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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PTCH2 All Species: 21.52
Human Site: Y247 Identified Species: 59.17
UniProt: Q9Y6C5 Number Species: 8
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9Y6C5 NP_003729.3 1203 130544 Y247 K A Q V G Q A Y V G R P C L H
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001111868 801 89943
Dog Lupus familis XP_539636 1126 122022 L237 S L E G F R E L L D K A Q V G
Cat Felis silvestris
Mouse Mus musculus O35595 1182 128568 Y247 K A Q V G Q A Y V G R P C L D
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus Q90693 1442 160559 Y291 K A E V G H G Y M D R P C L N
Frog Xenopus laevis NP_001081438 1413 157355 Y272 K A E V G Q A Y M E R P C L D
Zebra Danio Brachydanio rerio Q98864 1220 135526 Y274 K A Q V G H A Y M N R P C L D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P18502 1286 142812 Y277 R A A I G S G Y M E K P C L N
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q09614 1408 155799 Y361 R A G V S H G Y M D R P C I D
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 36 87.3 N.A. 89.4 N.A. N.A. N.A. 47.7 58.2 64.4 N.A. 35.9 N.A. 27.2 N.A.
Protein Similarity: 100 N.A. 49.3 89.9 N.A. 93 N.A. N.A. N.A. 62.6 70.4 77.5 N.A. 55.2 N.A. 43.3 N.A.
P-Site Identity: 100 N.A. 0 0 N.A. 93.3 N.A. N.A. N.A. 60 73.3 73.3 N.A. 40 N.A. 40 N.A.
P-Site Similarity: 100 N.A. 0 33.3 N.A. 93.3 N.A. N.A. N.A. 80 86.6 80 N.A. 73.3 N.A. 60 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 78 12 0 0 0 45 0 0 0 0 12 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 78 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 34 0 0 0 0 45 % D
% Glu: 0 0 34 0 0 0 12 0 0 23 0 0 0 0 0 % E
% Phe: 0 0 0 0 12 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 12 12 67 0 34 0 0 23 0 0 0 0 12 % G
% His: 0 0 0 0 0 34 0 0 0 0 0 0 0 0 12 % H
% Ile: 0 0 0 12 0 0 0 0 0 0 0 0 0 12 0 % I
% Lys: 56 0 0 0 0 0 0 0 0 0 23 0 0 0 0 % K
% Leu: 0 12 0 0 0 0 0 12 12 0 0 0 0 67 0 % L
% Met: 0 0 0 0 0 0 0 0 56 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 12 0 0 0 0 23 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 78 0 0 0 % P
% Gln: 0 0 34 0 0 34 0 0 0 0 0 0 12 0 0 % Q
% Arg: 23 0 0 0 0 12 0 0 0 0 67 0 0 0 0 % R
% Ser: 12 0 0 0 12 12 0 0 0 0 0 0 0 0 0 % S
% Thr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % T
% Val: 0 0 0 67 0 0 0 0 23 0 0 0 0 12 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 78 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _