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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PTCH2
All Species:
10.91
Human Site:
Y749
Identified Species:
30
UniProt:
Q9Y6C5
Number Species:
8
Phosphosite Substitution
Charge Score:
0.13
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9Y6C5
NP_003729.3
1203
130544
Y749
V
T
Q
G
G
F
D
Y
A
H
S
Q
R
A
L
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001111868
801
89943
L377
I
R
V
A
S
G
Y
L
L
M
L
A
Y
A
C
Dog
Lupus familis
XP_539636
1126
122022
L696
V
L
V
L
F
G
A
L
L
G
L
S
L
Y
G
Cat
Felis silvestris
Mouse
Mus musculus
O35595
1182
128568
Y749
V
T
Q
G
G
F
D
Y
A
H
S
Q
R
A
L
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q90693
1442
160559
P812
V
T
Q
K
A
D
Y
P
N
V
Q
H
L
L
Y
Frog
Xenopus laevis
NP_001081438
1413
157355
Y793
V
T
K
D
G
F
D
Y
P
K
A
Q
E
S
L
Zebra Danio
Brachydanio rerio
Q98864
1220
135526
M792
K
Y
F
S
F
Y
N
M
Y
L
V
T
M
D
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P18502
1286
142812
Y743
V
T
Q
G
N
F
E
Y
P
T
Q
Q
Q
L
L
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q09614
1408
155799
D967
V
I
K
G
P
N
I
D
Y
A
H
Q
Q
R
Q
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
36
87.3
N.A.
89.4
N.A.
N.A.
N.A.
47.7
58.2
64.4
N.A.
35.9
N.A.
27.2
N.A.
Protein Similarity:
100
N.A.
49.3
89.9
N.A.
93
N.A.
N.A.
N.A.
62.6
70.4
77.5
N.A.
55.2
N.A.
43.3
N.A.
P-Site Identity:
100
N.A.
6.6
6.6
N.A.
100
N.A.
N.A.
N.A.
20
53.3
0
N.A.
53.3
N.A.
20
N.A.
P-Site Similarity:
100
N.A.
13.3
6.6
N.A.
100
N.A.
N.A.
N.A.
20
73.3
13.3
N.A.
66.6
N.A.
33.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
12
12
0
12
0
23
12
12
12
0
34
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
12
% C
% Asp:
0
0
0
12
0
12
34
12
0
0
0
0
0
12
0
% D
% Glu:
0
0
0
0
0
0
12
0
0
0
0
0
12
0
0
% E
% Phe:
0
0
12
0
23
45
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
45
34
23
0
0
0
12
0
0
0
0
23
% G
% His:
0
0
0
0
0
0
0
0
0
23
12
12
0
0
0
% H
% Ile:
12
12
0
0
0
0
12
0
0
0
0
0
0
0
0
% I
% Lys:
12
0
23
12
0
0
0
0
0
12
0
0
0
0
0
% K
% Leu:
0
12
0
12
0
0
0
23
23
12
23
0
23
23
45
% L
% Met:
0
0
0
0
0
0
0
12
0
12
0
0
12
0
0
% M
% Asn:
0
0
0
0
12
12
12
0
12
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
12
0
0
12
23
0
0
0
0
0
0
% P
% Gln:
0
0
45
0
0
0
0
0
0
0
23
56
23
0
12
% Q
% Arg:
0
12
0
0
0
0
0
0
0
0
0
0
23
12
0
% R
% Ser:
0
0
0
12
12
0
0
0
0
0
23
12
0
12
0
% S
% Thr:
0
56
0
0
0
0
0
0
0
12
0
12
0
0
0
% T
% Val:
78
0
23
0
0
0
0
0
0
12
12
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
12
0
0
0
12
23
45
23
0
0
0
12
12
12
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _