
UniProt:
Q9Y6E7
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9Y6E7
NP_036372.1
314
35188
S208
P
D
G
D
V
F
L
S
E
E
Q
V
R
S
F
Chimpanzee
Pan troglodytes
XP_001160214
314
35188
S208
P
D
G
D
V
F
L
S
E
E
Q
V
R
S
F
Rhesus Macaque
Macaca mulatta
XP_001115744
165
18788
I71
G
I
S
T
E
S
G
I
P
D
Y
R
S
E
K
Dog
Lupus familis
XP_863164
312
34885
T206
P
D
G
D
V
F
L
T
E
E
Q
V
Q
S
F
Cat
Felis silvestris
Mouse
Mus musculus
Q8R216
333
37536
T205
P
D
G
D
V
F
L
T
E
E
Q
V
R
S
F
Rat
Rattus norvegicus
NP_001100617
311
35126
T205
P
D
G
D
V
F
L
T
E
E
Q
V
R
S
F
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001517990
321
35140
G204
L
A
E
E
E
V
R
G
F
R
V
A
P
C
G
Chicken
Gallus gallus
XP_415273
512
56313
T406
P
D
G
D
A
F
L
T
D
E
Q
V
R
N
F
Frog
Xenopus laevis
NP_001084634
322
36258
T207
P
D
G
D
V
F
L
T
D
E
Q
V
A
N
F
Zebra Danio
Brachydanio rerio
NP_001005988
310
34078
E204
P
D
G
D
V
F
L
E
E
E
Q
V
L
N
F
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_572241
312
34972
N205
I
P
L
E
Y
I
E
N
F
R
I
P
E
C
T
Honey Bee
Apis mellifera
XP_623654
302
34567
I205
V
E
E
F
K
V
P
I
C
E
K
C
D
G
I
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_793816
295
33325
C201
T
Q
F
Q
V
P
S
C
E
S
C
G
G
L
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
51.2
84
N.A.
80.7
84.3
N.A.
71
45.7
61.1
59.8
N.A.
47.7
45.5
N.A.
56.3
Protein Similarity:
100
99.6
51.5
91.4
N.A.
86.1
90.4
N.A.
80.3
51.9
76
73.8
N.A.
67.1
63
N.A.
71
P-Site Identity:
100
100
0
86.6
N.A.
93.3
93.3
N.A.
0
73.3
73.3
80
N.A.
0
6.6
N.A.
13.3
P-Site Similarity:
100
100
6.6
100
N.A.
100
100
N.A.
6.6
93.3
93.3
86.6
N.A.
13.3
20
N.A.
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
0
8
0
0
0
0
0
0
8
8
0
0
% A
% Cys:
0
0
0
0
0
0
0
8
8
0
8
8
0
16
0
% C
% Asp:
0
62
0
62
0
0
0
0
16
8
0
0
8
0
0
% D
% Glu:
0
8
16
16
16
0
8
8
54
70
0
0
8
8
0
% E
% Phe:
0
0
8
8
0
62
0
0
16
0
0
0
0
0
62
% F
% Gly:
8
0
62
0
0
0
8
8
0
0
0
8
8
8
8
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
8
8
0
0
0
8
0
16
0
0
8
0
0
0
8
% I
% Lys:
0
0
0
0
8
0
0
0
0
0
8
0
0
0
8
% K
% Leu:
8
0
8
0
0
0
62
0
0
0
0
0
8
8
8
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
8
0
0
0
0
0
24
0
% N
% Pro:
62
8
0
0
0
8
8
0
8
0
0
8
8
0
0
% P
% Gln:
0
8
0
8
0
0
0
0
0
0
62
0
8
0
0
% Q
% Arg:
0
0
0
0
0
0
8
0
0
16
0
8
39
0
0
% R
% Ser:
0
0
8
0
0
8
8
16
0
8
0
0
8
39
0
% S
% Thr:
8
0
0
8
0
0
0
39
0
0
0
0
0
0
8
% T
% Val:
8
0
0
0
62
16
0
0
0
0
8
62
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
8
0
0
0
0
0
8
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _